A clinical trial is a research study involving human volunteers, and is designed to answer specific health questions. Carefully conducted clinical trials are the safest and fastest way to find effective treatments, and new ways to improve health.
You can search for all studies that are currently enrolling participants at the University of Rochester by typing in keywords in the search box below. If you don’t find a study that interests you right now, consider signing up for our Volunteer Registry, which will notify you of future studies.
*RTOG 1216 / RHAN13055 / Surgery and Postoperative Radiation / Yuhchyau Chen
Lead Researcher: Yuhchyau Chen
This phase II/III trial studies how well radiation therapy works when given together
with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating
patients with high-risk stage III-IV head and neck cancer the begins in the thin,
flat cells (squamous cell). Specialized radiation therapy that delivers a high dose
of radiation directly to the tumor may kill more tumor cells and cause less damage
to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work
in different ways to stop the growth of tumor cells, either by killing the cells or
by stopping them from dividing. Cetuximab is a monoclonal antibody that may interfere
with the ability of tumor cells to grow and spread. Immunotherapy with monoclonal
antibodies, such as atezolizumab, may help the body's immune system attack the cancer,
and may interfere with the ability of tumor cells to grow and spread. The purpose
of this study is to compare the usual treatment (radiation therapy with cisplatin
chemotherapy) to using radiation therapy with docetaxel and cetuximab chemotherapy,
and using the usual treatment plus an immunotherapy drug, atezolizumab.
View Study Details
Atorvastatin Study in HNSCC/UHAN21082/Newlands
Lead Researcher: Shawn Newlands
Background:
Cisplatin is used to treat head and neck cancer. People who take this drug are at
risk for hearing loss. Atorvastatin is a drug used to treat high cholesterol. It might
reduce the risk of cisplatin-induced hearing loss.
Objective:
To find out if atorvastatin reduces hearing loss in people treated with cisplatin
and radiation.
Eligibility:
People ages 18 and older with squamous cell carcinoma of the head and neck who will
undergo treatment with cisplatin-based chemotherapy and radiation
Design:
Participants will be screened with their medical records.
Participants currently taking a cholesterol-lowering statin medication are invited
to participate in the observational arm of the study. Those not taking such a medication
are invited to participate in the interventional arm of the study.
All participants will have 3 study visits for the purpose of evaluating hearing. One
before starting cisplatin treatment, one within 3 months of completing cancer treatment,
and one within 2 years of completing cancer treatment. They will have tympanograms.
A small flexible tip will be placed in the ear canal. A puff of air will be delivered
to assess mobility of the ear drum. They will have hearing tests. They will wear headphones.
They will listen to tones that vary in loudness. They will be asked to indicate when
they hear a sound. They will complete 3 questionnaires at the time of each hearing
test.
Participants will have 2 visits for blood tests. These will occur upon consent and
12 weeks after. They will be randomly assigned to take the study drug or placebo orally,
once daily. They will take it during cisplatin treatment and for 3 months after treatment.
Long-term follow up will include a chart review 2 years after participants complete
their cisplatin therapy.
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CHAN21104 / NRG-HN009 / Patel
Lead Researcher: Arpan Patel
This phase II/III trial compares the effect of the combination of high-dose cisplatin
every three weeks and radiation therapy versus low-dose cisplatin weekly and radiation
therapy for the treatment of patients with locoregionally advanced head and neck cancer.
Chemotherapy drugs, such as cisplatin, work in different ways to stop the growth of
tumor cells, either by killing the cells, by stopping them from dividing, or by stopping
them from spreading. Radiation therapy uses high energy x-rays to kill tumor cells
and shrink tumors. This study is being done to find out if low-dose cisplatin given
weekly together with radiation therapy is the same or better than high-dose cisplatin
given every 3 weeks together with radiation therapy in treating patients with head
and neck cancer.
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DRO2005 / RHAN20083 / ALTENS / Michael Cummings
Lead Researcher: Michael Cummings
The purpose of this study would like to learn if acupuncture-like electrical therapy
can be used in patients with head and neck cancer who have had radiation treatment
to treat dry mouth.
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