Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages.
Effects of particle exposure on lung function, airway inflammation, and cardiovascular function.
Defining the role of environmental exposures on innate and adaptive immunity in asthma and other chronic lung diseases, with an emphasis on how particulate matter and endocrine disruptors act as risk factors.
Defining the impact of environmental chemicals on immunity and immune-mediated diseases and as a mechanism for susceptibility to other disease outcomes, such as neurobehavioral disorders.
Neurodegenerative diseases affecting the basal ganglia, particularly Parkinson disease, Huntington disease, and HIV related neurologic disorders
Translational Research in Autoimmune Disease, B Cell Depletion
Systems Biology of Lung Development and Disease
Determining the impact of maternal stress and other maternal factors on the birth outcomes and in the children.
Environmental toxins, specifically mercury; methyl mercury exposure
Understanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan.
Delineating multifactorial causes of respiratory morbidity in infants and young children, including environmental exposures on lung development, microbial infection and dysbiosis, and pulmonary immune responses; levering unique human lung and immune cell repositories that support the in vitro study of mechanisms of toxicity of environmental agents.
Deciphering the molecular signals that govern osteoporosis and arthritis, as well as cellular changes that contribute to difficulties such as the loosening of artificial joints, including defining how environmental toxins such as lead, play a role in bone and joint diseases.
Examining associations between air pollution and cardiopulmonary and pregnancy outcomes, validating biomarkers that may explain associations and developing spatial-temporal models of air pollution to enable field studies of these biomarkers and clinical outcomes associated with residential air pollution exposures.
Conducting clinical and translational toxicology research focusing on the lung, from studies of silica and radiation in lung fibrosis, to the effects of biomass and cigarette smoke exposure on lung inflammation and resolution pathways, to identifying key pathophysiologic pathways and developing novel therapeutics for lung inflammation and fibrosis.
Defining influences of environmental exposures, in particular toxic metals, on cognitive outcomes in children and adults.