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Doug Anderson, Ph.D.Doug Anderson, Ph.D.
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Anderson Lab

LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.

Paul Boutz, Ph.D.Paul L. Boutz, Ph.D.
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Biochemistry & Biophysics
Boutz Lab

Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.

Scott Butler, Ph.D.Scott Butler, Ph.D.
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Microbiology & Immunology
Butler Lab

Regulation of Gene Expression by Targeted Degradation of RNA

Gloria Culver, Ph.D.Gloria Culver, Ph.D.
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Culver Lab

Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.

Paul Dunman, Ph.D.Paul Dunman, Ph.D.
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Microbiology & Immunology
Dunman Lab

Antimicrobial drug discovery using pathogenic Staphylococcus aureus and Acinetobacter baumannii: exploiting components of the bacterial RNA metabolism machinery; characterizing prokaryotic ribonucleases; understanding the impact of the host environment on antibiotic resistance and virulence factor expression.

Dmitri Ermolenko, Ph.D.Dmitri N. Ermolenko, Ph.D.
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Biochemistry & Biophysics
Ermolenko Lab

Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.

Dragony Fu, Ph.D.Dragony Fu, Ph.D.
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Fu Lab

Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.

Elizabeth Grayhack, Ph.D.Elizabeth Grayhack, Ph.D.
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Biochemistry & Biophysics
Grayhack Lab

Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.

Clara Kielkopf, Ph.D.Clara L. Kielkopf, Ph.D.
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Biochemistry & Biophysics
Kielkopf Lab

Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.

Xin Li, Ph.D.Xin Zhiguo Li, Ph.D.
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Biochemistry & Biophysics
Li Lab

Our research is to define the RNA functions in reproduction and transgenerational epigenetic inheritance.

John Lueck, Ph.D.John D. Lueck, Ph.D.
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Pharmacology & Physiology
Lueck Lab

Determining the therapeutic promise of engineered tRNAs for treatment of nonsense associated diseases and investigating the pathomechanisms of skeletal muscle weakness and wasting in myotonic dystrophy

Lynne Maquat, Ph.D.Lynne Maquat, Ph.D.
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Biochemistry & Biophysics
Maquat Lab

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.

Luis Martinez-Sobrido, Ph.D.Luis Martinez-Sobrido, Ph.D.
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Microbiology & Immunology
Martinez-Sobrido Lab
Program for Advanced Immune Bioimaging

Molecular biology, immunology, and pathogenesis of negative-stranded viruses (Influenza viruses, Respiratory Syncytial Virus, Metapneumovirus, Arenavirus, Thogoto virus, Ebola virus, Crimean Congo Hemorrhagic Fever virus), positive-stranded viruses (Dengue virus, SARS coronavirus, Hepatitis virus), and RNA and DNA (cytomegalovirus and vaccinia virus)

David Mathews, M.D., Ph.D.David H. Mathews, M.D., Ph.D.
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Biochemistry & Biophysics
Mathews Lab

Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.

Stephano Mello, Ph.D.Stephano Mello, Ph.D.
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Biomedical Genetics
Mello Lab

Understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation.

Joseph Miano, Ph.D.Joseph M. Miano, Ph.D.
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Miano Lab

Genomics and gene regulation and function in normal and pathological processes in the cardiovascular system

Mitchell O'Connell, Ph.D.Mitchell O'Connell, Ph.D.
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Biochemistry & Biophysics
O'Connell Lab

Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development

Eric Phizicky, Ph.D.Eric Phizicky, Ph.D.
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Biochemistry & Biophysics
Phizicky Lab

tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.

Hitomi Sakano, M.D., Ph.D.Hitomi Sakano, M.D., Ph.D.
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Dr. Sakano specializes Otology and Neurotology, treating the disorders of the ear and lateral skull base. She also has a research interest in the activity dependent changes of the auditory neural pathways.

Gaurav Sharma, Ph.D.Gaurav Sharma, Ph.D.
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Electrical & Computer Engineering
Sharma Lab

Computational biology of RNA; RNA comparative sequence analysis; RNA structure prediction; analysis of HIV RNA genomes.

Harold Smith, Ph.D.Harold C. Smith, Ph.D.
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Biochemistry & Biophysics
Smith Lab

Msg RNA editing in health and disease

Charles Thornton, M.D.Charles A. Thornton, M.D.
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Thornton Lab

Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.

Douglas Turner, Ph.D.Douglas H. Turner, Ph.D.
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Turner Lab

Biophysical chemistry of RNA folding/stacking using NMR; RNA-targeted therapeutics

Joseph Wedekind, Ph.D.Joseph E. Wedekind, Ph.D.
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Biochemistry & Biophysics
Wedekind Lab

Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.

Peng Yao, Ph.D.Peng Yao, Ph.D.
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Yao Lab

Pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease.

Yi-Tao Yu, Ph.D.Yi-Tao Yu, Ph.D.
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Biochemistry & Biophysics
Yu Lab

RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.