Trainees

Research Interest:

Investigating differential intron sensitivity to core spliceosome factors that are amplified or deleted in developmental syndromes and cancer

Research Interest:

Identifying structurally conserved motifs in Respiratory Syncytial Virus (RSV)

Research Interest: Understanding the role of lncRNA Neat1 in maintaining cell identity.

Research Interest:

Pathomechanism of skeletal muscle weakness and degeneration in Myotonic Dystrophy

Research Interest:

Translational control and metabolism

Research Interest:

 Picking up the Pieces: The Fragmented Process of Cas13 Mediated RNA Cleavage in Human Cells

Research Interest: Understanding the roles of lncRNA Neat1 in regulating gene expression and early oncogenesis.

Research Interest:

Suppression of cerebral cavernous malformation nonsense mutation using anti-codon edited tRNAs 

Research Interest:

A UHM-ULM interface contributes to the pre-mRNA splicing functions of U2AF2 and SF3B1

Research Interest:

mRNA degradosomes, tRNA processing and penicillin binding proteins-4 as targets to develop novel classes of  antibacterial drugs.

Research Interest:

Investigating the Role of RNA Helicases in Splicing Changes caused by Cancer Associated SF3B1 Mutations

Research Interest:

Modeling the effects of cancer-associated spliceosome mutations and identifying driving intronic features using deep-learning neural networks

Research Interest:

Understanding the Role of RNA Structures in Regulating Upstream Open Reading Frames

Research Interest:

Modeling CDK12 and CDK13 Loss-of-Function to Investigate Their Roles in Alternative Polyadenylation and Neoantigen Expression

Research Interest:

Identification and Structural Basis of a Novel Cellular Inhibitor of the Integrator Cleavage Module

Research Interest:

The Molecular Mechanism and Biological Impact of Cis-acting Elements and Trans-acting Factors in mRNA Translation Regulation

Research Interest:

Exploring the use of suppressor tRNAs for suppression of nonsense mutations in the CFTR gene as a potential treatment for cystic fibrosis

Research Interest:

Inferring RNA Secondary Structure Using a Multiple Homologous Sequence Alignment

Research Interest: RNA biology, CRISPR-Cas systems. Understanding gRNA design rules for efficient and specific Cas13 RNA-binding in human cells.

Research Interest:

The role of the Type VI CRISPR-Cas accessory protein Csx27 in CRISPR-Cas13 mediated anti-viral immunity

Research Interest:

Targeted tRNA pseudouridylation reveals a novel base interaction that facilitates nonsense suppression

Research Interest:

RNA structure and translational control

Research Interest:

Nucleic Acid Biology, Epigenetics, and Development. My project is focused on the role of H2A.Z in epigenetic inheritance.

Research Interest:

The function of lncRNAs in heart development; optimizing techniques to identify direct protein interactions with lncRNAs.

Research Interest:

Elucidating the Epigenetic Mechanisms that Regulate stress and steady-state Erythropoiesis, with the overarching goal of ameliorating symptoms in hemoglobinopathies.

Research Interest:

Seven-Dimensional Clustering of RNA Backbone Conformations to Define RNA ‘Suites’

Research Interest:

Characterizing the molecular underpinnings of muscle excitability in Myotonic Dystrophy and the development of potential therapeutics

Research Interest:

Structure and Function Analysis of Bacterial Riboswitches that Control Translation

Research Interest:

Inhibition of Precancerous Transformation via Drug-Induced p53 Activation

Research Interest:

Stress-responsive regulation of translation initiation