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New Research Faculty 2016

Krishnan Padmanabhan, Ph.D.Krishnan Padmanabhan, Ph.D.

Assistant Professor of Neuroscience

Dr. Krishnan Padmanabhan is an Assistant Professor in the Department of Neuroscience at University of Rochester School of Medicine and Dentistry. Dr. Padmanabhan received his BS in Biology and History and his MS in Physiological Sciences at the University of California, Los Angeles, his PhD at Carnegie Mellon University and was the Francis Crick-Irwin Jacobs Junior Fellow at the Salk Institute of Biological Studies before arriving at the University of Rochester in 2016. His research aims to understand principles of neuronal function in the mammalian brain using experimental and computational methods with a focus on uncovering the biological bases of psychiatric disorders. Work in the Padmanabhan lab uses multi-electrode electrophysiology, induced-Pluripotent Stem Cell (iPSC) technology, imaging, and theoretical models to address three outstanding questions in neuroscience:

  1. How does the brain represents features of the world via patterns of neuronal activity?
  2. How does memory and experience shape the process of sensory perception?
  3. How are these functions disrupted in neurological and psychiatric disorders?

Tingting Yang, Ph.D.Tingting Yang, Ph.D.

Assistant Professor of Pharmacology and Physiology

Dr. Tingting Yang is an Assistant Professor in the Department of Pharmacology and Physiology. She received her PhD in Biomedical Engineering from Johns Hopkins University School of Medicine and her postdoctoral training at Columbia University Medical Center. The Yang Lab employs an interdisciplinary platform combining both crystallography and electrophysiology approaches to study the structure and function of disease-related ion channels. Her lab is currently focused on two families of Ca2+-activated Cl- channels, namely bestrophin and TMEM16, respectively. In particular, human bestrophin-1 resides on the retina, and its mutations have been linked to multiple degenerative eye diseases featured by vision loss, while TMEM16 proteins are involved in a wide range of physiological processes including mucus secretion, neuronal excitability, smooth muscle contraction, olfactory signal transduction and cell proliferation. She is also interested in designing specific channel activators/inhibitors. Dr. Yang’s research is supported by an R00 grant from the NEI.