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We are interested in finding new approaches to treat ischemic brain injury. In particular, our lab focuses on signaling nodes in transcriptional networks that regulate neuron survival and are amenable to small molecule regulation. Putative targets identified through genomic and proteomic-based screens are first validated in vivo and studied further using primary neuronal cultures, neurospheres and related in vitro assays. To manipulate gene function we use several complementary approaches including knockout mouse models, viral mediated gene regulation, site-directed mutagenesis and pharmacological inhibition. Ultimately, our goal is to identify novel therapeutic targets and treatments for disorders in which ischemia is a central component.
Marc Halterman Full CV
Transcription-based Therapies for Stroke
Anti-inflammatory Strategies for Post Cardiac Arrest Syndrome (PCAS)
Phosphatase Regulation of HIF-1α Activity in Glioblastoma Multiforme (GBM)
Medical Crowdsourcing / Mobile Health Technology Development
June 27, 2018AHA Grants Will Accelerate Search for New Stroke Therapies
April 23, 2018Neuroscience Graduate Student Receives American Heart Association Pre-Doctoral Fellowship
January 31, 2018Lungs Mays Hold Key to Thwarting Brain Damage after a Stroke
December 19, 2017Prize winning Undergraduate
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Marc Halterman, M.D., Ph.D.
University of Rochester Medical Center
Neurology, Center for Neurotherapeutics Discovery
601 Elmwood Avenue
Rochester, NY 14642
We’re located in the Kornberg Medical Research Building at the University of Rochester School of Medicine and Dentistry. Parking is available in a small lot in front of our building. At the KMRB atrium walk past the coffee cart, go up the short flight of steps on the right and take the elevator up to 1. Using the phone by the locked doors, call x3-3030 (Lab) to let us know you’re here. For driving directions, please refer to the map below.