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**All work performed by the University of Rochester Genomics Research Center (GRC) should be acknowledged in scholarly publications, posters, and oral presentations. Proper recognition allows us to measure the impact of our work and supports our initiatives in obtaining sponsored funding. In addition, any GRC personnel who make a substantial intellectual or experimental contribution are deserving of further recognition as co-author on any published material at the discretion of the Director and Principal Investigator.  Please send citations of any published material to John Ashton or Michelle Zanche.**

We are proud to share the following publications supported by the Genomics Research Center:


Wong, E.L., Lutz, N.M., Hogan, V.A., Lamantia, C.E., McMurray, H.R., Myers, J.R., Ashton, J.M., and Majewska, A.K. (2017). Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex. Brain Behav Immun.

Elbarbary, R.A., Miyoshi, K., Hedaya, O., Myers, J.R., and Maquat, L.E. (2017). UPF1 helicase promotes TSN-mediated miRNA decay. Genes Dev 31, 1483-1493.

Bhattacharya S, Rosenberg AF, Peterson DR, Grzesik K, Baran AM, Ashton JM, Gill SR, Corbett AM, Holden-Wiltse J, Topham DJ, Walsh EE, Mariani TJ, Falsey AR. "Transcriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness." Scientific reports. 2017 Jul 26; 7(1):6548. Epub 2017 Jul 26.

Martinson, E. O., Mrinalini, Kelkar, Y. D., Chang, C. H., & Werren, J. H. (2017). The Evolution of Venom by Co-option of Single-Copy Genes. Curr Biol, 27(13), 2007-2013 e2008. doi:10.1016/j.cub.2017.05.032.

Beach, T. A., C. J. Johnston, A. M. Groves, J. P. Williams and J. N. Finkelstein (2017). "Radiation induced pulmonary fibrosis as a model of progressive fibrosis: Contributions of DNA damage, inflammatory response and cellular senescence genes." Exp Lung Res 43(3): 134-149.

Elbarbary, R. A., K. Miyoshi, J. R. Myers, P. Du, J. M. Ashton, B. Tian and L. E. Maquat (2017). "Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition." Science 356(6340): 859-862.

Farnsworth, C. W., E. M. Schott, S. E. Jensen, J. Zukoski, A. M. Benvie, M. A. Refaai, S. L. Kates, E. M. Schwarz, M. J. Zuscik, S. R. Gill and R. A. Mooney (2017). "Adaptive Upregulation of Clumping Factor A (ClfA) by Staphylococcus aureus in the Obese, Type 2 Diabetic Host Mediates Increased Virulence." Infect Immun 85(6).

Gasparetto, M., S. Pei, M. Minhajuddin, N. Khan, D. A. Pollyea, J. R. Myers, J. M. Ashton, M. W. Becker, V. Vasiliou, K. R. Humphries, C. T. Jordan and C. A. Smith (2017). "Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1." Haematologica 102(6): 1054-1065.

Hilimire, T. A., J. M. Chamberlain, V. Anokhina, R. P. Bennett, O. Swart, J. R. Myers, J. M. Ashton, R. A. Stewart, A. L. Featherston, K. Gates, E. D. Helms, H. C. Smith, S. Dewhurst and B. L. Miller (2017). "HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells." ACS Chem Biol 12(6): 1674-1682.

Le Bleu, H. K., F. A. Kamal, M. Kelly, J. P. Ketz, M. J. Zuscik and R. A. Elbarbary (2017). "Extraction of high-quality RNA from human articular cartilage." Anal Biochem 518: 134-138.

Nakatsuji, T., T. H. Chen, S. Narala, K. A. Chun, A. M. Two, T. Yun, F. Shafiq, P. F. Kotol, A. Bouslimani, A. V. Melnik, H. Latif, J. N. Kim, A. Lockhart, K. Artis, G. David, P. Taylor, J. Streib, P. C. Dorrestein, A. Grier, S. R. Gill, K. Zengler, T. R. Hata, D. Y. Leung and R. L. Gallo (2017). "Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis." Sci Transl Med 9(378).

Shen, J., C. Wang, D. Li, T. Xu, J. Myers, J. M. Ashton, T. Wang, M. J. Zuscik, A. McAlinden and R. J. O'Keefe (2017). "DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism." JCI Insight 2(12).

Yang, F., L. Zhang, H. Wakabayashi, J. Myers, Y. Jiang, Y. Cao, C. Jimenez-Ortigosa, D. S. Perlin and E. Rustchenko (2017). "Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling." Antimicrob Agents Chemother 61(5).


Berrondo, C., Flax, J., Kucherov, V., Siebert, A., Osinski, T., Rosenberg, A., Fucile, C., Richheimer, S., and Beckham, C.J. (2016). Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes. PLoS One 11, e0147236.

Chu, C. Y., X. Qiu, L. Wang, S. Bhattacharya, G. Lofthus, A. Corbett, J. Holden-Wiltse, A. Grier, B. Tesini, S. R. Gill, A. R. Falsey, M. T. Caserta, E. E. Walsh and T. J. Mariani (2016). "The Healthy Infant Nasal Transcriptome: A Benchmark Study." Sci Rep 6: 33994.

Ho, T. C., M. LaMere, B. M. Stevens, J. M. Ashton, J. R. Myers, K. M. O'Dwyer, J. L. Liesveld, J. H. Mendler, M. Guzman, J. D. Morrissette, J. Zhao, E. S. Wang, M. Wetzler, C. T. Jordan and M. W. Becker (2016). "Evolution of acute myelogenous leukemia stem cell properties after treatment and progression." Blood 128(13): 1671-1678.

Li, X., N. Chatterjee, K. Spirohn, M. Boutros and D. Bohmann (2016). "Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes." Sci Rep 6: 21455.

Malcolm, D. W., J. E. Sorrells, D. Van Twisk, J. Thakar and D. S. Benoit (2016). "Evaluating side effects of nanoparticle-mediated siRNA delivery to mesenchymal stem cells using next generation sequencing and enrichment analysis." Bioeng Transl Med 1(2): 193-206.

Misra, R. S., S. Bhattacharya, H. L. Huyck, J. C. Wang, C. G. Slaunwhite, S. L. Slaunwhite, T. R. Wightman, S. Secor-Socha, S. K. Misra, T. P. Bushnell, A. M. Reynolds, R. M. Ryan, S. A. Quataert, G. S. Pryhuber and T. J. Mariani (2016). "Flow-based sorting of neonatal lymphocyte populations for transcriptomics analysis." J Immunol Methods 437: 13-20.

Nedelkovska, H., A. F. Rosenberg, S. P. Hilchey, O. Hyrien, W. R. Burack, S. A. Quataert, C. M. Baker, M. Azadniv, S. L. Welle, S. M. Ansell, M. Kim and S. H. Bernstein (2016). "Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node." PLoS One 11(5): e0155347.

Pei, S., M. Minhajuddin, A. D'Alessandro, T. Nemkov, B. M. Stevens, B. Adane, N. Khan, F. K. Hagen, V. K. Yadav, S. De, J. M. Ashton, K. C. Hansen, J. A. Gutman, D. A. Pollyea, P. A. Crooks, C. Smith and C. T. Jordan (2016). "Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells." J Biol Chem 291(48): 25280.

Ye, H., B. Adane, N. Khan, T. Sullivan, M. Minhajuddin, M. Gasparetto, B. Stevens, S. Pei, M. Balys, J. M. Ashton, D. J. Klemm, C. M. Woolthuis, A. W. Stranahan, C. Y. Park and C. T. Jordan (2016). "Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche." Cell Stem Cell 19(1): 23-37.


Baras, A. S., C. J. Mitchell, J. R. Myers, S. Gupta, L. C. Weng, J. M. Ashton, T. C. Cornish, A. Pandey and M. K. Halushka (2015). "miRge - A Multiplexed Method of Processing Small RNA-Seq Data to Determine MicroRNA Entropy." PLoS One 10(11): e0143066.

Garrigan, D., S. B. Kingan, A. J. Geneva, J. P. Vedanayagam and D. C. Presgraves (2015). "Genome Diversity and Divergence in Drosophila mauritiana: Multiple Signatures of Faster X Evolution." Genome Biol Evol 7(5): 1331.

Hansen, J., C. Snow, E. Tuttle, D. H. Ghoneim, C. S. Yang, A. Spencer, S. A. Gunter, C. D. Smyser, C. A. Gurnett, M. Shinawi, W. B. Dobyns, J. Wheless, M. W. Halterman, L. A. Jansen, B. M. Paschal and A. R. Paciorkowski (2015). "De novo mutations in SIK1 cause a spectrum of developmental epilepsies." Am J Hum Genet 96(4): 682-690.

Merkley, M. A., T. C. Bice, A. Grier, A. M. Strohl, L. X. Man and S. R. Gill (2015). "The effect of antibiotics on the microbiome in acute exacerbations of chronic rhinosinusitis." Int Forum Allergy Rhinol 5(10): 884-893.

Sharma-Kuinkel, B. K., E. F. Mongodin, J. R. Myers, K. L. Vore, G. S. Canfield, C. M. Fraser, T. H. Rude, V. G. Fowler, Jr. and S. R. Gill (2015). "Potential Influence of Staphylococcus aureus Clonal Complex 30 Genotype and Transcriptome on Hematogenous Infections." Open Forum Infect Dis 2(3): ofv093.

Sivagnanalingam, U., M. Balys, A. Eberhardt, N. Wang, J. R. Myers, J. M. Ashton, M. W. Becker, L. M. Calvi and J. H. Mendler (2015). "Residual Disease in a Novel Xenograft Model of RUNX1-Mutated, Cytogenetically Normal Acute Myeloid Leukemia." PLoS One 10(7): e0132375.

Bennett, J. A., K. P. Singh, Z. Unnisa, S. L. Welle and T. A. Gasiewicz (2015). "Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells." PLoS One 10(7): e0133791.


Dardas, M., S. R. Gill, A. Grier, G. S. Pryhuber, A. L. Gill, Y. H. Lee and R. Guillet (2014). "The impact of postnatal antibiotics on the preterm intestinal microbiome." Pediatr Res 76(2): 150-158.

Garrigan, D., S. B. Kingan, A. J. Geneva, J. P. Vedanayagam and D. C. Presgraves (2014). "Genome diversity and divergence in Drosophila mauritiana: multiple signatures of faster X evolution." Genome Biol Evol 6(9): 2444-2458.

Ghoneim, D. H., J. R. Myers, E. Tuttle and A. R. Paciorkowski (2014). "Comparison of insertion/deletion calling algorithms on human next-generation sequencing data." BMC Res Notes 7: 864.

Militello, K. T., L. M. Chen, S. E. Ackerman, A. H. Mandarano and E. L. Valentine (2014). "A map of 5-methylcytosine residues in Trypanosoma brucei tRNA revealed by sodium bisulfite sequencing." Mol Biochem Parasitol 193(2): 122-126.

Singh, K. P., J. A. Bennett, F. L. Casado, J. L. Walrath, S. L. Welle and T. A. Gasiewicz (2014). "Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice." Stem Cells Dev 23(2): 95-106.


Edholm, E. S., L. M. Albertorio Saez, A. L. Gill, S. R. Gill, L. Grayfer, N. Haynes, J. R. Myers and J. Robert (2013). "Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians." Proc Natl Acad Sci U S A 110(35): 14342-14347.

Lagadinou, E. D., A. Sach, K. Callahan, R. M. Rossi, S. J. Neering, M. Minhajuddin, J. M. Ashton, S. Pei, V. Grose, K. M. O'Dwyer, J. L. Liesveld, P. S. Brookes, M. W. Becker and C. T. Jordan (2013). "BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells." Cell Stem Cell 12(3): 329-341.

Pei, S., M. Minhajuddin, K. P. Callahan, M. Balys, J. M. Ashton, S. J. Neering, E. D. Lagadinou, C. Corbett, H. Ye, J. L. Liesveld, K. M. O'Dwyer, Z. Li, L. Shi, P. Greninger, J. Settleman, C. Benes, F. K. Hagen, J. Munger, P. A. Crooks, M. W. Becker and C. T. Jordan (2013). "Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells." J Biol Chem 288(47): 33542-33558.


Ashton, J. M., M. Balys, S. J. Neering, D. C. Hassane, G. Cowley, D. E. Root, P. G. Miller, B. L. Ebert, H. R. McMurray, H. Land and C. T. Jordan (2012). "Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells." Cell Stem Cell 11(3): 359-372.


Casado, F. L., K. P. Singh and T. A. Gasiewicz (2011). "Aryl hydrocarbon receptor activation in hematopoietic stem/progenitor cells alters cell function and pathway-specific gene modulation reflecting changes in cellular trafficking and migration." Mol Pharmacol 80(4): 673-682.