Skip to main content
Explore URMC


Primary Faculty

Paul Boutz
Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Mark Dumont
Signal transduction; membrane protein structure, yeast molecular biology
Dmitri Ermolenko
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Barry Goldstein
Crystallography and structural chemistry of enzyme-ligand interactions.
Elizabeth Grayhack
Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Alan Grossfield
Investigating membranes and membrane proteins via computer simulation
Jeffrey Hayes
Regulation of transcription, nuclear processes, related to chromatin structure and function
Clara Kielkopf
Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Xin Li
Our research is to define the RNA functions in reproduction and transgenerational epigenetic inheritance.
Lynne Maquat
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
David Mathews
Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Kermit Mercer
Electron paramagnetic resonance (epr) research and instrumentation
Joshua Munger
Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Mitchell O'Connell
Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Eric Phizicky
tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Joseph Wedekind
Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Yi-Tao Yu
RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.

Research Faculty

Fred Hagen
Glycosyltransferases, proteomics, role of glycosylation in development
Jermaine Jenkins
Crystallography of RNA and Protein-RNA complexes
Scott Kennedy
NMR imaging and spectroscopy; Tumor biology; RNA structure determination; anion transport
Tatsuaki Kurosaki
Tatsuaki Kurosaki, Ph.D.
mRNA quality control (or mRNA surveillance) in human cells, fragile X syndrome
Elizabeth Mathew
Structure and functions of G protein coupled receptors (GPCRs), in particular, the yeast GPCR, Ste2p
Bogdan Polevoda
The two cotranslational processes, cleavage of N-terminal methionine and N-terminal acetylation (N- acetylation).
Maximilian Popp
Maximilian Popp, Ph.D.
mRNA metabolism in mammalian cells
Elena Rustchenko-Bulgac
Chromosomes instability of human fungal pathogen Candida albicans.
Hironao Wakabayashi
Structural and functional analyses of factor VIII

Secondary Faculty

Michael Bulger
Chromatin domains and long-range activation by enhancers
Scott Butler
Regulation of Gene Expression by Targeted Degradation of RNA
Gloria Culver
Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.
Chin-To Fong
Genetics of orofacial clefts
Hartmut Land
Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Benjamin Miller
Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Peng Yao
Pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease.

Emeritus Faculty

Robert Bambara
Human genome stability, DNA damage response, HIV replication and evolution
Thomas Gunter
Membrane transport, bioenergetics, calcium regulation
Russell Hilf
Hormone action in mammary cancer; Photodynamic therapy of neoplasia
George Kimmich
George Kimmich, Ph.D.

Regulation of neurotransmitter uptake by glial and neuronal cells
Mahin Maines
Heme oxygenases and second messenger gases: CO and NO.
Terry Platt
Terry Platt, Ph.D.

Molecular mechanisms of gene expression; transcription termination and mRNA 3' and formation in Escherichia coli and yeast; protein-nucleic acid.
Alan Senior
Multidrug-resistance in cancer; ATP synthesis in bacteria and mitochondria
William Simon
Optical pattern recognition of biological specimens
Harold Smith
Msg RNA editing in health and disease