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Toxicology Training Program Annual Retreat

Schedule of Events

Mark HahnModels to Mechanisms: Evolutionary toxicology and the intersection of human and environmental health

Mark E. Hahn, Ph.D.
Senior Scientist / Biology Department, Woods Hole Oceanographic Institution

Thursday, May 24, 2018
11:00 – 12:00 pm

Adolph Lower Auditorium (1-7619)

Abstract

Understanding the impact of toxic chemicals on human and environmental health is a challenging problem that benefits from diverse perspectives and approaches. Research in toxicology employs a variety of model systems that provide complementary insight into the impact of chemicals on humans and wildlife. Evolutionary toxicology is a framework for considering how chemicals can influence evolutionary processes and how evolutionary relationships can inform the design and interpretation of studies to understand mechanisms of toxicity. In this presentation, I will describe the results of a long-term study of evolved resistance to dioxin-like chemicals in populations of an estuarine fish experiencing multi-generational exposure to PCBs and related chemicals. I will explore the various roles of the aryl hydrocarbon receptor signaling pathway in the mechanisms of differential sensitivity and discuss how this and related research may inform our understanding of chemical impacts in both wildlife and humans.

1:30 – 2:30 pm –Adolph Auditorium -  Platform presentations by Postdocs, Drs. Sarah Latchney and Thivanka Muthumalage and Graduate students, Christina Post and Denise Herr

2:30 – 4:00 pm – Sarah Flaum Atrium – Poster Session

Please contact Christine Gramza with any questions.