Principal Investigator

Hartmut Land, Ph.D. University of Rochester work Box 633 601 Elmwood Ave Rochester NY 14642 office: KMRB 2-9633 p (585) 273-1142

Critical Role of Cooperation Response Genes (CRGs) for the Cancer Phenotype

Our discovery that most of the CRGs we identified appear to be critical for the cancer phenotype provides us with the exciting opportunity to establish the entire cohort of CRGs, out of the 100-strong gene set, that is causally relevant to malignancy of colon cancer cells. We are performing comprehensive gene perturbation experiments in malignant murine and human cancer cells targeting all cooperation response genes for which a causative role for the cancer phenotype has not yet been established. The list of CRGs contains many genes with unknown functions and thus represents a considerable novel resource for cancer intervention.

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