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Minsoo Kim, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 273-1400

Office: (585) 276-3917

Fax: (585) 273-2452

Research Labs

Lab: (585) 273-1435

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Biography

Dr. Minsoo Kim is Dean's Professor of Microbiology and Immunology and Director of the Tumor Immunotherapy Research Program at the Wilmot Cancer Institute, and a member of the David H. Smith Center for Vaccine Biology and Immunology. His research interests are in the area of innate and adaptive immune responses and cancer immunotherapy. He is especially noted for his pioneering contributions to the developments of the most advanced imaging techniques that enable real-time observation and control of dynamic immune responses both in live cells and live animal models.

Research

Precise spatial and temporal regulation of cell migration is critical not only for normal immune responses, but also for successful organ development, wound healing, and tumor metastasis. Integrins, a family of membrane receptors, are expressed in all different types of cells in human body and regulate important cell adhesion and migration. Early in his career, Dr. Kim developed a highly innovative bio-imaging assay using FRET (Fluorescence Resonance Energy Transfer) techniques and show for the first time in live cells that the intracellular domains of integrin LFA-1 moved apart substantially during immune cell migration, and his paper describing this (Kim et al. 2003, Science) has been highly cited and is regarded as a cornerstone of the integrin field. Dr. Kim has continued to develop this area in his lab in Rochester, establishing a role for conformational change in other important integrins like Mac-1 and VLA-4.

Dr. Kim has continued to break new ground, most recently with the identification of important cross-talks between the innate immune and adaptive immune systems during influenza virus infection. This study, published in Science in 2015, developed from the Kim lab's careful observation of innovative fluorescence markers, using their high-resolution live animal imaging technique. In this paper, Dr. Kim showed that, much like birds fly in flocks to conserve energy, dolphins swim in pods to mate and find food, and colonies of ants create complex nests to protect their queens, immune cells engage in coordinated behavior to wipe out viruses like the flu. The findings reveal, for the first time, how immune cells work together to get to their final destination - the site of an injury or infection. The Kim lab discovered that neutrophils - the "first responders" of the immune system - arrive at the site of injury within an hour of infection and leave a chemical "trail" behind them. Killer immune cells called T cells use this trail to find the site of injury and subsequently destroy the virus. This study led to the important paradigm that the adaptive immune system doesn't generate the successful response without instruction from the innate immune system. This novel concept will be highly influential and are of special interest to clinicians. For example, in people with autoimmune disorders like multiple sclerosis and lupus, the immune system mistakenly attacks and destroys healthy body tissue. If scientists understood how to disrupt or stop immune cells' movement to healthy tissue, they may be able to improve the quality of life of people living with these devastating diseases. Similarly, recognizing how to boost the number of immune cells that travel to fight an infection could help scientists design better vaccines for viruses like the flu.

Dr. Kim has continued to develop sophisticated new biomedical technologies. Recently, he established a remarkable optogenetic system in which he constructed hybrid receptors that connected the light-sensing properties of rhodopsin to the signaling functions of two chemokine receptors. In this ground-breaking study, his carefully-constructed system allows the migration of T cells to be controlled by light, e.g. attracting more effector T cells into local tumor sites and reducing tumor growth. The achievement of functional hybrid photosensitive receptors represents a real tour de force, and opens up many analytical and therapeutic possibilities. This is particularly important because of the increasing success of adoptive cell therapies for cancer – Dr. Kim's optogenetics approaches will provide further capabilities to such cells.

Credentials

Faculty Appointments

Education

1993
BS | Korea-Korea University
Genetic Engineering

2001
PhD | Ohio State University
Pharmacology

2004
Post-doctoral training | Harvard Medical School
Immunology

Awards

2017
University of Rochester Dean's Professorship

2016
Dolph O. Adams Award
Sponsor: Society for Leukocyte Biology

2015
University of Rochester School of Medicine and Dentistry Trainee Academic Mentoring Award

2007
Brown University Seed Fund Award (Co-investigator)

2005
Rhode Island Foundation, Medical Research Grant

2005
American Heart Association, Scientist Developmental Grant

2001
DDW Poster of Distinction

2000
DDW Poster of Distinction

2000
American Digestive Health Foundation Student Abstract Award

1999
Digestive Disease Week (DDW) Poster of Distinction

1992
Honor student of 1992 by Korea University

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Publications

Journal Articles

11/6/2017
Capece T, Walling BL, Lim K, Kim KD, Bae S, Chung HL, Topham DJ, Kim M. "A novel intracellular pool of LFA-1 is critical for asymmetric CD8(+) T cell activation and differentiation." The Journal of cell biology.. 2017 Nov 6; 216(11):3817-3829. Epub 2017 Sep 27.

10/15/2017
Sarangi PP, Lee HW, Lerman YV, Trzeciak A, Harrower EJ, Rezaie AR, Kim M. "Activated Protein C Attenuates Severe Inflammation by Targeting VLA-3(high) Neutrophil Subpopulation in Mice." The Journal of immunology : official journal of the American Association of Immunologists.. 2017 Oct 15; 199(8):2930-2936. Epub 2017 Sep 06.

9/2017
Chiu YH, Schwarz E, Li D, Xu Y, Sheu TR, Li J, Bentley KL, Feng C, Wang B, Wang JC, Albertorio-Saez L, Wood R, Kim M, Wang W, Ritchlin CT. "Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca(2+) /NFATc1 Axis." Journal of cellular physiology.. 2017 Sep 0; 232(9):2538-2549. Epub 2017 Apr 12.

Books & Chapters

2011
Chapter Title: Fluorescence resonance energy transfer in the studies of integrin activation.
Book Title: Current Topics in Membrane
Author List: CT Lefort and M. Kim
Published By: Academic Press2011

2006
Chapter Title: Adhesion Molecules: Function and Inhibition.
Book Title: Progress in Inflammation Research,
Author List: A. Schenkel and M. Kim
Edited By: M.J. Parnham
Published By: Birkhauser Publishing2006 in Basel, Switzerland

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