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topham photoDavid Topham, PhD (Founding Director)

Dr. Topham has been successfully leading teams of investigators in Rochester and across the country in NIH funded, multidisciplinary, clinical and translational research centers since 2007. He has over 25 years of experience in immunology and infectious disease research, with a particular emphasis on clinical and translational research into respiratory pathogens such as influenza, RSV, coronavirus and experimental vaccines. The Topham Lab has a combined program in basic, clinical, and translational research using animal and computational models of infectious diseases, vaccines, and immunity, combined with clinical studies and trials. The lab routinely conducts studies of human immune responses to respiratory infections and experimental vaccines. In our clinical and translational research, we have established cutting edge technologies for multidimensional, systems biology-based analysis of immune responses.

Branche photoAngela Branche, MD (Director of Clinical Studies of Infectious Disease)

Dr. Branche is an assistant professor at the University of Rochester, School of Medicine. She received her Bachelor of Arts degree in Biology at the University of Pennsylvania and Doctorate in Medicine at American University of the Caribbean. She completed residency in Internal Medicine at NYU Lutheran in Brooklyn, NY and infectious disease fellowship at the University of Rochester. She currently has a clinical inpatient practice comprised of both general infectious diseases and HIV medicine patients. Dr. Branche is also a New York State designated HIV/AIDS provider and has a practice comprised of adult patients ages 18 and older at the URMC HIV Clinic.The focus of Dr. Blanche’s research has been clinical and translational research in the field of respiratory viral and bacterial infections in adults. 

Pillars of the Institute - Lead Investigators

Each Pillar has an appointed lead investigator whose task is to facilitate faculty collaborations and seeking of funding opportunities.

Pediatric Infectious Disease and Immunology

Barrier Immunology


Coronavirus, Influenza and other Respiratory Pathogens

Antibiotic Resistance


Computational Biology and Bioinformatics

Community and Public Health

Cancer Immunology and Immunosuppression

Executive Committee

Mission is to advise on day to day and annual operations of the institute including administrative decisions.

Scientific Advisory Committee

Administration and Project Management

Mission is manage communication and reporting, and to provide administration and financial oversight

Erin Lee photoErin Lee
Sr. Information Analyst
Translational Immunology and Infectious Disease Institute
Program for Advanced Immune Bioimaging