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Institute for Innovative Education

Lab 1: Basic Reactions to Injury

Lab 2: Vascular Diseases

Lab 3: Edema and Herniation

Lab 4: Neoplasms

Lab 5: Demyelinating Disorders

Lab 6: Infectious Diseases

Lab 7: Cranio-Spinal Trauma

Lab 8: Toxic and Metabolic Disorders

Lab 9: Developmental Disorders

Lab 10: Degenerative Disorders


Alzheimer disease, microscopic: On H&E, typical features of Alzheimer disease are neuron loss, gliosis (circle) and inclusion formation. An extracellular plaque (yellow arrowhead) and intraneuronal (cytoplasmic) neurofibrillary tangle (black arrow) are both present in this image. Silver stains (e.g. Bielschowsky) allow one to more easily view plaques and NFTs can be subtle on H&E. Immunohistochemistry for phosphorylated tau protein, a component of NFTs, and beta-amyloid protein, a component of plaques, may also be helpful. This image is from the amygdala of a 55-year-old male with Down syndrome.