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Research Resident Spotlight

2024

Surgery Resident Spotlight: Alexa Melucci, MD

Tuesday, June 4, 2024

Alexa Melucci, MD

PGY6

Tell us a little about your path to Surgery Residency. Melucci

My interest in surgery began with many visits to the orthopedic surgeon in high school for various soccer¬related knee injuries. As a result, I had six surgeries which ultimately ended my soccer career but were some of my first exposures to the field of surgery and these experiences solidified my desire to pursue medicine and surgery. I earned my BS in Biology, Vertebrae Physiology, and a minor in Kinesiology from Penn State in 2014 and matriculated directly into medical school at Rutgers Robert Wood Johnson. There I met my now husband, and we couples matched to the University of Rochester in 2018 - him into orthopedic surgery and me into general surgery.
 

What was your motivation to pursue research during your residency?

I did not have a dedicated research experience in medical school, so research was something I knew I wanted to pursue during my time in residency. Specifically, I wanted to learn how to ask the right research question and acquire a subset of skills to begin to answer it. As I am interested in surgical oncology, I initially thought basic science was where my interests lie. However, after six months I quickly realized it was not where I was going to excel. The department was extremely supportive in allowing me to shift gears to health services and outcomes-based research, which better aligned with my goals.
 

Who is your research mentor?

David Linehan, MD  

Fergal Fleming, MD
Associate Professor of Surgery
Clinical Director:SHORE: Surgical Health Outcomes Reaching for Equity

 

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Jacob Moalem, MD
Professor of Surgery and Endocrinology
Director, Department of Surgery Quality and Safety
Opioid Reduction Program 
  

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Larissa Temple, MD
Professor of Surgery and Chief 
Division of Colorectal Surgery
Co-Director, Surgical Value Incubator Program

What does the role of mentorship in research mean to you?

A research mentor's role is vital to a mentee's academic and personal development. The mentor-mentee relationship is dynamic always adjusting to the various levels of support and guidance that a mentee may need for skill development and growth. Importantly, a research mentor knows their own skill set and strengths and is willing to connect mentees with other mentors to help achieve the mentee's goals.

What is your research focus?

My research focused on the outcomes of older adults with cancer after surgery. One project focused on the development of hospital acquired geriatric syndromes (malnutrition, delirium, etc.) after elective surgery for gastrointestinal cancer. We found older patients who undergo surgery for cancer are at risk for developing a syndrome in the hospital and development of the syndromes was associated with a higher risk of one-year mortality and significantly fewer days alive and out of hospital. Another project evaluating adherence to guideline care in older adults with rectal cancer found older patients were less likely to receive guideline¬ adherent care and a left-digit bias (disproportionate influence of left most age digit - i.e. 58-59-year-old treated differently than 60-year-old) was present.

What are your recent presentations/awards/manuscripts?

Awards:

University of Rochester Department of Surgery 4th Annual Research Symposium – Second Place in Clinical Outcomes, Spring 2024

University of Rochester Medical Faculty Group Healthcare Innovation Pilot Grant, Co-investigator, 2021-2023

Publications:

Melucci, A. D., Loria, A., Aquina, C. T., McDonald, G., Schymura, M. J., Schiralli, M. P., Cupertino, A., Temple, L. K., Ramsdale, E., & Fleming, F. J. (2024). New Onset Geriatric Syndromes and One-year Outcomes Following Elective Gastrointestinal Cancer Surgery. Annals of surgery, 279(5), 781–788. https://doi.org/10.1097/SLA.0000000000006108

Melucci, A. D., Erlick, M. R., Loria, A., Russell, M. M., Temple, L. K., & Poles, G. C. (2023). Surgical Informed Consent: A Scoping Review of Physician-facing Decision Support Tools. Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 4(1), e259. https://doi.org/10.1097/AS9.0000000000000259

Melucci, A. D., Loria, A., Ramsdale, E., Temple, L. K., Fleming, F. J., & Aquina, C. T. (2022). An assessment of left-digit bias in the treatment of older patients with potentially curable rectal cancer. Surgery, 172(3), 851–858. https://doi.org/10.1016/j.surg.2022.04.038

Melucci, A. D., Lynch, O. F., Wright, M. J., Baran, A., Temple, L. K., Poles, G. C., & Moalem, J. (2022). Evaluating Age as a Predictor of Postoperative Opioid Use and Prescribing Habits in Older Adults With Cancer. Journal of the American Medical Directors Association, 23(4), 678–683.e1. https://doi.org/10.1016/j.jamda.2022.01.081

Melucci, A. D., Chacon, A. C., Burchard, P. R., Tsagkalidis, V., Casabianca, A. S., Goyal, S., Switchenko, J. M., Kooby, D. A., Staley, C. A., Carpizo, D. R., & Shah, M. M. (2022). The Impact of Carbohydrate Antigen 19-9 on Survival in Patients with Clinical Stage I and II Pancreatic Cancer. Annals of surgical oncology, 29(13), 8536–8547. https://doi.org/10.1245/s10434-022-12497-x

Melucci, A. D., Liu, J. B., Brajcich, B. C., Collins, C. E., Kazaure, H. S., Ko, C. Y., Pusic, A. L., & Temple, L. K. (2022). Scaling and spreading the electronic capture of patient-reported outcomes using a national surgical quality improvement programme: a feasibility study protocol. BMJ open quality, 11(4), e001909. https://doi.org/10.1136/bmjoq-2022-001909

Melucci, A. D., Dave, Y. A., Lynch, O. F., Hsu, S., Erlick, M. R., Linehan, D. C., Moalem, J., & University of Rochester's Efforts to Decrease Unnecessary Controlled substances in Surgery (UReduces) Initiative (2023). Predictors of opioid-free discharge after laparoscopic cholecystectomy. American journal of surgery, 225(1), 206–211. https://doi.org/10.1016/j.amjsurg.2022.07.027

Melucci, A. D., Flodman, K., Loria, A., Swanson, H. L., Robinson, M. K., Hasselberg, M. J., Evans, L., Temple, L. K., & Fleming, F. J. (2023). Is there an outcome benefit? Patient engagement technology in addition to the electronic medical record patient portal following elective colorectal surgery. Surgical endoscopy, 37(12), 9275–9282. https://doi.org/10.1007/s00464-023-10478-z

Jacob, E. A., Melucci, A. D., Talbot, E. A., Fleming, F., Schiralli, M., Foster, C., Foster, L., Donovan, K., Simran, K., John, V. J., & Hellenthal, N. J. (2024). The Upstate New York Surgical Quality Improvement Opioid Reduction Project. The American surgeon, 90(5), 1100–1102. https://doi.org/10.1177/00031348231220583

 

Presentations:

Older Adults and Opioids Webinar Series, 2023: Oral Presentation - The impact of CA 19-9 on survival in patients with clinical stage I pancreatic cancer

Society of Surgical Oncology, 2023: Oral Presentation - Impact of Incident Hospital-Acquired Geriatric Syndromes on Short-term Outcomes following Gastrointestinal Cancer Resection

American Society of Clinical Oncology, 2022: On Demand Presentation - The impact of CA 19-9 on survival in patients with clinical stage I pancreatic cancer

American College of Surgeons Clinical Congress, 2021: Oral Presentation - Caloric Restriction Sensitizes Melanoma to Immune Checkpoint Inhibition

University of Rochester Medical Center, 2021: Grand Rounds Presentation – Minimizing Variation in Opioid Prescribing 

What are your future goals?

I am looking forward to rotating on surgical oncology in the upcoming years as a chief resident and providing care with a new lens based on my research experience. I hope to translate my findings to the clinical setting and continue to advance the perioperative care of adults with cancer.

 

 

Surgery Resident Spotlight: Paul Burchard, MD

Wednesday, May 1, 2024

Paul Burchard, MD

PGY3

Tell us a little about your path to Surgery Residency.Paul Burchard

My interest in surgery stemmed largely from my father, who was a trauma, acute care, and critical care surgeon. For my undergraduate degree at the University of Richmond, I pursued a BS in biology and minor in medical humanities, which included a semester abroad at the Danish Institute studying medical practice and policy. Following graduation, I spent two years in a molecular pathology lab at Dartmouth Hitchcock Medical Center. Through this experience, I expanded my knowledge in basic science research and manuscript writing, and was fortunate to matriculate into West Virginia University School of Medicine. While in medical school, I solidified my surgical interest by completing a surgical externship between my first and second year. I was selected as a leader for the medical school's Surgery Interest Group, organizing multiple activities between medical students and surgical residency program at WVU. Following clinical rotations, I was inducted into the Gold Humanism Honor Society and was elected president of the Alpha Omega Alpha Honor Society. With my wife pursuing a career in pediatrics, we both matched and were thrilled to join the University of Rochester Medical Center for our training!

What was your motivation to pursue research during your residency?

During my first two clinical years in our general surgery program, I developed a keen interest in surgical oncology. There were multiple clinical aspects and biological characteristics of cancer patient care that I wanted to explore and understand further. I decided to join Dr. Linehan's lab because this offered me the opportunity to apply my basic sciences background and further pursue my career interest, while providing the foundation for understanding how to improve perioperative care.

Who is your research mentor?

David Linehan, MD  

David C. Linehan, MD
CEO of the University of Rochester Medical Center (URMC),
Dean of the School of Medicine and Dentistry (SMD)
Senior Vice President for Health Sciences at the University of Rochester
Director, Center for Tumor Immunology and Research 

Hernandez-Alejandro, MD
Chief of the Division of Transplantation
​Principal Investigator, Liver Transplant (LT) for Unresectable Colorectal Liver Metastasis (CRLM)
American Registry for Transplant Oncology (ARTx-Onc)

Brian A. Belt, MA, JD
Research Assistant Professor
Center Manager, Center for Tumor Immunology and Research 

What does the role of mentorship in research mean to you?

Research mentors take on the unique task of unbiased guidance towards the career and personal goals we set forth as trainees. Often these goals change over the course of our research and strong mentors are able to adapt and maintain a positive influence. My mentors have all emphasized my growth as a researcher, clinician, and person during the three years I spent in the lab while becoming friends and colleagues throughout the process.

What is your research focus?

My research focused on targeting the highly treatment-resistant tumor microenvironment of cholangiocarcinoma by utilizing a novel agent that disrupts collagen-crosslinking to alter the tumor matrix. Through this project, we were able to reduce tumor stiffness and augment chemotherapeutic penetration to improve tumor control and survival in mouse models of cholangiocarcinoma. Notably, our efforts also shifted the immune cell composition to favor anti-tumor immunity and functionally disrupted immunosuppressive macrophage migration/invasion into the tumors, revealing another link between tumor stroma and immunity in cholangiocarcinoma.

What are your recent presentations/awards/manuscripts?

Awards:

University of Rochester Department of Surgery 4th Annual Research Symposium

- First Place in Basic Science, Spring 2024

Medical Faculty Council Travel Award in Basic Science Research, Spring 2022 Department of Surgery, Dr. James T. Adams Distinguished Intern Award, 2018-2019 Department of Surgery, Burn Surgery Resident of the Year Award, 2018-2019

Publications:

Ullman, N. A., Burchard, P. R., Dunne, R. F., & Linehan, D. C. (2022). Immunologic Strategies in Pancreatic Cancer: Making Cold Tumors HotJournal of clinical oncology : official journal of the American Society of Clinical Oncology, 40(24), 2789–2805. https://doi.org/10.1200/JCO.21.02616

Burchard, P. R., Melucci, A. D., Lynch, O., Loria, A., Dave, Y. A., Strawderman, M., Schoeniger, L. O., Galka, E., Moalem, J., & Linehan, D. C. (2022). Intrathecal Morphine and Effect on Opioid Consumption and Functional Recovery after Pancreaticoduodenectomy. Journal of the American College of Surgeons, 235(3), 392–400. https://doi.org/10.1097/XCS.0000000000000261

Burchard, P. R., Lay, R., Ruffolo, L. I., Ramazani, S. N., Walton, J. M., & Livingston, M. H. (2022). Glycerin Suppositories and Enemas in Premature Infants: A Meta-analysis. Pediatrics, 149(4), e2021053413. https://doi.org/10.1542/peds.2021-053413

Burchard, P. R., Dave, Y. A., Loria, A. P., Parikh, N. B., Pineda-Solis, K., Ruffolo, L. I., Strawderman, M., Schoeniger, L. O., Galka, E., Tomiyama, K., Orloff, M. S., Carpizo, D. R., Linehan, D. C., & Hernandez-Alejandro, R. (2022). Early postoperative ERAS compliance predicts decreased length of stay and complications following liver resection. HPB : the official journal of the International Hepato Pancreato Biliary Association, 24(9), 1425–1432. https://doi.org/10.1016/j.hpb.2022.01.008

Pineda-Solis, K., Burchard, P. R., Ruffolo, L. I., Schoeniger, L. O., Linehan, D. C., Moalem, J., & Galka, E. (2021). Early Prediction of Length of Stay After Pancreaticoduodenectomy. The Journal of surgical research, 260, 499–505. https://doi.org/10.1016/j.jss.2020.11.060

Publications Under Review:

Paul R. Burchard, Luis I. Ruffolo, Nicholas A. Ullman, Benjamin S. Dale, Yatee A. Dave, Bailey K. Hilty, Jian Ye, Mary Georger, Rachel Jewell, Christine Miller, Luis De Las Casas, Wolfgang Jarolimek, Lara Perryman, Matthew M. Byrne, Anthony Loria, Bailey K. Hilty, Chelsea Marin, Mariana Chavez Villa, Jen Jen Yeh, Brian A. Belt, David C. Linehan, Roberto Hernandez-Alejandro. Pan-Lysyl Oxidase Inhibition Disrupts Fibroinflammatory Tumor Strama Rendering Cholangiocarcinoma Susceptible to Chemotherapy.

Book Chapters Under Review:

Paul R. Burchard, Richard D. Schulick, David C. Linehan. Surgical Considerations in Cancer Patients. Sabiston Textbook of Surgery (22nd Edition), 2025.

Presentations:

Society of Surgical Oncology, 2023: Oral Presentation - Pan-Lysyl Oxidase Inhibition Disrupts Macrophage Invasion and Renders Tumor­ Associated Macrophages Susceptible to Cytotoxic Chemotherapy in Cholangiocarcinoma

Americas Hepato-Pancreato-Biliary Association, 2023: Oral Presentation - PREOPERATIVE THERAPY CONFERS SURVIVAL ADVANTAGE IN EARLY-STAGE PANCREATIC CANCER

Society of Surgical Oncology, 2022: Oral Presentation - Combination Therapy of PXS-5505 with 5-FU and Oxaliplatin Reduces Myeloid Suppression and Improves Overall Survival in Murine Cholangiocarcinoma - A Novel Therapeutic Strategy for Clinical Translation

Society of Surgical Oncology, 2021: Oral Presentation - Cox-2 Expression is Associated with Poor Disease-Free and Overall Survival in Cholangiocarcinoma - A Potential Target for Intervention

American College of Surgeons, Clinical Congress 2021: Oral Presentation - lntrathecal Morphine Decreases Narcotic Requirements And Is Associated With Shortened Length Of Stay Following Pancreaticoduodenectomy

Americas Hepato-Pancreato-Biliary Association, 2021: Oral Presentation - Should Systemic Therapy Be Standard of Care for Early-Stage Pancreatic Acincar Cell Carcinoma?

What are your future goals?

I am looking forward to the publication of my basic science research project that was the result of my 3 years in Dr. Linehan's lab as well as my upcoming surgical oncology fellowship application. I would like to pursue a career in surgical oncology that will combine university and community practice to provide a conduit for surgical care in cancer patients.