Faculty
Doug Anderson, Ph.D.
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Medicine
Anderson Lab
LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.
Paul L. Boutz, Ph.D.
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Biochemistry & Biophysics
Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Scott Butler, Ph.D.
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Microbiology & Immunology
Butler Lab
Regulation of Gene Expression by Targeted Degradation of RNA
Gloria Culver, Ph.D.
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Biology
Culver Lab
Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.
Paul Dunman, Ph.D.
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Microbiology & Immunology
Dunman Lab
Antimicrobial drug discovery using pathogenic Staphylococcus aureus and Acinetobacter baumannii: exploiting components of the bacterial RNA metabolism machinery; characterizing prokaryotic ribonucleases; understanding the impact of the host environment on antibiotic resistance and virulence factor expression.
Dmitri N. Ermolenko, Ph.D.
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Biochemistry & Biophysics
Ermolenko Lab
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Dragony Fu, Ph.D.
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Biology
Fu Lab
Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Elizabeth Grayhack, Ph.D.
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Biochemistry & Biophysics
Grayhack Lab
Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Clara L. Kielkopf, Ph.D.
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Biochemistry & Biophysics
Kielkopf Lab
Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Xin Zhiguo Li, Ph.D.
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Biochemistry & Biophysics
Li Lab
Our research is to define the RNA functions in reproduction and transgenerational epigenetic inheritance.
John D. Lueck, Ph.D.
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Pharmacology & Physiology
Lueck Lab
Use of engineered tRNAs for suppression of nonsense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) transcripts as therapeutic intervention for cystic fibrosis
Lynne Maquat, Ph.D.
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Biochemistry & Biophysics
Maquat Lab
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases. 
Luis Martinez-Sobrido, Ph.D.
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Microbiology & Immunology
Martinez-Sobrido Lab
Program for Advanced Immune Bioimaging
Molecular biology, immunology, and pathogenesis of negative-stranded viruses (Influenza viruses, Respiratory Syncytial Virus, Metapneumovirus, Arenavirus, Thogoto virus, Ebola virus, Crimean Congo Hemorrhagic Fever virus), positive-stranded viruses (Dengue virus, SARS coronavirus, Hepatitis virus), and RNA and DNA (cytomegalovirus and vaccinia virus)
David H. Mathews, M.D., Ph.D.
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Biochemistry & Biophysics
Mathews Lab
Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Stephano Mello, Ph.D.
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Biomedical Genetics
Mello Lab
Understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation.
Joseph M. Miano, Ph.D.
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Medicine
Miano Lab
Discovery and function of long noncoding RNAs and CArG regulatory elements in mouse and human genomes; genome editing in mice
Mitchell O'Connell, Ph.D.
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Biochemistry & Biophysics
O'Connell Lab
Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Eric Phizicky, Ph.D.
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Biochemistry & Biophysics
Phizicky Lab
tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Gaurav Sharma, Ph.D.
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Electrical & Computer Engineering
Sharma Lab
Computational biology of RNA; RNA comparative sequence analysis; RNA structure prediction; analysis of HIV RNA genomes.
Harold C. Smith, Ph.D.
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Biochemistry & Biophysics
Smith Lab
RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.
Charles A. Thornton, M.D.
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Neurology
Thornton Lab
Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.
Douglas H. Turner, Ph.D.
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Chemistry
Turner Lab
Biophysical chemistry of RNA folding/stacking using NMR; RNA-targeted therapeutics
Joseph E. Wedekind, Ph.D.
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Biochemistry & Biophysics
Wedekind Lab
Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Peng Yao, Ph.D.
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Medicine
Yao Lab
Pathophysiological function of microRNAs, RNA-binding proteins, and defects in protein synthesis in cardiovascular disease; RNA riboswitch-like mechanisms of gene regulation
Yi-Tao Yu, Ph.D.
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Biochemistry & Biophysics
Yu Lab
RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.