Unraveling the Contribution of DC-STAMP in Bone Resorption and Immunity
Osteoporosis drastically affects the quality of life in menopausal women and patients affected by rheumatic inflammatory diseases, has significant economic repercussions, and increases the mortality associated with fractures provoked as a result of pathological and exacerbated bone resorption. The focus of the laboratory is to understand the contribution of DC-STAMP in rheumatoid arthritis and psoriatic arthritis using a preclinical model of inflammatory arthritis. Our group has access to well-characterized clinical samples which facilitate the development of humanized mice to test palliative and therapeutic treatments to ameliorate the onset of arthritis.
Maria de la Luz Garcia-Hernandez, Ph.D.
Investigator
Publications
View All Publications- Influenza virus and Staphylococcus aureus super-infection disrupts spatially coordinated cellular immunity in the mouse lung.; Communications biology. 2025 Nov 23.
- Influenza infection exacerbates high-fat diet-induced atherosclerosis in apolipoprotein gene-deficient mice.; Journal of immunology (Baltimore, Md. : 1950). 2025 Oct 30.
- TNF drives aberrant BMP signaling to induce endothelial and mesenchymal dysregulation in pulmonary hypertension.; JCI insight. 2025 Jun 26.
- New Insights into the Pathogenesis of Psoriatic Arthritis.; Rheumatic diseases clinics of North America; Vol 51(3), pp. 397-415. 2025 Jun 11.
Affiliations
News
November 21, 2025
Rangel-Moreno an International Speaker at the Research Seminars in Biological Sciences and International Biomedicine Workshop
October 22, 2025
Jennifer Anolik Presents at Upstate Medical Center Symposium
October 20, 2025
National Scleroderma Foundation Rochester Education Forum Held at URMC
September 29, 2025
Jessica Stern, MD Awarded a Mentored Patient-Oriented Research Career Development Award (K23)
May 23, 2025
AIR Research Presented at the 2025 AAI Meeting
Contact Us
Garcia-Hernandez Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642