Ann R. Falsey, M.D., professor of Infectious Diseases, and Thomas J. Mariani, Ph.D., professor of Pediatrics, received a 5-year, $3.8 million grant from the National Institutes of Health to search for a better way to distinguish bacterial and viral respiratory infections. The goal of the study is to define predictive genes -- using gene expression profiling of blood -- that can be developed into a simple point of care diagnostic that can be used by clinicians to discriminate bacterial and non-bacterial illness. Such a test would allow physicians to optimally manage patients with acute respiratory infections, which are a leading cause of antibiotic overuse and are linked to the rise of antibiotic resistant organisms.
The grant is the result of research done as part of the NIH-funded Respiratory Pathogens Research Center. Falsey and Mariani are the co-principal investigators, and Edward Walsh, M.D., Angela Branche, M.D. and Derick Peterson, Ph.D. are co-investigators.