J. Scott Butler, Ph.D.
| Microbiology & Immunology
Butler Lab
| Regulation of Gene Expression by Targeted Degradation of RNA |
Gloria Culver, Ph.D.
| Biology
Culver Lab
| Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points. |
Paul Dunman, Ph.D.
| Microbiology & Immunology
Dunman Lab
| Antimicrobial drug discovery using pathogenic Staphylococcus aureus and Acinetobacter baumannii: exploiting components of the bacterial RNA metabolism machinery; characterizing prokaryotic ribonucleases; understanding the impact of the host environment on antibiotic resistance and virulence factor expression. |
Thomas Eickbush, Ph.D.
| Biology
Eickbush Lab
| Retrotransposable elements, protein: RNA and protein: DNA interactions, sequence specific endonucleases. |
Reyad Elbarbary, Ph.D.
| Biochemistry & Biophysics
Maquat Lab
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Dmitri N. Ermolenko, Ph.D.
| Biochemistry & Biophysics
Ermolenko Lab
| Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action. |
Dragony Fu, Ph.D.
| Biology
Fu Lab
| Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer. |
Elizabeth Grayhack, Ph.D.
| Biochemistry & Biophysics
Grayhack Lab
| Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae. |
Clara L. Kielkopf, Ph.D.
| Biochemistry & Biophysics
Kielkopf Lab
| Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets. |
Xin Zhiguo Li, Ph.D.
| Biochemistry & Biophysics
Li Lab
| Small non-coding RNA regulation in germ cells; paternal aging; transgenerational inheritance. |
Lynne Maquat, Ph.D.
| Biochemistry & Biophysics
Maquat Lab
| RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases. |
Luis Martinez-Sobrido, Ph.D.
| Microbiology & Immunology
Martinez-Sobrido Lab
| Molecular biology, immunology, and pathogenesis of negative-stranded (Influenza viruses, Respiratory Syncytial Virus, Human Metapneumovirus, arenavirus, Thogoto virus, Ebola virus, Crimean Congo Hemorrhagic Fever virus) and positive-stranded (Dengue virus, SARS coronavirus, Mouse Hepatitis virus) RNA and DNA (human cytomegalovirus and vaccinia) viruses. |
David H. Mathews, M.D., Ph.D.
| Biochemistry & Biophysics
Mathews Lab
| Computational biology of RNA, including structure prediction, molecular dynamics, and genomics. |
Joseph M. Miano, Ph.D.
| Medicine
Miano Lab
| Discovery and function of long noncoding RNAs and CArG regulatory elements in mouse and human genomes; genome editing in mice |
Eric Phizicky, Ph.D.
| Biochemistry & Biophysics
Phizicky Lab
| tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications. |
Bogdan Polevoda, Ph.D.
| Biochemistry & Biophysics
Smith Lab
| The two cotranslational processes, cleavage of N-terminal methionine and N-terminal acetylation (N- acetylation). |
Mohammad Salim, Ph.D.
| Biochemistry & Biophysics
Wedekind Lab
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Gaurav Sharma, Ph.D.
| Electrical & Computer Engineering
Sharma Lab
| Computational biology of RNA; RNA comparative sequence analysis; RNA structure prediction; analysis of HIV RNA genomes. |
Harold C. Smith, Ph.D.
| Biochemistry & Biophysics
Smith Lab
| RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins. |
Charles A. Thornton, M.D.
| Neurology
Thornton Lab
| Neurogenetic disorders, including myotonic dystrophy; therapeutics, including antisense approaches. |
Douglas H. Turner, Ph.D.
| Chemistry
Turner Lab
| Biophysical chemistry of RNA folding/stacking using NMR; RNA-targeted therapeutics |
Joseph E. Wedekind, Ph.D.
| Biochemistry & Biophysics
Wedekind Lab
| Structure and function analysis of gene regulation by riboswitches and microRNAs as a basis for therapeutic development. |
Yi-Tao Yu, Ph.D.
| Biochemistry & Biophysics
Yu Lab
| RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.
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