Affiliated Faculty
Optics
Research Interest: Biomedical optics, specifically spectroscopic diagnostic techniques
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Research Interest: Diffuse optics for in vivo cancer detection, diagnosis and therapy monitoring
Biochemistry & Biophysics
Research Interest:
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Research Interest: Molecular mechanisms of prion propagation and pathogenesis
Research Interest:
Investigating membranes and membrane proteins via computer simulation
William A. Bernhard Memorial Lab
Biochemistry & BiophysicsResearch Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function
Research Interest: G protein coupled receptor signaling and modulation of ion channels in neurons
Research Interest: Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Research Interest:
Biomimetic nanoparticles, super-resolution microscopy, and bio-inspired photocatalysis
Research Interest:
Nuclear and cytoplasmic RNA metabolism in mammalian cells: Co- and post-transcriptional pre-mRNA processing; influence of pre-mRNA splicing on mRNA metabolism, including the structure and function of modular exon-junction complexes and effects of AKT-signaling; Nonsense-mediated mRNA decay; Fragile X Syndrome (FXS)/Autism/Intellectual disabilities; mRNP Structure and function in non-polar cells and in neurons; Development of FXS therapeutics.
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Research Interest:
In vitro models of human lung and vascular barriers during inflammation.
Biomedical Engineering
Dermatology
Research Interest:
Research in the Miller group centers on (1) photonic sensors, particularly with regard to continuous monitoring of microphysiological systems and biomanufacturing; (2) medical diagnostics, including paper-based point-of-care and self-tests for RNA viruses.
Microbiology & Immunology
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Pharmacology & Physiology
Research Interest:
Molecular mechanisms and spatiotemporal regulation of cell signaling pathways using cryo-EM, biochemical, and pharmacologic studies; RNA/protein therapeutic targets and treatments; instrumentation and methods development in structural biology.
Research Interest: tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Research Interest: Computational biology of RNA; RNA comparative sequence analysis; RNA structure prediction; analysis of HIV RNA genomes.
Program for Advanced Immune Bioimaging
Microbiology & ImmunologyResearch Interest: Systems approach utilizing bioinformatics, and dynamic modeling tools to study immune response to infections and vaccination.
Research Interest:
Mechanism and physiological importance of alternative polyadenylation; Integrator Complex and transcriptional control, development and application of next-generation sequencing technologies
Research Interest: Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Imaging Sciences
Biomedical Engineering
Research Interest: Intelligent image acquisition and analysis systems in biomedicine
Pharmacology & Physiology
Research Interest: Mechanisms Underlying Ca2+ Signaling Events in Exocrine Cells