A postdoctoral position is available in the laboratory of Dmitri Ermolenko at the Department of Biochemistry and Biophysics & Center for RNA Biology, School of Medicine and Dentistry, University of Rochester.
We use single-molecule fluorescent microscopy and biochemical methods to study how structural dynamics of the ribosome and ribosomal ligands enable protein synthesis. In addition to studying ribosomal translation in bacteria and eukaryotes, we investigate the folding and dynamics of structured mRNA molecules, including mRNAs containing riboswitches or structural elements that induce programmed ribosome frameshifting. Applicants must have a recent Ph.D. and expertise in molecular biology/biophysics with publications in international peer-reviewed journals.
Applicants with experience in RNA biochemistry and/or single-molecule FRET are encouraged to apply. Please submit a statement of research interests and experience, and a current curriculum vitae to Dr. Dmitri Ermolenko.
Our lab is currently recruiting graduate students. Motivated candidates who are interested in studying mechanisms of bacterial and eukaryotic translation using ensemble and single-molecule fluorescent methods are encouraged to email Dr. Dmitri Ermolenko.
Join the Fu Lab as a postdoc!
We are seeking a postdoctoral candidate with outstanding experience in bioinformatics and transcriptomics, especially ribosome profiling. Current projects are aimed at understanding the role of RNA modifications in human disorders using mammalian tissue culture and mouse models.
Successful candidates are expected to have:
- PhD in Molecular Biology, Computational Biology or related field.
- Expertise in RNA biochemistry coupled with deep sequencing approaches such as ribosome profiling, CLIP-seq etc.
- Strong background in transcriptomics, bioinformatics and programming
- Self-motivation and the ability to work independently as well as collaboratively
Candidates should provide the following:
- Cover letter with a short statement of research experience, interests and goals
- CV with a publication list and contact information for at least two professional references.
Please submit all application materials electronically to: firstname.lastname@example.org
The position is available immediately with a flexible start date.
Post-doctoral and Technical Associate Opportunities in the Kielkopf Lab at the University of Rochester: Structural Biology of Pre-mRNA Splicing in Human Disease
Positions for post-doctoral and technical associates to study the structural biology of pre-mRNA splicing in human disease are available at the University of Rochester. Projects seek to understand severe defects in pre-mRNA splicing that accompany most human hematologic malignancies and many metabolic disorders, as well as the dependence of HIV-1 and other complex retroviruses on RNA splicing for infectivity at the structural and molecular level. We use multi-pronged and innovative approaches, including X-ray crystallography, fluorescence, calorimetry, small-angle X-ray scattering, HIV-1 assays and human cell culture.
For more information on projects, please see the Kielkopf lab website or contact Dr. Kielkopf.
Interested individuals should send a C.V., including a description of past and on-going research, and the names and contact information of three references to Dr. Kielkopf.
Successful applicants should be well-equipped to contribute to a productive group of interactive lab members with diverse backgrounds and expertise.
A postdoctoral researcher position or staff scientist (research assistant professor) position is available in the laboratory of Dr. Xin Li, Assistant Professor at the University of Rochester Center for RNA Biology, Genome to Therapeutics, Department of Biochemistry and Biophysics and Department of Urology. Research in the Li Lab is at the interface of reproductive and RNA biology.
Research Technician III Position
A full-time Laboratory Research Technician position is available in the laboratory of Dr. Xin Li (posted job number 224416), Associate Professor at the University of Rochester Center for RNA Biology, Genome to Therapeutics, Department of Biochemistry and Biophysics and Department of Urology, NIEHS Environmental Health Sciences Center, Goergen Institute for Data Science, and Department of Biology. Li lab works on the epigenetic and RNA regulation of fertility and inheritance on human, mice, chickens, and lizards. This 6-year-old lab looks for reliable persons who are passionate about science but understands the necessary groundwork required to keep a bustling lab afloat.
Full Research Technician Description
Other Job Opportunities in the Li Lab
We are always interested in hearing from highly motivated, enthusiastic individuals interested in joining our research team.
Current Graduate Students
The Lueck Lab is currently accepting rotation students. Students interested in setting up a rotation should contact Dr. Lueck with your CV and research interests.
Individuals with interest in our multidisciplinary research are encouraged to send a CV and cover letter.
Students interested in RNA biology and their use as therapeutics and skeletal muscle ion channel biophysics should contact Dr. Lueck with your CV and future research interests. Students with backgrounds in the Biological Sciences, Biomedical Engineering or related fields are encouraged to apply.
A Post-Doctoral Position is open in the Maquat Lab at the University of Rochester Medical Center in Rochester, NY. Applicants should hold a PhD or MD/PhD degree(s) and have expertise in molecular, cellular, or structural biology to study one of a number of ongoing projects, including but not limited to FMRP function in Fragile X Syndrome (FXS), newly defined effectors of nonsense-mediated mRNA decay, or the mechanistic coupling of transcription and RNA processing on chromatin and beyond. A background in neurobiology and/or stem-cell biology would facilitate the work on FXS (see, e.g., https://www.nature.com/articles/s41556-020-00618-1), and a background in computational biology would facilitate all projects, but neither is required.
Interested individuals should submit:
- A complete curriculum vitae
- The names and email addresses of three references (applicants should state their relationship to each)
- A description of RNA research experience, including experimental approaches and technologies with which the applicant has experience
The successful applicant will join a very productive, interactive lab and a lively, supportive RNA community that consists of more than 25 labs spanning the University of Rochester Medical Center and the adjacent Colleges of Arts, Sciences & Engineering. The Maquat lab offers an outstanding research environment, excellent opportunities to collaborate with basic scientists and clinicians, and a strong record of training post-docs for academic positions.
Please submit applications to: Liz Leverenz
Lab Technician Opportunity
There is a full-time laboratory technician position available in the Maquat Lab to assist in day-to-day operations. The Maquat lab consists of RNA-centric groups of biochemists/molecular biologists studying the molecular basis of human diseases, including fragile X syndrome, the most common single-gene cause of autism spectrum disorder.
Responsibilities consist of overall lab maintenance, including ordering reagents and supplies; basic molecular biology experiments, including large- and small-scale plasmid preparations, molecular cloning, and analyses of proteins and RNAs; and record keeping. Organizational skills are critical. Prior laboratory experience is optimal. Requirements: BA/BS in Biochemistry, Chemistry, Biology, Neuroscience, Biomedical Engineering or a related field.
Please send Resume, including courses taken and grades obtained, and a cover letter with the names and contact information of three references to:
Liz Leverenz in c/o Dr. Lynne Maquat, Director, Center for RNA Biology; Professor, Depts. of Biochemistry & Biophysics, Oncology, and Pediatrics; University of Rochester School of Medicine.
We're looking for motivated trainees at all levels! We are also hiring a laboratory technician. If you are interested, please contact Stephano Mello.
Trainees will be exposed to a collaborative and interdisciplinary environment and will receive a broad training in cancer research, including genomics-based approaches to study cancer and the use of animal models. Trainees are expected to develop and execute an independent research plan that lead to peer-reviewed publication. We strive to create a diverse, collegial environment, while fostering collaboration and intellectual rigour.
tRNA biology in model eukaryotes
A postdoctoral position is available in the laboratory of Eric Phizicky, Dept. of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester Medical Center, to work in the area of tRNA biology. Research in the lab focuses on the biology of tRNA modifications and tRNA decay pathways in two model organisms: the budding yeast Saccharomyces cerevisiae and the distantly related fission yeast Schizosaccharomyces pombe. The research employs cutting edge techniques in molecular biology, genetics, genomics, and biochemistry to understand problems in tRNA biology, most recently revealing interactions between the biology of modifications and a major cellular stress response pathway. Candidates should have a Ph.D. degree, with a background in genetics, molecular biology, biochemistry, biology, chemistry, pharmacology, or microbiology. Experience with molecular biology, RNA detection/quantification, protein expression/detection, enzyme assays, statistics, or computational analysis would be an asset.
To apply, please send an email to Dr. Eric Phizicky with a curriculum vitae, names of three references, and a brief summary of previous research experience and research interests.
A full-time postdoctoral associate position is available in Dr. Peng Yao’s laboratory in Aab Cardiovascular Research Institute at the University of Rochester Medical Center. Research in the Yao laboratory focuses on the roles of RNA-binding proteins and noncoding RNAs in cardiovascular health and disease. We aim to understand how translational regulation of protein synthesis influence cardiac health and disease and provide new insights into discovery of novel therapeutic approaches to treat heart disease. This position represents an opportunity to join a top-rated biomedical research campus. We are looking for candidates with experiences or interest in following areas: cardiac biology, cardiovascular disease, biochemistry and molecular biology, RNA biology, bioinformatic data analysis, and genetic and disease animal models.
Full Post-Doc Position