Clinical Research in Ob/Gyn The faculty of Obstetrics and Gynecology regularly conduct clinical research on new devices and medications that may assist in the future health of women. Scroll down to see what we're studying and how you can participate. Studies for Pregnant Women Comparison of gabapentin and ondansetron in the treatment of hyperemesis gravidarum About the study: Double-blind clinical trial enrolling pregnant women who have received intravenous fluids and have not had much benefit with previous treatments for nausea and vomiting. Study participants will be randomly assigned to take gabapentin (Neurontin) or ondansetron (Zofran). Click here for more information. Enrolling: Yes PI: Loralei Thornburg, MD Contact: Heather Fiore, MS Ed, RD, CDE 585-275-9165 Prenatally Diagnosed Lower Urinary Tract Obstruction (LUTO) with Normal Amniotic Fluid About the Study: The purpose of this study is to determine whether infants who had normal amniotic fluid volume, but enlarged bladders and kidneys before birth, suffer renal injury before birth and develop renal insufficiency or failure before birth or during the first two years of life. Participants are not compensated. Enrolling? Yes PI: Tulin Ozcan, MD Contact: Shaya Greathouse, 585-275-3565 North American Fetal Therapy Network Complicated Monochorionic Twin Pregnancy Registry About the Study: The purpose of this study is to create a registry database of information from many hospitals that care for women with monochorionic twin pregnancies. This registry will allow these specialized high risk pregnancy hospitals to compile their data to better evaluate the best way to care for these patients. Participants will give permission for the collection of their medical record data regarding demographics and pregnancy information. Participants are not compensated. Enrolling? Yes PI: Tulin Ozcan, MD Contact: Shaya Greathouse, 585-275-3565 Indications for Delivery for Twin-Twin Transfusion after Selective Fetoscopic Laser Photocoagulation About the Study:This study assesses the reasons for delivery in pregnancies with Twin-Twin Transfusion (TTTS) when treated with Selective Fetoscopic Laser Photocoagulation (SFLP). Participants will give permission for the collection of their medical record data regarding demographics and pregnancy information. Participants are not compensated. Enrolling? Yes PI: Tulin Ozcan, MD Contact: Shaya Greathouse, 585-275-3565 Sources of Fetal Iron During Pregnancy (Prelabeled Iron study) About the Study: Study is enrolling only women who are less than 16 weeks into their pregnancy, single gestation, between 15-35 years of age, and who do not smoke. Compensation is $160 in Wal-Mart gift cards. Participants must be receiving care through URMC Midwifery practice. Enrolling? Yes PI: Eva Pressman, MD; Kimberly O'Brien, PhD Contact: Melissa Miller 585-410-0119 Study Title: Vitamin D and Infection during Pregnancy About the Study: Study is enrolling only young women who are 13-18 years of age and do not smoke. Participants must be receiving care through the RAMP clinic. Compensation is $125 in gift cards ($90 Wal-Mart, $35 CVS pharmacy). In addition, we are also offering to print and frame a baby picture for those who are interested. Enrolling? Yes PI: Eva Pressman, MD; Kimberly O'Brien, PhD Contact: Melissa Miller 585-410-0119 Studies of Polycystic Ovarian Syndrome Prenatal Androgens and PCOS About the Study: We are recruiting women with polycystic ovary syndrome (PCOS) for a study on whether PCOS might be related to hormones circulating in mothers’ bodies during pregnancy. The study involves a one-time visit similar to a gynecological exam. Blood draw optional. Payment up to $40.00 for completion of study. Enrolling? Yes PI: Emily Barrett, PhD Contact: Lynda Kochman, RN, CCRC 585-275-4149, 585-273-2995 firstname.lastname@example.org ADAPT (PCOS) Study About the Study: The purpose of this study is to determine whether or not treatment of PCOS with hormonal contraception, either in the form of Mirena-IUD, Nexplanon or oral contraceptive pills affects levels of depression and anxiety in women with PCOS compared to those who choose no hormonal treatment for PCOS. This is a survey-based study, and no payment is provided. PI: Kathleen Hoeger, MD, MPH and Snigdha Alur, MD Enrolling? Yes Contact: Lynda Kochman, RN, CCRC 585-275-4149, 585-273-2995; Shaya Greathouse, 585-275-3565. Studies of Other Conditions Localized Provoked Vulvodynia Pathogenesis About the Study: We are planning to enroll 30 women between 18 and 50 who meet Friedrich’s Criteria for localized provoked vulvodynia with 30 controls between 18 and 50 years old, negative Friedrich’s criteria, and planned surgical procedure to lower genital tract. Both groups will undergo biopsy of the vulva. Both groups will be compensated. Enrolling? Yes PI: David Foster, MD Contact: Sarah Caveglia, MPH 585-275-3160 Global Endometrial Ablation Prospective Data Study About the Study: This study aims to develop a database of information about women undergoing the Novasure endometrial ablation procedure. Subjects enrolled in this study will be asked to complete a series of questionnaires before they undergo the Novasure procedure, 6 months after the procedure, and every year after the procedure for three years. The main purpose of the study is to gain a better understanding of the long term effects of the Novasure ablation. Enrolling? Yes PI: Bala Bhagavath, MD Contact: Divya Kumar, MPH 585-275-9204 GeneXperts About the Study: Identification of Herpes Simplex Virus (HSV) Shedding in the Female Genital Tract of Pregnant and Nonpregnant Women by Xpert ½ Assay, Routine PCR, and Culture. This study will see whether herpes simplex virus can reliably be detected in pregnant women at the time of their delivery. Subjects should have no active herpes lesions at enrollment, and at delivery a vaginal swab and a small blood sample will be collected. Payment for completion is $20. Sponsored by National Institutes of Allergy and Infectious Disease Enrolling? Yes PI: Mary Caserta, MD Contact: Shaya Greathouse, 585-275-3565 A current list of open clinical trials at the University of Rochester is available here.