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FacultyDepartment/LabInterests
Doug Anderson, Ph.D.

Doug Anderson, Ph.D.

Medicine

LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.
J. Butler, Ph.D.

J. Scott Butler, Ph.D.

Microbiology & Immunology

Butler Lab

Regulation of Gene Expression by Targeted Degradation of RNA
Gloria Culver, Ph.D.

Gloria Culver, Ph.D.

Biology

Culver Lab

Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.
Paul Dunman, Ph.D.

Paul Dunman, Ph.D.

Microbiology & Immunology

Dunman Lab

Antimicrobial drug discovery using pathogenic Staphylococcus aureus and Acinetobacter baumannii: exploiting components of the bacterial RNA metabolism machinery; characterizing prokaryotic ribonucleases; understanding the impact of the host environment on antibiotic resistance and virulence factor expression.
Dmitri Ermolenko, Ph.D.

Dmitri N. Ermolenko, Ph.D.

Biochemistry & Biophysics

Ermolenko Lab

Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Dragony Fu, Ph.D.

Dragony Fu, Ph.D.

Biology

Fu Lab

Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Elizabeth Grayhack, Ph.D.

Elizabeth Grayhack, Ph.D.

Biochemistry & Biophysics

Grayhack Lab

Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Clara Kielkopf, Ph.D.

Clara L. Kielkopf, Ph.D.

Biochemistry & Biophysics

Kielkopf Lab

Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Xin Li, Ph.D.

Xin Zhiguo Li, Ph.D.

Biochemistry & Biophysics

Li Lab

Small non-coding RNA regulation in germ cells; paternal aging; transgenerational inheritance.
Lynne Maquat, Ph.D.

Lynne Maquat, Ph.D.

Biochemistry & Biophysics

Maquat Lab

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Luis Martinez-Sobrido, Ph.D.

Luis Martinez-Sobrido, Ph.D.

Microbiology & Immunology

Martinez-Sobrido Lab

Molecular biology, immunology, and pathogenesis of negative-stranded viruses (Influenza viruses, Respiratory Syncytial Virus, Metapneumovirus, Arenavirus, Thogoto virus, Ebola virus, Crimean Congo Hemorrhagic Fever virus), positive-stranded viruses (Dengue virus, SARS coronavirus, Hepatitis virus), and RNA and DNA (cytomegalovirus and vaccinia virus)
David Mathews, M.D., Ph.D.

David H. Mathews, M.D., Ph.D.

Biochemistry & Biophysics

Mathews Lab

Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Joseph Miano, Ph.D.

Joseph M. Miano, Ph.D.

Medicine

Miano Lab

Discovery and function of long noncoding RNAs and CArG regulatory elements in mouse and human genomes; genome editing in mice
Mitchell O'Connell, Ph.D.

Mitchell O'Connell, Ph.D.

Biochemistry & Biophysics

O'Connell Lab

Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Eric Phizicky, Ph.D.

Eric Phizicky, Ph.D.

Biochemistry & Biophysics

Phizicky Lab

tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Gaurav Sharma, Ph.D.

Gaurav Sharma, Ph.D.

Electrical & Computer Engineering

Sharma Lab

Computational biology of RNA; RNA comparative sequence analysis; RNA structure prediction; analysis of HIV RNA genomes.
Harold Smith, Ph.D.

Harold C. Smith, Ph.D.

Biochemistry & Biophysics

Smith Lab

RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.
Charles Thornton, M.D.

Charles A. Thornton, M.D.

Neurology

Thornton Lab

Neurogenetic disorders, including myotonic dystrophy; therapeutics, including antisense approaches.
Douglas Turner, Ph.D.

Douglas H. Turner, Ph.D.

Chemistry

Turner Lab

Biophysical chemistry of RNA folding/stacking using NMR; RNA-targeted therapeutics
Joseph Wedekind, Ph.D.

Joseph E. Wedekind, Ph.D.

Biochemistry & Biophysics

Wedekind Lab

Structure and function analysis of gene regulation by riboswitches and microRNAs as a basis for therapeutic development.
Peng Yao, Ph.D.

Peng Yao, Ph.D.

Medicine

Yao Lab

Pathophysiological function of microRNAs, RNA-binding proteins, and defects in protein synthesis in cardiovascular disease; RNA riboswitch-like mechanisms of gene regulation
Yi-Tao Yu, Ph.D.

Yi-Tao Yu, Ph.D.

Biochemistry & Biophysics

Yu Lab

RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.