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Faculty

Primary Faculty

Paul Boutz
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Mark Dumont
Research Interest: Signal transduction; membrane protein structure, yeast molecular biology
Dmitri Ermolenko
Research Interest: Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Barry Goldstein
Research Interest: Crystallography and structural chemistry of enzyme-ligand interactions.
Elizabeth Grayhack
Research Interest: Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Alan Grossfield
Research Interest: Investigating membranes and membrane proteins via computer simulation
Jeffrey Hayes
Research Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function
Clara Kielkopf
Research Interest: Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Xin Li
Research Interest: Epigenetic inheritance, small silencing non-coding RNAs, translational control, lead toxicity, and comparative genomics.
Lynne Maquat
Research Interest: RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
David Mathews
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Kermit Mercer
Research Interest: Electron paramagnetic resonance (EPR) research and instrumentation
Joshua Munger
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Mitchell O'Connell
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Eric Phizicky
Research Interest: tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Joseph Wedekind
Research Interest: Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Yi-Tao Yu
Research Interest: RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.

Research Faculty

Fred Hagen
Research Interest: Glycosyltransferases, proteomics, role of glycosylation in development
Jermaine Jenkins
Research Interest: Crystallography of RNA and Protein-RNA complexes
Scott Kennedy
Research Interest: NMR imaging and spectroscopy; Tumor biology; RNA structure determination; anion transport
Tatsuaki Kurosaki
Tatsuaki Kurosaki, Ph.D.
Research Interest: mRNA quality control (or mRNA surveillance) in human cells, fragile X syndrome
Bogdan Polevoda
Research Interest: The two cotranslational processes, cleavage of N-terminal methionine and N-terminal acetylation (N- acetylation).
Maximilian Popp
Maximilian Popp, Ph.D.
Research Interest: mRNA metabolism in mammalian cells
Elena Rustchenko-Bulgac
Research Interest: Chromosomes instability of human fungal pathogen Candida albicans.
Hironao Wakabayashi
Research Interest: Structural and functional analyses of factor VIII

Secondary Faculty

Michael Bulger
Research Interest: Chromatin domains and long-range activation by enhancers
Scott Butler
Research Interest: Regulation of Gene Expression by Targeted Degradation of RNA
Gloria Culver
Research Interest: Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.
Chin-To Fong
Research Interest: Genetics of orofacial clefts
Hartmut Land
Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Benjamin Miller
Research Interest: Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Peng Yao
Research Interest: Pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease.

Emeritus Faculty

Robert Bambara
Research Interest: Human genome stability, DNA damage response, HIV replication and evolution
Thomas Gunter
Research Interest: Membrane transport, bioenergetics, calcium regulation
Russell Hilf
Research Interest: Hormone action in mammary cancer; Photodynamic therapy of neoplasia
George Kimmich
George Kimmich, Ph.D.

Research Interest: Regulation of neurotransmitter uptake by glial and neuronal cells
Mahin Maines
Research Interest: Heme oxygenases and second messenger gases: CO and NO.
Terry Platt
Terry Platt, Ph.D.

Research Interest: Molecular mechanisms of gene expression; transcription termination and mRNA 3' and formation in Escherichia coli and yeast; protein-nucleic acid.
Alan Senior
Research Interest: Multidrug-resistance in cancer; ATP synthesis in bacteria and mitochondria
William Simon
Research Interest: Optical pattern recognition of biological specimens
Harold Smith
Research Interest: Msg RNA editing in health and disease