Clinical Trials

Ongoing

Whole Food Plant-Based Lifestyle Adaptation for Nutrition Therapy in Patients with Metastatic Breast Cancer: The PLANT-MBC Study in NCORP (Funding: NIH Award #1U34CA304677-01A1 along with Highland Hospital Foundation/philanthropic donors)
This is a multi-site, randomized controlled trial across the national NCORP system (NCI Community Oncology Research Program). It is designed to investigate the feasibility and preliminary effects of delivering an intensive, whole food, plant-based dietary intervention across multiple, varied sites among women with metastatic breast cancer. Prepared meals and shelf-stable foods along with coaching and education will be provided to the intervention group. The cancer wellness program control group will receive the same time and attention from the study team by participating in a breast cancer wellness program and receiving compensation for their participation.

Completed

Breast Cancer Nutrition and Lifestyle Survey (Funding: Highland Hospital Foundation/philanthropic donors)
This is a one-time survey to learn how people with a diagnosis of breast cancer view nutrition and overall lifestyle. Those with an initial breast cancer diagnosis or a recurrence in the past 10 years may qualify.

Low-Carbohydrate and Plant-Based Dietary Effects on Vascular Health (Funding: Highland Hospital Foundation/philanthropic donors)
This is a randomized trial with a crossover design to investigate the short-term effects of two different dietary patterns on markers of vascular health. A low-carbohydrate diet and a whole-food, plant-based diet will be used. In addition to more traditional markers (cholesterol, blood pressure, inflammation), progenitor (blood vessel repair) cells and trimethylamine N-oxide will be assessed. Prepared meals provided. The trial is registered at https://clinicaltrials.gov/ct2/show/NCT05414851 (NCT05414851)

Whole-Food, Plant-Based Nutrition Among Women with Metastatic Breast Cancer: A Pilot Study of Recruitment, Retention, and Preliminary Changes in Biomarkers and Symptoms (Funding: Highland Hospital Foundation/philanthropic donors)
This is a randomized controlled trial that lays the groundwork for investigating how a plant-based diet and/or weight loss affects cancer and related biological problems (inflammation, cardiometabolic risk factors, etc.) and quality of life. Prepared meals provided. The trial is registered at https://clinicaltrials.gov/ct2/show/NCT03045289 (NCT03045289)

A Comparison of Whole Food Plant-Based Diet and Dietary Approaches to Stop Hypertension (DASH) Diet on the Effects of Insulin Requirements and Obesity Markers in Adults with Type 2 Diabetes (Funding: Highland Hospital Foundation/philanthropic donors)
This study is designed to understand the short-term effects of dietary change on advanced type 2 diabetes. Subjects cross over from a DASH diet to a whole-food, plant-based diet, back to a DASH diet, and changes in insulin requirements and various biomarkers are tracked. Prepared meals provided. The trial is registered at https://clinicaltrials.gov/ct2/show/NCT04048642 (NCT04048642)