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Important Programs and Facilities for Experimental Therapeutics

Translational Neurology: At the Bench

Translational Research

A joint initiative of the Departments of Neurology and Neurosurgery is the URMC Center for Translational Neuromedicine. The Center includes the Divisions of Cell and Gene Therapy of the Neurology Department, and of Glial Diseases and Therapeutics of the Department of Neurosurgery, Co-directed by Steven Goldman, M.D., Ph.D. and Maiken Nedergaard, M.D., DMSc. The Center is exploiting neuronal and glial progenitor cells to develop new treatments for a variety of diseases including the neurodegenerative diseases, myelin diseases, and CNS tumors.

Translational Neurology: Bench to Bedside

Clinical Coordination and Execution

The Center for Human Experimental Therapeutics (CHET) includes the headquarters for Coordinating Centers for multi-center therapeutic trials in a variety of neurological diseases. They include: Parkinson's disease, Huntington's disease, Friedreich's Ataxia, Tourette's syndrome, dystonia, Alzheimer's disease, multiple sclerosis, epilepsy, peripheral neuropathy, Duchenne dystrophy, facioscapulohumeral dystrophy, inclusion body myositis, myotonic dystrophy, non-dystrophic myotonia, periodic paralysis, episodic ataxia, AIDS dementia and attention deficit disorder.

Clinical Research Center

Neurology has major involvement in the NIH-funded Clinical Research Center of the University of Rochester. This facility accommodates both inpatient and outpatient clinical studies and is a part of Rochester's Clinical and Translational Science Institute. Rochester's Clinical and Translational Sciences Building is home to this research and to the Center for Human Experimental Therapeutics co-directed by Ray Dorsey, M.D., M.B.A. and Erika Augustine, M.D., M.S. Neurologist Giovanni Schifitto, M.D. is Director of the Clinical Research Center.

Translational Neurology: At the Bedside

The Neurology Department is a NeuroNEXT network site (PI Robert Holloway). The Rochester Center for Human Experimental Therapeutics is home to the NeuroNEXT research pharmacy.

Movement Disorders

Movement and Inherited Neurologic Disorders (MIND): Working with The Center for Human Experimental Therapeutics (CHET), the MIND Unit trains fellows in the clinical and experimental evaluation of movement disorders. Fellows are also trained in deep brain stimulation management, working together with colleagues in the Department of Neurosurgery.

Epilepsy

Strong Epilepsy Program at the University of Rochester Medical Center: Funded by New York State, federal and private support, this program brings state-of-the-art medical and surgical treatment to patients with epilepsy. Rochester is involved in multi-center clinical trials and in outcome research.

Neuromuscular Disease

Strong Epilepsy Program at the University of Rochester Medical Center: Funded by New York State, federal and private support, this program brings state-of-the-art medical and surgical treatment to patients with epilepsy. Rochester is involved in multi-center clinical trials and in outcome research.

Child Neurology

The Child Neurology division trains fellows in subspecialty care and research in a wide spectrum of pediatric disorders, including movement disorders and epilepsy. Ongoing work includes clinical trials (federal and private funding) as well as natural history, epidemiology, outcomes, and neurophysiology research. Child Neurology is home to both a Tourette Syndrome Center of Excellence and Batten Disease Center of Excellence in clinical care and research.

Multiple Sclerosis

The Multiple Sclerosis (MS) research program focuses on the experimental therapeutics of multiple sclerosis (MS) and improving methodology for MS clinical trials. Current investigations include trials of immune system modulation to prevent ongoing disease activity in patients with relapsing and progressive forms of MS, and treatments to limit functional impairment in MS. Among these studies is a NIH NeuroNext trial in secondary progressive MS for which Dr. Goodman serves on the protocol steering committee. A major activity over the next several years is the implementation of a NY state-funded research award for which Drs. Goodman and Steven Goldman are the URMC co-PI's. There is also collaboration with the NIAID Autoimmunity Center of Excellence at URMC (R John Looney, PI) providing additional opportunities for clinical immunology studies, and potential for translation of new strategies into MS clinical trials.

Translational Neurology: Design and Assessment

Health Services Delivery

Major programs in health services research with faculty who maintain joint appointments in the Department of Public Health Sciences, directed by Robert Holloway, M.D., M.P.H., Professor and Chair of Neurology.

Epidemiology and Statistics

Interactions with the Department of Biostatistics and Computational Biology include full-time joint faculty appointments, (Michael McDermott, Ph.D. and Christopher Beck, Ph.D.) and major computer and programming resources.