View Our Center Leadership & Administration
Lisa A. DeLouise, Ph.D., M.P.D.Email Lisa
Understanding the toxicological and biochemical properties of nanomaterial interactions with skin and the immune system; develop in vivo models to investigate nanoparticle skin penetration mechanisms, and develop novel biosensors to improve transdermal drug delivery and tissue engineering approaches.
Alison Elder, Ph.D.Email Alison
Defining the impact of inhaled ambient and workplace nano-/ultrafine particle-containing aerosols on the lung, cardiovascular system, and central nervous system, and defining the toxicological properties of the particles that are associated with a response.
Jacob N. Finkelstein, Ph.D.Email Jacob
Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages.
Steve Georas, M.D.Email Steve
Defining the role of environmental exposures on innate and adaptive immunity in asthma and other chronic lung diseases, with an emphasis on how particulate matter and endocrine disruptors act as risk factors.
B. Paige Lawrence, Ph.D.Email B. Paige
Delineating mechanisms by which environmental exposures during different life stages alter immune function; discovering how environmental factors modulate epigenetic programming of the developing immune system, and the consequences of these changes on susceptibility to infectious, allergic, or autoimmune disease later in life.
Mark Noble, Ph.D.Email Mark
Discovering new treatments for afflictions that lack satisfactory therapies, and to better understand the toxicity of currently used medicines; studies span normal and pathological cell function, with focus on stem and progenitor cells.
Thomas O'Connor, Ph.D.Email Thomas
The mechanisms by which early stress exposures, including prenatal maternal anxiety and caregiving stress, may persistently shape children's behavioral and biological health
Gloria S. Pryhuber, M.D.Email Gloria
Delineating multifactorial causes of respiratory morbidity in infants and young children, including environmental exposures on lung development, microbial infection and dysbiosis, and pulmonary immune responses; levering unique human lung and immune cell repositories that support the in vitro study of mechanisms of toxicity of environmental agents.
J. Edward Puzas, Ph.D.Email J. Edward
Deciphering the molecular signals that govern osteoporosis and arthritis, as well as cellular changes that contribute to difficulties such as the loosening of artificial joints, including defining how environmental toxins such as lead, play a role in bone and joint diseases.
Matthew D. Rand, Ph.D.Email Matthew
Mechanisms of toxicity of the environmental contaminant and neurotoxicant methylmercury (MeHg), defining MeHg effects on early life development of neural and muscular systems at the molecular, cellular, and organismal levels using invertebrate and mammalian models, and detailed characterization of MeHg metabolism and elimination kinetics in humans.
David Rich, Sc.D., M.P.H.Email David
Public Health Sciences
Examining associations between air pollution and cardiopulmonary and pregnancy outcomes, validating biomarkers that may explain associations and developing spatial-temporal models of air pollution to enable field studies of these biomarkers and clinical outcomes associated with residential air pollution exposures.
Patricia Sime, M.D.Email Patricia
Conducting clinical and translational toxicology research focusing on the lung, from studies of silica and radiation in lung fibrosis, to the effects of biomass and cigarette smoke exposure on lung inflammation and resolution pathways, to identifying key pathophysiologic pathways and developing novel therapeutics for lung inflammation and fibrosis.