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Pang Lab

Jinjiang Pang, B.Med., Ph.D

Assistant Professor, Department of Medicine, Cardiology
2004 | Ph.D. | Cardovascular Physiology | Physiology, Peking Union Medical College & Chinese Academy of Medical Sciences (PUMC & CAMC)
2001 | MS | Smooth Muscle Physiology | Medical College of Lanzhou University
1993 | MD | Clinic Medicine | Shanxi Medical University

Research Overview

Angiogenesis, the formation of new blood vessels from existing ones, is a critical event for tissue development and repair, as well as being associated with many diseases (e.g. bronchopulmonary dysplasia, pulmonary artery hypertension, ischemic cardiomyopathy, retinopathy and tumor growth). The long-term goal of Dr. Pang’s lab is to identify the critical targets that regulate angiogenesis under physiological and pathological conditions. Dr. Pang’s lab also focuses on molecular mechanisms involved cardiac metabolism.

Pang Lab Photo

Imaging shows reduced vasculature in lungs of
GIT1 KO mice.

Projects

Current project goals are to:

  1. Define the role of Dll4-Notch signaling in postnatal lung vasculature development and lung vascular diseases.
  2. Determine the therapeutic effect of a cell permeable Ankyrin repeat peptides on prostate cancer.
  3. Determine the molecular mechanisms involve in mitochondrial biogenesis during cardiac development and diseases.

Recent Publications

  1. Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice, Yin G, Sheu TJ, Menon P, et al., PLoS One. 2014;9(2):e89127.
  2. G-protein-coupled receptor-2-interacting protein- 1 is required for endothelial cell directional migration and tumor angiogenesis via cortact-independent lamellipodia formation, Majumder S, Sowden MP, Gerber SA, et al., Arterioscler Thromb Vasc Biol. 2014;34(2):419-426.
  3. Phospholipase Cepsilon hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertroph., Zhang L, Malik S, Pang J, et al., Cell. 2013;153(1):216-227.
  4. Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis, Park SY, Shi X, Pang J, Yan C, Berk BC., Arterioscler Thromb Vasc Biol. 2013;33(4):737-743.
  5. G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migration, Pang J, Xu X, Wang X, et al., Arterioscler Thromb Vasc Biol. 2013;33(5):999-1005.
  6. G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart, Pang J, Xu X, Getman MR, et al., J Mol Cell Cardiol. 2011;51(5):769-776.
  7. Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells, Wang J, Yin G, Menon P, et al. , Arterioscler Thromb Vasc Biol. 2010;30(10):1976-1982.

More papers:PubMed