Trainees

Research Interest:

Investigating differential intron sensitivity to PUF60, a gene that is deleted or amplified in developmental syndromes and cancers

Research Interest:

Development of gene delivery techniques to the lung using electroporation and modified nucleic acids

Research Interest:

The Effect of Integrator Subunit 11 Mutations on Integrator Function and Neuronal Development

Research Interest: Understanding the role of lncRNA Neat1 in maintaining cell identity.

Research Interest:

Pathomechanism of skeletal muscle weakness and degeneration in Myotonic Dystrophy

Research Interest:

Investigating the roles of the SF3B1 ULMs in recruiting protein phosphatases for pre-mRNA splicing

Research Interest:

Translational control and metabolism

Research Interest:

 Picking up the Pieces: The Fragmented Process of Cas13 Mediated RNA Cleavage in Human Cells

Research Interest:

Understanding the mechanism of pre-mRNA splicing regulation by the long non-coding RNA Neat1.

Research Interest:

Suppression of cerebral cavernous malformation nonsense mutation using anti-codon edited tRNAs 

Research Interest:

Development of tools and tRNA-based therapeutics for rescue of PTC-derived disease and improved target protein expression

Research Interest:

Evidence for a non-canonical mode of translation regulation by preQ1 riboswitches

Research Interest:

mRNA degradosomes, tRNA processing and penicillin binding proteins-4 as targets to develop novel classes of  antibacterial drugs.

Research Interest:

Investigating the Role of RNA Helicases in Splicing Changes caused by Cancer Associated SF3B1 Mutations

Research Interest:

Identification and Characterization of Transcription Factors Associating with the Integrator Complex

Research Interest:

Modeling the effects of cancer-associated spliceosome mutations and identifying driving intronic features using deep-learning neural networks

Research Interest:

Modeling CDK12 and CDK13 Loss-of-Function to Investigate Their Roles in Alternative Polyadenylation and Neoantigen Expression

Research Interest:

Cytoplasmic binding partners of Integrator endonuclease INTS11 and paralog CPSF73 are required for their nuclear function

Research Interest:

Structural Studies of Cas13b Accessory Protein Csx27

Research Interest:

Structure and Function Analysis of a Type III PreQ1 Riboswitch from Escherichia coli

Research Interest:

Structural Investigation of Early Splicing Factor Complexes

Research Interest:

Pulling the plug on bacteriophage infection: investigating the molecular mechanism of activation of CRISPR-Csx28

Research Interest:

Structure and Function Analysis of a Spermidine-Sensing Bacterial Riboswitch

Research Interest:

Regulation of transcription machinery by phosphorylation

Research Interest:

Targeting A. baumannii efflux pumps via small molecule inhibitors to improve existing antibiotic treatments' effectiveness and combat adaptive efflux-mediated drug resistance.

Research Interest:

Predicting conserved non-canonical RNA interactions using sequence comparison

Research Interest:

Inferring RNA Secondary Structure Using a Multiple Homologous Sequence Alignment

Research Interest:

The role of the Type VI CRISPR-Cas accessory protein Csx27 in CRISPR-Cas13 mediated anti-viral immunity

Research Interest:

Defining the roles of 5’UTR length and secondary structure in eukaryotic translation initiation

Research Interest:

Targeted tRNA pseudouridylation reveals a novel base interaction that facilitates nonsense suppression

Research Interest:

Nucleic Acid Biology, Epigenetics, and Development. My project is focused on the role of H2A.Z in epigenetic inheritance.

Research Interest:

The function of lncRNAs in heart development; optimizing techniques to identify direct protein interactions with lncRNAs.

Research Interest:

Developing a platform for experimental identification of genetic barriers to horizontal gene transfer in Staphylococcus aureus

Research Interest:

Elucidating the Epigenetic Mechanisms that Regulate stress and steady-state Erythropoiesis, with the overarching goal of ameliorating symptoms in hemoglobinopathies.

Research Interest:

Clustering of RNA backbone conformations to define RNA ‘Suite’ conformers

Research Interest:

Type VI CRISPR and associated bacterial anti-phage defense systems

Research Interest:

Isolating the Role of Myotonia in Myotonic Dystrophy Pathogenesis

Research Interest:

Structure and Function Analysis of Bacterial Riboswitches that Control Translation

Research Interest:

Inhibition of Precancerous Transformation via Drug-Induced p53 Activation

Research Interest:

In Vitro Selection Identifies Cardiac Cell Targeting RNA Motifs/p>