What is a bone biopsy?
A biopsy is a procedure to remove tissue or cells from the body to be looked at under
a microscope. A bone biopsy is a procedure in which bone samples are removed (with
a special biopsy needle or during surgery) to find out if cancer or other abnormal
cells are present. A bone biopsy involves the outer layers of bone, unlike a bone
marrow biopsy, which involves the innermost part of the bone.
There are 2 types of biopsy:
Needle biopsy. After a local anesthetic is given, your healthcare provider makes a small cut (incision)
in your skin. He or she inserts the special biopsy needle into your bone to get a
Open biopsy. After a general anesthetic is given, your healthcare provider makes a larger incision
in your skin and surgically removes a piece of bone. Depending on the lab findings,
you may need more surgery.
Other related procedures that may be used to help diagnose bone problems include CT
scan, X-ray, MRI of the bones, and bone scan.
Why might I need a bone biopsy?
Bone biopsies may be done to:
Evaluate bone pain or tenderness
Investigate an abnormality seen on X-ray
Find out if a bone tumor is cancer (malignant) or not cancer (benign)
Find the cause of an unexplained infection or inflammation
Your healthcare provider may have other reasons to recommend a bone biopsy.
What are the risks of a bone biopsy?
As with any surgical procedure, complications can happen. Some possible complications
Bruising and discomfort at the biopsy site
Prolonged bleeding from the biopsy site
Infection near the biopsy site or in the bone
Other risks may exist, depending on your specific health condition. Be sure to discuss
any concerns with your healthcare provider before the procedure.
How do I get ready for a bone biopsy?
Your healthcare provider will explain the procedure to you. This is the time to ask
any questions that you might have about the procedure.
You will be asked to sign a consent form that gives your permission to do the procedure.
Read the form carefully and ask questions if something is not clear.
In addition to a complete health history, your healthcare provider may do a complete
physical exam. This is to make sure you are in good health before undergoing the procedure.
You may have blood tests or other diagnostic tests.
Tell your healthcare provider if you are allergic to any medicines, latex, tape, or
anesthesia (local and general).
Tell your healthcare provider about all medicines you take. This includes prescribed
and over-the-counter medicines, and herbal supplements.
Tell your healthcare provider if you have a history of bleeding disorders, or if you
take any blood-thinner (anticoagulant) medicines, aspirin, or other medicines that
affect blood clotting. You may need to stop taking these medicines before the procedure.
If you are pregnant or think you could be, tell your healthcare provider.
You may be asked to fast for 8 hours before the procedure, generally starting at midnight
of the previous day. This is most likely if you are to have general anesthesia for
You may get a sedative before the procedure to help you relax. Because the sedative
may make you drowsy, you will need to arrange for someone to drive you home.
Based on your health condition, your healthcare provider may have other instructions
for how to prepare.
What happens during a bone biopsy?
A bone biopsy may be done on an outpatient basis, or as part of your stay in a hospital.
Procedures may vary, depending on your condition and your healthcare provider’s practices.
In addition, some biopsies may be done using local anesthesia to numb the area. Others
may be done under general or spinal anesthesia. If spinal anesthesia is used, you
will have no feeling from your waist down. Your healthcare provider will discuss this
with you in advance.
Generally, a bone biopsy follows this process:
You will be asked to remove clothing and will be given a gown to wear.
An intravenous (IV) line may be started in your arm or hand.
You will be positioned so that your healthcare provider can easily reach the bone
that is to be sampled. A belt or strap may be used to hold you in the correct position.
The skin over the biopsy site will be cleansed with an antiseptic solution.
If a local anesthetic is used, you will feel a needle stick when the anesthetic is
injected. This may cause a brief stinging sensation. If general anesthesia is used,
you will be put to sleep using IV (intravenous) medicine.
If local anesthesia is used to numb the area, you will need to lie still during the
The provider will make a small cut (incision) over the biopsy site. He or she will
insert the biopsy needle into your bone.
If you are awake, you may feel discomfort or pressure when your healthcare provider
takes the bone sample.
The biopsy needle will be withdrawn, and firm pressure will be applied to the biopsy
site for a few minutes, until the bleeding has stopped.
Your healthcare provider will close the opening in your skin with stitches or skin
adhesive strips, if needed.
A sterile bandage or dressing will be applied.
The bone sample will be sent to the lab for testing.
What happens after a bone biopsy?
Your recovery process will vary, depending on the type of anesthesia that is given.
You will be taken to the recovery room for observation. Once your blood pressure,
pulse, and breathing are stable and you are alert, you will be taken to your hospital
room or discharged to your home.
Once you are home, it's important to keep the biopsy area clean and dry. Your healthcare
provider will give you specific bathing instructions. If stitches are used, they will
be removed during a follow-up office visit. If adhesive strips are used, they should
be kept dry and generally will fall off on their own within a few days.
The biopsy site may be tender or sore for several days after the bone biopsy. Take
a pain reliever for soreness as your healthcare provider recommends. Aspirin or certain
other pain medicines may increase the chance of bleeding. Be sure to take only recommended
Tell your healthcare provider if you have:
Fever or chills
Redness, swelling, bleeding, or other drainage from the biopsy site
Increased pain around the biopsy site
You may go back to your usual diet and activities unless your healthcare provider
advises you otherwise. Your provider may ask you to avoid strenuous physical activity
for a few days.
Your healthcare provider may give you more instructions after the procedure, depending
on your particular case.
Before you agree to the test or the procedure make sure you know:
The name of the test or procedure
The reason you are having the test or procedure
What results to expect and what they mean
The risks and benefits of the test or procedure
What the possible side effects or complications are
When and where you are to have the test or procedure
Who will do the test or procedure and what that person’s qualifications are
What would happen if you did not have the test or procedure
Any alternative tests or procedures to think about
When and how you will get the results
Who to call after the test or procedure if you have questions or problems
How much you will have to pay for the test or procedure