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The David H. Smith Center for Vaccine Biology and Immunology (CVBI) has a rich and varied association with several other Centers and Groups at the University of Rochester Medical Center.

Logo for NY Influenza Center of ExcellenceNYICE is a multidisciplinary, multi-institutional, center that emphasizes basic and clinical research on human influenza surveillance, pathogenesis, and host responses to infection and vaccination. Research in the NYICE focuses on clinical studies of influenza infection and vaccination in partnership with immunologists, virologists, and computational biologists. The focus of our center is on the fundamental question of why immune protection from influenza often fails, even in individuals who have generated an apparently robust immune response following infection or vaccination.

Photo of leaders of the Program for Advanced Immune BiologyThe objective of this Program Project is to bring together scientific expertise in migration and effector function to address fundamental effector T cell processes in infected tissues using cutting-edge intra-vital imaging approaches. When effector T cells enter the inflamed tissue they encounter a tissue environment that has been differentially altered depending on the type of pathogen and corresponding inflammation. The ability of T cells sense and interpret different inflammatory environments and the impact on effective pathogen clearance are poorly understood.

Photo of researchers on Rochester Human Immunology CenterThe Rochester Human Immunology Center (RHIC) within the David H. Smith Center for Vaccine Biology and Immunology has been established to acquire, refine and develop expertise in cutting-edge techniques and to support applications in Human Immunology research. The RHIC is designed with capabilities to enhance multi-disciplinary research initiatives catalyzing key clinical and basic immunology research in vaccines, HIV/AIDS, autoimmunity, allergy/asthma, transplantation and cancer immunology as well as clinical translational studies.

The Respiratory Pathogens Research Center (RPRC) was created to develop new insight, tools, and strategies in order to decrease the significant global health burden caused by viruses and bacteria that take aim at the respiratory system.  These pathogens cause pneumonia and flu, as well as other infections caused by lesser-known but still-deadly microbes such as coronaviruses, metapneumoviruses, parainfluenza viruses, and respiratory syncytial virus, as well as a host of bacteria.