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URMC / Center for AIDS Research
 

Center for AIDS Research

Improving the prevention, detection and treatment of HIV infection, AIDS and related diseases.

HIV Graphic

Mission

To provide leadership, services and infrastructure necessary to: establish multidisciplinary collaborations that achieve high-impact discoveries; support the early career development of diverse young HIV/AIDS investigators; and to establish a distinctive scientific identity, placing the University of Rochester at the forefront of HIV/AIDS research.

Recent Publications

Maxime J. Jean, Tsuyoshi Hayashi, Huachao Huang, Justin Brennan, Sydney Simpson, Andrei Purmal, Katerina Gurova, Michael C. Keefer, James J. Kobie, Netty G. Santoso, Jian Zhu (2017). Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional ElongationFrontiers in Microbiology8, 2007. http://doi.org/10.3389/fmicb.2017.02007 PMID: 29089933 PMCID: PMC5651003

Kushwaha, S., Lalani, Y., Maina, G., Ogunbajo, A., Wilton, L., Agyarko-Poku, T., … Nelson, L. E. (2017). “But the moment they find out that you are MSM…”: a qualitative investigation of HIV prevention experiences among men who have sex with men (MSM) in Ghana’s health care system BMC Public Health, 17, 770. http://doi.org/10.1186/s12889-017-4799-1 PMID: 28974257 PMCID: PMC5627492

Singh, V. B., Singh, M. V., Piekna-Przybylska, D., Gorantla, S., Poluektova, L. Y., & Maggirwar, S. B. (2017). Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infectionScientific Reports7, 9578. http://doi.org/10.1038/s41598-017-10241-0 PMID: 28852071 PMCID: PMC5575104

Zhuang, Y., Qiu, X., Wang, L., Ma, Q., Mapstone, M., Luque, A., … Schifitto, G. (2017). Combination antiretroviral therapy improves cognitive performance and functional connectivity in treatment-naïve HIV-infected individualsJournal of Neurovirology23(5), 704–712. http://doi.org/10.1007/s13365-017-0553-9  PMID: 28791662 PMCID: PMC5655604

Huang H, Liu S, Jean M, Simpson S, Huang H, Merkley M, Hayashi T, Kong W, Rodriguez-Sanchez I, Yosief H, Zhang X, Miao H, Que J, Kobie J, Bradner J, Santoso N, Zhang W, Zhu J.   A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association.  Frontiers in Microbiology. 07 June 2017 | https://doi.org/10.3389/fmicb.2017.01035 PMID: 28638377  PMCID: PMC5461361

McGee TD Jr, Yi HA, Allen WJ, Jacobs A, Rizzo RC.Structure-based identification of inhibitors targeting obstruction of the HIVgp41 N-heptad repeat trimer.  Bioorg Med Chem Lett. 2017 Jul 15;27(14):3177-3184. doi: 10.1016/j.bmcl.2017.05.020. Epub 2017May 8.  PMID: 28558972 PMCID: PMC5551449

Hilimire TA, Chamberlain JM, Anokhina V, Bennett RP, Swart O, Myers JR, Ashton JM, Stewart RA, Featherston AL, Gates K, Helms ED, Smith HC, Dewhurst S, Miller BL.HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells. ACS Chem Biol. 2017 Jun 16;12(6):1674-1682. doi: 10.1021/acschembio.7b00052. Epub 2017 May 5. PMID: 28448121 PMCID: PMC5477779

Piekna-Przybylska D, Sharma G, Maggirwar SB, Bambara RA. Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1.Cell Cycle. 2017 May 19;16(10):968-978. doi: 10.1080/15384101.2017.1312225. Epub 2017 Apr 7.  PMID: 28388353 PMCID: PMC5462075

Polevoda B, Joseph R, Friedman AE, Bennett RP, Greiner R, De Zoysa T, Stewart RA, Smith HC. DNA mutagenic activity and capacity for HIV-1 restriction of the cytidine deaminase APOBEC3G depend on whether DNA or RNA binds to tyrosine 315. J Biol Chem. 2017 May 26;292(21):8642-8656. doi: 10.1074/jbc.M116.767889. Epub 2017 Apr 5.  PMID: 28381554 PMCID: PMC5448093

Morse DS, Wilson JL, McMahon JM, Dozier AM, Quiroz A, Cerulli C.Does a Primary Health Clinic for Formerly Incarcerated Women Increase Linkage to Care? Womens Health Issues. 2017 Jul - Aug;27(4):499-508. doi: 10.1016/j.whi.2017.02.003. Epub 2017 Mar 13.  PMID: 28302351 PMCID: PMC5511582

Khan A, Katanic D, Thakar J. Meta-analysis of cell- specific transcriptomic data using fuzzy c-means clustering discovers versatile viral responsive genes. BMC bioinformatics 2017; 18(1):295.  PMID: 28587632  PMCID: PMC5461682

Jean MJ, Power D, Kong W, Huang H, Santoso N, Zhu J. Viruses. Identification of HIV-1 Tat-Associated Proteins Contributing to HIV-1 Transcription and Latency. 2017 Apr 1;9(4). PMID: 28368303  PMCID: PMC5408673

Araínga M, Edagwa B, Mosley RL, Poluektova LY, Gorantla S, Gendelman HE. A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy. Retrovirology. 2017 Mar 9;14(1):17.  PMID: 28279181  PMCID: PMC5345240

Spinelli, S. L., Lannan, K. L., Loelius, S. G., & Phipps, R. P. (2017). In Vitro and Ex Vivo Approaches to Evaluate Next-Generation Tobacco and Non-Tobacco Products on Human Blood PlateletsApplied in Vitro Toxicology3(1), 110–120. http://doi.org/10.1089/aivt.2016.0034 PMID: 28337466  PMCID: PMC5338183

Jaworski, J.P., Bryk, P., Brower, Z., Zheng, B., Hessell, A.J., Rosenberg, A.F., Wu, T.T., Sanz, I., Keefer, M.C., Haigwood, N.L., and Kobie, J.J. 2017 Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques, submitted to PLoS One  PMID: 28222180 PMCID: PMC5319772

Gnanadhas DP, Dash PK, Sillman B, Bade AN, Lin Z, Palandri DL, Gautam N, Alnouti Y, Gelbard HA, McMillan J, Mosley RL, Edagwa B, Gendelman HE, Gorantla S. J Clin Invest. 2017 Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs. Mar 1;127(3):857-873. 2017 Jan 30.  PMID: 28134625 PMCID: PMC5330738

Antwi S, Yang H, Enimil A, et al. Pharmacokinetics of the First-Line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with or without HIV Coinfection. Antimicrobial agents and chemotherapy 2016:AAC. 01701-16.  PMID: 27855070 PMCID: PMC5278726

Lu X, Johnson BA. Direct Estimation for Adaptive Treatment Length Policies: Methods and Application to Evaluating the Effect of Delayed PEG Insertion. Biometrics 2016.  PMID: 28009454 PMCID: PMC5491382

Blanchard C, Brooks L, Ebsworth-Mojica K, Didione L, Wucher B, Dewhurst S, Krysan D, Dunman PM, Wozniak RA. Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment. mSphere. 2016 Sep 14;1(5)  PMID: 27642637 PMCID: PMC5023846

Gleghorn ML, Zhao J, Turner DH, Maquat LE. Crystal structure of a poly(rA) staggered zipper at acidic pH: evidence that adenine N1 protonation mediates parallel double helix formation. Nucleic Acids Research 2016. 44:8417  PMID: 27288442 PMCID: PMC5041459

Singh VB, Singh MV, Gorantla S, Poluektova LY, Maggirwar SB. Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice. Sci Rep. 2016 May 31;6:26876  PMID: 27241024 PMCID: PMC4886511

Hammond, J. W., Lu, S.-M., & Gelbard, H. A. (2016). Corrigendum: Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation. Frontiers in Cellular Neuroscience, 10, 113. http://doi.org/10.3389/fncel.2016.00113  PMID: 27199666  PMCID: PMC4854892

Jones LD, Jackson JW, Maggirwar SB. Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction. PLoS One. 2016 Mar 17;11(3):e0151702  PMID: 26986758  PMCID: PMC4795798

Liu B, Qiu X, Zhu T, Tian W, Hu R, Ekholm S, et al. Spatial regression analysis of serial DTI for subject-specific longitudinal changes of neurodegenerative disease. NeuroImage : Clinical 2016; 11:291-301.  PMID: 26977399 PMCID: PMC4782002

Blanchard, C., Brooks, L., Beckley, A., Colquhoun, J., Dewhurst, S., & Dunman, P. M. (2016). Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial OintmentsAntimicrobial Agents and Chemotherapy60(2), 862–872. http://doi.org/10.1128/AAC.02083-15  PMID: 26596945 PMCID: PMC4750660

Hammond, JW, Lu, S-M and Gelbard, HA. Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation. Front. Cell. Neurosci. | doi: 10.3389/fncel.2015.00505.  PMID: 26778968   PMCID: PMC4705275

Fedor TM, Kohler HP, McMahon JM. Changing attitudes and beliefs towards a woman’s right to protect against HIV risk in Malawi. Cult Health Sex 2016;18:435-52.  PMID: 26503918 PMCID: PMC4766023

Hayashi T, Jean M, Huang H, Simpson S, Santoso NG, Zhu J. (2017) Screening of an FDA-approved compound library identifies levosimendan as a novel anti-HIV-1 agent that inhibits viral transcription. Antiviral Res. 2017 Oct;146:76-85. doi: 10.1016/j.antiviral.2017.08.013. Epub 2017 Aug 24.  PMID: 28842263 PMCID: PMC5654649

Brewer MG, DiPiazza A, Acklin J, Feng C, Sant AJ, Dewhurst S. Nanoparticles decorated with viral antigens are more immunogenic at low surface density. Vaccine 2017.  PMID: 28057386   PMCID: In Process

Keefer MC, Zheng B, Rosenberg AF, Kobie JJ. Increased steady-state memory B cell subsets among high-risk participants in an HIV vaccine trial. AIDS research and human retroviruses 2016;32:1143-8.   PMID: 27612555   PMCID: PMC5067846

Zhang G, Guo D, Dash PK, Gelbard H, et al. The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy. Nanomedicine: nanotechnology, biology, and medicine 2016;12:109-22.    PMID: 26472049   PMCID: PMC4728028

Clark KM, Jenkins JL, Fedoriw N, Dumont ME (2016) Human CaaX Protease ZMPSTE24 Expressed in Yeast: Structure and Inhibition by HIV Protease Inhibitors. Protein Sci. [Epub ahead of print]  PMID: 27774687  PMCID: PMC5275749

Kutscher, H. L., Prasad, P. N., Morse, G. D., & Reynolds, J. L. (2016). Emerging Nanomedicine Approaches to Targeting HIV-1 and Antiretroviral TherapyFuture Virology11(2), 101–104. http://doi.org/10.2217/fvl.15.114 PMID: 28123446  PMCID: PMC5257175

Makita-Chingombe F, Kutscher HL, DiTursi SL, Morse GD, Maponga CC. Poly(lactic-co-glycolic) Acid-Chitosan Dual Loaded Nanoparticles for Antiretroviral Nanoformulations. J Drug Deliv. 2016;2016:3810175. doi: 10.1155/2016/3810175. PMID: 27190651 PMCID: PMC4852115

Niu L, Luo D, Liu Y, Silenzio VM, Xiao S. The Mental Health of People Living with HIV in China, 1998-2014: A Systematic Review. PLoS One. 2016 Apr 15;11(4):e0153489. doi: 10.1371/journal.pone.0153489. Review. PMID: 27082749   PMCID: PMC4833336

Piepenbrink MS, Samuel M, Zheng B, Carter B, Fucile C, Bunce C, Kiebala M, Khan AA, Thakar J, Maggirwar SB, Morse D, Rosenberg AF, Haughey NJ, Valenti W, Keefer MC, Kobie JJ. Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users. PLoS One. 2016 Jul 5;11(7):e0158641. doi: 10.1371/journal.pone.0158641. PMID: 27379802  PMCID: PMC4933366

Senn, T. E., Braksmajer, A., Coury-Doniger, P., Urban, M. A., & Carey, M. P. (in press) Mobile technology use and desired technology-based intervention characteristics among HIV+ Black men who have sex with menAIDS Care. 2016 Aug 18:1-5. [Epub ahead of print]   PMID:  27535069   PMC: PMC5503699

Senn, T.E., Braksmajer A., Coury-Doniger P., Urban M.A., Rossi, A. and Carey, M.P. (in press). Development and preliminary pilot testing of a peer support text messaging intervention for HIV+ Black men who have sex with men.  Journal of Acquired Immune Deficiency Syndromes. 2017 Feb 1;74 Suppl 2:S121-S127   PMID: 28079722  PMC: PMC5503687

Shah KN, Majeed Z, Yoruk YB, Yang H, Hilton TN, McMahon JM, Hall WJ, Walck D, Luque AE, Ryan RM. Enhancing Physical Function in HIV-Infected Older Adults: A Randomized Controlled Clinical Trial. Health Psychol. 2016. Epub 2016/02/13. doi: 10.1037/hea0000311.   PMID: 26867045    PMCID: PMC4868650

Valentine JL, Chen L, Perregaux EC, Weyant KB, Rosenthal JA, Heiss C, Azadi P, Fisher AC, Putnam D, Moe GR, Merritt JH, DeLisa MP. Immunization with Outer Membrane Vesicles Displaying Designer Glycotopes Yields Class-Switched, Glycan-Specific Antibodies. Cell Chem Biol. 2016 Jun 23;23(6):655-65. doi: 10.1016/j.chembiol.2016.05.014.   PMID: 27341433  PMCID: PMC5116915

Vats K, Marsh G, Harding K, Zampetakis I, Waugh RE, Benoit DS. Nanoscale physicochemical properties of chain- and step-growth polymerized PEG hydrogels affect cell-material interactions. J Biomed Mater Res A. 2017 Jan 17. doi: 10.1002/jbm.a.36007. [Epub ahead of print] PubMed  PMID: 28093865  PMC: PMC5329027

Antwi S, Yang H, Enimil A, et al. Pharmacokinetics of the First-line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with and without HIV Coinfection. Antimicrobial agents and chemotherapy 2016:AAC. 01701-16.    PMID: 27855070  PMCID: PMC5278726

Johnson BA, McKenney J, Ricca AV, Rosenberg ES, Liu C, Sharma A, Sullivan PS. Risk Factors Associated With Repeated HIV Testing Among Internet-Using Men Who Have Sex With Men. AIDS Education and Prevention 2016;28:511-23.  PMID: 27925484     PMCID: In Process

McMahon JM, Chimenti R, Trabold N, Fedor T, Mittal M, Tortu S. Risk of Intimate Partner Violence and Relationship Conflict Following Couple-Based HIV Prevention Counseling Results From the Harlem River Couples Project. Journal of interpersonal violence 2015:0886260515600878.   PMID:  26319710    PMCID: PMC4769677

McMahon JM, Pouget ER, Tortu S, Volpe EM, Torres L, Rodriguez W. Couple-based HIV counseling and testing: a risk reduction intervention for US drug-involved women and their primary male partners. Prevention science : the official journal of the Society for Prevention Research 2015;16:341-51.  PMID: 25512179   PMCID: PMC4310810 

McMahon JM, Volpe EM, Klostermann K, Trabold N, Xue Y. A systematic review of the psychometric properties of the Sexual Relationship Power Scale in HIV/AIDS research. Arch Sex Behav 2015;44:267   PMID: 25331613    PMCID: PMC4324007

Morse DS, Silverstein J, Thomas K, Bedel P, Cerulli C. Finding the loopholes: a cross-sectional qualitative study of systemic barriers to treatment access for women drug court participants. Health & justice 2015;3:1-9.    PMID: 26478853   PMCID: PMC4607061

Puccini JM, Marker DF, Fitzgerald T, Barbieri J, Kim CS, Miller-Rhodes P, Lu SM, Dewhurst S, Gelbard HA. Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders. The Journal of neuroscience: the official journal of the Society for Neuroscience 2015;35:5271-83.   PMID: 25834052    PMCID: PMC4381000

Jackson JW, Singh MV, Singh VB, Jones LD, Davidson GA, Ture S, Morrell CN, Schifitto G, Maggirwar SB. Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis. PLoS One. 2016 Jun  6;11(6):e0157115  PMID: 27270236  PMCID: PMC4894566

Yang H, Baker SF, González ME, Topham DJ, Martínez-Sobrido L, Zand M, Holden-Wiltse J, Wu H. An improved method for estimating antibody titers in microneutralization assay using green fluorescent protein. J Biopharm Stat. 2016;26(3):409-20   PMID: 26010892   PMCID: PMC4661136

Johnson BA, Long Q, Huang Y, Chansky K, Redman M. (2016) “Model selection and inference for lifetime medical expenditures.” Biometrics 72: 731-741.  PMID: 26689300  PMCID: In Process

Liu*, B., Qiu*, X., Zhu, T., Tian, W., Hu, R., Ekholm, S., Schifitto, G., Zhong, J. (2016) Improved spatial regression analysis of diffusion tensor imaging for lesion detection during longitudinal progression of multiple sclerosis in individual subjects, Physics in Medicine and Biology, 61(6): 2497. [*First authorship shared]   PMID: 26948513  PMCID: In Process