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Faculty

Doug Anderson, Ph.D.Doug Anderson, Ph.D.
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Medicine

LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.

Scott Butler, Ph.D.Scott Butler, Ph.D.
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Microbiology & Immunology
Butler Lab

Regulation of Gene Expression by Targeted Degradation of RNA

Gloria Culver, Ph.D.Gloria Culver, Ph.D.
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Biology
Culver Lab

Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.

Paul Dunman, Ph.D.Paul Dunman, Ph.D.
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Microbiology & Immunology
Dunman Lab

Antimicrobial drug discovery using pathogenic Staphylococcus aureus and Acinetobacter baumannii: exploiting components of the bacterial RNA metabolism machinery; characterizing prokaryotic ribonucleases; understanding the impact of the host environment on antibiotic resistance and virulence factor expression.

Dmitri Ermolenko, Ph.D.Dmitri N. Ermolenko, Ph.D.
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Biochemistry & Biophysics
Ermolenko Lab

Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.

Dragony Fu, Ph.D.Dragony Fu, Ph.D.
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Biology
Fu Lab

Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.

Elizabeth Grayhack, Ph.D.Elizabeth Grayhack, Ph.D.
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Biochemistry & Biophysics
Grayhack Lab

Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.

Clara Kielkopf, Ph.D.Clara L. Kielkopf, Ph.D.
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Biochemistry & Biophysics
Kielkopf Lab

Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.

Xin Li, Ph.D.Xin Zhiguo Li, Ph.D.
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Biochemistry & Biophysics
Li Lab

Small RNAs in germ cells; epigenetic inheritance; bioinformatics

Lynne Maquat, Ph.D.Lynne Maquat, Ph.D.
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Biochemistry & Biophysics
Maquat Lab

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.

Luis Martinez-Sobrido, Ph.D.Luis Martinez-Sobrido, Ph.D.
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Microbiology & Immunology
Martinez-Sobrido Lab

Molecular biology, immunology, and pathogenesis of negative-stranded viruses (Influenza viruses, Respiratory Syncytial Virus, Metapneumovirus, Arenavirus, Thogoto virus, Ebola virus, Crimean Congo Hemorrhagic Fever virus), positive-stranded viruses (Dengue virus, SARS coronavirus, Hepatitis virus), and RNA and DNA (cytomegalovirus and vaccinia virus)

David Mathews, M.D., Ph.D.David H. Mathews, M.D., Ph.D.
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Biochemistry & Biophysics
Mathews Lab

Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.

Joseph Miano, Ph.D.Joseph M. Miano, Ph.D.
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Medicine
Miano Lab

Discovery and function of long noncoding RNAs and CArG regulatory elements in mouse and human genomes; genome editing in mice

Mitchell O'Connell, Ph.D.Mitchell O'Connell, Ph.D.
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Biochemistry & Biophysics
O'Connell Lab

Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development

Eric Phizicky, Ph.D.Eric Phizicky, Ph.D.
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Biochemistry & Biophysics
Phizicky Lab

tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.

Gaurav Sharma, Ph.D.Gaurav Sharma, Ph.D.
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Electrical & Computer Engineering
Sharma Lab

Computational biology of RNA; RNA comparative sequence analysis; RNA structure prediction; analysis of HIV RNA genomes.

Harold Smith, Ph.D.Harold C. Smith, Ph.D.
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Biochemistry & Biophysics
Smith Lab

RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.

Charles Thornton, M.D.Charles A. Thornton, M.D.
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Neurology
Thornton Lab

Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.

Douglas Turner, Ph.D.Douglas H. Turner, Ph.D.
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Chemistry
Turner Lab

Biophysical chemistry of RNA folding/stacking using NMR; RNA-targeted therapeutics

Joseph Wedekind, Ph.D.Joseph E. Wedekind, Ph.D.
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Biochemistry & Biophysics
Wedekind Lab

Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.

Peng Yao, Ph.D.Peng Yao, Ph.D.
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Medicine
Yao Lab

Pathophysiological function of microRNAs, RNA-binding proteins, and defects in protein synthesis in cardiovascular disease; RNA riboswitch-like mechanisms of gene regulation

Yi-Tao Yu, Ph.D.Yi-Tao Yu, Ph.D.
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Biochemistry & Biophysics
Yu Lab

RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.