Keshov Sharma Presents Late-Breaking Data at Society for Biological Psychiatry in San Diego
Monday, May 22, 2017
Keshov Sharma, a second-year student in the Medical Scientist Training Program (MSTP), presented work collected in part during his laboratory last summer at the SOBP Annual meeting in May. The study, “Dual Neural Connections between the Amygdala and the Ventromedial (BA25) and Dorsomedial (BA24) Prefrontal Cortex in the Macaque”, was inspired by recent data in rodents implicating separate subcircuits between amygdala and infralimbic cortex, and amygdala and the prelimbic cortex, in fear extinction and fear consolidation, respectively. To find a comparable bridge to human fear studies, we designed studies to examine this question in monkeys because of their relatively larger and more subdivided cortical architecture that parallels the human. Analyzing dual retrograde injections into proposed ‘homologues’ of these rodent cortical regions in monkeys, we found that cells projecting to these cortical regions were mostly intermixed in several specific amygdala subnuclei in primates. Moreover, a subpopulation of neurons projected to both prefrontal regions, indicating common neural modulation of these functionally dissociated areas. Thus, amygdala inputs to separable, functionally opposed cortical regions exist in close proximity to one another in specific parts of the amygdala, and some of these cells participate in both ‘subcircuits’. Understanding this organization may provide clues about how to ‘tip the balance’ between fear learning and fear extinction learning in higher species, including humans that suffer from illnesses characterized by aberrant fear learning.
Richard M. Locksley, M.D. Delivers Keynote Address to School of Medicine
Friday, March 17, 2017
On Friday, April 7, in the School of Medicine’s Class of ’62 Auditorium, Medical Scientist Research Symposium (MSRS) showcased the research and scientific accomplishments of Medical Scientist Training Program students. As a highlight of this event, students invite an inspiring translational medical researcher to give a keynote address. This year’s speaker, Richard Locksley, M.D., is an alumnus of the University of Rochester School of Medicine & Dentistry (1976). In addition to being a Howard Hughes Medical Institute Investigator, Dr. Locksley is a Professor in the Departments of Medicine (Infectious Disease) and Microbiology and Immunology at University of California, San Francisco. He is also Director of the Strategic Asthma Basic Research Center at UCSF. Dr. Locksley’s work investigates the orchestration of innate and adaptive immunity, with a focus on allergic disease. His laboratory contributed to the discovery of group 2 innate lymphoid cells, a key immune population implicated in allergy and asthma but also important for tissue homeostasis.
His keynote, “Innate Allergy?” was jointly sponsored by the Medical Scientist Training Program and the Dr. Thomas A. and Joyce E. Pearson Endowed Lectureship fund)
More information on the MSRS.