Trainees

Research Interest: Define the information carriers in semen underlying Pb-induced transgenerational behavioral alterations.

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Identifying Distant Homologs of the ncRNA Lep5

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How do mRNA Stem-Loops Induce Ribosome Pausing?

Research Interest: Understanding the role of lncRNA Neat1 in maintaining cell identity.

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A cyclic peptide library that targets HIV TAR RNA reveals key roles for cyclization linkers and peptide sequences in antiviral function

Research Interest: Arginine Forks Are a Widespread Motif to Recognize Phosphate Backbones and Guanine Nucleobases in the RNA Major Groove

Research Interest: Pathomechanism of skeletal muscle weakness and degeneration in Myotonic Dystrophy

Research Interest: Understanding Rules for Cas13 Mediated RNA Targeting in Human Cells

Research Interest: Understanding the roles of lncRNA Neat1 in regulating gene expression and early oncogenesis.

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Distinguishing the role of a putative U2AF65 - SF3B1 complex in pre-mRNA splicing

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Modeling the Effects of Cancer-Associated Spliceosome Mutations and Identifying Driving Intronic Features Using Deep-Learning Neural Networks

Research Interest: Understanding the role of the RNA secondary structure context in regulating upstream open reading frames

Research Interest: A reading frame quality control system acts during ribosome collisions in Saccharomyces cerevisiae

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Identification of intron-encoded neoantigens upregulated by cancer-associated CDK12/13 mutations

Research Interest: Cracking the Function of PRRC2B in Translation Initiation

Research Interest: Exploring the use of suppressor tRNAs for suppression of nonsense mutations in the CFTR gene as a potential treatment for cystic fibrosis

Research Interest: Structure and Function of the Disease-Relevant Pre-mRNA Splicing Factor U2AF2

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Inferring RNA Secondary Structure from Multiple Sequence Alignment

Research Interest: RNA biology, CRISPR-Cas systems. Understanding gRNA design rules for efficient and specific Cas13 RNA-binding in human cells.

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The role of the Type VI CRISPR-Cas accessory protein Csx27 in the regulation of CRISPR-Cas13 mediated anti-viral immunity

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Exploring the potential role of U2 m6Am modification in branch site recognition during pre-mRNA splicing

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Nucleic Acid Biology, Epigenetics, and Development. My project is focused on the role of H2A.Z in epigenetic inheritance.

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The function of lncRNAs in heart development; optimizing techniques to identify direct protein interactions with lncRNAs.

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Discovery of a PreQ1 Riboswitch with a Fundamentally Different Mode of Effector Recognition and Gene Regulation

Research Interest: Characterizing the molecular underpinnings of muscle excitability in Myotonic Dystrophy and the development of potential therapeutics

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Two riboswitches with identical binding pockets show different tolerances to equivalent mutations and varied promiscuities for cognate effector binding

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tRNA Modifications and Quality Control Decay Pathways in Evolutionarily Distant Yeast Species

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Evaluating the Potential of Tumor Suppressor p53 to Preserve Pancreatic Acinar Cell Identity

Research Interest: The Role of Csx28 in CRISPR-Cas13b Anti-Bacteriophage Defense

Research Interest: Molecular and Cellular Mechanisms that Control Tissue Homeostasis and Somatic Stem Cells.