Skip to main content

Coronavirus (COVID-19): Latest Updates | Visitation PoliciesVisitation PoliciesVisitation PoliciesVisitation PoliciesVisitation Policies | COVID-19 Testing | Vaccine InformationVaccine InformationVaccine Information

menu

Pathology & Laboratory Medicine

URMC / Pathology & Laboratory Medicine / Education / Case of the Month / Case 32: Skin Lesion / Discussion

 

Diagnosis and Discussion

Diagnosis 

Esophageal adenocarcinoma, initially presenting as a cutaneous metastasis.

Discussion

Esophageal cancer is the eighth most common cancer worldwide and the sixth most common cause of cancer-related death. The two most common types of esophageal cancer are adenocarcinoma (EAC) and squamous cell carcinoma (ESCC). ESCC is more common worldwide; however, EAC is more common in the United States and has increased 7-fold since the 1970s. ESCC most commonly occurs in the mid to upper esophagus and is most commonly associated with tobacco and alcohol use, yet may be seen with increased nitrosamine or hot beverage consumption, Plummer-Vinson syndrome, and achalasia. In contrast, EAC risk factors include obesity, male gender, gastroesophageal reflux disease (GERD), and tobacco use.

Most often, patients with GERD develop intestinal metaplasia (Barrett esophagus), which develops into dysplasia and ultimately EAC. The majority of patients with esophageal cancer, whether ESCC or EAC, present with dysphagia between 65-70 years old. Unfortunately, approximately 50 percent of patients with esophageal cancer present with lymph node or distant organ metastasis with a 5-year survival rate around 25-30 percent. The most common sites of metastasis for esophageal cancer include the liver, lungs, and brain. Metastasis to the skin is rare; however, cases from both EAC and ESCC have been documented.

Involvement of the skin from extracutaneous malignancies can result from direct extension or via metastasis. Less than 1 percent of all cancers metastasize to the skin. Skin metastasis is most commonly seen with lung, breast, and colorectal carcinomas. Breast cancer is the most common cancer metastasizing to the skin in females, while lung cancer is the most common in males. The presence of skin metastasis usually indicates advanced disease and poor prognosis. Most patients with skin metastasis present with painless lesions, which may vary in appearance from skin papules or nodules to plaques, rashes, or ulcers. As is demonstrated by our case of metastatic EAC to skin on the upper abdomen, it is important for clinicians to recognize and biopsy new/atypical skin lesions, as these may be the first sign of an underlying visceral malignancy. 

References

Adyanthaya R. Multiple cutaneous metastases from esophageal adenocarcinoma. J Gastrointest Cancer. 2008;39(1-4):22-5.

Fereidooni F, Kovacs K, Azizi MR, Nikoo M. Skin metastasis from an occult esophageal adenocarcinoma. Can J Gastroenterol. 2005;19(11):673-6.

Doumit G, Abouhassan W, Piliang MP, Uchin JM, Papay F. Scalp metastasis from esophageal adenocarcinoma: comparative histopathology dictates surgical approach. Ann Plast Surg. 2013;71(1):60-

Shaheen O, Ghibour A, Alsaid B. Esophageal Cancer Metastases to Unexpected Sites: A Systematic Review. Gastroenterol Res Pract. 2017;2017:1657310.

Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol. 1995;33(2 Pt 1):161-82; quiz 83-6.

Triantafyllou S, Georgia D, Gavriella-Zoi V, Dimitrios M, Stulianos K, Theodoros L, et al. Cutaneous metastases from esophageal adenocarcinoma. Int Surg. 2015;100(3):558-61.

Wu SG, Zhang WW, He ZY, Sun JY, Chen YX, Guo L. Sites of metastasis and overall survival in esophageal cancer: a population-based study. Cancer management and research. 2017;9:781-8.

Go Back