Darren R. Carpizo, M.D., Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 275-1611

A member of the University of Rochester Medical Faculty Group

An Accountable Health Partner

Accepting New Patients

Research Labs

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Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box SURG
Rochester, NY 14642

Faculty Appointments

Professor - Department of Surgery , Oncology (SMD)
Professor - Cancer Center - Joint

Patient Care Setting

Surgery

Biography

“My goal is to educate my patients about their cancer and help them make the best choice for themselves and their family on how it should be treated. I provide the same level of care that I would give to any member of my family.”

Areas of Expertise

• Liver cancer
• Pancreatic cancer
• Gallbladder and Bile duct cancer
• Metastatic colon cancer to the liver
• Gastric cancer
• Gastrointestinal neuroendocrine tumors

I chose this field to treat hepatobiliary and pancreatic cancer because they are aggressive cancers that require a high degree of complex multidisciplinary oncologic management. This is challenging, but can also be very rewarding. I wanted to apply myself to this field not only to try to help patients afflicted with these cancers, but to also move the field forward through research.

In addition, I chose the field of liver surgery for several reasons. For one, I am fascinated by the liver. It is one of the most complex organs in the body both structurally and functionally and is essential for life. It is one of the most common places that cancers spread to as they progress and, it is the only organ capable of regeneration. As a surgeon, I can use this to my advantage when performing liver surgery as we have techniques to grow more liver when it is necessary to remove a very large part to treat a cancer.

Patients and providers alike can be confident knowing I have devoted the greater part of my career to the study of cancer and the treatment of it. This is due to the strong empathy I have for cancer patients and my intense passion for cancer research. I also have a Ph.D. in molecular and cell biology and have been performing cancer research for over 20 years. I am intensely curious, which drives my desire to understand what we do not know. My curiosity is also fueled by experiences in patient care, resulting in new clinical trials that I lead as well as research conducted by my laboratory.

Research

Gastrointestinal cancers such as pancreatic, bile duct and liver cancers are plagued by ineffective systemic therapies underscoring the tremendous unmet need for novel therapies. The Carpizo Laboratory studies cancer biology with an emphasis on developmental therapeutics. Our studies range from early drug discovery projects to translational studies of novel therapies that are about to enter or just have entered into clinical trials. These translational studies employ a variety of experimental systems including mouse cancer models, patient derived tissues as well as therapeutic clinical protocols.

Another major avenue of research in the Carpizo lab is the study of cancer metastasis and dormancy. Most solid organ cancers (i.e. breast, lung, pancreas) are treated with surgery when it appears that the disease has not spread to distant organs. This is highly effective (curative) for a number of tumor types such as breast, prostate, and thyroid cancer. However, for a number of gastrointestinal cancers such as pancreas, liver and bile duct cancer, surgery is relatively ineffective as the majority of these patients go on to suffer metastatic recurrence. This means that at the time of the surgery, they harbor disseminated tumor cells in their bodies that for a period of time after surgery remain dormant. We want to understand what the molecular mechanisms that control cancer dormancy are, what awakens these cells and how can we devise therapies that either maintain the dormant state, or drive the cells into senescence.

Credentials

Specialties

Education

1997
MD | University of Illinois College of Medicine (USA)

2003
PHD | University of California Los Angeles Medical Center
Pathology, Medical Microbiology

Post-doctoral Training & Residency

07/01/2006 - 06/30/2008
Fellowship in Surgical Oncology at Memorial Sloan-Kettering Cancer Center

07/01/1997 - 06/30/1998
Internship in Surgery (General Surgery) at Mattel Children's Hospital at UCLA Medical Center

Awards

2019
Elected Membership
Sponsor: Surgical Biology Club II

2018
Elected Membership
Sponsor: Society of University Surgeons

2013
Harrington Scholar Innovator Award
Sponsor: Harrington Discovery Institute

2013
Most Outstanding Faculty Basic Science Research Paper
Sponsor: Rutgers Robert Wood Johnson University Medical School Deans Awar

2012
Sidney Kimmel Scholar Award
Sponsor: Sidney Kimmel Cancer Research Foundation

2006
Scientific Day Research Award
Sponsor: UCLA Longmire

2005
Scientific Day Research Award
Sponsor: UCLA Longmire

2003
Scholar in Training Award
Sponsor: American Association for Cancer Research

2003
Resident Teaching Award
Sponsor: UCLA Department of Surgery

2001
Scholar in Training Award
Sponsor: American Association for Cancer Research

2001
Postdoctoral Investigators
Sponsor: Giannini Family Foundation Medical Research Fellowship Award

2000
Scholar in Training Award
Sponsor: American Association for Cancer Research

1997
Medical Honor Society
Sponsor: Alpha Omega Alpha

1994
Student Abstract Prize
Sponsor: AGA Foundation

1993
Student Research Award
Sponsor: American Gastroenterological Association (AGA)

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Publications

Journal Articles

11/7/2023
Ajay PS, Rajamanickam RK, Rhee K, NeMoyer R, Goyal S, Switchenko JM, Lin Y, Jabbour SK, Carpizo DR, Kennedy TJ, Shah MM. "Identifying the optimal treatment strategy in patients with resectable non-cardia gastric cancer." Surgical endoscopy.. 2023 Nov 7; Epub 2023 Nov 07.

11/2/2023
Ladner DP, Goldstein AM, Billiar TR, Cameron AM, Carpizo DR, Chu DI, Coopersmith CM, DeMatteo RP, Feng SH, Gallagher KA, Gillanders WE, Lal BK, Lipshutz GS, Liu A, Maier RV, Mittendorf EA, Morris AM, Sicklick JK, Velazquez OC, Whitson BA, Wilke LG, Yoon SS, Zeiger MA, Farmer DL, Hwang ES, . "Transforming the Future of Surgeon-Scientists." Annals of surgery.. 2023 Nov 2; Epub 2023 Nov 02.

11/2/2023
Dudgeon C, Casabianca A, Harris C, Ogier C, Bellina M, Fiore S, Bernet A, Ducarouoge B, Goldschneider D, Su X, Pitarresi J, Hezel A, De S, Narrow W, Soliman F, Shields C, Vendramini-Costa DB, Prela O, Wang L, Astsaturov I, Mehlen P, Carpizo DR. "Netrin-1 feedforward mechanism promotes pancreatic cancer liver metastasis via hepatic stellate cell activation, retinoid, and ELF3 signaling." Cell reports.. 2023 Nov 2; 42(11):113369. Epub 2023 Nov 02.

Books & Chapters

2018
Book Title: Precision Molecular Pathology of Liver Cancer
Author List: Greco SH, Spencer K, Carpizo DR
Edited By: Chen Liu
Published By: Springer Publishing 2018

2008
Book Title: : Metastatic Liver Cancer in Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach.
Author List: Fong Y, Carpizo D, Kemeny NE, Covey AM, Willet CG, Czito BG
Edited By: Janusz Jankowski, Richard Sampliner, David Kerr, Yuman Fong
Published By: Blackwell Publishing 2008

2004
Chapter Title: Brooks: Re-operative Breast Surgery
Book Title: Handbook of Re-operative General Surgery
Author List: Chang H, Carpizo, DR
Published By: Blackwell Publishing, Inc. 2004 in Malden, MA

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Reviews

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