A clinical trial is a research study involving human volunteers, and is designed to answer specific health questions. Carefully conducted clinical trials are the safest and fastest way to find effective treatments, and new ways to improve health.
You can search for all studies that are currently enrolling participants at the University of Rochester by typing in keywords in the search box below. If you don’t find a study that interests you right now, consider signing up for our Volunteer Registry, which will notify you of future studies.
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Study of Tecovirimat for Human Monkeypox Virus (STOMP)
Lead Researcher: Sonal Munsiff
Tecorvirimat is an oral medication used to treat monkeypox. Participants are eligible
if they have a laboratory confirmed Monkeypox infection within 7 days of enrollment.
Participants will take either Tecorvirimat or placebo for 14 days. Participants with
severe disease, significant skin conditions, or participants with severe immune suppression
will receive open-label tecovirimat. Participants who are pregnant or breastfeeding
will receive open-label tecovirimat after discussion of the potential risks and benefits.
Participants less than 18 years of age will receive open-label tecovirimat. Participants
receiving a potent inducing concomitant medication will receive open-label tecovirimat.
Participants will self-monitor skin and/or mucosal lesions daily through 29 days or
resolution (whichever comes first), complete a daily diary of symptoms and complete
a daily numerical rating scale for pain assessment. Participants will be seen at
day 57 to assess for possible recrudescence of infection (i.e., new lesions occurring
after initial resolution of disease.
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