The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease
Molecular and Cellular Mechanisms that Control Tissue Homeostasis and Somatic Stem Cells
Cellular Signaling in Neural Development and Disease
Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Deciphering the impact of nutritional, toxicological, viral, and genetic insults, singly and in combination, on mammalian brain development and disease later in life.
Systems Biology of Cancer Cells
Discovering new treatments for afflictions that lack satisfactory therapies, and to better understand the toxicity of currently used medicines; studies span normal and pathological cell function, with focus on stem and progenitor cells.
Analysis of Genes Involved in Salivary Gland Function
Neural circuit development and function; Genetic control of behavior; Sex differences in neurobiology
Defining roles of glial progenitor cells and astrocytes as critical modulators in responses to chemical exposure, injury, or stress; discovering how exogenous factors contribute to neurodegenerative diseases; and developing new approaches to treat traumatic injury and neurodegenerative diseases.
Understanding Aging at the Genetic, Molecular, Cellular, and Organismal Level
GPR56 in Cancer
Signal transduction and development of therapeutic agents in B-lymphomas; Cell cycle regulation