Doug Anderson, Ph.D.
MedicineLncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.
Paul L. Boutz, Ph.D.
Biochemistry & BiophysicsRegulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Scott Butler, Ph.D.
Microbiology & ImmunologyRegulation of Gene Expression by Targeted Degradation of RNA
Gloria Culver, Ph.D.
BiologyAssembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.
Paul Dunman, Ph.D.
Microbiology & ImmunologyAntimicrobial drug discovery using pathogenic Staphylococcus aureus and Acinetobacter baumannii: exploiting components of the bacterial RNA metabolism machinery; characterizing prokaryotic ribonucleases; understanding the impact of the host environment on antibiotic resistance and virulence factor expression.
Dmitri N. Ermolenko, Ph.D.
Biochemistry & BiophysicsStructural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Dragony Fu, Ph.D.
BiologyNucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Elizabeth Grayhack, Ph.D.
Biochemistry & BiophysicsRole of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Clara L. Kielkopf, Ph.D.
Biochemistry & BiophysicsSplicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Xin Zhiguo Li, Ph.D.
Biochemistry & BiophysicsOur research is to define the RNA functions in reproduction and transgenerational epigenetic inheritance.
John D. Lueck, Ph.D.
Pharmacology & PhysiologyUse of engineered tRNAs for suppression of nonsense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) transcripts as therapeutic intervention for cystic fibrosis
Lynne Maquat, Ph.D.
Biochemistry & BiophysicsRNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Luis Martinez-Sobrido, Ph.D.
Microbiology & ImmunologyMolecular biology, immunology, and pathogenesis of negative-stranded viruses (Influenza viruses, Respiratory Syncytial Virus, Metapneumovirus, Arenavirus, Thogoto virus, Ebola virus, Crimean Congo Hemorrhagic Fever virus), positive-stranded viruses (Dengue virus, SARS coronavirus, Hepatitis virus), and RNA and DNA (cytomegalovirus and vaccinia virus)
Program for Advanced Immune Bioimaging
David H. Mathews, M.D., Ph.D.
Biochemistry & BiophysicsComputational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Stephano Mello, Ph.D.
Biomedical GeneticsUnderstanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation.
Joseph M. Miano, Ph.D.
MedicineDiscovery and function of long noncoding RNAs and CArG regulatory elements in mouse and human genomes; genome editing in mice
Mitchell O'Connell, Ph.D.
Biochemistry & BiophysicsBiochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Eric Phizicky, Ph.D.
Biochemistry & BiophysicstRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Gaurav Sharma, Ph.D.
Electrical & Computer EngineeringComputational biology of RNA; RNA comparative sequence analysis; RNA structure prediction; analysis of HIV RNA genomes.
Harold C. Smith, Ph.D.
Biochemistry & BiophysicsRNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.
Charles A. Thornton, M.D.
NeurologyMyotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.
Douglas H. Turner, Ph.D.
ChemistryBiophysical chemistry of RNA folding/stacking using NMR; RNA-targeted therapeutics
Joseph E. Wedekind, Ph.D.
Biochemistry & BiophysicsStructure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Peng Yao, Ph.D.
MedicinePathophysiological function of microRNAs, RNA-binding proteins, and defects in protein synthesis in cardiovascular disease; RNA riboswitch-like mechanisms of gene regulation
Yi-Tao Yu, Ph.D.
Biochemistry & BiophysicsRNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.