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URMC / Center for AIDS Research

Center for AIDS Research

Improving the prevention, detection and treatment of HIV infection, AIDS and related diseases.

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To provide leadership, services and infrastructure necessary to: establish multidisciplinary collaborations that achieve high-impact discoveries; support the early career development of diverse young HIV/AIDS investigators; and to establish a distinctive scientific identity, placing the University of Rochester at the forefront of HIV/AIDS research.

Recent Publications

Brewer MG, DiPiazza A, Acklin J, Feng C, Sant AJ, Dewhurst S. Nanoparticles decorated with viral antigens are more immunogenic at low surface density. Vaccine 2017.  PMID: 28057386   PMCID: In Process

Keefer MC, Zheng B, Rosenberg AF, Kobie JJ. Increased steady-state memory B cell subsets among high-risk participants in an HIV vaccine trial. AIDS research and human retroviruses 2016;32:1143-8.   PMID: 27612555   PMCID: PMC5067846

Zhang G, Guo D, Dash PK, Gelbard H, et al. The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy. Nanomedicine: nanotechnology, biology, and medicine 2016;12:109-22.    PMID: 26472049   PMCID: PMC4728028

Clark KM, Jenkins JL, Fedoriw N, Dumont ME (2016) Human CaaX Protease ZMPSTE24 Expressed in Yeast: Structure and Inhibition by HIV Protease Inhibitors. Protein Sci. [Epub ahead of print]  PMID: 27774687  PMCID: PMC5275749

Kutscher, H. L., Prasad, P. N., Morse, G. D., & Reynolds, J. L. (2016). Emerging Nanomedicine Approaches to Targeting HIV-1 and Antiretroviral TherapyFuture Virology11(2), 101–104. PMID: 28123446  PMCID: PMC5257175

Makita-Chingombe F, Kutscher HL, DiTursi SL, Morse GD, Maponga CC. Poly(lactic-co-glycolic) Acid-Chitosan Dual Loaded Nanoparticles for Antiretroviral Nanoformulations. J Drug Deliv. 2016;2016:3810175. doi: 10.1155/2016/3810175. PMID: 27190651 PMCID: PMC4852115

Niu L, Luo D, Liu Y, Silenzio VM, Xiao S. The Mental Health of People Living with HIV in China, 1998-2014: A Systematic Review. PLoS One. 2016 Apr 15;11(4):e0153489. doi: 10.1371/journal.pone.0153489. Review. PMID: 27082749   PMCID: PMC4833336

Piepenbrink MS, Samuel M, Zheng B, Carter B, Fucile C, Bunce C, Kiebala M, Khan AA, Thakar J, Maggirwar SB, Morse D, Rosenberg AF, Haughey NJ, Valenti W, Keefer MC, Kobie JJ. Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users. PLoS One. 2016 Jul 5;11(7):e0158641. doi: 10.1371/journal.pone.0158641. PMID: 27379802  PMCID: PMC4933366

Senn, T. E., Braksmajer, A., Coury-Doniger, P., Urban, M. A., & Carey, M. P. (in press) Mobile technology use and desired technology-based intervention characteristics among HIV+ Black men who have sex with menAIDS Care. 2016 Aug 18:1-5. [Epub ahead of print]   PMID:  27535069   PMC: In Process

Senn, T.E., Braksmajer A., Coury-Doniger P., Urban M.A., Rossi, A. and Carey, M.P. (in press). Development and preliminary pilot testing of a peer support text messaging intervention for HIV+ Black men who have sex with men.  Journal of Acquired Immune Deficiency Syndromes. 2017 Feb 1;74 Suppl 2:S121-S127   PMID: 28079722   PMC: In Process

Shah KN, Majeed Z, Yoruk YB, Yang H, Hilton TN, McMahon JM, Hall WJ, Walck D, Luque AE, Ryan RM. Enhancing Physical Function in HIV-Infected Older Adults: A Randomized Controlled Clinical Trial. Health Psychol. 2016. Epub 2016/02/13. doi: 10.1037/hea0000311.   PMID: 26867045    PMCID: PMC4868650

Valentine JL, Chen L, Perregaux EC, Weyant KB, Rosenthal JA, Heiss C, Azadi P, Fisher AC, Putnam D, Moe GR, Merritt JH, DeLisa MP. Immunization with Outer Membrane Vesicles Displaying Designer Glycotopes Yields Class-Switched, Glycan-Specific Antibodies. Cell Chem Biol. 2016 Jun 23;23(6):655-65. doi: 10.1016/j.chembiol.2016.05.014.   PMID: 27341433  PMCID: PMC5116915

Vats K, Marsh G, Harding K, Zampetakis I, Waugh RE, Benoit DS. Nanoscale physicochemical properties of chain- and step-growth polymerized PEG hydrogels affect cell-material interactions. J Biomed Mater Res A. 2017 Jan 17. doi: 10.1002/jbm.a.36007. [Epub ahead of print] PubMed PMID: 28093865. [Epub ahead of print]    PMID: 28093865    PMC: In Process

Antwi S, Yang H, Enimil A, et al. Pharmacokinetics of the First-line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with and without HIV Coinfection. Antimicrobial agents and chemotherapy 2016:AAC. 01701-16.    PMID: 27855070  PMCID: PMC5278726

Fedor TM, Kohler HP, McMahon JM. Changing attitudes and beliefs towards a woman's right to protect against HIV risk in Malawi. Cult Health Sex 2016;18:435-52.    PMID: 26503918   PMCID: PMC4766023

Johnson BA, McKenney J, Ricca AV, Rosenberg ES, Liu C, Sharma A, Sullivan PS. Risk Factors Associated With Repeated HIV Testing Among Internet-Using Men Who Have Sex With Men. AIDS Education and Prevention 2016;28:511-23.  PMID: 27925484     PMCID: In Process

McMahon JM, Chimenti R, Trabold N, Fedor T, Mittal M, Tortu S. Risk of Intimate Partner Violence and Relationship Conflict Following Couple-Based HIV Prevention Counseling Results From the Harlem River Couples Project. Journal of interpersonal violence 2015:0886260515600878.   PMID:  26319710    PMCID: PMC4769677

McMahon JM, Pouget ER, Tortu S, Volpe EM, Torres L, Rodriguez W. Couple-based HIV counseling and testing: a risk reduction intervention for US drug-involved women and their primary male partners. Prevention science : the official journal of the Society for Prevention Research 2015;16:341-51.  PMID: 25512179   PMCID: PMC4310810 

McMahon JM, Volpe EM, Klostermann K, Trabold N, Xue Y. A systematic review of the psychometric properties of the Sexual Relationship Power Scale in HIV/AIDS research. Arch Sex Behav 2015;44:267   PMID: 25331613    PMCID: PMC4324007

Morse DS, Silverstein J, Thomas K, Bedel P, Cerulli C. Finding the loopholes: a cross-sectional qualitative study of systemic barriers to treatment access for women drug court participants. Health & justice 2015;3:1-9.    PMID: 26478853   PMCID: PMC4607061

Puccini JM, Marker DF, Fitzgerald T, Barbieri J, Kim CS, Miller-Rhodes P, Lu SM, Dewhurst S, Gelbard HA. Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders. The Journal of neuroscience: the official journal of the Society for Neuroscience 2015;35:5271-83.   PMID: 25834052    PMCID: PMC4381000

Blanchard C, Brooks L, Ebsworth-Mojica K, Didione L, Wucher B, Dewhurst S, Krysan D, Dunman PM, Wozniak RA. Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment. mSphere. 2016 Sep 14;1(5)   PMID: 27642637   PMCID: PMC5023846

Jackson JW, Singh MV, Singh VB, Jones LD, Davidson GA, Ture S, Morrell CN, Schifitto G, Maggirwar SB. Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis. PLoS One. 2016 Jun  6;11(6):e0157115  PMID: 27270236  PMCID: PMC4894566

Jones LD, Jackson JW, Maggirwar SB. Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction. PLoS One. 2016 Mar 17;11(3):e0151702  PMID: 26986758  PMCID: PMC4795798

Singh VB, Singh MV, Gorantla S, Poluektova LY, Maggirwar SB. Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice. Sci Rep. 2016 May 31;6:26876   PMID: 27241024   PMCID: PMC4886511

Yang H, Baker SF, González ME, Topham DJ, Martínez-Sobrido L, Zand M, Holden-Wiltse J, Wu H. An improved method for estimating antibody titers in microneutralization assay using green fluorescent protein. J Biopharm Stat. 2016;26(3):409-20   PMID: 26010892   PMCID: PMC4661136

Johnson BA, Long Q, Huang Y, Chansky K, Redman M. (2016) “Model selection and inference for lifetime medical expenditures.” Biometrics 72: 731-741.  PMID: 26689300  PMCID: In Process

Liu*, B., Qiu*, X., Zhu, T., Tian, W., Hu, R., Ekholm, S., Schifitto, G., Zhong, J. (2016) Spatial regression analysis of serial DTI for subject-specific longitudinal changes of neurodegenerative disease, NeuroImage Clinical, 11: 291-301. [*First authorship shared]    PMID: 26977399   PMCID: PMC4782002

Liu*, B., Qiu*, X., Zhu, T., Tian, W., Hu, R., Ekholm, S., Schifitto, G., Zhong, J. (2016) Improved spatial regression analysis of diffusion tensor imaging for lesion detection during longitudinal progression of multiple sclerosis in individual subjects, Physics in Medicine and Biology, 61(6): 2497. [*First authorship shared]   PMID: 26948513   PMCID: In Process

Lu X, Johnson BA. (2016) Direct estimation for adaptive treatment length policies: methods and application to evaluating the effect of delayed PEG insertion. Biometrics. Doi: 10.1111/biom.12639 [Epub ahead of print]   PMID: 28009454   PMCID: In Process

Hammond, J. W., Lu, S.-M., & Gelbard, H. A. (2016). Corrigendum: Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation. Frontiers in Cellular Neuroscience, 10, 113.    PMID: 27199666    PMCID: PMC4854892

Gleghorn ML, Zhao J, Turner DH, Maquat LE. Crystal structure of a poly (rA) staggered zipper at acidic pH: evidence that adenine N1 protonation mediates parallel double helix formation. Nucleic Acids Research 2016. 44:8417    PMID: 27288442   PMCID: PMC5041459

Adler D, Wallace M, Bennie T, Abar B, Sadeghi R, Meiring M, Williamson A, Bekker L. (2015) High Risk HPV Persistence Among HIV-infected Young Women in South Africa. International Journal of Infectious Diseases. 33: e219-21.  PMID: 25697074 PMCID: PMC4397173

Anderson AM, Harezlak J, Bharti A, Mi D, Taylor MJ, Daar ES, Schifitto G, Zhong J, Alger JR, Brown MS et al: (2015) Plasma and cerebrospinal fluid biomarkers predict cerebral injury in HIV-infected individuals on stable combination antiretroviral therapy.  Journal of acquired immune deficiency syndromes. 2015;69(1):29-35.  PMID: 25622053 PMCID: PMC4424074

Blanchard C, Brooks L, Beckley A, Colquhoun J, Dewhurst S, Dunman PMNeomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments. Antimicrob Agents Chemother. 2015 Nov 23;60(2):862-72.  PMID: 26596945 PMCID: PMC4750660

Huang H, Santoso  N, Power D, Simpson S, Dieringer M, Miao H, Gurova K, Giam CZ, Elledge SJ, Zhu J. (2015) FACT Proteins, SUPT16H and SSRP1, are Transcriptional Suppressors of Human Retroviruses (HIV-1/HTLV-1) that Facilitate Viral LatencyJ Biol Chem. 290(45): 27297-310.  PMID: 26378236 PMCID: PMC4646377

Johnson BA. (2015) “On Huberized calibration regression for censored medical cost data.” Statistics in Biosciences 7(2):367-378.  PMID: 26528376 PMCID: PMC4627645

Kiebala M, Singh MV, Piepenbrink MS, Qiu X, Kobie JJ, Maggirwar SB. Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse. PLoS One. 2015 Jun 15;10(6):e0130061.  PMID: 26076359 PMCID: PMC4467977

Kobie, J.J., Zheng, B., Piepenbrink, M.S., Hessell A.J., Haigwood, N.L., Keefer, M.C., and Sanz, I.  (2015) Functional and molecular characterization of novel and conserved cross-clade HIV envelope specific human monoclonal antibodies.   Monoclon Antib Immunodiagn Immunother. Apr;34(2):65-72.  PMID: 25897603 PMCID: PMC4410305

Lin M, He H, Schifitto G, Zhong J. (2015) Simulation of changes in diffusion related to different pathologies at cellular level after traumatic brain injury. Magn Reson Med. 2015. Epub 2015/08/11. doi: 10.1002/mrm.25816.  PMID: 26256558 PMCID: PMC4769952

Liu, Z.P., Wu, C., Miao H., Wu, H. (2015). RegNetwork: an Integrated Database of Transcriptional and Posttranscriptional Regulatory Networks in Human and Mouse.  PMID: 26424082 PMCID: PMC4589691

Power D, Santoso N, Dieringer M, Yu J, Huang H, Simpson S, Seth I, Miao H, Zhu J. (2015) IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. Virology, 2015. 481: p. 142-50.    PMID: 25776761 PMCID: PMC4437885

Shah K, Majeed Z, Yang H, Guido J, Polesskaya O, Hilton TN, Hall WJ, Luque AE. (2015) Functional Limitations and Adipokines in HIV-Infected Older Adults. J Frailty Aging, 4(1), 41–46.  PMID: 26312240 PMCID: PMC4547479

Shah K, McMahon JM, Trabold N, Aidala AA, Chen M, Pouget ER, Simmons J, Klostermann K. (2015). Determinants of physical and global functioning in adult HIV-positive heterosexual men. AIDS Care, 27(9), 1079–1086.  PMID: 25812466 PMCID: PMC4584165

Sheik DA, Brooks L, Frantzen K, Dewhurst S, Yang J. Inhibition of the enhancement of infection of human immunodeficiency virus by semen-derived enhancer of virus infection using amyloid-targeting polymeric nanoparticles. ACS  Nano. 2015 Feb 24;9(2):1829-36.  PMID: 25619867 PMCID: PMC4426188

Singh, V. B., Wooten, A. K., Jackson, J. W., Maggirwar, S. B., Kiebala, M. (2015). Investigating the role of ankyrin-rich membrane spanning protein in human immunodeficiency virus type-1 Tat-induced microglia activation. J Neurovirol. 2015 Apr;21(2):186-98. doi: 10.1007/s13365-015-0318-2. Epub 2015 Jan 31. PMID: 25636783 PMCID: PMC4375029

Stephenson R, Finneran, C, Goldenberg, T, Coury-Doniger, P, Senn, T,  Urban, M, Schwartz, A, Sullivan, P. (2015). Willingness to use couples HIV testing and discussion of sexual agreements among heterosexuals. SpringerPlus, 4, 169.  PMID: 25897413 PMCID: PMC4395621

Tivarus ME, Pester B, Schmidt C, Lehmann T, Zhu T, Zhong J, Leistritz L, Schifitto G. (2015) Are structural changes Induced by lithium in the HIV Brain accompanied by changes in functional connectivity? PLoS One. 2015 Oct 5;10(10):e0139118. doi: 10.1371/journal.pone.0139118. eCollection 2015.  PMID: 26436895 PMCID: PMC4593570