Dmitri N. Ermolenko, Ph.D.Email Dmitri
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Clara L. Kielkopf, Ph.D.Email Clara
Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Lynne Maquat, Ph.D.Email Lynne
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Mitchell O'Connell, Ph.D.Email Mitchell
Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Yi-Tao Yu, Ph.D.Email Yi-Tao
RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.