Publications
2025
Abraham SV, Krishnan SV, George T, Thomas VK, Sunny SP, Hassan S, Thekekara AJ, Jothi VH. Calibrating a functional assay for variant classification in RYR1-related malignant hyperthermia susceptibility. Hum Mol Genet. 2025 Apr 7:ddaf038. doi: 10.1093/hmg/ddaf038. Online ahead of print. PMID: 40192509
Abraham SV, Krishnan SV, George T, Thomas VK, Sunny SP, Hassan S, Thekekara AJ, Jothi VH. Baseline Knowledge and Change in Confidence after Learning First Aid from Emergency Physicians: A Pre-Post Interventional Study of 2462 High School Junior Red Cross Cadets. Indian J Public Health. 2025 Apr 1;69(2):153-158. doi: 10.4103/ijph.ijph_1458_22. Epub 2025 Jun 30. PMID: 40586649
Arige V, Wagner LE 2nd, Malik S, Baker MR, Fan G, Serysheva II, Yule DI. Functional investigation of a putative calcium-binding site involved in the inhibition of inositol 1,4,5-trisphosphate receptor activity. J Biol Chem. 2025 Feb 11:108302. doi:10.1016/j.jbc.2025.108302. Online ahead of print PMID: 39947469
Bhat SY, Bhattacharya A, Li H, Cui X, Lueck JD, Goldman YE, Cooperman BS Mechanism-based approach in designing patient-specific combination therapies for nonsense mutation diseases. Nucleic Acids Res. 2025 Mar 20;53(6):gkaf216. doi: 10.1093/nar/gkaf216. PMID: 40156864
Blanc RS, Shah N, Hachmer S, Salama NAS, Meng FW, Mousaei A, Puri G, Hwang JH, Wacker EE, Yang BA, Aguilar CA, Chakkalakal JV, Onukwufor JO, Murphy PJ, Calvi LM, Dilworth FJ, Dirksen RT. Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis. Nat Aging. 2025 Jun 30. doi: 10.1038/s43587-025-00902-5. Online ahead of print. PMID: 40588650
Couch T, McCullock TW, MacLean DM. The impact of subunit type, alternative splicing, and auxiliary proteins on AMPA receptor trafficking J Biol Chem. 2025 Apr 30:108569. doi: 10.1016/j.jbc.2025.108569. Online ahead of print. PMID: 40316023
Franchini L, Porter JJ, Lueck JD, Orlandi C. GzESTY as an optimized cell-based assay for initial steps in GPCR deorphanization. Nat Commun. 2025 May 15;16(1):4521. doi: 10.1038/s41467-025-59850-8. PMID: 40374633
Gong T, Maffei C, Dann E, Lee HH, Lee H, Augustinack JC, Huang SY, Haber SN, Yendiki A. Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain. Imaging Neurosci (Camb). 2025 May 12;3:imag_a_00576. doi: 10.1162/imag_a_00576. eCollection 2025. PMID: 40800960.
Grieble GM, Knapp BI, Bidlack JM.Mu Opioid Receptor Positive Allosteric Modulator BMS-986122 Confers Agonist-Dependent G Protein Subtype Signaling Bias. Biochemistry. 2025 Jun 3;64(11):2376-2393. doi: 10.1021/acs.biochem.5c00022. Epub 2025 May 16. PMID: 40378294
Ko W, Porter JJ, Spelier S, Sorensen EG, Bhatt P, Gabell JT, van der Windt I, Couch T, Coote K, Mense M, Beekman JM, Lueck JD. ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis. Nucleic Acids Res. 2025 Jul 8;53(13):gkaf675. doi: 10.1093/nar/gkaf675. PMID: 40650978
Kundu D, Franchini L, Hasdemir HS, Lloyd E, Maturano J, Rabl K, Denissiouk AN, Schumacher M, Sarlah D, Hellman J, Tajkhorshid E, Orlandi C, Das A.Distinct Interactions of Cannabinol and Its Cytochrome P450-Generated Metabolites with Receptors and Sensory Neurons. J Med Chem. 2025 Jun 26. doi: 10.1021/acs.jmedchem.5c00938. Online ahead of print. PMID: 40568800
Kwon J, Kawase H, Mattonet K, Guenther S, Hahnefeld L, Shamsara J, Heering J, Kurz M, Kirchhofer S, Krasel C, Ulrich M, Persechino M, Murthy S, Orlandi C, Sadik CD, Geisslinger G, Bünemann M, Kolb P, Offermanns S, Wettschureck N. Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling. Nat Commun. 2025 Feb 7;16(1):1448. doi: 10.1038/s41467-025-56713-0. Free PMC article. PMID: 39920161
Lawal TA, Riekhof W, Groom L, Varma P, Chrismer IC, Kokkinis A, Grunseich C, Witherspoon JW, Razaqyar MS, Sinaii N, Meilleur KG, Xiang L, Buzkova J, Euro L, Mohassel P, Dirksen RT, Todd JJ. NAD+ dyshomeostasis in RYR1-related myopathies. Skelet Muscle. 2025 Aug 22;15(1):22. doi: 10.1186/s13395-025-00390-6. PMID: 40846977
Mayer A, Derua R, Spahn E, Verbinnen I, Zhang Y, Guzman M, Swingle MR, Wadzinski BE, Honkanen R, Janssens V, Xia H. The phosphatase activity of the PPP2R5D-PP2A holoenzyme modulates liprin-α1 liquid-liquid phase separation. J Biol Chem. 2025 Jun 6:110349. doi: 10.1016/j.jbc.2025.110349. Online ahead of print. PMID: 40484382
McCullock TW, Couch T, Kammermeier PJ.Metabotropic glutamate receptor homo- and heterodimers exhibit distinct responses to orthosteric and allosteric ligands. Mol Pharmacol. 2025 Jul 18;107(9):100063. doi: 10.1016/j.molpha.2025.100063. Online ahead of print. PMID: 40829337
Nagel DJ, Okutani T, Lopa S, Mariani TJ, Sime PJ, Kottmann RM, Hocking D.Elastokines are Associated with a Poor Prognosis in Idiopathic Pulmonary Fibrosis. medRxiv [Preprint]. 2025 Jun 7:2025.06.06.25327886. doi: 10.1101/2025.06.06.25327886. PMID: 40502618
Niemeyer BA, Yule DI. Changing of the guards while steering a familiar course. Cell Calcium. 2025 Mar;126:103002. doi: 10.1016/j.ceca.2025.103002. Epub 2025 Feb 15. No abstract available. PMID: 39978167
Onofre-Oliveira P, Groom L, Liang C, Cowling B, Ghahramani-Seno MM, Dirksen RT, Dowling JJ. Evaluation of dynamin 2 knockdown as a therapeutic strategy for RYR1 related myopathy. Neuromuscul Disord. 2025 Mar 28;50:105339. doi: 10.1016/j.nmd.2025.105339. Online ahead of print. PMID: 40273816
Riazi S, Biesecker LG, Rosenberg H, Dirksen RT. Nonsyndromic Malignant Hyperthermia Susceptibility. 2003 Dec 19 [updated 2025 Aug 7]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025 PMID: 20301325
Sotiropoulos SN, Thiebaut de Schotten M, Haber SN, Forkel SJ Cross-species neuroanatomy in primates using tractography Brain Struct Funct. 2025 May 28;230(5):75. doi: 10.1007/s00429-025-02914-8. PMID: 40434442 Free PMC article. Review.
Sundaresan V, Lehman JF, Maffei C, Haber SN, Yendiki A. Self-supervised segmentation and characterization of fiber bundles in anatomic tracing data. Imaging Neurosci (Camb). 2025 Mar 24;3:imag_a_00514. doi: 10.1162/imag_a_00514. eCollection 2025. PMID: 40800953
Takano T, Franchini L, Wagner LE 2nd, Cooley M, Groblewski GE, Orlandi C, Yule DI.Pancreatic acinar cell signalling and function exhibit an absolute requirement for activation of Gαq. J Physiol. 2025 Jun 25. doi: 10.1113/JP288957. Online ahead of print. PMID: 40563241
Ying EZ, Douglass A, Hawari MA, Groom L, Stowell K, Dirksen RT, Johnston JJ, Biesecker LG. Calibrating a functional assay for variant classification in RYR1-related malignant hyperthermia susceptibility. Hum Mol Genet. 2025 Apr 7:ddaf038. doi: 10.1093/hmg/ddaf038. Online ahead of print. PMID: 40192509
Zanetti L, Franchini L, Saha S, Liao Y, Muntean BS, Orlandi C. Go/z-biased coupling profile of the dopamine D3 receptor. bioRxiv [Preprint]. 2025 Aug 12:2025.08.08.668522. doi: 10.1101/2025.08.08.668522. PMID: 40832361
2024
Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Duncan RP, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith ZR, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS. Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nat Comm un. 2024 Jul 21;15(1):6152. doi: 10.1038/s41467-024-50454-2.
Chen X, Bell NA, Coffman BL, Rabino AA, Garcia-Mata R, Kammermeier PJ, Yule DI, Axelrod D, Smrcka AV, Giovannucci DR, Anantharam A. A PACAP-activated network for secretion requires coordination of Ca 2+ influx and Ca 2+ mobilization. Mol Biol Cell. 2024 May 17:mbcE24020083. doi: 10.1091/mbc.E24-02-0083. Online ahead of print. PMID: 38758660
Cisco LA, Sipple MT, Edwards KM, Thornton CA, Lueck JD. Verapamil mitigates chloride and calcium bi-channelopathy in a myotonic dystrophy mouse model. J Clin Invest. 2024 Jan 2;134(1):e173576. doi: 10.1172/JCI173576. PMID: 38165038
Franchini L, Orlandi C. Deorphanization of G Protein Coupled Receptors (GPCRs): a historical perspective. Mol Pharmacol. 2024 Apr 15:MOLPHARM-MR-2024-000900. doi: 10.1124/molpharm.124.000900. Online ahead of print. PMID: 38622017
Franchini L, Porter JJ, Lueck JD, Orlandi C. Gz Enhanced Signal Transduction assaY (G Z ESTY) for GPCR deorphanization. bioRxiv [Preprint]. 2024 Jul 26:2024.07.26.605282. doi: 10.1101/2024.07.26.605282. PMID: 39091869
Ghane M, Trambaiolli L, Bertocci MA, Martinez-Rivera FJ, Chase HW, Brady T, Skeba A, Graur S, Bonar L, Iyengar S, Quirk GJ, Rasmussen SA, Haber SN, Phillips ML. Specific patterns of endogenous functional connectivity are associated with harm avoidance in OCD. Biol Psychiatry. 2024 Feb 7:S0006-3223(24)00078-7.
Glading AJ. KRIT1 in vascular biology and beyond. Biosci Rep. 2024 Jul 31;44(7):BSR20231675. doi: 10.1042/BSR20231675. PMID: 38980708
Gong T, Maffei C, Dann E, Lee HH, Lee H, Augustinack JC, Huang SY, Haber SN, Yendiki A. Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain. ArXiv [Preprint]. 2024 Jul 2:arXiv:2407.02227v1. PMID: 39010869
Huang KT, Wagner LE, Takano T, Lin XX, Bagavant H, Deshmukh U. Yule DI. Dysregulated Ca 2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren's syndrome. bioRxiv [Preprint]. 2024 Mar 19:2024.03.19.585719. doi: 10.1101/2024.03.19.585719. PMID: 38562738
Lemos FO, de Ridder I, Wagner L, Bootman MD, Bultynck G, Yule DI, Parys JB. Tetrameric, active PKM2 inhibits IP3 receptors, potentially requiring GRP75 as an additional interaction partner. Biochim Biophys Acta Mol Cell Res. 2024 Jul 20;1871(7):119796. doi: 10.1016/j.bbamcr.2024.119796. Online ahead of print.
Porter JJ, Lueck JD. A cystic fibrosis gene editing approach that is on target. Mol Ther Nucleic Acids. 2024 May 8;35(2):102197. doi: 10.1016/j.omtn.2024.102197. eCollection 2024 Jun 11. PMID: 38766524
Mayer A, Derua R, Spahn E, Verbinnen I, Zhang Y, Wadzinski B, Swingle MR, Honkanen R, Janssens V, Xia H. The role of liprin-α1 phosphorylation in its liquid-liquid phase separation: regulation by PPP2R5D/PP2A holoenzyme. bioRxiv [Preprint]. 2024 Jun 22:2024.06.18.599485. doi: 10.1101/2024.06.18.599485. PMID: 38948786
McKee C, Foley K, Andersh KM, Marola OJ, Wadzinski B, Libby RT, Shrager P, Xia H. Neuronal protein phosphatase 1β regulates glutamate release, cortical myelination, node of Ranvier formation, and action potential propagation in the optic nerve. bioRxiv [Preprint]. 2024 May 10:2024.05.10.593531. doi: 10.1101/2024.05.10.593531. PMID: 38766050
Patel S, Yule DI. Stretching the role of TMEM63a to gatekeeping Ca2+ release in pancreatic acinar cells. Cell Calcium. 2024 May 11;121:102890. doi: 10.1016/j.ceca.2024.102890. Online ahead of print. PMID: 38759307
Porter JJ, Lueck JD. A cystic fibrosis gene editing approach that is on target. Mol Ther Nucleic Acids. 2024 May 8;35(2):102197. doi: 10.1016/j.omtn.2024.102197. eCollection 2024 Jun 11.
Phan BN, Ray MH, Xue X, Fu C, Fenster RJ, Kohut SJ, Bergman J, Haber SN, McCullough KM, Fish MK, Glausier JR, Su Q, Tipton AE, Lewis DA, Freyberg Z, Tseng GC, Russek SJ, Alekseyev Y, Ressler KJ, Seney ML, Pfenning AR, Logan RW. Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder. Nat Commun. 2024 Jan 31;15(1):878. doi: 10.1038/s41467-024-45165-7. PMID: 38296993
Purohit R, Couch T, MacLean DM. Proline substitutions in the ASIC1 β11-12 linker slow desensitization. bioRxiv [Preprint]. 2024 May 13:2024.05.09.593312. doi: 10.1101/2024.05.09.593312. PMID: 38798386
Sahasrabudhe DM, Liesveld JL, Minhajuddin M, Singh NA, Nath S, Kumar VM, Balys M, Evans AG, Azadniv M, Hansen JN, Becker MW, Sharon A, Thomas VK, Moore RG, Khera MK, Jordan CT, Singh RK. In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia. Sci Rep. 2024 Jun 4;14(1):12868. doi: 10.1038/s41598-024-63392-2. PMID: 38834690
Saluja S, Qiu L, Wang AR, Campos G, Selheimer R, McNab JA, Haber SN, Barbosa DAN, Halpern CH. Diffusion MRI tractography guides investigation of the zona incerta: a novel target for deep brain stimulation. Biol Psychiatry. 2024 Feb 22:S0006-3223(24)01105-3.
Son GY, Zou A, Wahl A, Huang KT, Vinu M, Zorgit S, Zhou F, Wagner L, Idaghdour Y, Yule DI, Feske S, Lacruz RS. Loss of STIM1 and STIM2 in salivary glands disrupts ANO1 function but does not induce Sjogren's disease. bioRxiv. 2024 Jan 8:2024.01.08.574702. doi: 10.1101/2024.01.08.574702. Preprint. PMID: 38260625
Tao S, Hulpiau P, Wagner LE 2nd, Witschas K, Yule DI, Bultynck G, Leybaert L. IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin-43 hemichannels. Acta Physiol (Oxf). 2024 Jan 19:e14086.
Takano T, Yule DI. Neuronal and hormonal control of Ca2+ signalling in exocrine glands: insight from in vivo studies. J Physiol. 2024 Jun 7. doi: 10.1113/JP285461. Online ahead of print. PMID: 38847391
Yule DI, Takano T. Pacing intracellular Ca2+ signals in exocrine acinar cells. J Physiol. 2024 Jan 10. doi: 10.1113/JP284755. Online ahead of print. PMID: 38197224
2023
Alabdali R, Franchini L, Orlandi C. Gα Protein Signaling Bias at Serotonin 1A Receptor. Mol Pharmacol. 2023 Nov;104(5):230-238. doi: 10.1124/molpharm.123.000722. Epub 2023 Aug 11. PMID: 37567783
Allaire NE, Griesenbach U, Kerem B, Lueck JD, Stanleigh N, Oren YS. Gene, RNA, and ASO-based therapeutic approaches in Cystic Fibrosis. J Cyst Fibros. 2023 Mar;22 Suppl 1(Suppl 1):S39-S44. doi: 10.1016/j.jcf.2022.12.016. Epub 2023 Jan 17. PMID: 36658041
Allen JP, Garber KB, Perszyk R, Khayat CT, Kell SA, Kaneko M, Quindipan C, Saitta S, Ladda RL, Hewson S, Inbar-Feigenberg M, Prasad C, Prasad AN, Olewiler L, Mu W, Rosenthal LS, Scala M, Striano P, Zara F, McCullock TW, Jauss RT, Lemke JR, MacLean DM, Zhu C, Yuan H, Myers SJ, Traynelis SF. Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants. Hum Mol Genet. 2023 Nov 7:ddad188. doi: 10.1093/hmg/ddad188. Online ahead of print. PMID: 37944084
Anderson DE, Broun KG, Kundu P, Jing X, Tang X, Lu C, Kotelsky A, Mannava S, Lee W. PIEZO1 is downregulated in glenohumeral chondrocytes in early cuff tear arthropathy following a massive rotator cuff tear in a mouse model. Front Bioeng Biotechnol. 2023 Sep 5;11:1244975. eCollection 2023. PMID: 37731766. doi: 10.3389/fbioe.2023.1244975
Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Duncan R, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith Z, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS. Glutathione supports lipid abundance in vivo. bioRxiv. 2023 Feb 11:2023.02.10.524960.
Baker MR, Fan G, Arige V, Yule DI, Serysheva II. Understanding IP3R channels: From structural underpinnings to ligand-dependent conformational landscape. Cell Calcium. 2023 Jun 22;114:102770. doi: 10.1016.
Bekauri T, Fischer S, Honn KV, Maddipati KR, Love T, Little C, Wood RW, Bonham AD, Linder MA, Yule DI, Emanuelle C, Falsetta ML. Inflammation, lipid dysregulation, and transient receptor potential cation channel subfamily V member 4 signaling perpetuate chronic vulvar pain. Pain. 2023 Oct 26. doi: 10.1097/j.pain.0000000000003088. Online ahead of print.PMID: 37889581
Benson JC, Romito O, Abdelnaby AE, Xin P, Pathak T, Weir SE, Kirk V, Castaneda F, Yoast RE, Emrich SM, Tang PW, Yule DI, Hempel N, Potier-Cartereau M, Sneyd J, Trebak M. A multiple-oscillator mechanism underlies antigen-induced Ca2+ oscillations in Jurkat T-cells. J Biol Chem. 2023 Nov;299(11):105310. doi: 10.1016/j.jbc.2023.105310. Epub 2023 Sep 29.PMID: 37778728
Chakraborty P, Deb BK, Arige V, Musthafa T, Malik S, Yule DI, Taylor CW, Hasan G. Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2. Elife. 2023 Jul 19;12:e80447. doi: 10.7554/eLife.80447.PMID: 37466241
Chang SL, Seth P, Zhu J, Pendyala G, Bidlack JM, Kumar S. The 27th Scientific Conference of the Society on NeuroImmune Pharmacology: New Delhi, India, March 15-18, 2023. NeuroImmune Pharm Ther. 2023 Apr 10;2(2):187-244. doi: 10.1515/nipt-2023-0006. eCollection 2023 Jun.PMID: 37476290
Chaubey AH, Sojka SE, Onukwufor JO, Ezak MJ, Vandermeulen MD, Bowitch A, Vodičková A, Wojtovich AP, Ferkey DM. The Caenorhabditis elegans innexin INX-20 regulates nociceptive behavioral sensitivity. Genetics. 2023 Apr 6;223(4):iyad017. doi: 10.1093/genetics/iyad017.PMID: 36753530
Cisco LA, Sipple MT, Edwards KM, Thornton CA, Lueck JD. Combinatorial chloride and calcium channelopathy in myotonic dystrophy. bioRxiv. 2023 Jun 1:2023.05.29.542752.
Colodete DAE, Silva NR, Pedrazzi JFC, Fogaça MV, Cortez I, Del-Bel EA, Breuer A, Mechoulam R, Gomes FV, Guimarães FS. Behavioral effects induced by the cannabidiol analogs HU-502 and HU-556. Behav Pharmacol. 2023 Jun 1;34(4):213-224. doi: 10.1097/FBP.0000000000000727. Epub 2023 May 10.PMID: 37171460
Comeau ES, Vander Horst MA, Raeman CH, Child SZ, Hocking DC, Dalecki D. In vivo acoustic patterning of endothelial cells for tissue vascularization. Sci Rep. 2023 Sep 26;13(1):16082. doi: 10.1038/s41598-023-43299-0.PMID: 37752255
Endo Y, Groom L, Wang SM, Pannia E, Griffiths NW, Van Gennip JLM, Ciruna B, Laporte J, Dirksen RT, Dowling JJ. Two zebrafish cacna1s loss-of-function variants provide models of mild and severe CACNA1S-related myopathy. Hum Mol Genet. 2023 Oct 31:ddad178. doi: 10.1093/hmg/ddad178. Online ahead of print.PMID: 37930228
Fogaça MV, Wu M, Li C, Li XY, Duman RS, Picciotto MR. M1 acetylcholine receptors in somatostatin interneurons contribute to GABAergic and glutamatergic plasticity in the mPFC and antidepressant-like responses. Neuropsychopharmacology. 2023 Aug;48(9):1277-1287. doi: 10.1038/s41386-023-01583-7. Epub 2023 May 4.PMID: 3714266
Franchini L, Orlandi C. Probing the orphan receptors: Tools and directions. Prog Mol Biol Transl Sci. 2023;195:47-76. doi: 10.1016/bs.pmbts.2022.06.011. Epub 2022 Jul 13.PMID: 36707155
Haber SN, Lehman J, Maffei C, Yendiki A. The Rostral Zona Incerta: A Subcortical Integrative Hub and Potential Deep Brain Stimulation Target for Obsessive-Compulsive Disorder. Biol Psychiatry. 2023 Jan 18:S0006-3223(23)00010-0.
Lei Yang, Rodolfo J Ricart Arbona,Carl S Smith, Kelly M Banks, V Kaye Thomas, Lawrence Palmer, Todd Evans, Romulo Hurtado. An evolutionarily conserved pacemaker role for HCN ion channels in smooth muscle. J Physiol . 2023 Apr;601(7):1225-1246. doi: 10.1113/JP283701. Epub 2023 Mar 17
Li C, Zhang J, Liu H, Yuan H, Cai J, Fogaça MV, Zhang YW. The synergistic mechanism of action of Dajianzhong decoction in conjunction with ketamine in the treatment of depression. Biomed Pharmacother. 2023 Sep;165:115137. doi: 10.1016/j.biopha.2023.115137. Epub 2023 Jul 14.PMID: 37453197
Magyar ZÉ, Hevesi J, Groom L, Dirksen RT, Almássy J. Function of a mutant ryanodine receptor (T4709M) linked to congenital myopathy. Sci Rep. 2023 Sep 5;13(1):14659. doi: 10.1038/s41598-023-41801-2.PMID: 37670077
Martínez-Rivera FJ, Pérez-Torres J, Velázquez-Díaz CD, Sánchez-Navarro MJ, Huertas-Pérez CI, Diehl MM, Phillips ML, Haber SN, Quirk GJ. A Novel Insular/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior. Biol Psychiatry. 2023 Jun 1;93(11):1000-1009. doi: 10.1016/j.biopsych.2022.02.008. Epub 2022 Feb 19.PMID: 35491274
McCullock TW, Cardani LP, Kammermeier PJ. Signaling specificity and kinetics of the human metabotropic glutamate receptors. bioRxiv. 2023 Jul 28:2023.07.24.550373. doi: 10.1101/2023.07.24.550373. Preprint.PMID: 37546908
Morales A, Mohan R, Chen X, Coffman BL, Bendahmane M, Watch L, West JL, Bakshi S, Traynor JR, Giovannucci DR, Kammermeier PJ, Axelrod D, Currie KPM, Smrcka AV, Anantharam A. PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells. J Gen Physiol. 2023 Feb 6;155(2):e202213180.
Neumann J, Van Nieuwenhove E, Terry LE, Staels F, Knebel TR, Welkenhuyzen K, Ahmadzadeh K, Baker MR, Gerbaux M, Willemsen M, Barber JS, Serysheva II, De Waele L, Vermeulen F, Schlenner S, Meyts I, Yule DI, Bultynck G, Schrijvers R, Humblet-Baron S, Liston A. : Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects. Cell Mol Immunol. 2023 Jan;20(1):114. doi: 10.1038/s41423-022-00960-4.PMID: 36471115
Nobiletti N, Liu J, Glading AJ. KRIT1-mediated regulation of neutrophil adhesion and motility. FEBS J. 2023 Feb;290(4):1078-1095. doi: 10.1111/febs.16627. Epub 2022 Sep 20.PMID: 36107440
Norris EG, Pan XS, Hocking DC. Receptor-binding domain of SARS-CoV-2 is a functional αv-integrin agonist. J Biol Chem. 2023 Mar;299(3):102922. doi: 10.1016/j.jbc.2023.102922. Epub 2023 Jan 18.PMID: 36669646
O'Connor TN, Zhao N, Orciuoli HM, Brasile A, Pietrangelo L, He M, Groom L, Leigh J, Mahamed Z, Liang C, Malik S, Protasi F, Dirksen RT. Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse model of tubular aggregate myopathy. bioRxiv. 2023 Sep 29:2023.09.29.559036. doi: 10.1101/2023.09.29.559036. Preprint.PMID: 37808709
O'Connor TN, van den Bersselaar LR, Chen YS, Nicolau S, Simon B, Huseth A, Todd JJ, Van Petegem F, Sarkozy A, Goldberg MF, Voermans NC, Dirksen RT; RYR-1-Related Diseases International Research Workshop: From Mechanisms to Treatments Pittsburgh, PA, U.S.A., 21-22 July 2022. RYR1 Myopathy Consortium. J Neuromuscul Dis. 2023;10(1):135-154. doi: 10.3233/JND-221609.PMID: 36404556
Onukwufor JO, Somo DA, Richards JG, Wood CM. Osmo-respiratory compromise in the mosshead sculpin (Clinocottus globiceps): effects of temperature, hypoxia, and re-oxygenation on rates of diffusive water flux and oxygen uptake. Fish Physiol Biochem. 2023 Oct;49(5):853-866. doi: 10.1007/s10695-023-01226-0. Epub 2023 Aug 1.PMID: 37526893
Perrelli A, Ferraris C, Berni E, Glading AJ, Retta SF. KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation Disease. Antioxid Redox Signal. 2023 Mar;38(7-9):496-528. doi: 10.1089/ars.2021.0263. Epub 2022 Nov 1.PMID: 36047808
Rook ML, McCullock TW, Couch T, Lueck JD, MacLean DM. Photomodulation of the ASIC1a acidic pocket destabilizes the open state. Protein Sci. 2023 Nov;32(11):e4800. doi: 10.1002/pro.4800.PMID: 37805833
Strohm AO, O'Connor TN, Oldfield S, Young S, Hammond C, McCall M, Dirksen RT, Majewska AK. Cortical Microglia Dynamics Are Conserved During Voluntary Wheel Running. J Appl Physiol (1985). 2023 Nov 16. doi: 10.1152/japplphysiol.00311.2023. Online ahead of print. PMID: 37969082
Sundaresan V, Lehman JF, Maffei C, Haber SN, Yendiki A. Self-supervised segmentation and characterization of fiber bundles in anatomic tracing data. bioRxiv. 2023 Oct 2:2023.09.30.560310. doi: 10.1101/2023.09.30.560310. Preprint.PMID: 37873366
Takano T, Yule DI. Ca2+ signals in pancreatic acinar cells in response to physiological stimulation in vivo. J Physiol. 2023 Mar 25.
Takano T, Yule DI. In vivo Ca2+ Imaging in Mouse Salivary Glands. Bio Protoc. 2022 Apr 5;12(7):e4380. doi: 10.21769/BioProtoc.4380. eCollection 2022 Apr 5.PMID: 35530515
Wahl AM, Takano T, Su S, Warner BM, Perez P, Sneyd J, Yule DI. Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype. J Physiol. 2023 Oct;601(20):4539-4556. doi: 10.1113/JP285104. Epub 2023 Sep 19.PMID: 37724716
Yang L, Arbona RJR, Smith CS, Banks KM, Thomas VK, Palmer L, Evans T, Hurtado R. An evolutionarily conserved pacemaker role for HCN ion channels in smooth muscle. J Physiol. 2023 Apr;601(7):1225-1246.
2022
Ahmad M, Ong HL, Saadi H, Son GY, Shokatian Z, Terry LE, Trebak M, Yule DI, Ambudkar I. Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2114928118.
Arige V, Terry LE, Wagner LE 2nd, Malik S, Baker MR, Fan G, Joseph SK, Serysheva II, Yule DI. Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2209267119.
Arige V, Yule DI. Spatial and temporal crosstalk between the cAMP and Ca2+ signaling systems. Biochim Biophys Acta Mol Cell Res. 2022 Sep;1869(9):119293. doi: 10.1016/j.bbamcr.2022.119293. Epub 2022 May 16.PMID: 35588944
Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Rep. 2022 Jan 25;38(4):110308. doi: 10.1016/j.celrep.2022.110308.PMID: 35081351
Concepcion AR, Wagner LE 2nd, Zhu J, Tao AY, Yang J, Khodadadi-Jamayran A, Wang YH, Liu M, Rose RE, Jones DR, Coetzee WA, Yule DI, Feske S The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling. Nat Immunol. 2022 Feb;23(2):287-302.
Dirksen RT, Eisner DA, Ríos E, Sipido KR. Excitation-contraction coupling in cardiac, skeletal, and smooth muscle. J Gen Physiol. 2022 Sep 5;154(9):e202213244. doi: 10.1085/jgp.202213244. Epub 2022 Aug 19.PMID: 35984377
Dorval L, Knapp BI, Majekodunmi OA, Eliseeva S, Bidlack JM. Mice with high FGF21 serum levels had a reduced preference for morphine and an attenuated development of acute antinociceptive tolerance and physical dependence. Neuropharmacology. 2022 Jan 1;202:108858.
Endo Y, Groom L, Celik A, Kraeva N, Lee CS, Jung SY, Gardner L, Shaw MA, Hamilton SL, Hopkins PM, Dirksen RT, Riazi S, Dowling JJ. Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility. Nat Commun. 2022 Jun 13;13(1):3403. doi: 10.1038/s41467-022-31088-8.PMID: 35697689
Espinosa KG, Geissah S, Groom L, Volpatti J, Scott IC, Dirksen RT, Zhao M, Dowling JJ. Characterization of a novel zebrafish model of SPEG-related centronuclear myopathy. Dis Model Mech. 2022 May 1;15(5):dmm049437.
Fan G, Baker MR, Terry LE, Arige V, Chen M, Seryshev AB, Baker ML, Ludtke SJ, Yule DI, Serysheva II. Conformational motions and ligand-binding underlying gating and regulation in IP3R channel. Nat Commun. 2022 Nov 14;13(1):6942.
Foley K, Altimimi H, Hou H, Zhang Y, McKee C, Papasergi-Scott MM, Yang H, Mayer A, Ward N, MacLean DM, Nairn AC, Stellwagen D, Xia H. Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission. Front Synaptic Neurosci. 2022 Oct 6;14:1021832.
Foley K, Ward N, Hou H, Mayer A, McKee C, Xia H. Regulation of PP1 interaction with I-2, neurabin, and F-actin. Mol Cell Neurosci. 2022 Nov 25;124:103796.
Fraser D, Nguyen T, Kotelsky A, Lee W, Buckley M, Benoit DSW. Hydrogel Swelling-Mediated Strain Induces Cell Alignment at Dentin Interfaces. ACS Biomater Sci Eng. 2022 Aug 8;8(8):3568-3575. doi: 10.1021/acsbiomaterials.2c00566. Epub 2022 Jul 6.PMID: 35793542
Fu W, Franchini L, Orlandi C. Comprehensive Spatial Profile of the Orphan G Protein Coupled Receptor GPRC5B Expression in Mouse Brain. Front Neurosci. 2022 Jun 23;16:891544. doi: 10.3389/fnins.2022.891544. eCollection 2022.PMID: 35812210
Gao W, Hasan H, Anderson DE, Lee W. The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis. Front Cell Dev Biol. 2022 May 4;10:885224. doi: 10.3389/fcell.2022.885224. eCollection 2022.PMID: 35602590
García-Castañeda M, Michelucci A, Zhao N, Malik S, Dirksen RT. Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy. J Gen Physiol. 2022 Sep 5;154(9):e202213081. doi: 10.1085/jgp.202213081. Epub 2022 Aug 8.PMID: 35939054
Garcia-Hernandez ML, Rangel-Moreno J, Garcia-Castaneda M, Kenney HM, Paine A, Thullen M, Anandarajah AP, Schwarz EM, Dirksen RT, Ritchlin CT. Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis. Front Immunol. 2022 Nov 7;13:1026574.
Haber SN, Liu H, Seidlitz J, Bullmore E. Prefrontal connectomics: from anatomy to human imaging. Neuropsychopharmacology. 2022 Jan;47(1):20-40.
Haber SN, Ford JM. Society of Biological Psychiatry's 2022 Meeting: Hybrid and Happy! Biol Psychiatry. 2022 May 1;91(9S):A11.
Haber SN, Robbins T. The prefrontal cortex. Neuropsychopharmacology. 2022 Jan;47(1):1-2. doi: 10.1038/s41386-021-01184-2. Epub 2021 Sep 23.PMID: 34556807
Jin X, Amoni M, Gilbert G, Dries E, Doñate Puertas R, Tomar A, Nagaraju CK, Pradhan A, Yule DI, Martens T, Menten R, Vanden Berghe P, Rega F, Sipido K, Roderick HL. InsP3R-RyR Ca2+ channel crosstalk facilitates arrhythmias in the failing human ventricle. Basic Res Cardiol. 2022 Nov 15;117(1):60.
Johnston JJ, Dirksen RT, Girard T, Hopkins PM, Kraeva N, Ognoon M, Radenbaugh KB, Riazi S, Robinson RL, Saddic Iii LA, Sambuughin N, Saxena R, Shepherd S, Stowell K, Weber J, Yoo S, Rosenberg H, Biesecker LG. Updated variant curation expert panel criteria and pathogenicity classifications for 251 variants for RYR1-related malignant hyperthermia susceptibility. Hum Mol Genet. 2022 Nov 28;31(23):4087-4093. doi: 10.1093/hmg/ddac145.PMID: 35849058
Katona M, Bartók Á, Nichtova Z, Csordás G, Berezhnaya E, Weaver D, Ghosh A, Várnai P, Yule DI, Hajnóczky G. at the ER-mitochondrial contacts licenses IP3 receptors to stimulate local Ca2+ transfer and oxidative metabolism. Nat Commun. 2022 Nov 9;13(1):6779.
Ko W, Porter, JJ, Sipple MT, Edwards, KM, Lueck, JD. Efficient suppression of endogenous CFTR nonsense mutations using anticodon-engineered transfer RNAs. Mol Ther Nucleic Acids. 2022 May 4:28:685-701. doi: 10.1016/j.omtn.2022.04.033. eCollection 2022 Jun 14.
Kotelsky A, Elahi A, Nejat Yigit C, Proctor A, Mannava S, Pröschel C, Lee W. Effect of knee joint loading on chondrocyte mechano-vulnerability and severity of post-traumatic osteoarthritis induced by ACL-injury in mice. Osteoarthr Cartil Open. 2021 Dec 15;4(1):100227. eCollection 2022
MacLean DM, Soto E. Editorial: ASICs: Structure, Function, and Pharmacology. Front Physiol. 2022 Jan 31;13:831830.
McKee C, Shrager P, Mazumder AG, Ganguly A, Mayer A, Foley K, Ward N, Youngman M, Hou H, Xia H. Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development. Mol Neurobiol. 2022 Dec;59(12):7486-7494.
Maffei C, Girard G, Schilling KG, Aydogan DB, Adluru N, Zhylka A, Wu Y, Mancini M, Hamamci A, Sarica A, Teillac A, Baete SH, Karimi D, Yeh FC, Yildiz ME, Gholipour A, Bihan-Poudec Y, Hiba B, Quattrone A, Quattrone A, Boshkovski T, Stikov N, Yap PT, de Luca A, Pluim J, Leemans A, Prabhakaran V, Bendlin BB, Alexander AL, Landman BA, Canales-Rodríguez EJ, Barakovic M, Rafael-Patino J, Yu T, Rensonnet G, Schiavi S, Daducci A, Pizzolato M, Fischi-Gomez E, Thiran JP, Dai G, Grisot G, Lazovski N, Puch S, Ramos M, Rodrigues P, Prčkovska V, Jones R, Lehman J, Haber SN, Yendiki A. Insights from the IronTract challenge: Optimal methods for mapping brain pathways from multi-shell diffusion MRI. Neuroimage. 2022 May 26;257:119327.
Mestre H, Verma N, Greene TD, Lin LA, Ladron-de-Guevara A, Sweeney AM, Liu G, Thomas VK, Galloway CA, de Mesy Bentley KL, Nedergaard M, Mehta RI. Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease. Nat Commun 2022 Jul 6;13(1):3897. doi: 10.1038/s41467-022-31257-9.
Michelucci A, Pietrangelo L, Rastelli G, Protasi F, Dirksen RT, Boncompagni S. Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice. J Gen Physiol. 2022 Dec 5;154(12):e202213114.
Monosov IE, Ogasawara T, Haber SN, Heimel JA, Ahmadlou M. The zona incerta in control of novelty seeking and investigation across species. Curr Opin Neurobiol. 2022 Dec;77:102650.
Morrell CN, Mix D, Aggarwal A, Bhandari R, Godwin M, Owens P 3rd, Lyden SP, Doyle A, Krauel K, Rondina MT, Mohan A, Lowenstein CJ, Shim S, Stauffer S, Josyula VP, Ture SK, Yule DI, Wagner LE 3rd, Ashton JM, Elbadawi A, Cameron SJ. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms. J Clin Invest. 2022 May 2;132(9):e152373.
Neumann J, Van Nieuwenhove E, Terry LE, Staels F, Knebel TR, Welkenhuyzen K, Ahmadzadeh K, Baker MR, Gerbaux M, Willemsen M, Barber JS, Serysheva II, De Waele L, Vermeulen F, Schlenner S, Meyts I, Yule DI, Bultynck G, Schrijvers R, Humblet-Baron S, Liston A. Author Correction: Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects. Cell Mol Immunol. 2022 Dec 6.
Nobiletti N, Liu J, Glading AJ. KRIT1-mediated regulation of neutrophil adhesion and motility. FEBS J. 2022 Sep 15.
O'Connor TN, Kallenbach JG, Orciuoli HM, Paris ND, Bachman JF, Johnston CJ, Hernady E, Williams JP, Dirksen RT, Chakkalakal JV. Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress. Skelet Muscle. 2022. Apr 12;12(1):8.
O'Connor TN, van den Bersselaar LR, Chen YS, Nicolau S, Simon B, Huseth A, Todd JJ, Van Petegem F, Sarkozy A, Goldberg MF, Voermans NC, Dirksen RT; RYR1 Myopathy Consortium. RYR-1-Related Diseases International Research Workshop: From Mechanisms to Treatments Pittsburgh, PA, U.S.A., 21-22 July 2022. J Neuromuscul Dis. 2022 Nov 16.
Onukwufor JO, Dirksen RT, Wojtovich AP. Iron Dysregulation in Mitochondrial Dysfunction and Alzheimer's Disease. Antioxidants (Basel). 2022 Mar 31;11(4):692. doi: 10.3390/antiox11040692.PMID: 35453377
Onukwufor JO, Farooqi MA, Vodičková A, Koren SA, Baldzizhar A, Berry BJ, Beutner G, Porter GA Jr, Belousov V, Grossfield A, Wojtovich AP. A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans. Nat Commun. 2022 May 3;13(1):2403. doi: 10.1038/s41467-022-30169-y.PMID: 35504873
Packard RRS, Cooke CD, Van Train KF, Votaw JR, Sayre JW, Lazewatsky JL, Champagne KM, Orlandi C, Garcia EV, Maddahi J. Development, diagnostic performance, and interobserver agreement of a 18F-flurpiridaz PET automated perfusion quantitation system. J Nucl Cardiol. 2022 Apr;29(2):698-708. doi: 10.1007/s12350-020-02335-6. Epub 2020 Sep 7.PMID: 32895856
Passardi S, Hocking DC, Morina N, Sundram S, Alisic E. Moral injury related to immigration detention on Nauru: a qualitative study. Eur J Psychotraumatol. 2022 Feb 24;13(1):2029042. doi: 10.1080/20008198.2022.2029042. eCollection 2022.
Rosa N, Ivanova H, Wagner LE 2nd, Kale J, La Rovere R, Welkenhuyzen K, Louros N, Karamanou S, Shabardina V, Lemmens I, Vandermarliere E, Hamada K, Ando H, Rousseau F, Schymkowitz J, Tavernier J, Mikoshiba K, Economou A, Andrews DW, Parys JB, Yule DI, Bultynck G. Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis. Cell Death Differ. 2022 Apr;29(4):788-805.
Sneyd J, Rugis J, Su S, Suresh V, Wahl AM, Yule DI. Simulation of Calcium Dynamics in Realistic Three-Dimensional Domains. Biomolecules. 2022 Oct 11;12(10):1455.
Swamy H, Glading AJ. Is Location Everything? Regulation of the Endothelial CCM Signaling Complex. Front Cardiovasc Med. 2022 Jul 11;9:954780. doi: 10.3389/fcvm.2022.954780. eCollection 2022.PMID: 35898265
Swamy H, Glading AJ. Contribution of protein-protein interactions to the endothelial-barrier-stabilizing function of KRIT1. J Cell Sci. 2022 Jan 15;135(2):jcs258816.
Terry LE, Arige V, Neumann J, Wahl AM, Knebel TR, Chaffer JW, Malik S, Liston A, Humblet-Baron S, Bultynck G, Yule DI. Missense mutations in inositol 1,4,5-trisphosphate receptor type 3 result in leaky Ca2+ channels and activation of store-operated Ca2+ entry. iScience. 2022 Nov 7;25(12):105523.
Trambaiolli LR, Peng X, Lehman JF, Linn G, Russ BE, Schroeder CE, Liu H, Haber SN. Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex. Elife. 2022 May 5;11:e76334.
Wei-LaPierre L, Groom L, Dirksen RT. Acute exposure to extracellular BTP2 does not inhibit Ca2+ release during EC coupling in intact skeletal muscle fibers. J Gen Physiol. 2022 Sep 5;154(9):e202112976.
Yendiki A, Aggarwal M, Axer M, Howard AFD, van Walsum AVC, Haber SN.
Post mortem mapping of connectional anatomy for the validation of diffusion MRI. Neuroimage. 2022 Aug 1;256:119146.
Young MP, Schug ZT, Booth DM, Yule DI, Mikoshiba K, Hajnόczky G, Joseph SK. adaptation to the chronic loss of Ca2+ signaling induced by KO of IP3 receptors or the mitochondrial Ca2+ uniporter. J Biol Chem. 2022 Jan;298(1):101436. doi: 10.1016/j.jbc.2021.101436. Epub 2021 Nov 19.PMID: 34801549
Yuan Y, Jaślan D, Rahman T, Bolsover SR, Arige V, Wagner LE 2nd, Abrahamian C, Tang R, Keller M, Hartmann J, Rosato AS, Weiden EM, Bracher F, Yule DI, Grimm C, Patel S. Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes. Nat Commun. 2022 Aug 2;13(1):4481. doi: 10.1038/s41467-022-31959-0.PMID: 35918320
2021
Arige V, Yule DI. A KRAP(y) job: Defining the localization of active IP3R. Cell Calcium. 2021 Sep 9;100:102470. Online ahead of print.
Arige V, Terry LE, Malik S, Knebel TR, Wagner LE, Yule DI. CREB regulates the expression of Type 1 Inositol 1,4,5-trisphosphate receptors. J Cell Sci. 2021 Sep 17:jcs.258875. Online ahead of print.
Arige V, Emrich SM, Yoast RE, Trebak M, Yule DI. A protocol for detecting elemental calcium signals (Ca2+ puffs) in mammalian cells using total internal reflection fluorescence microscopy. STAR Protoc. 2021 Jun 17;2(3):100618.
Baldermann JC, Schüller T, Kohl S, Voon V, Li N, Hollunder B, Figee M, Haber SN, Sheth SA, Mosley PE, Huys D, Johnson KA, Butson C, Ackermans L, Bouwens van der Vlis T, Leentjens AFG, Barbe M, Visser-Vandewalle V, Kuhn J, Horn A. Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder. Biol Psychiatry. 2021 Jul 19:S0006-3223(21)01461-X. Online ahead of print.
Bidlack JM. Chang SL, Fitting S, Gendelman HE, Gorantla S, Kumar S, Marcondes MCG, Meigs DD, Melendez LM, Sariyer IK, Yelamanchili S. The COVID-19 Pandemic: Reflections of Science, Person, and Challenge in Academic Research Settings. J Neuroimmune Pharmacol. 2021 Dec;16(4):706-717.
Couch T, Berger K, Kneisley DL, McCullock TW, Kammermeier PJ, MacLean DM. Topography and motion of the acid-sensing ion channel intracellular domains. Elife. 2021 Jul 22;10:e68955. Online ahead of print.
De Luca E, Perrelli A, Swamy H, Nitti M, Passalacqua M, Furfaro AL, Salzano AM, Scaloni A, Glading AJ, Retta SF. Protein kinase Cα regulates the nucleocytoplasmic shuttling of KRIT1. J Cell Sci. 2021 Feb 4;134(3):jcs250217.
Emrich SM, Yoast RE, Xin P, Arige V, Wagner LE, Hempel N, Gill DL, Sneyd J, Yule DI, Trebak M. Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling. Cell Rep. 2021 Mar 2;34(9):108760.
Foley K, McKee C, Nairn AC Xia H. Regulation of Synaptic Transmission and Plasticity by Protein Phosphatase 1. J Neurosci. 2021 Apr 7;41(14):3040-3050.
Grisot G, Haber SN, Yendiki A. Diffusion MRI and anatomic tracing in the same brain reveal common failure modes of tractography. Neuroimage. 2021 Oct 1;239:118300.
Haber SN, Robbins T. The prefrontal cortex. Neuropsychopharmacology. 2021 Sep 23. doi: 10.1038/s41386-021-01184-2. Online ahead of print.
Haber SN, Yendiki A, Jbabdi S. Four Deep Brain Stimulation Targets for Obsessive-Compulsive Disorder: Are They Different? Biol Psychiatry. 2021 Nov 15;90(10):667-677.
Hocking DC. To strive, to seek, to find, and not to yield: Narratives on the road to asylum. Transcult Psychiatry. 2021 Apr;58(2):200-214.
Jezzini A, Bromberg-Martin ES, Trambaiolli LR, Haber SN, Monosov IE. A prefrontal network integrates preferences for advance information about uncertain rewards and punishments. Neuron. 2021 Jul 21;109(14):2339-2352.e5. Epub 2021 Jun 11.
Johnston JJ, Dirksen RT, Girard T, Gonsalves SG, Hopkins PM, Riazi S, Saddic LA, Sambuughin N, Saxena R, Stowell K, Weber J, Rosenberg H, Biesecker LG.
Variant curation expert panel recommendations for RYR1 pathogenicity classifications in malignant hyperthermia susceptibility. Genet Med. 2021 Jul;23(7):1288-1295. Epub 2021 Mar 25.
Kelly EA, Thomas VK, Indraghanty A, Fudge JL. Perigenual and Subgenual Anterior Cingulate Afferents Converge on Common Pyramidal Cells in Amygdala Subregions of the Macaque. J Neurosci. 2021 Nov 24;41(47):9742-9755.
Kumar S, Pendyala G, Yelamanchili SV, Seth P, Maggirwar S, Bidlack JM, Chang SL. Society on NeuroImmune Pharmacology COVID-19 Virtual Workshop. J Neuroimmune Pharmacol. 2021 Sep;16(3):519-530.
Kumar S, Yelamanchili S, Seth P, Bidlack JM, Pendyala G, Maggirwar S, Chang SL. The Neuroimmune Pharmacology of SARS-CoV-2. J Neuroimmune Pharmacol. 2021 Dec;16(4):699-705.
Larouche J, Mohiuddin M, Choi JJ, Ulintz PJ, Fraczek PM, Sabin K, Pitchiaya S, Kurpiers SJ, Castor-Macias J, Liu W, Hastings RL, Brown LA, Markworth JF, De Silva K, Levi BD, Merajver SD, Valdez G, Chakkalakal JV, Jang Y, Brooks S, Aguilar CA. Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging. Elife. 2021 Jul 29;10:e66749. Online ahead of print.
Lee, W, Nims, R. J., Savadipour, A., Zhang, Q., Leddy, H. A., Liu, F., McNulty, A. L., Chen, Y., Guilak, F., & Liedtke, W. B. (2021). Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America, 118(13), e2001611118.
McCullock TW, Kammermeier PJ. The evidence for and consequences of metabotropic glutamate receptor heterodimerization. Neuropharmacology. 2021 Sep 18:108801. Online ahead of print.
Maffei C, Lee C, Planich M, Ramprasad M, Ravi N, Trainor D, Urban Z, Kim M, Jones RJ, Henin A, Hofmann SG, Pizzagalli DA, Auerbach RP, Gabrieli JDE, Whitfield-Gabrieli S, Greve DN, Haber SN, Yendiki A. Using diffusion MRI data acquired with ultra-high gradient strength to improve tractography in routine-quality data. Neuroimage. 2021 Dec 15;245:118706.
Michelucci A, Liang C, Protasi F, Dirksen RT. Altered Ca2+ Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease. Metabolites. 2021 Jun 28;11(7):424.
Rook ML, Ananchenko A, Musgaard M, MacLean DM. Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 β11-12 Linker Isomerization and Channel Kinetics. Front Cell Neurosci. 2021 Nov 24;15:761813.
Rook ML, Miaro M, Couch T, Kneisley DL, Musgaard M, MacLean DM. Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1. J Gen Physiol. 2021 Aug 2;153(8):e202012855.
Rook ML, Musgaard M, MacLean DM. Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors. J Physiol. 2021 Jan;599(2):417-430.
Rosa N, Shabardina V, Ivanova H, Sebé-Pedrós A, Yule DI, Bultynck G. Tracing the evolutionary history of Ca2+-signaling modulation by human Bcl-2: Insights from the Capsaspora owczarzaki IP3 receptor ortholog. Biochim Biophys Acta Mol Cell Res. 2021 Aug 14:119121.
Takano T, Wahl A, Huang KT, Narita T, Rugis J, Sneyd J, Yule DI. Highly Localized intracellular Ca2+ signals promote optimal salivary gland fluid secretion. Elife. 2021 Jul 9;10:e66170.
Tang W, Choi EY, Heilbronner SR, Haber SN. Nonhuman primate meso-circuitry data: a translational tool to understand brain networks across species. Brain Struct Funct. 2021 Jan;226(1):1-11.
Vander Horst MA, Raeman CH, Dalecki D, Hocking DC. Time- and Dose-Dependent Effects of Pulsed Ultrasound on Dermal Repair in Diabetic Mice.
Ultrasound Med Biol. 2021 Apr;47(4):1054-1066. Epub 2021 Jan 13.
Wan J, Wang J, Wagner Ii LE, Wang OH, Gui F, Chen J, Zhu X, Haddock AN, Edenfield BH, Haight B, Mukhopadhyay D, Wang Y, Yule DI, Bi Y, Ji B. Pancreatic specific CHRM3 activation causes pancreatitis in mice. JCI Insight. 2021 Jul 27:132585. Online ahead of print.
Watkins LR, Orlandi C. In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity. Br J Pharmacol. 2021 Aug;178(15):2963-2975.
Yoast RE, Emrich SM, Zhang X, Xin P, Arige V, Pathak T, Benson JC, Johnson MT, Abdelnaby AE, Lakomski N, Hempel N, Han JM, Dupont G, Yule DI, Sneyd J, Trebak M. The Mitochondrial Ca2+ Uniporter is a Central Regulator of Interorganellar Ca2+ Transfer and NFAT Activation. J Biol Chem. 2021 Sep 6:101174. Online ahead of print.