Faculty

Research Interest: Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.

Co-Director of the Rochester Genomics Center
Director, Wilmot Cancer Institute Shared Resources
Director, Functional Genomics Resource

Research Interest: Molecular mechanisms of cancer stem cell interactions with tumor microenvironment in disease progression

Research Interest: Molecular and Cellular Mechanisms that Control Tissue Homeostasis and Somatic Stem Cells

Research Interest: The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease

Research Interest: Understanding the roles of antioxidants in cancer

Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism

Research Interest: Identification of different stem and precursor cell pools in CNS that may be critical for cell replacement therapies or are targets of insults that lead to developmental pathologies.

Research Interest: Understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation.

Research Interest: The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.

Research Interest: Neuro stem cell biology and medicine, developing pharmacological and cell based approaches to peripheral and spinal cord injury.

Research Interest: Protective and regenerative strategies for salivary gland function and radiation therapies.

Research Interest: Neural circuit development and function; Genetic control of behavior; Sex differences in neurobiology

Research Interest: Glial progenitor cells and role of astrocytes as critical modulators in CNS disease and repair

Research Interest: Understanding the genetic, cell biological and molecular basis for age-driven proteostatic deterioration

Research Interest: Cancer epigenetics: the role of DNA methylation and chromatin in driving cancer phenotypes and as a target for therapeutic intervention

Research Interest: Signal transduction and development of therapeutic agents in B-lymphomas; Cell cycle regulation

Research Interest: Genetics of Congenital Diaphragmatic Hernia in lung development

Research Interest: Investigating cell division and adhesion in epithelial tissues, with a particular interest in how tissue integrity is established and maintained during development.

Research Interest: Molecular mechanisms that control the exchange of molecules and information between the nucleus and cytoplasm

Research Interest: The molecular biology and genetics of pancreatic and biliary tract cancers

Research Interest: Molecular development of the eye and inner ear; anterior segment dysgenesis (ASD) and developmental glaucoma; congenital deafness and vestibular dysfunction

Research Interest: Neurobiology of glaucoma, molecular processes that lead to retinal ganglion cell death.

Research Interest: Genetic mechanisms of susceptibility to chronic lung diseases, focusing on developmental antecedents and influence of environmental factors.

Research Interest: Developing methods to estimate gene regulatory networks from gene perturbation experiments

Research Interest: Pediatric Neurology, Human Genetics

Research Interest: Cellular and Molecular events underlying the ontogeny of the hematopoietic system.

Research Interest: Using patient-derived human induced pluripotent stem cells (hiPSCs) to study the molecular mechanism of specific retinal and neurological diseases and applying that knowledge to pharmacologically target certain retinal disorders in patient-derived cells.