Publications

2024

Chen X, Bell NA, Coffman BL, Rabino AA, Garcia-Mata R, Kammermeier PJ, Yule DI, Axelrod D, Smrcka AV, Giovannucci DR, Anantharam A. A PACAP-activated network for secretion requires coordination of Ca ²⁺ influx and Ca ²⁺ mobilization. bioRxiv. 2024 Jan 3:2024.01.03.574069.

Cisco LA, Sipple MT, Edwards KM, Thornton CA, Lueck JD. Verapamil mitigates chloride and calcium bi-channelopathy in a myotonic dystrophy mouse model.  J Clin Invest. 2024 Jan 2;134(1):e173576.

Di Carli MF, Gormsen LC, Chareonthaitawee P, Johnson GB, Beanlands R, DeKemp R, Schindler T, Gropler R, Kulkarni H, McNeely P, Soman P, Oz O, Zaha V, Sorensen J, Harms H, Orlandi C, Vandenbroucke E, Udelson J. Rationale and design of the RAPID-WATER-FLOW trial: Radiolabeled perfusion to identify coronary artery disease using water to evaluate responses of myocardial FLOW.  J Nucl Cardiol. 2023 Dec 5;31:101779.

Ghane M, Trambaiolli L, Bertocci MA, Martinez-Rivera FJ, Chase HW, Brady T, Skeba A, Graur S, Bonar L, Iyengar S, Quirk GJ, Rasmussen SA, Haber SN, Phillips ML.

Specific patterns of endogenous functional connectivity are associated with harm avoidance in OCD.  Biol Psychiatry. 2024 Feb 7:S0006-3223(24)00078-7.

McCullock TW, Cardani LP, Kammermeier PJ. Signaling specificity and kinetics of the human metabotropic glutamate receptors.  Mol Pharmacol. 2023 Dec 8:MOLPHARM-AR-2023-000795.

Phan BN, Ray MH, Xue X, Fu C, Fenster RJ, Kohut SJ, Bergman J, Haber SN, McCullough KM, Fish MK, Glausier JR, Su Q, Tipton AE, Lewis DA, Freyberg Z, Tseng GC, Russek SJ, Alekseyev Y, Ressler KJ, Seney ML, Pfenning AR, Logan RW. Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder.  Nat Commun. 2024 Jan 31;15(1):878.

Saluja S, Qiu L, Wang AR, Campos G, Selheimer R, McNab JA, Haber SN, Barbosa DAN, Halpern CH. Diffusion MRI tractography guides investigation of the zona incerta: a novel target for deep brain stimulation.  Biol Psychiatry. 2024 Feb 22:S0006-3223(24)01105-3.

Son GY, Zou A, Wahl A, Huang KT, Vinu M, Zorgit S, Zhou F, Wagner L, Idaghdour Y, Yule DI, Feske S, Lacruz RS. Loss of STIM1 and STIM2 in salivary glands disrupts ANO1 function but does not induce Sjogren's disease.  bioRxiv. 2024 Jan 8:2024.01.08.574702.

Tao S, Hulpiau P, Wagner LE 2nd, Witschas K, Yule DI, Bultynck G, Leybaert L. IP3RPEP6, a novel peptide inhibitor of IP₃ receptor channels that does not affect connexin-43 hemichannels.  Acta Physiol (Oxf). 2024 Jan 19:e14086.

Wise BC, Mora KE, Lee W, Buckley MR. Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement.  J Vis Exp. 2023 Dec 8;(202).

Yuan Y, Arige V, Saito R, Mu Q, Brailoiu GC, Pereira GJS, Bolsover SR, Keller M, Bracher F, Grimm C, Brailoiu E, Marchant JS, Yule DI, Patel S. Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca²⁺ signals between lysosomes and the endoplasmic reticulum.  Cell Rep. 2023 Dec 30;43(1):113628

Yule DI, Takano T. Pacing intracellular Ca²⁺ signals in exocrine acinar cells. J Physiol. 2024 Jan 10.

2023

Alabdali R, Franchini L, Orlandi C. Gα Protein Signaling Bias at Serotonin 1A Receptor. Mol Pharmacol. 2023 Nov;104(5):230-238. doi: 10.1124/molpharm.123.000722. Epub 2023 Aug 11. PMID: 37567783

Allaire NE, Griesenbach U, Kerem B, Lueck JD, Stanleigh N, Oren YS. Gene, RNA, and ASO-based therapeutic approaches in Cystic Fibrosis. J Cyst Fibros. 2023 Mar;22 Suppl 1(Suppl 1):S39-S44. doi: 10.1016/j.jcf.2022.12.016. Epub 2023 Jan 17. PMID: 36658041

Allen JP, Garber KB, Perszyk R, Khayat CT, Kell SA, Kaneko M, Quindipan C, Saitta S, Ladda RL, Hewson S, Inbar-Feigenberg M, Prasad C, Prasad AN, Olewiler L, Mu W, Rosenthal LS, Scala M, Striano P, Zara F, McCullock TW, Jauss RT, Lemke JR, MacLean DM, Zhu C, Yuan H, Myers SJ, Traynelis SF. Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants. Hum Mol Genet. 2023 Nov 7:ddad188. doi: 10.1093/hmg/ddad188. Online ahead of print. PMID: 37944084

Anderson DE, Broun KG, Kundu P, Jing X, Tang X, Lu C, Kotelsky A, Mannava S, Lee W. PIEZO1 is downregulated in glenohumeral chondrocytes in early cuff tear arthropathy following a massive rotator cuff tear in a mouse model. Front Bioeng Biotechnol. 2023 Sep 5;11:1244975. eCollection 2023. PMID: 37731766. doi: 10.3389/fbioe.2023.1244975

Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Duncan R, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith Z, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS. Glutathione supports lipid abundance in vivo. bioRxiv. 2023 Feb 11:2023.02.10.524960.

Baker MR, Fan G, Arige V, Yule DI, Serysheva II. Understanding IP3R channels: From structural underpinnings to ligand-dependent conformational landscape.  Cell Calcium. 2023 Jun 22;114:102770. doi: 10.1016.

Bekauri T, Fischer S, Honn KV, Maddipati KR, Love T, Little C, Wood RW, Bonham AD, Linder MA, Yule DI, Emanuelle C, Falsetta ML. Inflammation, lipid dysregulation, and transient receptor potential cation channel subfamily V member 4 signaling perpetuate chronic vulvar pain. Pain. 2023 Oct 26. doi: 10.1097/j.pain.0000000000003088. Online ahead of print.PMID: 37889581

Benson JC, Romito O, Abdelnaby AE, Xin P, Pathak T, Weir SE, Kirk V, Castaneda F, Yoast RE, Emrich SM, Tang PW, Yule DI, Hempel N, Potier-Cartereau M, Sneyd J, Trebak M. A multiple-oscillator mechanism underlies antigen-induced Ca²⁺ oscillations in Jurkat T-cells. J Biol Chem. 2023 Nov;299(11):105310. doi: 10.1016/j.jbc.2023.105310. Epub 2023 Sep 29.PMID: 37778728

Chakraborty P, Deb BK, Arige V, Musthafa T, Malik S, Yule DI, Taylor CW, Hasan G. Regulation of store-operated Ca²⁺ entry by IP₃ receptors independent of their ability to release Ca². Elife. 2023 Jul 19;12:e80447. doi: 10.7554/eLife.80447.PMID: 37466241

Chang SL, Seth P, Zhu J, Pendyala G, Bidlack JM, Kumar S. The 27th Scientific Conference of the Society on NeuroImmune Pharmacology: New Delhi, India, March 15-18, 2023. NeuroImmune Pharm Ther. 2023 Apr 10;2(2):187-244. doi: 10.1515/nipt-2023-0006. eCollection 2023 Jun.PMID: 37476290

Chaubey AH, Sojka SE, Onukwufor JO, Ezak MJ, Vandermeulen MD, Bowitch A, Vodičková A, Wojtovich AP, Ferkey DM. The Caenorhabditis elegans innexin INX-20 regulates nociceptive behavioral sensitivity. Genetics. 2023 Apr 6;223(4):iyad017. doi: 10.1093/genetics/iyad017.PMID: 36753530

Cisco LA, Sipple MT, Edwards KM, Thornton CA, Lueck JD. Combinatorial chloride and calcium channelopathy in myotonic dystrophy. bioRxiv. 2023 Jun 1:2023.05.29.542752.

Colodete DAE, Silva NR, Pedrazzi JFC, Fogaça MV, Cortez I, Del-Bel EA, Breuer A, Mechoulam R, Gomes FV, Guimarães FS. Behavioral effects induced by the cannabidiol analogs HU-502 and HU-556. Behav Pharmacol. 2023 Jun 1;34(4):213-224. doi: 10.1097/FBP.0000000000000727. Epub 2023 May 10.PMID: 37171460

Comeau ES, Vander Horst MA, Raeman CH, Child SZ, Hocking DC, Dalecki D. In vivo acoustic patterning of endothelial cells for tissue vascularization. Sci Rep. 2023 Sep 26;13(1):16082. doi: 10.1038/s41598-023-43299-0.PMID: 37752255

Endo Y, Groom L, Wang SM, Pannia E, Griffiths NW, Van Gennip JLM, Ciruna B, Laporte J, Dirksen RT, Dowling JJ.  Two zebrafish cacna1s loss-of-function variants provide models of mild and severe CACNA1S-related myopathy. Hum Mol Genet. 2023 Oct 31:ddad178. doi: 10.1093/hmg/ddad178. Online ahead of print.PMID: 37930228

Fogaça MV, Wu M, Li C, Li XY, Duman RS, Picciotto MR.  M1 acetylcholine receptors in somatostatin interneurons contribute to GABAergic and glutamatergic plasticity in the mPFC and antidepressant-like responses. Neuropsychopharmacology. 2023 Aug;48(9):1277-1287. doi: 10.1038/s41386-023-01583-7. Epub 2023 May 4.PMID: 3714266

Franchini L, Orlandi C. Probing the orphan receptors: Tools and directions. Prog Mol Biol Transl Sci. 2023;195:47-76. doi: 10.1016/bs.pmbts.2022.06.011. Epub 2022 Jul 13.PMID: 36707155

Haber SN, Lehman J, Maffei C, Yendiki A. The Rostral Zona Incerta: A Subcortical Integrative Hub and Potential Deep Brain Stimulation Target for Obsessive-Compulsive Disorder. Biol Psychiatry. 2023 Jan 18:S0006-3223(23)00010-0.

Lei Yang, Rodolfo J Ricart Arbona,Carl S Smith, Kelly M Banks, V Kaye Thomas, Lawrence Palmer, Todd Evans, Romulo Hurtado. An evolutionarily conserved pacemaker role for HCN ion channels in smooth muscle. J Physiol . 2023 Apr;601(7):1225-1246.  doi: 10.1113/JP283701. Epub 2023 Mar 17

Li C, Zhang J, Liu H, Yuan H, Cai J, Fogaça MV, Zhang YW. The synergistic mechanism of action of Dajianzhong decoction in conjunction with ketamine in the treatment of depression. Biomed Pharmacother. 2023 Sep;165:115137. doi: 10.1016/j.biopha.2023.115137. Epub 2023 Jul 14.PMID: 37453197

Magyar ZÉ, Hevesi J, Groom L, Dirksen RT, Almássy J.  Function of a mutant ryanodine receptor (T4709M) linked to congenital myopathy. Sci Rep. 2023 Sep 5;13(1):14659. doi: 10.1038/s41598-023-41801-2.PMID: 37670077

Martínez-Rivera FJ, Pérez-Torres J, Velázquez-Díaz CD, Sánchez-Navarro MJ, Huertas-Pérez CI, Diehl MM, Phillips ML, Haber SN, Quirk GJ. A Novel Insular/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior. Biol Psychiatry. 2023 Jun 1;93(11):1000-1009. doi: 10.1016/j.biopsych.2022.02.008. Epub 2022 Feb 19.PMID: 35491274

McCullock TW, Cardani LP, Kammermeier PJ. Signaling specificity and kinetics of the human metabotropic glutamate receptors. bioRxiv. 2023 Jul 28:2023.07.24.550373. doi: 10.1101/2023.07.24.550373. Preprint.PMID: 37546908

Morales A, Mohan R, Chen X, Coffman BL, Bendahmane M, Watch L, West JL, Bakshi S, Traynor JR, Giovannucci DR, Kammermeier PJ, Axelrod D, Currie KPM, Smrcka AV, Anantharam A. PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells. J Gen Physiol. 2023 Feb 6;155(2):e202213180.

Neumann J, Van Nieuwenhove E, Terry LE, Staels F, Knebel TR, Welkenhuyzen K, Ahmadzadeh K, Baker MR, Gerbaux M, Willemsen M, Barber JS, Serysheva II, De Waele L, Vermeulen F, Schlenner S, Meyts I, Yule DI, Bultynck G, Schrijvers R, Humblet-Baron S, Liston A. : Disrupted Ca²⁺ homeostasis and immunodeficiency in patients with functional IP₃ receptor subtype 3 defects. Cell Mol Immunol. 2023 Jan;20(1):114. doi: 10.1038/s41423-022-00960-4.PMID: 36471115

Nobiletti N, Liu J, Glading AJ.  KRIT1-mediated regulation of neutrophil adhesion and motility. FEBS J. 2023 Feb;290(4):1078-1095. doi: 10.1111/febs.16627. Epub 2022 Sep 20.PMID: 36107440

Norris EG, Pan XS, Hocking DC. Receptor-binding domain of SARS-CoV-2 is a functional αv-integrin agonist. J Biol Chem. 2023 Mar;299(3):102922. doi: 10.1016/j.jbc.2023.102922. Epub 2023 Jan 18.PMID: 36669646

O'Connor TN, Zhao N, Orciuoli HM, Brasile A, Pietrangelo L, He M, Groom L, Leigh J, Mahamed Z, Liang C, Malik S, Protasi F, Dirksen RT. Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse model of tubular aggregate myopathy. bioRxiv. 2023 Sep 29:2023.09.29.559036. doi: 10.1101/2023.09.29.559036. Preprint.PMID: 37808709

O'Connor TN, van den Bersselaar LR, Chen YS, Nicolau S, Simon B, Huseth A, Todd JJ, Van Petegem F, Sarkozy A, Goldberg MF, Voermans NC, Dirksen RT;  RYR-1-Related Diseases International Research Workshop: From Mechanisms to Treatments Pittsburgh, PA, U.S.A., 21-22 July 2022. RYR1 Myopathy Consortium. J Neuromuscul Dis. 2023;10(1):135-154. doi: 10.3233/JND-221609.PMID: 36404556

Onukwufor JO, Somo DA, Richards JG, Wood CM. Osmo-respiratory compromise in the mosshead sculpin (Clinocottus globiceps): effects of temperature, hypoxia, and re-oxygenation on rates of diffusive water flux and oxygen uptake. Fish Physiol Biochem. 2023 Oct;49(5):853-866. doi: 10.1007/s10695-023-01226-0. Epub 2023 Aug 1.PMID: 37526893

Perrelli A, Ferraris C, Berni E, Glading AJ, Retta SF.  KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation Disease. Antioxid Redox Signal. 2023 Mar;38(7-9):496-528. doi: 10.1089/ars.2021.0263. Epub 2022 Nov 1.PMID: 36047808

Rook ML, McCullock TW, Couch T, Lueck JD, MacLean DM. Photomodulation of the ASIC1a acidic pocket destabilizes the open state. Protein Sci. 2023 Nov;32(11):e4800. doi: 10.1002/pro.4800.PMID: 37805833

Strohm AO, O'Connor TN, Oldfield S, Young S, Hammond C, McCall M, Dirksen RT, Majewska  AK. Cortical Microglia Dynamics Are Conserved During Voluntary Wheel Running. J Appl Physiol (1985). 2023 Nov 16. doi: 10.1152/japplphysiol.00311.2023. Online ahead of print. PMID: 37969082

Sundaresan V, Lehman JF, Maffei C, Haber SN, Yendiki A.  Self-supervised segmentation and characterization of fiber bundles in anatomic tracing data. bioRxiv. 2023 Oct 2:2023.09.30.560310. doi: 10.1101/2023.09.30.560310. Preprint.PMID: 37873366

Takano T, Yule DI. Ca2+ signals in pancreatic acinar cells in response to physiological stimulation in vivo. J Physiol. 2023 Mar 25.

Takano T, Yule DI. In vivo Ca²⁺ Imaging in Mouse Salivary Glands. Bio Protoc. 2022 Apr 5;12(7):e4380. doi: 10.21769/BioProtoc.4380. eCollection 2022 Apr 5.PMID: 35530515

Wahl AM, Takano T, Su S, Warner BM, Perez P, Sneyd J, Yule DI. Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype. J Physiol. 2023 Oct;601(20):4539-4556. doi: 10.1113/JP285104. Epub 2023 Sep 19.PMID: 37724716

Yang L, Arbona RJR, Smith CS, Banks KM, Thomas VK, Palmer L, Evans T, Hurtado R. An evolutionarily conserved pacemaker role for HCN ion channels in smooth muscle. J Physiol. 2023 Apr;601(7):1225-1246.

2022

Ahmad M, Ong HL, Saadi H, Son GY, Shokatian Z, Terry LE, Trebak M, Yule DI, Ambudkar I. Functional communication between IP₃R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2114928118.

Arige V, Terry LE, Wagner LE 2nd, Malik S, Baker MR, Fan G, Joseph SK, Serysheva II, Yule DI.  Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2209267119.

Arige V, Yule DI. Spatial and temporal crosstalk between the cAMP and Ca²⁺ signaling systems. Biochim Biophys Acta Mol Cell Res. 2022 Sep;1869(9):119293. doi: 10.1016/j.bbamcr.2022.119293. Epub 2022 May 16.PMID: 35588944

Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Rep. 2022 Jan 25;38(4):110308. doi: 10.1016/j.celrep.2022.110308.PMID: 35081351

Concepcion AR, Wagner LE 2nd, Zhu J, Tao AY, Yang J, Khodadadi-Jamayran A, Wang YH, Liu M, Rose RE, Jones DR, Coetzee WA, Yule DI, Feske S The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling. Nat Immunol. 2022 Feb;23(2):287-302.

Dirksen RT, Eisner DA, Ríos E, Sipido KR. Excitation-contraction coupling in cardiac, skeletal, and smooth muscle. J Gen Physiol. 2022 Sep 5;154(9):e202213244. doi: 10.1085/jgp.202213244. Epub 2022 Aug 19.PMID: 35984377

Dorval L, Knapp BI, Majekodunmi OA, Eliseeva S, Bidlack JM. Mice with high FGF21 serum levels had a reduced preference for morphine and an attenuated development of acute antinociceptive tolerance and physical dependence. Neuropharmacology. 2022 Jan 1;202:108858.

Endo Y, Groom L, Celik A, Kraeva N, Lee CS, Jung SY, Gardner L, Shaw MA, Hamilton SL, Hopkins PM, Dirksen RT, Riazi S, Dowling JJ. Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility. Nat Commun. 2022 Jun 13;13(1):3403. doi: 10.1038/s41467-022-31088-8.PMID: 35697689

Espinosa KG, Geissah S, Groom L, Volpatti J, Scott IC, Dirksen RT, Zhao M, Dowling JJ. Characterization of a novel zebrafish model of SPEG-related centronuclear myopathy. Dis Model Mech. 2022 May 1;15(5):dmm049437.

Fan G, Baker MR, Terry LE, Arige V, Chen M, Seryshev AB, Baker ML, Ludtke SJ, Yule DI, Serysheva II.  Conformational motions and ligand-binding underlying gating and regulation in IP₃R channel.  Nat Commun. 2022 Nov 14;13(1):6942.

Foley K, Altimimi H, Hou H, Zhang Y, McKee C, Papasergi-Scott MM, Yang H, Mayer A, Ward N, MacLean DM, Nairn AC, Stellwagen D, Xia H.  Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission.  Front Synaptic Neurosci. 2022 Oct 6;14:1021832.

Foley K, Ward N, Hou H, Mayer A, McKee C, Xia H.  Regulation of PP1 interaction with I-2, neurabin, and F-actin.  Mol Cell Neurosci. 2022 Nov 25;124:103796.

Fraser D, Nguyen T, Kotelsky A, Lee W, Buckley M, Benoit DSW. Hydrogel Swelling-Mediated Strain Induces Cell Alignment at Dentin Interfaces. ACS Biomater Sci Eng. 2022 Aug 8;8(8):3568-3575. doi: 10.1021/acsbiomaterials.2c00566. Epub 2022 Jul 6.PMID: 35793542

Fu W, Franchini L, Orlandi C. Comprehensive Spatial Profile of the Orphan G Protein Coupled Receptor GPRC5B Expression in Mouse Brain. Front Neurosci. 2022 Jun 23;16:891544. doi: 10.3389/fnins.2022.891544. eCollection 2022.PMID: 35812210

Gao W, Hasan H, Anderson DE, Lee W. The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis. Front Cell Dev Biol. 2022 May 4;10:885224. doi: 10.3389/fcell.2022.885224. eCollection 2022.PMID: 35602590

García-Castañeda M, Michelucci A, Zhao N, Malik S, Dirksen RT. Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy. J Gen Physiol. 2022 Sep 5;154(9):e202213081. doi: 10.1085/jgp.202213081. Epub 2022 Aug 8.PMID: 35939054

Garcia-Hernandez ML, Rangel-Moreno J, Garcia-Castaneda M, Kenney HM, Paine A, Thullen M, Anandarajah AP, Schwarz EM, Dirksen RT, Ritchlin CT.  Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis.  Front Immunol. 2022 Nov 7;13:1026574.

Haber SN, Liu H, Seidlitz J, Bullmore E.  Prefrontal connectomics: from anatomy to human imaging. Neuropsychopharmacology. 2022 Jan;47(1):20-40.

Haber SN, Ford JM.  Society of Biological Psychiatry's 2022 Meeting: Hybrid and Happy! Biol Psychiatry. 2022 May 1;91(9S):A11.

Haber SN, Robbins T. The prefrontal cortex. Neuropsychopharmacology. 2022 Jan;47(1):1-2. doi: 10.1038/s41386-021-01184-2. Epub 2021 Sep 23.PMID: 34556807

Jin X, Amoni M, Gilbert G, Dries E, Doñate Puertas R, Tomar A, Nagaraju CK, Pradhan A, Yule DI, Martens T, Menten R, Vanden Berghe P, Rega F, Sipido K, Roderick HL. InsP₃R-RyR Ca²⁺ channel crosstalk facilitates arrhythmias in the failing human ventricle.  Basic Res Cardiol. 2022 Nov 15;117(1):60.

Johnston JJ, Dirksen RT, Girard T, Hopkins PM, Kraeva N, Ognoon M, Radenbaugh KB, Riazi S, Robinson RL, Saddic Iii LA, Sambuughin N, Saxena R, Shepherd S, Stowell K, Weber J, Yoo S, Rosenberg H, Biesecker LG. Updated variant curation expert panel criteria and pathogenicity classifications for 251 variants for RYR1-related malignant hyperthermia susceptibility. Hum Mol Genet. 2022 Nov 28;31(23):4087-4093. doi: 10.1093/hmg/ddac145.PMID: 35849058

Katona M, Bartók Á, Nichtova Z, Csordás G, Berezhnaya E, Weaver D, Ghosh A, Várnai P, Yule DI, Hajnóczky G.   at the ER-mitochondrial contacts licenses IP₃ receptors to stimulate local Ca²⁺ transfer and oxidative metabolism. Nat Commun. 2022 Nov 9;13(1):6779.

Ko W, Porter, JJ, Sipple MT, Edwards, KM, Lueck, JD. Efficient suppression of endogenous CFTR nonsense mutations using anticodon-engineered transfer RNAs.  Mol Ther Nucleic Acids. 2022 May 4:28:685-701. doi: 10.1016/j.omtn.2022.04.033. eCollection 2022 Jun 14.

Kotelsky A, Elahi A, Nejat Yigit C, Proctor A, Mannava S, Pröschel C, Lee W. Effect of knee joint loading on chondrocyte mechano-vulnerability and severity of post-traumatic osteoarthritis induced by ACL-injury in mice. Osteoarthr Cartil Open. 2021 Dec 15;4(1):100227.  eCollection 2022

MacLean DM, Soto E. Editorial: ASICs: Structure, Function, and Pharmacology. Front Physiol. 2022 Jan 31;13:831830.

McKee C, Shrager P, Mazumder AG, Ganguly A, Mayer A, Foley K, Ward N, Youngman M, Hou H, Xia H.  Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development.  Mol Neurobiol. 2022 Dec;59(12):7486-7494.

Maffei C, Girard G, Schilling KG, Aydogan DB, Adluru N, Zhylka A, Wu Y, Mancini M, Hamamci A, Sarica A, Teillac A, Baete SH, Karimi D, Yeh FC, Yildiz ME, Gholipour A, Bihan-Poudec Y, Hiba B, Quattrone A, Quattrone A, Boshkovski T, Stikov N, Yap PT, de Luca A, Pluim J, Leemans A, Prabhakaran V, Bendlin BB, Alexander AL, Landman BA, Canales-Rodríguez EJ, Barakovic M, Rafael-Patino J, Yu T, Rensonnet G, Schiavi S, Daducci A, Pizzolato M, Fischi-Gomez E, Thiran JP, Dai G, Grisot G, Lazovski N, Puch S, Ramos M, Rodrigues P, Prčkovska V, Jones R, Lehman J, Haber SN, Yendiki A. Insights from the IronTract challenge: Optimal methods for mapping brain pathways from multi-shell diffusion MRI. Neuroimage. 2022 May 26;257:119327.

Mestre H, Verma N, Greene TD, Lin LA, Ladron-de-Guevara A, Sweeney AM, Liu G, Thomas VK, Galloway CA, de Mesy Bentley KL, Nedergaard M, Mehta RI. Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease. Nat Commun 2022 Jul 6;13(1):3897. doi: 10.1038/s41467-022-31257-9.

Michelucci A, Pietrangelo L, Rastelli G, Protasi F, Dirksen RT, Boncompagni S. Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice.  J Gen Physiol. 2022 Dec 5;154(12):e202213114.

Monosov IE, Ogasawara T, Haber SN, Heimel JA, Ahmadlou M. The zona incerta in control of novelty seeking and investigation across species.  Curr Opin Neurobiol. 2022 Dec;77:102650.

Morrell CN, Mix D, Aggarwal A, Bhandari R, Godwin M, Owens P 3rd, Lyden SP, Doyle A, Krauel K, Rondina MT, Mohan A, Lowenstein CJ, Shim S, Stauffer S, Josyula VP, Ture SK, Yule DI, Wagner LE 3rd, Ashton JM, Elbadawi A, Cameron SJ. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms. J Clin Invest. 2022 May 2;132(9):e152373.

Neumann J, Van Nieuwenhove E, Terry LE, Staels F, Knebel TR, Welkenhuyzen K, Ahmadzadeh K, Baker MR, Gerbaux M, Willemsen M, Barber JS, Serysheva II, De Waele L, Vermeulen F, Schlenner S, Meyts I, Yule DI, Bultynck G, Schrijvers R, Humblet-Baron S, Liston A.  Author Correction: Disrupted Ca²⁺ homeostasis and immunodeficiency in patients with functional IP₃ receptor subtype 3 defects. Cell Mol Immunol. 2022 Dec 6.

Nobiletti N, Liu J, Glading AJ. KRIT1-mediated regulation of neutrophil adhesion and motility. FEBS J. 2022 Sep 15.

O'Connor TN, Kallenbach JG, Orciuoli HM, Paris ND, Bachman JF, Johnston CJ, Hernady E, Williams JP, Dirksen RT, Chakkalakal JV. Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress. Skelet Muscle. 2022. Apr 12;12(1):8.

O'Connor TN, van den Bersselaar LR, Chen YS, Nicolau S, Simon B, Huseth A, Todd JJ, Van Petegem F, Sarkozy A, Goldberg MF, Voermans NC, Dirksen RT; RYR1 Myopathy Consortium. RYR-1-Related Diseases International Research Workshop: From Mechanisms to Treatments Pittsburgh, PA, U.S.A., 21-22 July 2022.  J Neuromuscul Dis. 2022 Nov 16.

Onukwufor JO, Dirksen RT, Wojtovich AP.  Iron Dysregulation in Mitochondrial Dysfunction and Alzheimer's Disease. Antioxidants (Basel). 2022 Mar 31;11(4):692. doi: 10.3390/antiox11040692.PMID: 35453377

Onukwufor JO, Farooqi MA, Vodičková A, Koren SA, Baldzizhar A, Berry BJ, Beutner G, Porter GA Jr, Belousov V, Grossfield A, Wojtovich AP. A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans. Nat Commun. 2022 May 3;13(1):2403. doi: 10.1038/s41467-022-30169-y.PMID: 35504873

Packard RRS, Cooke CD, Van Train KF, Votaw JR, Sayre JW, Lazewatsky JL, Champagne KM, Orlandi C, Garcia EV, Maddahi J. Development, diagnostic performance, and interobserver agreement of a ¹⁸F-flurpiridaz PET automated perfusion quantitation system. J Nucl Cardiol. 2022 Apr;29(2):698-708. doi: 10.1007/s12350-020-02335-6. Epub 2020 Sep 7.PMID: 32895856

Passardi S, Hocking DC, Morina N, Sundram S, Alisic E. Moral injury related to immigration detention on Nauru: a qualitative study. Eur J Psychotraumatol. 2022 Feb 24;13(1):2029042. doi: 10.1080/20008198.2022.2029042. eCollection 2022.

Rosa N, Ivanova H, Wagner LE 2nd, Kale J, La Rovere R, Welkenhuyzen K, Louros N, Karamanou S, Shabardina V, Lemmens I, Vandermarliere E, Hamada K, Ando H, Rousseau F, Schymkowitz J, Tavernier J, Mikoshiba K, Economou A, Andrews DW, Parys JB, Yule DI, Bultynck G. Bcl-xL acts as an inhibitor of IP₃R channels, thereby antagonizing Ca²⁺-driven apoptosis. Cell Death Differ. 2022 Apr;29(4):788-805.

Sneyd J, Rugis J, Su S, Suresh V, Wahl AM, Yule DI.  Simulation of Calcium Dynamics in Realistic Three-Dimensional Domains.  Biomolecules. 2022 Oct 11;12(10):1455.

Swamy H, Glading AJ. Is Location Everything? Regulation of the Endothelial CCM Signaling Complex. Front Cardiovasc Med. 2022 Jul 11;9:954780. doi: 10.3389/fcvm.2022.954780. eCollection 2022.PMID: 35898265

Swamy H, Glading AJ. Contribution of protein-protein interactions to the endothelial-barrier-stabilizing function of KRIT1. J Cell Sci. 2022 Jan 15;135(2):jcs258816.

Terry LE, Arige V, Neumann J, Wahl AM, Knebel TR, Chaffer JW, Malik S, Liston A, Humblet-Baron S, Bultynck G, Yule DI.  Missense mutations in inositol 1,4,5-trisphosphate receptor type 3 result in leaky Ca²⁺ channels and activation of store-operated Ca²⁺ entry.  iScience. 2022 Nov 7;25(12):105523.

Trambaiolli LR, Peng X, Lehman JF, Linn G, Russ BE, Schroeder CE, Liu H, Haber SN. Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex. Elife. 2022 May 5;11:e76334.

Wei-LaPierre L, Groom L, Dirksen RT. Acute exposure to extracellular BTP2 does not inhibit Ca2+ release during EC coupling in intact skeletal muscle fibers. J Gen Physiol. 2022 Sep 5;154(9):e202112976.

Yendiki A, Aggarwal M, Axer M, Howard AFD, van Walsum AVC, Haber SN.

Post mortem mapping of connectional anatomy for the validation of diffusion MRI. Neuroimage. 2022 Aug 1;256:119146.

Young MP, Schug ZT, Booth DM, Yule DI, Mikoshiba K, Hajnόczky G, Joseph SK.  adaptation to the chronic loss of Ca²⁺ signaling induced by KO of IP₃ receptors or the mitochondrial Ca²⁺ uniporter. J Biol Chem. 2022 Jan;298(1):101436. doi: 10.1016/j.jbc.2021.101436. Epub 2021 Nov 19.PMID: 34801549

Yuan Y, Jaślan D, Rahman T, Bolsover SR, Arige V, Wagner LE 2nd, Abrahamian C, Tang R, Keller M, Hartmann J, Rosato AS, Weiden EM, Bracher F, Yule DI, Grimm C, Patel S.  Segregated cation flux by TPC2 biases Ca²⁺ signaling through lysosomes. Nat Commun. 2022 Aug 2;13(1):4481. doi: 10.1038/s41467-022-31959-0.PMID: 35918320

2021

Arige V, Yule DI.  A KRAP(y) job: Defining the localization of active IP3R. Cell Calcium. 2021 Sep 9;100:102470. Online ahead of print.

Arige V, Terry LE, Malik S, Knebel TR, Wagner LE, Yule DI. CREB regulates the expression of Type 1 Inositol 1,4,5-trisphosphate receptors.  J Cell Sci. 2021 Sep 17:jcs.258875. Online ahead of print.

Arige V, Emrich SM, Yoast RE, Trebak M, Yule DI. A protocol for detecting elemental calcium signals (Ca2+ puffs) in mammalian cells using total internal reflection fluorescence microscopy. STAR Protoc. 2021 Jun 17;2(3):100618.

Baldermann JC, Schüller T, Kohl S, Voon V, Li N, Hollunder B, Figee M, Haber SN, Sheth SA, Mosley PE, Huys D, Johnson KA, Butson C, Ackermans L, Bouwens van der Vlis T, Leentjens AFG, Barbe M, Visser-Vandewalle V, Kuhn J, Horn A.  Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder.  Biol Psychiatry. 2021 Jul 19:S0006-3223(21)01461-X. Online ahead of print.

Bidlack JM. Chang SL, Fitting S, Gendelman HE, Gorantla S, Kumar S, Marcondes MCG, Meigs DD, Melendez LM, Sariyer IK, Yelamanchili S. The COVID-19 Pandemic: Reflections of Science, Person, and Challenge in Academic Research Settings. J Neuroimmune Pharmacol. 2021 Dec;16(4):706-717. 

Couch T, Berger K, Kneisley DL, McCullock TW, Kammermeier PJ, MacLean DM.  Topography and motion of the acid-sensing ion channel intracellular domains. Elife. 2021 Jul 22;10:e68955. Online ahead of print.

De Luca E, Perrelli A, Swamy H, Nitti M, Passalacqua M, Furfaro AL, Salzano AM, Scaloni A, Glading AJ, Retta SF.  Protein kinase Cα regulates the nucleocytoplasmic shuttling of KRIT1.  J Cell Sci. 2021 Feb 4;134(3):jcs250217. 

Emrich SM, Yoast RE, Xin P, Arige V, Wagner LE, Hempel N, Gill DL, Sneyd J, Yule DI, Trebak M. Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling. Cell Rep. 2021 Mar 2;34(9):108760.

Foley K, McKee C, Nairn AC Xia H. Regulation of Synaptic Transmission and Plasticity by Protein Phosphatase 1. J Neurosci. 2021 Apr 7;41(14):3040-3050. 

Grisot G, Haber SN, Yendiki A. Diffusion MRI and anatomic tracing in the same brain reveal common failure modes of tractography. Neuroimage. 2021 Oct 1;239:118300.

Haber SN, Robbins T. The prefrontal cortex. Neuropsychopharmacology. 2021 Sep 23. doi: 10.1038/s41386-021-01184-2. Online ahead of print.

Haber SN, Yendiki A, Jbabdi S. Four Deep Brain Stimulation Targets for Obsessive-Compulsive Disorder: Are They Different? Biol Psychiatry. 2021 Nov 15;90(10):667-677.

Hocking DC.  To strive, to seek, to find, and not to yield: Narratives on the road to asylum. Transcult Psychiatry. 2021 Apr;58(2):200-214.

Jezzini A, Bromberg-Martin ES, Trambaiolli LR, Haber SN, Monosov IE. A prefrontal network integrates preferences for advance information about uncertain rewards and punishments.  Neuron. 2021 Jul 21;109(14):2339-2352.e5. Epub 2021 Jun 11.

Johnston JJ, Dirksen RT, Girard T, Gonsalves SG, Hopkins PM, Riazi S, Saddic LA, Sambuughin N, Saxena R, Stowell K, Weber J, Rosenberg H, Biesecker LG.
Variant curation expert panel recommendations for RYR1 pathogenicity classifications in malignant hyperthermia susceptibility.  Genet Med. 2021 Jul;23(7):1288-1295. Epub 2021 Mar 25.

Kelly EA, Thomas VK, Indraghanty A, Fudge JL. Perigenual and Subgenual Anterior Cingulate Afferents Converge on Common Pyramidal Cells in Amygdala Subregions of the Macaque. J Neurosci. 2021 Nov 24;41(47):9742-9755. 

Kumar S, Pendyala G, Yelamanchili SV, Seth P, Maggirwar S, Bidlack JM, Chang SL.  Society on NeuroImmune Pharmacology COVID-19 Virtual Workshop.   J Neuroimmune Pharmacol. 2021 Sep;16(3):519-530. 

Kumar S, Yelamanchili S, Seth P, Bidlack JM, Pendyala G, Maggirwar S, Chang SL. The Neuroimmune Pharmacology of SARS-CoV-2. J Neuroimmune Pharmacol. 2021 Dec;16(4):699-705.

Larouche J, Mohiuddin M, Choi JJ, Ulintz PJ, Fraczek PM, Sabin K, Pitchiaya S, Kurpiers SJ, Castor-Macias J, Liu W, Hastings RL, Brown LA, Markworth JF, De Silva K, Levi BD, Merajver SD, Valdez G, Chakkalakal JV, Jang Y, Brooks S, Aguilar CA.  Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging.  Elife. 2021 Jul 29;10:e66749. Online ahead of print.

Lee, W, Nims, R. J., Savadipour, A., Zhang, Q., Leddy, H. A., Liu, F., McNulty, A. L., Chen, Y., Guilak, F., & Liedtke, W. B. (2021). Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America, 118(13), e2001611118. 

McCullock TW, Kammermeier PJ.  The evidence for and consequences of metabotropic glutamate receptor heterodimerization.  Neuropharmacology. 2021 Sep 18:108801. Online ahead of print.

Maffei C, Lee C, Planich M, Ramprasad M, Ravi N, Trainor D, Urban Z, Kim M, Jones RJ, Henin A, Hofmann SG, Pizzagalli DA, Auerbach RP, Gabrieli JDE, Whitfield-Gabrieli S, Greve DN, Haber SN, Yendiki A. Using diffusion MRI data acquired with ultra-high gradient strength to improve tractography in routine-quality data. Neuroimage. 2021 Dec 15;245:118706. 

Michelucci A, Liang C, Protasi F, Dirksen RT. Altered Ca2+ Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease.  Metabolites. 2021 Jun 28;11(7):424.

Rook ML, Ananchenko A, Musgaard M, MacLean DM. Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 β11-12 Linker Isomerization and Channel Kinetics. Front Cell Neurosci. 2021 Nov 24;15:761813.

Rook ML, Miaro M, Couch T, Kneisley DL, Musgaard M, MacLean DM. Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1. J Gen Physiol. 2021 Aug 2;153(8):e202012855.

Rook ML, Musgaard M, MacLean DM. Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors. J Physiol. 2021 Jan;599(2):417-430.

Rosa N, Shabardina V, Ivanova H, Sebé-Pedrós A, Yule DI, Bultynck G. Tracing the evolutionary history of Ca2+-signaling modulation by human Bcl-2: Insights from the Capsaspora owczarzaki IP3 receptor ortholog.  Biochim Biophys Acta Mol Cell Res. 2021 Aug 14:119121. 

Takano T, Wahl A, Huang KT, Narita T, Rugis J, Sneyd J, Yule DI.  Highly Localized intracellular Ca2+ signals promote optimal salivary gland fluid secretion. Elife. 2021 Jul 9;10:e66170. 

Tang W, Choi EY, Heilbronner SR, Haber SN. Nonhuman primate meso-circuitry data: a translational tool to understand brain networks across species. Brain Struct Funct. 2021 Jan;226(1):1-11.

Vander Horst MA, Raeman CH, Dalecki D, Hocking DC.  Time- and Dose-Dependent Effects of Pulsed Ultrasound on Dermal Repair in Diabetic Mice.  
Ultrasound Med Biol. 2021 Apr;47(4):1054-1066. Epub 2021 Jan 13.

Wan J, Wang J, Wagner Ii LE, Wang OH, Gui F, Chen J, Zhu X, Haddock AN, Edenfield BH, Haight B, Mukhopadhyay D, Wang Y, Yule DI, Bi Y, Ji B. Pancreatic specific CHRM3 activation causes pancreatitis in mice.   JCI Insight. 2021 Jul 27:132585. Online ahead of print.

Watkins LR, Orlandi C. In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity. Br J Pharmacol. 2021 Aug;178(15):2963-2975. 

Yoast RE, Emrich SM, Zhang X, Xin P, Arige V, Pathak T, Benson JC, Johnson MT, Abdelnaby AE, Lakomski N, Hempel N, Han JM, Dupont G, Yule DI, Sneyd J, Trebak M. The Mitochondrial Ca2+ Uniporter is a Central Regulator of Interorganellar Ca2+ Transfer and NFAT Activation.  J Biol Chem. 2021 Sep 6:101174. Online ahead of print.

2020

Aulestia FJ, Groeling J, Bomfim GHS, Costiniti V, Manikandan V, Chaloemtoem A, Concepcion AR, Li Y, Wagner LE 2nd, Idaghdour Y, Yule DI, Lacruz RS.  Fluoride exposure alters Ca²⁺ signaling and mitochondrial function in enamel cells.  Sci Signal. 2020 Feb 18;13(619).

Bachman JF, Blanc RS, Paris ND, Kallenbach JG, Johnston CJ, Hernady E, Williams JP, Chakkalakal JV.   Radiation-Induced Damage to Prepubertal Pax7+ Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number.  iScience. 2020 Nov 2;23(11):101760.

Barnett ME, Knapp BI, Bidlack JM. Unique Pharmacological Properties of the Kappa Opioid Receptor Signaling Through Gαz as Shown with Bioluminescence Resonance Energy Tranfer.  Mol Pharmacol. 2020 Oct;98(4):462-474. Epub 2020 Jul 27.

Biesecker LG, Dirksen RT, Girard T, Hopkins PM, Riazi S, Rosenberg H, Stowell K, Weber J.   Genomic Screening for Malignant Hyperthermia Susceptibility.  Anesthesiology. 2020 Sep 7. Online ahead of print.

Blanc RS, Kallenbach JG, Bachman JF, Mitchell A, Paris ND, Chakkalakal JV.  Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury.   Nat Commun. 2020 Aug 20;11(1):4167.

Board PG, Anders MW. Moonlighting in Drug Metabolism. Drug Metab. Rev. 2020 Dec 2.

Chakkalakal JV, Krolewski JJ Nastiuk KL. Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia.; JCI insight. 2020 Feb 20.

Chase HW, Graur S, Versace A, Greenberg T, Bonar L, Hudak R, Quirk GJ, Greenberg BD, Rasmussen SA, Haber SN, Phillips ML. Neural mechanisms of persistent avoidance in OCD: A novel avoidance devaluation study. Neuroimage Clin. 2020 Aug 28;28:102404. Online ahead of print.

Durham RJ, Paudyal N, Carrillo E, Bhatia NK, MacLean DM, Berka V, Dolino DM, Gorfe AA, Jayaraman V. Conformational spread and dynamics in allostery of NMDA receptors. Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3839-3847. doi: 10.1073/pnas.1910950117. Epub 2020 Feb

Farrar CS, Rouin GT, Miller BL, Raeman CH, Mooney NA, Hocking, DC.  A Matricryptic Conformation of the Integrin-Binding Domain of Fibronectin Regulates Platelet-Derived Growth Factor-Induced Intracellular Calcium Release. Cells. 2019 Oct 30;8(11):1351.

Fernandes NRJ, Reilly NS, Schrock DC, Hocking, DC, Oakes PW, Fowell DJ. CD4+ T Cell Interstitial Migration Controlled by Fibronectin in the Inflamed Skin.  Front Immunol. 2020 Jul 24;11:1501. eCollection 2020

Grainger N, Freeman RS, Shonnard CC, Drumm BT, Koh SD, Ward SM, Sanders KM. Identification and classification of interstitial cells in the mouse renal pelvis. J Physiol. 2020 May 15. Epub ahead of print.

Haber SN, Yendiki A, Jbabdi S. Four Deep Brain Stimulation Targets for Obsessive-Compulsive Disorder: Are They Different?   Biol Psychiatry. 2020 Jul 25:S0006-3223(20)31773-X. Online ahead of print.

Hanna PE, Anders MW.  The mercapturic acid pathway. Crit Rev Toxicol. 2019 Nov;49(10):819-929.  Epub 2020 Jan 16.

Hocking, DC.  To strive, to seek, to find, and not to yield: Narratives on the road to asylum. Transcult Psychiatry. 2020 Feb 11:1363461520901639. Epub ahead of print.

Hou H, Wang L, Fu T, Papasergi M, Yule DI, Xia H. Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons. Mol Neurobiol. 2020 Mar 25. Epub ahead of print.

Khire TS, Salminen AT, Swamy H, Lucas KS, McCloskey MC, Ajalik RE, Chung HH, Gaborski TR, Waugh RE, Glading AJ, McGrath JL. Microvascular Mimetics for the Study of Leukocyte-Endothelial Interactions. Cell Mol Bioeng. 2020 Jan 31;13(2):125-139.  eCollection 2020 Apr.

Kim JK, Jha NN, Feng Z, Faleiro MR, Chiriboga CA, Wei-Lapierre L, Dirksen RT, Ko CP, Monani UR.  Muscle-specific SMN reduction reveals motor neuron-independent disease in spinal muscular atrophy models. J Clin Invest. 2020 Mar 2;130(3):1271-1287.

Korponay C, Choi EY, Haber SN. Corticostriatal Projections of Macaque Area 44. Cereb Cortex Commun. 2020;1(1):tgaa079.  Epub 2020 Nov 5.

Lawal TA, Todd JJ, Witherspoon JW, Bönnemann CG, Dowling JJ, Hamilton SL, Meilleur KG, Dirksen RT. Ryanodine receptor 1-related disorders: an historical perspective and proposal for a unified nomenclature. Skelet Muscle. 2020 Nov 16;10(1):32.

Li J, Yi X, Yao Z, Chakkalakal JV, Xing L, Boyce BF. TNF receptor-associated factor 6 mediates TNFα-induced skeletal muscle atrophy in mice during aging .  J Bone Miner Res. 2020 Apr 8. doi: 10.1002/jbmr.4021. [Epub ahead of print]

McCullock TW, MacLean DM, Kammermeier PJ. Comparing the performance of mScarlet-I, mRuby3, and mCherry as FRET acceptors for mNeonGreen. PLoS One. 2020 Feb 5;15(2):e0219886. eCollection 2020

Michelucci A, Boncompagni S, Pietrangelo L, Takano T, Protasi F, Dirksen RT.  Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice.  J Gen Physiol. 2020 Oct 5;152(10):e202012617. doi: 10.1085/jgp.202012617.

Monosov IE, Haber SN, Leuthardt EC, Jezzini A. Anterior Cingulate Cortex and the Control of Dynamic Behavior in Primates.  Curr Biol. 2020 Dec 7;30(23):R1442-R1454.

Pan C, Jaiswal Agrawal N, Zulia Y, Singh S, Sha K, Mohler JL, Eng KH, Anterior Cingulate Cortex and the Control of Dynamic Behavior in Primates.  Curr Biol. 2020 Dec 7;30(23):R1442-R1454.

Pan C, Jaiswal Agrawal N, Zulia Y, Singh S, Sha K, Mohler JL, Eng KH, Chakkalakal JV, Krolewski JJ, Nastiuk KL. Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia.  JCI Insight. 2020 Mar 26;5(6).

Paris ND, Kallenbach JG, Bachman JF, Blanc RS, Johnston CJ, Hernady E, Williams JP, Chakkalakal JV. Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model.  Sci Rep. 2020 Nov 11;10(1):19501.

Peng H, Purkerson JM, Freeman RS, Schwaderer AL, Schwartz GJ. Acidosis induces antimicrobial peptide expression and resistance to uropathogenic <i>E. coli</i> infection in kidney collecting duct cells via HIF-1α. Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F468-F474.

Philip NS, McLaughlin NC, Carpenter LL, Phillips ML, Liu H, Haber SN, Greenberg BD. Transient aphasia induced by intermittent theta burst stimulation. Brain Stimul. 2020 Mar 25;13(4):941-942. Epub ahead of print.

Poulos HM, Freeman RS, Karberg JM, Beattie KC, O'Dell DI, Omand KA. Effects of Mowing and Prescribed Fire on Plant Community Structure and Function in Rare Coastal Sandplains, Nantucket Island, MA, USA. Environ Manage. 2020 Jan;65(1):111-121.

Rook ML, Musgaard M, MacLean DM. Coupling structure with function in acid-sensing ion channels: Challenges in pursuit of proton sensors.  J Physiol. 2020 Apr 19. Epub ahead of print.

Rook ML, Williamson A, Lueck JD, Musgaard M, MacLean DM. β11-12 linker isomerization governs Acid-sensing ion channel desensitization and recovery.  Elife. 2020 Feb 7;9. Epub ahead of print.

Sangkuhl K, Dirksen RT, Alvarellos ML, Altman RB, Klein TE. PharmGKB summary: very important pharmacogene information for CACNA1S.  Pharmacogenet Genomics. 2020 Feb;30(2):34-44.

Singh A, Van Slyke AL, Sirenko M, Song A, Kammermeier PJ, Zipfel WR. Stoichiometric analysis of protein complexes by cell fusion and single molecule imaging.   Sci Rep. 2020 Sep 10;10(1):14866.

Soo Kim B, Auerbach DA, Sadhra H, Godwin M, Bhandari R, Ling FS, Mohan A, Yule DI, Wagner L 2nd, Rich DQ, Ture S, Morrell CN, Timpanaro-Perrotta L, Younis A, Goldenberg I, Cameron SJ. Sex-Specific Platelet Activation Through Protease-Activated Receptors Reverses in Myocardial Infarction.  Arterioscler Thromb Vasc Biol. 2020 Nov 12:ATVBAHA120315033.

Stevenson GW, Giuvelis D, Cormier J, Cone K, Atherton P, Krivitsky R, Warner E, St Laurent B, Dutra J, Bidlack JM, Szabò L, Polt R, Bilsky EJ.  Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration. Psychopharmacology (Berl). 2020 Apr;237(4):1195-1208. doi: 10.1007/s00213-019-05449-z. Epub 2020 Jan 7. 

Tang W, Choi EY, Heilbronner SR, Haber SN. Nonhuman primate meso-circuitry data: a translational tool to understand brain networks across species.  Brain Struct Funct. 2020 Oct 30.  Online ahead of print.

Terry LE, Alzayady KJ, Wahl AM, Malik S, Yule DI. Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function.  J Biol Chem. 2020 Oct 22:jbc.RA120.015683. Online ahead of print.

Tylock KM, Auerbach DS, Tang ZZ, Thornton CA, Dirksen RT. Biophysical mechanisms for QRS- and QTc-interval prolongation in mice with cardiac expression of expanded CUG-repeat RNA. J Gen Physiol. 2020 Feb 3;152(2).

Vera-Sigüenza E, Pages N, Rugis J, Yule DI, Sneyd J. A Multicellular Model of Primary Saliva Secretion in the Parotid Gland.  Bull Math Biol. 2020 Mar 11;82(3):38. doi: 10.1007/s11538-020-00712-3.

Volpatti JR, Endo Y, Knox J, Groom L, Brennan S, Noche R, Zuercher WJ, Roy P, Dirksen RT, Dowling JJ.  Identification of drug modifiers for RYR1 related myopathy using a multi-species discovery pipeline. Elife. 2020 Mar 30;9. Epub ahead of print.

Wahl AM, Yule DI.  An inside job: Annexin 1A-Inositol 1,4,5-trisphosphate receptor interaction conveys endoplasmic reticulum luminal Ca2+ sensitivity.  Cell Calcium. 2020 Jul 8;90:102250. doi: 10.1016/j.ceca.2020.102250. Online ahead of print.

Wang HJ, Lee CS, Yee RSZ, Groom L, Friedman I, Babcock L, Georgiou DK, Hong J, Hanna AD, Recio J, Choi JM, Chang T, Agha NH, Romero J, Sarkar P, Voermans N, Gaber MW, Jung SY, Baker ML, Pautler RG, Dirksen RT, Riazi S, Hamilton SL. Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation. Nat Commun. 2020 Oct 9;11(1):5099.

Yoast RE, Emrich SM, Zhang X, Xin P, Johnson MT, Fike AJ, Walter V, Hempel N, Yule DI, Sneyd J, Gill DL, Trebak M. The native ORAI channel trio underlies the diversity of Ca2+ signaling events. Nat Commun. 2020 May 15;11(1):2444.

2019

Almássy J, Diszházi G, Skaliczki M, Márton I, Magyar ZÉ, Nánási PP, Yule DI. 2019. Expression of BK channels and Na⁺-K⁺ pumps in the apical membrane of lacrimal acinar cells suggests a new molecular mechanism for primary tear-secretion. Ocul Surf, 17(2):272-277.  

Bartok A, Weaver D, Golenár T, Nichtova Z, Katona M, Bánsághi S, Alzayady KJ, Thomas VK, Ando H, Mikoshiba K, Joseph SK, Yule DI, Csordás G, Hajnóczky G. 2019.  IP₃ receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer. Nat Commun. 19;10(1):3726.

Bell RD, Wu EK, Rudmann C, Forney M, Kaiser C, Wood RW, Chakkalakal JV, Paris N, Klose A, Xiao G, Rangel-Moreno J, Garcia-Hernandez ML, Ritchlin CT, Schwarz EM and Rahimi H. 2019.  Selective sexual dimorphism in musculoskeletal-cardiopulmonary pathologies and mortality in the TNF-transgenic mouse model of rheumatoid arthritis. Arthritis and Rheumatol. 71(9):1512-1523. 

Bennett JA, Ture SK, Schmidt RA, Mastrangelo MA, Cameron SJ, Terry LE, Yule DI, Morrell CN, Lowenstein CJ. 2019. Acetylcholine inhibits platelet activation. J Pharmacol Exp Ther, 369(2):182-187.

Brennan S, Garcia-Castañeda M, Michelucci A, Sabha N, Malik S, Groom L, Wei-La-Pierre L, Dowling JJ, Dirksen RT. 2019.  Mouse model of severe recessive RYR1-related myopathy. Hum Mol Genet, p.1-13.

Brennan BP, Wang D, Li M, Perriello C, Ren J, Elias JA, Van Kirk NP, Krompinger JW, Pope HG Jr, Haber SN, Rauch SL, Baker JT, Liu H. 2019.  Use of an Individual-Level Approach to Identify Cortical Connectivity Biomarkers in Obsessive-Compulsive Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging, 4(1):27-38.

Carrillo E, Shaikh SA, Berka V, Durham RJ, Litwin DB, Lee G, MacLean DM, Nowak LM, Jayaraman V. 2019. Mechanism of modulation of AMPA receptors by TARP-γ8.  J Gen Physiol. pii: jgp.201912451.

Dirksen RT, Allen PD, Lopez JR. 2019. Understanding malignant hyperthermia: each move forward opens our eyes to the distance left to travel. Br J Anaesth, 122:8-9.

Dirksen RT, Wang W, Sheu SS. 2019. Introduction. Arch. Biochem. Biophys. 666:31.

DiStefano PV, Glading AJ. 2019. VEGF signalling enhances lesion burden in KRIT1 deficient mice. J Cell Mol Med. [Epub ahead of print]

Dunn HA, Orlandi C, Martemyanov KA. 2019. Beyond the Ligand: Extracellular and Transcellular G Protein-Coupled Receptor Complexes in Physiology and Pharmacology. Pharmacological reviews.  71(4):503-519.

Dunn HA, Zucca S, Dao M, Orlandi C, Martemyanov KA. 2019.  ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior. Molecular psychiatry. Epub.

Farrar CS, Rouin GT, Miller BL, Raeman CH, Mooney NA, Hocking DC.  2019. A Matricryptic Conformation of the Integrin-Binding Domain of Fibronectin Regulates Platelet-Derived Growth Factor-Induced Intracellular Calcium Release.  Cells. 30;8(11). 

Gonsalves SG, Dirksen RT, Sangkuhl K, Pulk R, Alvarellos M, Vo T, Hikino K, Roden D, Klein T, Poler M, Patel S, Claudle KE, Gordon R, Brandom B, Biesecker LG. 2019. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of anesthetic agents in the context of RYR1 or CACNA1S genotypes. Clin Pharmacol Ther, 105:1338-1344.

Haber SN, Tang W, Choi EY, Yendiki A, Liu H, Jbabdi S, Versace A, Phillips M. 2019.  Circuits, Networks, and Neuropsychiatric Disease: Transitioning From Anatomy to Imaging. Biol Psychiatry. [Epub ahead of print] Review.

Ivanova H, Wagner LE, Tanimura A, Vandermarliere E, Luyten T, Welkenhuyzen K, Alzayady KJ, Wang L, Hamada K, Mikoshiba K, De Smedt H, Martens L, Yule DI, Parys JB, Bultynck G. 2019.  Bcl-2 and IP₃ compete for the ligand-binding domain of IP₃Rs modulating Ca²⁺ signaling output. Cell Mol Life Sci. 76(19):3843-3859. 

Ji C, Kittredge A, Hopiavuori A, Ward N, Chen S, Fukuda Y, Zhang Y, Yang T. 2019. Dual Ca²⁺-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2:240.

Leonard A, Su PY, Yule DI, Rahman A, Fazal F. 2019.  Critical Role of Mortalin/GRP75 In Endothelial Cell Dysfunction Associated With Acute Lung Injury. Shock.  [Epub ahead of print]

Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F. 2019. Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury. Sci Rep, 9(1):2096.

Lueck JD, Yoon JS, Perales-Puchalt A, Mackey AL, Infield DT, Pope MR, Behlke MA, Weiner DB, Skach, WR, McCray PB, Ahern CA.  Engineered tRNAs for suppression of nonsense mutations. Nature Communications, 10(1):822.

McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME. 2019. Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys, 663:239-248.

McCullock TM, Kammermeier PJ. 2019. Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less selective agonist. Pharmacology Research Perspectives. 7(3):e00471.

McCullock TW, Kammermeier PJ. 2019.  Target validation: Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less selective agonist. Pharmacol Res Perspect. 3;7(3):e00471.  eCollection.

Michelucci A, Boncompagni S, Pietrangelo L, García-Castañeda M, Takano T, Malik S, Dirksen RT, Protasi F. 2019.  Transverse tubule remodeling enhances Orai1-dependent Ca²⁺ entry in skeletal muscle. Elife. [Epub ahead of print]

Miguel EC, Lopes AC, McLaughlin NCR, Noren G, Gentil AF, Hamani C, Shavitt RG, Batistuzzo MC, Vattimo EFQ, Canteras M, De Salles A, Gorgulho A, Salvajoli JV, Fonoff ET, Paddick I, Hoexter MQ, Lindquist C, Haber SN, Greenberg BD, Sheth SA. 2019.  Evolution of gamma knife capsulotomy for intractable obsessive-compulsive disorder. Mol Psychiatry, 24(2):218-240.

Norris EG, Dalecki D, Hocking DC. 2019. Acoustic modification of collagen hydrogels facilitates cellular remodeling. Materials Today Bio, 3:10018.

Orlandi C, Sutton LP, Muntean BS, Song C, Martemyanov KA. 2019. Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology. 44(3):642-653. Epub.

Pages N, Vera-Sigüenza E, Rugis J, Kirk V, Yule DI, Sneyd J. 2019. A Model of [Formula: see text] Dynamics in an Accurate Reconstruction of Parotid Acinar Cells. Bull Math Biol. [Epub ahead of print]

Peng H, Purkerson JM, Freeman RS, Schwaderer AL, Schwartz GJ. 2019. Acidosis induces antimicrobial peptide expression and resistance to uropathogenic E coli infection in kidney collecting duct cells via HIF-1α. Am J Physiol Renal Physiol. [Epub ahead of print]

Peracchia C. 2019. In: Gap junction structure and chemical regulation: Direct calmodulin role in cell-to-cell channel gating. Academic Press, Elsevier Inc., London, UK.

Petersen MV, Mlakar J, Haber SN, Parent M, Smith Y, Strick PL, Griswold MA, McIntyre CC. 2019. Holographic Reconstruction of Axonal Pathways in the Human Brain. Neuron. [Epub ahead of print]

Poulos HM, Freeman RS, Karberg JM, Beattie KC, O'Dell DI, Omand KA. 2019. Effects of Mowing and Prescribed Fire on Plant Community Structure and Function in Rare Coastal Sandplains, Nantucket Island, MA, USA. Environ Manage. [Epub ahead of print]

Sangkuhl K, Dirksen RT, Alvarellos ML, Altman RB, Klein TE. 2019. PharmGKB summary: very important pharmacogene information for CACNA1S. Pharmacogenet Genomics. [Epub ahead of print]

Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE, Yule DI, Wojcikiewicz RJH. 2019.  Bok regulates mitochondrial fusion and morphology. Cell Death Differ.

Song C, Orlandi C, Sutton LP, Martemyanov KA. 2019. The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex. The Journal of biological chemistry. 30; 294(35):13145-13157. .

Stowell RD, Sipe GO, Dawes RP, Batchelor HN, Lordy KA, Whitelaw BS, Stoessel MB, Bidlack JM, Brown E, Sur M, Majewska AK. 2019.  Author Correction: Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex. Nat Neurosci. [Epub ahead of print]

Stowell RD, Sipe GO, Dawes RP, Batchelor HN, Lordy KA, Whitelaw BS, Stoessel MB, Bidlack JM, Brown E, Sur M, Majewska AK. 2019.  Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex. Nat Neurosci. [Epub ahead of print]

Sutton LP, Muntean BS, Ostrovskaya O, Zucca S, Dao M, Orlandi C, Song C, Xie K, Martemyanov KA. 2019.  NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control. PLoS biology. 17(10):e3000477. Epub.

Tang W, Jbabdi S, Zhu Z, Cottaar M, Grisot G, Lehman JF, Yendiki A, Haber SN. 2019. A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control.  eLife, 8:e43761.

Versace A, Graur S, Greenberg T, Lima Santos JP, Chase HW, Bonar L, Stiffler RS, Hudak R, Kim T, Yendiki A, Greenberg B, Rasmussen S, Liu H, Haber SN, Phillips ML. 2019. Reduced focal fiber collinearity in the cingulum bundle in adults with obsessive compulsive disorder. Neuropsychopharm, 44:1182-1188.

Wang D, Stoveken HM, Zucca S, Dao M, Orlandi C, Song C, Masuho I, Johnston C, Opperman KJ, Giles AC, Gill MS, Lundquist EA, Grill B, Martemyanov KA. 2019.  Genetic behavioral screen identifies an orphan anti-opioid system. Science. 365(6459):1267-1273.

Wei-LaPierre L, Ainbinder A, Tylock KM, Dirksen RT. 2019. Substrate-dependent and cyclophilin D-independent regulation of mitochondrial flashes in skeletal and cardiac muscle.  Arch Biochem Biophys, 665:122-131.

Wei-LaPierre L, Dirksen RT. 2019. Isolating a reverse-mode ATP synthase-dependent mechanism of mitoflash activation.  J Gen Physiol, 151:708-713.

White JK, Bromberg-Martin ES, Heilbronner SR, Zhang K, Pai J, Haber SN, Monosov IE. 2019. A neural network for information seeking. Nat Commun. 14;10(1):5168.

Yue L, Talukder MAH, Gurjar A, Lee JI, Noble M, Dirksen RT, Chakkalakal JV, Elfar JC. 2019.  4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice.  Muscle & Nerve, 60:192-201.

Zhang S, Ye D, Ma L, Ren Y, Dirksen RT, Liu X. 2019. Purinergic Signaling Modulates Survival/Proliferation of Human Dental Pulp Stem Cells. J Dent Res. 98(2):242-249.

2018

Almássy J, Siguenza E, Skaliczki M, Matesz K, Sneyd J, Yule DI, Nánási PP. (2018).  New saliva secretion model based on the expression of Na⁺-K⁺ pump and K⁺ channels in the apical membrane of parotid acinar cells. Pflugers Arch. doi: 10.1007/s00424-018-2109-0.

Auerbach DS, Biton Y, Polonsky B, McNitt S, Gross RA, Dirksen RT, Moss AJ. (2018). Risk of cardiac events in Long QT syndrome patients when taking antiseizure medications. Transl Res. 191:81-92.e7. Epub​

Bachman JF, Klose A, Liu W, Paris ND, Blanc RS, Schmalz M, Knapp E, Chakkalakal JV. (2018). Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution. Development. 25; 145(20) Epub​

Bellizzi MJ, Hammond JW, Li H, Gantz Marker MA, Marker DF, Freeman RS, Gelbard HA. (2018). The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis.  eNeuro. 3;5(6). 0245-18. eCollection.

Bidlack JM, Knapp BI, Deaver DR, Plotnikava M, Arnelle D, Wonsey AM, Toh MF, Pin SS, Namchuk MN. (2018). In Vitro Pharmacological Characterization of Buprenorphine, Samidorphan, and Combinations Being Developed as an Adjunctive Treatment for Major Depressive Disorder. J Pharmacol Exp Ther. pii: jpet.118.249839.

Boncompagni S, Michelucci A, Pietrangelo L, Dirksen RT, Protasi F. (2018). Addendum: Exercise-dependent formation of new junctions that promote STIM1-Orai1 assembly in skeletal muscle. Sci Rep. 11-27;8(1):17463.

Brennan BP, Wang D, Li M, Perriello C, Ren J, Elias JA, Van Kirk NP, Krompinger JW, Pope HG Jr, Haber SN, Rauch SL, Baker JT, Liu H. (2018). Use of an Individual-Level Approach to Identify Cortical Connectivity Biomarkers in Obsessive-Compulsive Disorder.  Biol Psychiatry Cogn Neurosci Neuroimaging. pii: S2451-9022(18)30189-7.

Callaghan CK, Rouine J, Dean RL, Knapp BI, Bidlack JM, Deaver DR, O'Mara SM. (2018). Antidepressant-like effects of 3-carboxamido seco-nalmefene (3CS-nalmefene), a novel opioid receptor modulator, in a rat IFN-α-induced depression model. Brain Behav Immun. 67:152-162.

Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. (2018). The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Reports. 2-27; 22(9):2307-2321.

Condomitti G, Wierda KD, Schroeder A, Rubio SE, Vennekens KM, Orlandi C, Martemyanov KA, Gounko NV, Savas JN, de Wit J. (2018). An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses. Neuron. 10; 100(1):201-215.e9. Epub​

de Rubio RG, Ransom RF, Malik S, Yule DI,, Anantharam A, Smrcka AV. (2018). Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production. Sci Signal. Sep 11;11(547).

Dirksen RT, Allen PD, Lopez JR. (2018). Understanding malignant hyperthermia: each move forward opens our eyes to the distance left to travel. Br J Anaesth. 122(1):8-9. doi: 10.1016. Epub​

Dunn HA, Patil DN, Cao Y, Orlandi C, Martemyanov KA. (2018). Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors.  Proceedings of the National Academy of Sciences of the United States of America.  115(19):5022-5027. Epub​

Farrar CS, Hocking DC. (2018). Assembly of fibronectin fibrils selectively attenuates platelet-derived growth factor-induced intracellular calcium release in fibroblasts. (2018)  J Biol Chem.  30;293(48):18655-18666. Epub​

Gonsalves SG, Dirksen RT, Sangkuhl K, Pulk R, Alvarellos M, Vo T, Hikino K, Roden D, Klein T, Mark Poler S, Patel S, Caudle KE, Gordon R, Brandom B, Biesecker LG. (2018). Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR1 or CACNA1S genotypes.  Clin Pharmacol Ther. 30. doi: 10.1002/cpt.1319. [Epub ahead of print]

Heilbronner SR, Meyer MAA, Choi EY, Haber SN. (2018) How do cortico-striatal projections impact on downstream pallidal circuitry? Brain Struct Funct. doi: 10.1007/s00429-018-1662-9. [Epub ahead of print]

Holmes B, Benavides-Serrato A, Freeman RS, Landon KA, Bashir T, Nishimura RN, Gera J. (2018). mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma. Oncogene. doi: 10.1038/onc.2017.360. [Epub ahead of print]

Hocking DC, Mancuso SG, Sundram S. (2018). Development and validation of a mental health screening tool for asylum-seekers and refugees: the STAR-MH.  BMC Psychiatry. 18(1):69.

Hocking DC. (2018). Tho' Much is Taken, Much Abides: Asylum Seekers' Subjective Wellbeing. J Immigr Minor Health. 20(5):1158-1165.

Huang AS, Mitchell JA, Haber SN., Alia-Klein N, Goldstein RZ. (2018). The thalamus in drug addiction: from rodents to humans.  Philos Trans R Soc Lond B Biol Sci. 373(1742).

Infield DT, Lueck JD, Galpin JD, Galles GD, Ahern CA. (2018). Orthogonality of Pyrrolysine tRNA in the Xenopus oocyte. Scientific reports. 26; 8(1):5166. Epub​

Joseph SK, Young M, Alzayady K, Yule DI, Ali M, Booth DM, Hajnóczky G. (2018). Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells. J Biol Chem. pii: jbc.RA118.005624. [Epub ahead of print]

Khan UW, Overli O, Hinkle PM, Pasha FA, Johansen IB, Berget I, Silva PI, Kittilsen S, Höglund E, Omholt SW, Våge DI. (2018). A novel role for pigment genes in the stress response in rainbow trout (Oncorhynchus mykiss). Sci Rep. 6:28969. doi: 10.1038/srep28969.

Klose A, Liu W, Paris ND, Forman S, Krolewski JJ, Nastiuk KL, Chakkalakal JV. (2018). Castration induces satellite cell activation that contributes to skeletal muscle maintenance. JCSM rapid communications. 1(1).

Liu W, Chakkalakal JV. (2018). The Composition, Development, and Regeneration of Neuromuscular Junctions. Current topics in developmental biology. 126:99-124. Epub​

Lock JT, Alzayady KJ, Yule DI, Parker I. (2018). All three IP₃ receptor isoforms generate Ca²⁺ puffs that display similar characteristics. Sci Signal. 18;11(561).

Maani N, Sabha N, Rezai K, Ramani A, Groom L, Eltayeb N, Mavandadnejad F, Pang A, Russo G, Brudno M, Haucke V, Dirksen RT, Dowling JJ. (2018). Tamoxifen therapy in a murine model of myotubular myopathy. Nat Commun. 19;9(1):4849. doi: 10.1038/s41467-018-07057.

Michelucci A, García-Castañeda M, Boncompagni S, Dirksen RT. (2018). Role of STIM1/ORAI1-mediated store-operated Ca²⁺ entry in skeletal muscle physiology and disease.  Cell Calcium. 76:101-115. Epub​

Miguel EC, Lopes AC, McLaughlin NCR, Norén G, Gentil AF, Hamani C, Shavitt RG, Batistuzzo MC, Vattimo EFQ, Canteras M, De Salles A, Gorgulho A, Salvajoli JV, Fonoff ET,

Paddick I, Hoexter MQ, Lindquist C, Haber SN., Greenberg BD, Sheth SA. (2018). Evolution of gamma knife capsulotomy for intractable obsessive-compulsive disorder. Mol Psychiatry. doi: 10.1038/s41380-018-0054-0. [Epub ahead of print]

Molinarolo S, Lee S, Leisle L, Lueck JD, Granata D, Carnevale V, Ahern CA. "Cross-kingdom auxiliary subunit modulation of a voltage-gated sodium channel." . (2018). The Journal of biological chemistry. 6; 293(14):4981-4992. Epub​

Nurbaeva MK, Eckstein M, Devotta A, Saint-Jeannet JP, Yule DI, Hubbard MJ, Lacruz RS. (2018). Evidence That Calcium Entry Into Calcium-Transporting Dental Enamel Cells Is Regulated by Cholecystokinin, Acetylcholine and ATP. Front Physiol. 9:801.

Orlandi C, Omori Y, Wang Y, Cao Y, Ueno A, Roux MJ, Condomitti G, de Wit J, Kanagawa M, Furukawa T, Martemyanov KA. (2018). Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors. Cell reports. 2; 25(1):130-145.e5.

Ostrovskaya OI, Orlandi C, Fajardo-Serrano A, Young SM, Lujan R, Martemyanov KA.  (2018). Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is Differentially Regulated by Alternative Macromolecular Complexes of RGS7. The Journal of Neuroscience: the official journal of the Society for Neuroscience. 14; 38(46):10002-10015. Epub​

Papasergi-Scott MM, Stoveken HM, MacConnachie L, Chan PY, Gabay M, Wong D, Freeman RS, Beg AA, Tall GG. (2018). Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange. Sci Signal. 11(532).

Safadi Z, Grisot G, Jbabdi S, Behrens T, Heilbronner SR, McLaughlin NCR, Mandeville J, Versace A, Phillips ML, Lehman J, Yendiki A, Haber SN. (2018). Functional segmentation of the anterior limb of the internal capsule: linking white matter abnormalities to specific connections.   J Neurosci. pii: 2335-17. doi: 10.1523. [Epub ahead of print]

Sarria I, Cao Y, Wang Y, Ingram NT, Orlandi C, Kamasawa N, Kolesnikov AV, Pahlberg J, Kefalov VJ, Sampath AP, Martemyanov KA. (2018). LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors. Cell reports. 27; 22(13):3562-3573.

Smith CO, Wang YT, Nadtochiy SM, Miller JH, Jonas EA, Dirksen RT, Nehrke K, Brookes PS. (2018). Cardiac metabolic effects of K_Na1.2 channel deletion and evidence for its mitochondrial localization. FASEB J. doi: 10.1096/fj.201800139R. [Epub ahead of print]

Sneyd J, Han JM, Wang L, Chen J, Yang X, Tanimura A, Sanderson MJ, Kirk V, Yule DI. (2018). On the dynamical structure of calcium oscillations. Proc Natl Acad Sci U S A. 114(7):1456-1461.

Sutton LP, Orlandi C, Song C, Oh WC, Muntean BS, Xie K, Filippini A, Xie X, Satterfield R, Yaeger JDW, Renner KJ, Young SM, Xu B, Kwon H, Martemyanov KA. (2018). Orphan receptor GPR158 controls stress-induced depression. eLife. Epub​

Terry LE, Alzayady KJ, Furati E, Yule DI. (2018). Inositol 1,4,5-trisphosphate Receptor Mutations associated with Human Disease. Messenger (Los Angel). 6(1-2):29-44.

Thompson JL, Zhao Y, Stathopulos PB, Grossfield A, Shuttleworth TJ. (2018). Phosphorylation-mediated structural changes within the SOAR domain of STIM1 enable specific activation of distinct Orai channels.  J Biol Chem. pii: jbc.M117.819078. [Epub ahead of print]

Trembley MA, Quijada P, Agullo-Pascual E, Tylock KM, Colpan M, Dirkx RA Jr., Myers JR, Mickelsen DM, de Mesy Bentley K, Rothenberg E, Moravec CS, Alexis JD, Gregorio CC, Dirksen RT, Delmar M, Small EM. (2018). Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy. Circulation. pii:117.031788. [Epub ahead of print]

Vera-Sigüenza E, Pages N, Rugis J, Yule DI, Sneyd J. (2018). A Mathematical Model of Fluid Transport in an Accurate Reconstruction of Parotid Acinar Cells.  Bull Math Biol. doi: 10.1007/s11538-018-0534-z. [Epub ahead of print]

Vervliet T, Yule DI,, Bultynck G. (2018). Carbohydrate Loading to Combat Acute Pancreatitis. Trends Biochem Sci. pii: S0968-0004(18)30149-X. [Epub ahead of print]

Wang L, Yule DI.  (2018). Differential regulation of ion channels function by proteolysis. Biochem Biophys Acta. pii: S0167-4889(18)30161-7. [Epub ahead of print]

Wang L, Wagner LE 2nd, Alzayady KJ, Yule DI. (2018). Region-specific proteolysis differentially modulates type 2 and type 3 inositol 1,4,5-trisphosphate receptor activity in models of acute pancreatitis.  J Biol Chem. 24;293(34):13112-13124. Epub​

Williams JA, Yule DI. (2018). Can pancreatitis be treated by inhibiting Ca²⁺ signaling? Ann Transl Med. 6(7):124.

Zhang S, Ye D, Ma L, Ren Y, Dirksen RT, Liu X. (2018). Purinergic Signaling Modulates Survival/Proliferation of Human Dental Pulp Stem Cells. J Dent Res. 1:22034518807920. doi: 10.1177/0022034518807920. [Epub ahead of print]

2017

Anders MW. (2017) Diacetyl and related flavorant α-Diketones: Biotransformation, cellular interactions, and respiratory-tract toxicity. Toxicology. 388:21-29.

Bittremieux M, Gerasimenko JV, Schuermans M, Luyten T, Stapleton E, Alzayady KJ, De Smedt H, Yule DI, Mikoshiba K, Vangheluwe P, Gerasimenko OV, Parys JB, Bultynck G. (2017)  DPB162-AE, an inhibitor of store-operated Ca²⁺ entry, can deplete the endoplasmic reticulum Ca²⁺ store. Cell Calcium. 62:60-70.

Brenowitz S, Duguid I, Kammermeier PJ. (2017)  Ion Channels: History, Diversity, and Impact. Cold Spring Harb Protoc. (7):pdb.top092288.

Boncompagni S, Michelucci A, Pietrangelo L, Dirksen RT, Protasi F. (2017) Exercise-dependent formation of new junctions that promote STIM1-Orai1 assembly in skeletal muscle. Sci Rep. 7(1):14286.

Chen W, Koop A, Liu Y, Guo W, Wei J, Wang R, MacLennan DH, Dirksen RT, Chen SRW. (2017) Reduced threshold for store overload-induced Ca²⁺ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease. Biochem J. 474(16):2749-2761.

Choi EY, Tanimura Y, Vage PR, Yates EH, Haber SN. (2017) Convergence of prefrontal and parietal anatomical projections in a connectional hub in the striatum. Neuroimage. 146:821-832.

Christian WV, Hinkle PM. (2017)  Global functions of extracellular, transmembrane and cytoplasmic domains of organic solute transporter β-subunit. Biochem J. 474(12):1981-1992.

Coizet V, Heilbronner SR, Carcenac C, Mailly P, Lehman JF, Savasta M, David O, Deniau JM, Groenewegen HJ, Haber SN. (2017) Organization of the Anterior Limb of the Internal Capsule in the Rat. J Neurosci. 37(10):2539-2554.

Comeau ES, Hocking DC, Dalecki D. (2017) Ultrasound patterning technologies for studying vascular morphogenesis in 3D. J Cell Sci. 130(1):232-242.

García M, González de Buitrago J, Jiménez-Rosés M, Pardo L, Hinkle PM, Moreno JC. (2017) Central Hypothyroidism Due to a TRHR Mutation Causing Impaired Ligand Affinity and Transactivation of Gq. J Clin Endocrinol Metab. 1;102(7):2433-2442.

García M, Barrio R, García-Lavandeira M, Garcia-Rendueles AR, Escudero A, Díaz-Rodríguez E, Gorbenko Del Blanco D, Fernández A, de Rijke YB, Vallespín E, Nevado J, Lapunzina P, Matre V, Hinkle PM, Hokken-Koelega AC, de Miguel MP, Cameselle-Teijeiro JM, Nistal M, Alvarez CV, Moreno JC.  (2017) The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFβ and Activin pathways.   Sci Rep. 6(7):42937.

Goitre L, DiStefano PV, Moglia A, Nobiletti N, Baldini E, Trabalzini L, Keubel J, Trapani E, Shuvaev VV, Muzykantov VR, Sarelius IH, Retta SF, Glading AJ. (2017) Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium. Sci Rep. 7(1):8296.

Hocking DC. (2017). Tho' Much is Taken, Much Abides: Asylum Seekers' Subjective Wellbeing. J Immigr Minor Health. [Epub ahead of print]

Hu JH, Worley PF, Kammermeier PJ.  (2017) Dynamic Regulation of Homer Binding to Group I Metabotropic Glutamate Receptors by Preso1 and Converging Kinase Cascades. J Pharmacol Exp Ther. 361(1):122-129.

Kim KD, Bae S, Capece T, Nedelkovska H, de Rubio RG, Smrcka AV, Jun CD, Jung W, Park B, Kim TI, Kim M.  (2017) Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.  Nat Commun. 15(8):15365

Linsley JW, Hsu IU, Groom L, Yarotskyy V, Lavorato M, Horstick EJ, Linsley D, Wang W, Franzini-Armstrong C, Dirksen RT, Kuwada JY. (2017) Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proc Natl Acad Sci U S A. 114(2):E228-E236.

Liu W, Klose A, Forman S, Paris ND, Wei-LaPierre L, Cortés-Lopéz M, Tan A, Flaherty M, Miura P, Dirksen RT, Chakkalakal JV. (2017) Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration. Elife.  6(6): e26464.

Liu X, Ma L, Zhang S, Ren Y, Dirksen RT. (2017)  CD73 Controls Extracellular Adenosine Generation in the Trigeminal Nociceptive Nerves.  J Dent Res. 96(6):671-677.

Luyten T, Welkenhuyzen K, Roest G, Kania E, Wang L, Bittremieux M, Yule DI, Parys JB, Bultynck G. (2017)  Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2. Biochim Biophys Acta.  1864(6):947-956.

Scott MB, Kammermeier PJ. (2017) Ca_V2 channel subtype expression in rat sympathetic neurons is selectively regulated by α₂δ subunits.  Channels (Austin). 11(6):555-573. 

Shuttleworth TJ. (2017) Selective activation of distinct Orai channels by STIM1. Cell Calcium. 63:40-42.

Skov M, Dirksen RT. (2017) Trojan triplets: RNA-based pathomechanisms for muscle dysfunction in Huntington's disease. J Gen Physiol. 149(1):49-53.

Sneyd J, Means S, Zhu D, Rugis J, Won JH, Yule DI. (2017) Modeling Calcium Waves in an Anatomically Accurate Three-Dimensional Parotid Acinar Cell. J Theor Biol. 419:383-393. 

Sneyd J, Han JM, Wang L, Chen J, Yang X, Tanimura A, Sanderson MJ, Kirk V, Yule DI.  (2017) On the dynamical structure of calcium oscillations.  Proc Natl Acad Sci U S A. 14;114(7):1456-1461. 

Wang L, Wagner LE 2nd, Alzayady KJ, Yule DI. (2017)  Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity. J Biol Chem. 292(28):11714-11726.

Wang L, Alzayady KJ, Yule DI. (2017) Proteolytic fragmentation of inositol 1,4,5-trisphosphate receptors: a novel mechanism regulating channel activity? J Physiol. 594(11):2867-76.

2016

Alzayady KJ, Wang L, Chandrasekhar R, Wagner LE 2nd, Van Petegem F, Yule DI. (2016) Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release. Sci Signal. 9(422).

Auerbach DS, McNitt S, Gross RA, Zareba W, Dirksen RT, Moss AJ. (2016) Genetic biomarkers for the risk of seizures in long QT syndrome. Neurology.  87(16):1660-1668.

Bijli KM, Fazal F, Slavin SA, Leonard A, Grose V, Alexander WB, Smrcka AV, Rahman A. (2016) Phospholipase C Epsilon Signaling Mediates Endothelial Cell Inflammation and Barrier Disruption in Acute Lung Injury.  Am J Physiol Lung Cell Mol Physiol.  311(2):L517-L524.

Carr R, Koziol-White C, Zhang J, Lam H, Ahn SS, Tall GG, Panettieri RA, Benovic JL. (2016) Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms. Mol Pharmacol. 89(1):94-104.

Carrell ST, Carrell EM, Auerbach D, Pandey SK, Bennett CF, Dirksen RT, Thornton CA. (2016)  Dmpk Gene Deletion or Antisense Knockdown Does Not Compromise Cardiac or Skeletal Muscle Function in Mice.  Hum Mol Genet. [Epub ahead of print]

Carrell EM, Coppola AR, McBride HJ, Dirksen RT. (2016)  Orai1 enhances muscle endurance by promoting fatigue-resistant type I fiber content but not through acute store-operated Ca2+ entry.  FASEB J. [Epub ahead of print]

Carstensen EL, Parker KJ, Dalecki D, Hocking DC. (2016) Biological Effects of Low-Frequency Shear Strain: 1. Physical Descriptors. Ultrasound Med Biol. 42(1)1-15.

Chandrasekhar R, Alzayady KJ, Wagner LE 2nd, Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs. J Biol Chem. 291(10):4846-60.

Comeau ES, Hocking DC, Dalecki D. (2016) Ultrasound patterning technologies for studying vascular morphogenesis in 3D.  J Cell Sci. [Epub ahead of print]

Concepcion AR, Vaeth M, Wagner LE 2nd, Eckstein M, Hecht L, Yang J, Crottes D, Seidl M, Shin HP, Weidinger C, Cameron S, Turvey SE, Issekutz T, Meyts I, Lacruz RS, Cuk M, Yule DI, Feske S. (2016)  Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.  J Clin Invest. 126(11):4303-4318.

Deffains M, Iskhakova L, Katabi S, Haber SN, Israel Z, Bergman H. (2016)  Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys.  Elife. [Epub ahead of print]

DiStefano PV, Smrcka AV, Glading AJ. (2016)  Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.  PLoS One.  11(9):e0162338.

Dougherty DD, Chou T, Corse AK, Arulpragasam AR, Widge AS, Cusin C, Evans KC, Greenberg BD, Haber SN, Deckersbach T. (2016) Acute deep brain stimulation changes in regional cerebral blood flow in obsessive-compulsive disorder. J Neurosurg. 125(5):1087-1093.

Gerber S, Alzayady KJ, Burglen L, Brémond-Gignac D, Marchesin V, Roche O, Rio M, Funalot B, Calmon R, Durr A, Gil-da-Silva-Lopes VL, Ribeiro Bittar MF, Orssaud C, Héron B, Ayoub E, Berquin P, Bahi-Buisson N, Bole C, Masson C, Munnich A, Simons M, Delous M, Dollfus H, Boddaert N, Lyonnet S, Kaplan J, Calvas P, Yule DI, Rozet JM, Fares Taie L. (2016) Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome. Am J Hum Genet. 98(5):971-80.

Haber SN. (2016) Corticostriatal circuitry. Dialogues Clin Neurosci. 18(1):7-21.

Heilbronner SR, Rodriguez-Romaguera J, Quirk GJ, Groenewegen HJ, Haber SN. (2016)  Circuit-Based Corticostriatal Homologies Between Rat and Primate.  Biol Psychiatry. 80(7):509-21.

Ivanova H, Ritane A, Wagner L, Luyten T, Shapovalov G, Welkenhuyzen K, Seitaj B, Monaco G, De Smedt H, Prevarskaya N, Yule DI, Parys JB, Bultynck G. (2016) The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition.  Oncotarget. [Epub ahead of print]

Khan UW, Øverli Ø, Hinkle PM, Pasha FA, Johansen IB, Berget I, Silva PI, Kittilsen S, Höglund E, Omholt SW, Våge DI. (2016)  A novel role for pigment genes in the stress response in rainbow trout (Oncorhynchus mykiss).  Sci Rep. 6:28969.

Ma L, Trinh T, Ren Y, Dirksen RT, Liu X. (2016)  Neuronal NTPDase3 Mediates Extracellular ATP Degradation in Trigeminal Nociceptive Pathway.  PLoS One. 11(10):e0164028.

Maben ZJ, Malik S, Jiang LH, Hinkle PM. (2016) Dual Topology of the Melanocortin-2 Receptor Accessory Protein Is Stable.  Front Endocrinol. 7:96.

Okech W, Abberton KM, Kuebel JM, Hocking DC, Sarelius IH. (2016) Extracellular matrix fibronectin mediates an endothelial cell responses to shear stress via the heparin-binding, matricryptic RWRPK sequence of FNIII1. Am J Physiol Heart Circ Physiol.  311(4):H1063-H1071.

Patel BR, Tall GG. (2016)  Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQ^Q209L-driven melanoma.  Oncogenesis. 5(6):e236.

Rangel-Moreno J, To JY, Owen T, Goldman BI, Smrcka AV, Anolik JH. (2016) Inhibition of G protein βγ subunit signaling abrogates nephritis in lupus prone mice.  Arthritis Rheumatol. 68(9):2244-56.

Salzman GS, Ackerman SD, Ding C, Koide A, Leon K, Luo R, Stoveken HM, Fernandez CG, Tall GG, Piao X, Monk KR, Koide S, Araç D. (2016) Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains.  Neuron. 91(6):1292-304.

Sánchez-Fernández G, Cabezudo S, Caballero Á, García-Hoz C, Tall GG, Klett J, Michnick SW, Mayor F Jr, Ribas C. (2016) Protein kinase C ζ interacts with a novel binding region of Gαq to act as functional effector protein. J Biol Chem. 291(18):9513-25.

Sneyd J, Means S, Zhu D, Rugis J, Won JH, Yule DI. (2016) Modeling Calcium Waves in an Anatomically Accurate Three-Dimensional Parotid Acinar Cell. J Theor Biol. [Epub ahead of print]

Stoveken HM, Bahr LL, Anders MW, Wojtovich AP, Smrcka AV, Tall GG. (2016) Dihydromunduletone is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist.  Mol Pharmacol. 90(3):214-24.

Surve CR, To JY, Malik S, Kim M, Smrcka AV. (2016) Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ. Sci Signal. 9(416):ra22.

Teos LY, Zhang Y, Cotrim AP, Swaim W, Won JH, Ambrus J, Shen L, Bebris L, Grisius M, Jang SI, Yule DI, Ambudkar IS, Alevizos I. (2016)  IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome. Sci Rep. 5:13953.

Wang W, Gong G, Wang X, Wei-LaPierre L, Cheng H, Dirksen RT, Sheu SS. (2016) Mitochondrial Flash: Integrative ROS and pH Signals in Cell and Organelle Biology.  Antioxid Redox Signal.  25(9):534-49.

Yang T, Colecraft HM. (2016) Calmodulin regulation of TMEM16A and 16B Ca(2+)-activated chloride channels. Channels. 10(1):38-44.

2015

Ainbinder A, Boncompagni S, Protasi F, Dirksen RT. (2015) Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle. Cell Calcium. 57(1):14-24.

Alzayady KJ, Sebé-Pedrós A, Chandrasekhar R, Wang L, Ruiz-Trillo I, Yule DI. (2015) Tracing the Evolutionary History of Inositol, 1, 4, 5-trisphosphate receptor: Insights from Analyses of Capsaspora owczarzaki Ca2+ Release Channel Orthologs. Mol Biol Evol. 32(9):2236-2253.

Boschi NM, Takeuchi K, Sterling C, Tank AW. (2015) Differential expression of polycytosine-binding protein isoforms in adrenal gland, locus coeruleus and midbrainNeuroscience. 12;286:1-12.

Brand CS, Sadana R, Malik S, Smrcka AV, Dessauer CW. (2015) Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform Specific Use of Multiple Interaction SitesMol Pharmacol. 88:758-767.

Brennan JR, Hocking DC. (2015) Cooperative effects of fibronectin matrix assembly and initial cell-substrate adhesion strength in cellular self-assembly Acta biomaterialia. [Epub ahead of print]

Chandrasekhar R, Alzayady KJ, Yule DI. (2015) Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors. Biochem Soc Trans. 43(3):364-370.

Dalecki D, Mercado KP, Hocking DC. (2015) Quantitative Ultrasound for Nondestructive Characterization of Engineered Tissues and Biomaterials. Ann Biomed Eng. [Epub ahead of print]

Dalecki D, Hocking DC. (2015) Ultrasound technologies for biomaterials fabrication and imagingAnnals of biomedical engineering. 43(3):747-761.

Dusaban SS, Kunkel MT, Smrcka AV, Brown JH. (2015) Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras Associating Domains of Phospholipase C-epsilonJ Biol Chem. 290(44):26776-26783.

Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL. (2015) Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism. J Biol Chem. 290(39):23751-65.

Hammond CL, Wheeler SG, Ballatori N, Hinkle PM. (2015) Ostα-/- mice are not protected from western diet-induced weight gainPhysiol Rep. 3(1):e12263.

Hedgepeth SC, Garcia MI, Wagner LE 2nd, Rodriguez AM, Chintapalli SV, Snyder RR, Hankins GD, Henderson BR, Brodie KM, Yule DI, van Rossum DB, Boehning D. (2015) The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium releaseJ Biol Chem. 290 (11):7304-7313.

Hocking DC. (2015) Therapeutic Applications of Extracellular Matrix. Advances in wound care. 4(8):441-443.

Hocking DC, Kennedy GA, Sundram S. (2015) Social factors ameliorate psychiatric disorders in community-based asylum seekers independent of visa status. Psychiatry Res. 230:628-636.

Jbabdi S, Sotiropoulos SN, Haber SN, Van Essen DC, Behrens TE. (2015) Measuring macroscopic brain connections in vivoNat Neurosci. 18(11):1546-1555.

Kammermeier PJ. (2015) Constitutive activity of metabotropic glutamate receptor 7.BMC Neurosci. 24 (16):17.

Kudrick N, Chan O, La Gamma EF, Kim JL, Tank AW, Sterling C, Nankova BB. (2015) Posttranscriptional regulation of adrenal TH gene expression contributes to the maladaptive responses triggered by insulin-induced recurrent hypoglycemia. Physiol Rep. 22;3(2).

Lamboley CR, Kake Guena SA, Touré F, Hébert C, Yaddaden L, Nadeau S, Bouchard P, Wei-LaPierre L, Lainé J, Rousseau EC, Frenette J, Protasi F, Dirksen RT, Pape PC. (2015) New method for determining total calcium content in tissue applied to skeletal muscle with and without calsequestrin.J Gen Physiol. 145(2):127-153.

Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Poché RA, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL. (2015) Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle functionSkelet Muscle. 29;5:4.

Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. (2015) Structural Requirements for CNS Active Opioid Glycopeptides.J Med Chem. 58:5728:5871.

Liu X, Wang C, Fujita T, Malmstrom HS, Nedergaard M, Ren YF, Dirksen RT. (2015) External Dentin Stimulation Induces ATP Release in Human Teeth. J Dent Res. 94(9):1259-1266.

Liu W, Wei-LaPierre L, Klose A, Dirksen RT, Chakkalakal JV. (2015) Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctionsElife. 27:4.

Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV. (2015) G Protein βγ Subunits Regulate Cardiomyocyte Hypertrophy Through a Perinuclear Golgi Phosphatidylinositol 4-phosphate Hydrolysis Pathway.Mol Biol Cell. 26(6):1188-1198.

Malik S, Dolan TM, Maben ZJ, Hinkle PM. (2015) ACTH Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane. J Biol Chem. 290(46):27972-27985.

Mercado KP, Langdon J, Helguera M, McAleavey SA, Hocking DC, Dalecki D. (2015) Scholte wave generation during single tracking location shear wave elasticity imaging of engineered tissueThe Journal of the Acoustical Society of America. 138(2):EL138-44.

Mercado KP, Helguera M, Hocking DC, Dalecki D. Noninvasive Quantitative Imaging of Collagen Microstructure in Three-Dimensional Hydrogels Using High-Frequency Ultrasound. Tissue engineering. Part C, Methods. 21(7):671-682.

Michelucci A, Paolini C, Canato M, Wei-Lapierre L, Pietrangelo L, De Marco A, Reggiani C, Dirksen RT, Protasi F (2015) Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden death. Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden death. Anesthesiology. 123:603-617.

Murrant CL, Sarelius IH. (2015) Local control of blood flow during active hyperAemia: what kinds of integration are important? J Physiol. 593(21)4699-4711.

Paolini C, Quarta M, Wei-LaPierre L, Michelucci A, Nori A, Reggiani C, Dirksen RT, Protasi F. (2015) Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice. Skelet Muscle. 5:10.

Pietrangelo L, D'Incecco A, Ainbinder A, Michelucci A, Kern H, Dirksen RT, Boncompagni S, Protasi F. (2015) Age-dependent uncoupling of mitochondria from Ca2+ release units in skeletal muscle.Oncotarget. 6(34):35358-35371.

Rebbeck RT, Willemse H, Groom L, Casarotto MG, Board PG, Beard NA, Dirksen RT, Dulhunty AF. (2015) Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit. Skelet Muscle. 5:23.

Rocheleau AD, Sumagin R, Sarelius IH, King MR. (2015) Simulation and Analysis of Tethering Behavior of Neutrophils with PseudopodsPLoS One. 10(6):e0128378.

Rodriguez-Romaguera J, Do-Monte FH, Tanimura Y, Quirk GJ, Haber SN. (2015) Enhancement of Fear Extinction with Deep Brain Stimulation: Evidence for Medial Orbitofrontal Involvement. Neuropsychopharmacology. 40 (7):1726-1733.

Rodriguez-Romaguera J, Greenberg BD, Haber SN, Quirk GJ. (2015) A Cross Species Approach to Understanding DBS Modulation of Fear. Brain Stimul. 8(5):986-988.

Sarelius IH, Glading AJ. (2015) Control of vascular permeability by adhesion molecules.Tissue Barriers. 3 (1-2):e985954.

Sarelius IH, Titus PA, Maimon N, Okech W, Wilke-Mounts SJ, Brennan JR, Hocking DC. (2015) Extracellular matrix fibronectin initiates endothelium-dependent arteriolar dilation via the heparin-binding, matricryptic RWRPK sequence of FNIII1The Journal of physiology. [Epub ahead of print]

Smrcka AV. (2015) Regulation of Phosphatidylinositol-specific Phospholipase C at the Nuclear Envelope in Cardiac Myocytes. J Cardiovasc Pharmacol. 65 (3):203-210

Smrcka AV. (2015) Fingerprinting G protein-coupled receptor signaling. Sci Signal.8(405).

Stoveken HM, Hajduczok AG, Xu L, Tall GG. (2015) Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist.Proc Natl Acad Sci USA. 112(19)6194-6199.

Tank AW, Lee Wong D. (2015) Peripheral and central effects of circulating catecholamines
Compr Physiol. 5 (1):1-15.

Teos LY, Zhang Y, Cotrim AP, Swaim W, Won JH, Ambrus J, Shen L, Bebris L, Grisius M, Jang SI, Yule DI, Ambudkar IS, Alevizos I. (2015) IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome. Sci Rep. 14;5:13953.

Thompson JL, Shuttleworth TJ. (2015) Anchoring protein AKAP79-mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store-independent Orai channelJ Physiol. 593(3):559-72.

Vervloessem T, Yule DI, Bultynck G, Parys JB. (2015) The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²?-release channel. Biochim Biophys Acta. Biochim Biophys Acta. 1853(9):1992-2005.

Wang L, Alzayady KJ, Yule DI. (2015) Proteolytic fragmentation of inositol 1,4,5-trisphosphate Receptors: A novel mechanism regulating channel activity? J Physiol. [Epub ahead of print]

Yang T, Justus S, Li Y, Tsang SH. (2015) BEST1: the Best Target for Gene and Cell Therapies.Molecular therapy. 23(12):1805-1809.

2014

Ainbinder A, Boncompagni S, Protasi F, Dirksen RT. (2014) Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle. Cell Calcium. 57 (1):14-24.

Averbeck BB, Lehman J, Jacobson M, Haber SN. (2014) Estimates of projection overlap and zones of convergence within frontal-striatal circuits.J Neurosci. 34 (29):9497-9505.

Bansaghi S, Golenar T, Madesh M, Csordas G, Ramachandrarao S, Sharma K, Yule DI, Joseph SK, Hajnoczky G. (2014) Isoform-and species-specific control of IP3 receptors by reactive oxygen species.J Biol Chem. 289 (12):8170-8181.

Bidlack JM. (2014) Mixed κ/μ partial opioid agonists as potential treatments for cocaine dependence. Adv Pharmacol. 69:387-418.

Cheng H, Wang W, Wang X, Sheu SS, Dirksen RT, Dong MQ. (2014) The ‘mitoflash’ probe cpYFP does not respond to superoxide Nature. 508:128-132.

Dalecki D, Hocking DC. (2014) Ultrasound for microvascular tissue engineering. J Acoust Soc Am. 135 (4):2337.

Dalecki D, Hocking DC. (2014) Ultrasound Technologies for Biomaterials Fabrication and ImagingAnn Biomed Eng. [Epub ahead of print]

DiStefano PV, Kuebel JM, Sarelius IH, Glading AJ. (2014) KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling. Biol Chem. 289 (47):33054-33065.

Dowling JJ, Lawlor MW, Dirksen RT. (2014) Triadopathies: An Emerging Class of Skeletal Muscle Diseases.Neurotherapeutics. 11 (4):773-785.

Gehret AU, Hinkle PM. (2014) siRNA screen identifies the phosphatase acting on the G protein-coupled thyrotropin-releasing hormone receptor. ACS Chem Biol. 8 (3):588-598.

Gildner CD, Roy DC, Farrar CS, Hocking DC. (2014) Opposing effects of collagen I and vitronectin on fibronectin fibril structure and function. Matrix Biol. 34:33-45.

Goonasekera SA, Davis J, Kwong JQ, Accornero F, Wei-Lapierre L, Sargent MA, Dirksen RT, Molkentin JD. (2014) Enhanced Ca2+ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Hum Mol Genet. 23 (14):3706-3715.

Haber SN, Behrens TE. (2014) The Neural Network Underlying Incentive-Based Learning: Implications for Interpreting Circuit Disruptions in Psychiatric Disorders.Neuron. 83 (5):1019-1039.

Heilbronner SR, Haber SN. (2014) Frontal cortical and subcortical projections provide a basis for segmenting the cingulum bundle: implications for neuroimaging and psychiatric disorders.J Neurosci. 34 (30):10041-10054.

Hocking DC, Raeman CH, Dalecki D. (2014) Investigation of effects of ultrasound on dermal wound healing in diabetic mice. J Acoust Soc Am. 135 (4):2370.

Hocking DC, Kennedy GA, Sundram S. (2014) Mental Disorders in Asylum Seekers: The Role of the Refugee Determination Process and Employment. J Nerv Ment Dis. 203 (1):28-32.

Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. (2014) Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression.J Am Coll Cardiol. 63 (23):2549-2557.

Kan W, Adjobo-Hermans M, Burroughs M, Faibis G, Malik S, Tall GG, Smrcka AV. (2014) M3 muscarinic receptor interaction with phospholipase C β3 determines its signaling efficiency.J Biol Chem. 289 (16):11206-11218.

Le NT, Takei Y, Izawa-Ishizawa Y, Heo KS, Lee H, Smrcka AV, Miller BL, Ko KA, Ture S, Morrell C, Fujiwara K, Akaike M, Abe JI. (2014) Identification of Activators of ERK5 Transcriptional Activity by High-Throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents. J Immunol. 193 (7):3803-3815.

Li Y, St Louis L, Knapp BI, Muthu D, Anglin B, Giuvelis D, Bidlack JM, Bilsky EJ, Polt R. (2014) Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin?.J Med Chem. 57 (6):2237-2246.

Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. (2014) New functions and signaling mechanisms for the class of adhesion G protein-coupled receptorsAnn N Y Acad Sci. 1333:43-64.

Maimon N, Titus PA, Sarelius IH. (2014) Pre-exposure to adenosine, acting via A2A receptors on endothelial cells, alters the PKA-dependence of adenosine-induced dilatation in skeletal muscle resistance arterioles. J Physiol. 592 (Pt12):2575-2590.

Mercado KP, Helguera M, Hocking DC, Dalecki D. (2014) Characterizing collagen microstructure using high frequency ultrasound. J Acoust Soc Am. 135 (4):2373.

Mercado KP, Helguera M, Hocking DC, Dalecki D. (2014) Estimating Cell Concentration in Three-Dimensional Engineered Tissues Using High Frequency Quantitative Ultrasound. Ann Biomed Eng. 42 (6):1292-1304.

O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS. (2014) Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxid Redox Signal. 21 (6):863-879.

Oldenburger A, Timens W, Bos S, Smit M, Smrcka AV, Laurent AC, Cao J, Hylkema M, Meurs H, Maarsingh H, Lezoualc'h F, Schmidt M. (2014) Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smokeFASEB J. 28 (11):4617-4628.

Papasergi MM, Patel BR, Tall GG. (2014) The G protein α chaperone Ric-8 as a potential therapeutic targetMol Pharmacol. 87 (1):52-63.

Riazi S, Kraeva N, Muldoon SM, Dowling J, Ho C, Petre MA, Parness J, Dirksen RT, Rosenberg H (2014) Malignant hyperthermia and the clinical significance of type-1 ryanodine receptor gene (RYR1) variants: proceedings of the 2013 MHAUS Scientific Conference.Can J Anaesth. 61:1040-1049.

Ruisanchez É, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z. (2014) Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.FASEB J. 28 (2):880-890.

Sevastyanova TN, Kammermeier PJ. (2014) Cooperative Signaling Between Homodimers of Metabotropic Glutamate Receptors 1 and 5.Mol Pharmacol. 86 (5):492-504.

Sromek AW, Provencher BA, Russell S, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. (2014) Preliminary Pharmacological Evaluation of Enantiomeric Morphinans.ACS Chem Neurosci. 5 (2): 93-99.

Surve CR, Lehmann D, Smrcka AV. (2014) A Chemical Biology Approach Demonstrates GTP-binding Protein Gβγ Subunits are Sufficient to Mediate Directional Neutrophil Chemotaxis. J Biol Chem. 289 (25):17791-17801.

Thompson JL, Shuttleworth TJ. (2014) AKAP79-mediated PKA-phosphorylation of STIM1 determines selective activation of ARC channels, a store-independent Orai channel.
J Physiol. [Epub ahead of print]

Tziortzi AC, Haber SN, Searle GE, Tsoumpas C, Long CJ, Shotbolt P, Douaud G, Jbabdi S, Behrens TE, Rabiner EA, Jenkinson M, Gunn RN.(2014) Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography.Cereb Cortex. 24 (5):1165-1177.

Vervloessem T, Yule DI, Bultynck G, Parys JB. (2014) The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel.Biochim Biophys Acta. [Epub ahead of print]

Wagner LE 2nd, Groom LA, Dirksen RT, Yule DI. (2014) Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp .Cell Calcium. 56:96-107.

Wheeler SG, Hammond CL, Jornayvaz FR, Samuel VT, Shulman GI, Soroka CJ, Boyer JL, Hinkle PM, Ballatori N. (2014) Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity. Am J Physiol Gastrointest Liver Physiol. 306:G425-G438.

Yarotskyy V, Dirksen RT. (2014) RGK proteins: fashioning muscle with “Rad” new brakes.Channels (Austin). 8 (4):286-7.

Yarotskyy V, Dirksen RT (2014). Monovalent cationic channel activity in the inner membrane of nuclei from skeletal muscle fibersBiophys J. 107 (9):2027-2036.

Yule DI. (2014) Special issue: Ca²? signaling and secretory function. Preface. Cell Calcium. 55(6):281.

2013

Alzayady KJ, Chandrasekhar R, Yule DI. (2013) Fragmented Inositol 1,4,5-Trisphosphate Receptors Retain Tetrameric Architecture and Form Functional Ca2+ Release Channels. J. Biol. Chem. 288 (16):11122-11134.

Alzayady KJ, Wagner LE 2nd, Chandrasekhar R, Monteagudo AM, Godiska R, Tall GG, Joseph SK, Yule DI. (2013) Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits. J Biol Chem. 288 (41) :29772-29784.

Anders MW. (2013) Exploiting endobiotic metabolic pathways to target xenobiotic antioxidants to mitochondria. Mitochondrion 13 (5) 454-463.

Beqollari D, Kammermeier PJ. (2013) The interaction between mGluR1 and the calcium channel Cav2.1 preserves coupling in the presence of long Homer proteins. Neuropharmacology 66:302-310.

Chan P, Thomas CJ, Sprang SR, Tall GG. (2013) Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein alpha subunits. Proc. Natl. Acad. Sci. U.S.A. 110 (10):3794-3799.

Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, Brown JH. (2013) Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. Proc. Natl. Acad. Sci. U.S.A. 110 (9):3609-3614.

Garvin KA, Dalecki D, Yousefhussien M, Helguera M, Hocking DC. (2013) Spatial patterning of endothelial cells and vascular network formation using ultrasound standing wave fields. J Acoust Soc Am. 134 (2):1483-1490.

Garvin KA, Vanderburgh J, Hocking DC, Dalecki D. (2013) Controlling collagen fiber microstructure in three-dimensional hydrogels using ultrasound. J Acoust Soc Am. 134 (2):1491-1502.

Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Valentine WM, Aschner M, Yule DI. (2013) Manganese Transport via the Transferrin Mechanism. Neurotoxicology 34:118-127.

Haber SN, Heilbronner SR. (2013) Translational research in OCD: circuitry and mechanisms. Neuropsychopharmacology 38 (1):252-253.

Haber SN, Safadi Z, Milad MR. (2013) Meeting report: "Depression and Anxiety Spectrum disorders: from basic science to the clinic and back". Biol. Mood Anxiety Disord. 3 (1):6.

Haynes WIA, Haber SN. (2013) The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: implications for Basal Ganglia models and deep brain stimulation. J. Neurosci. 33 (11):4804-4814.

Hoot MR, Sypek EI, Reilley KJ, Carey AN, Bidlack JM, McLaughlin JP. (2013) Inhibition of Gβγ-subunit signaling potentiates morphine-induced antinociception but not respiratory depression, constipation, locomotion, and reward. Behav. Pharmacol. 24 (2):144-152.

Jbabdi S, Lehman JF, Haber SN, Behrens TE. (2013) Human and Monkey Ventral Prefrontal Fibers Use the Same Organizational Principles to Reach Their Targets: Tracing versus Tractography. J. Neurosci. 33 (7):3190-3201.

Kemeny LV, Schnur A, Czepan M, Rakonczay Z Jr, Gal E, Lonovics J, Lázár G, Simonka Z, Venglovecz V, Maleth J, Judak L, Németh IB, Szabó K, Almássy J, Virag L, Geisz A, Tiszlavicz L, Yule DI, Wittmann T, Varro A, Hegyi P. (2013) Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 305 (8):G552-563

Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, Riazi S. (2013) Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease. Neuromuscul Disord. 23 (2):120-132.

Lefebvre R, Legrand C, Groom L, Dirksen RT, Jacquemond V. (2013) Ca(2+) Release in Muscle Fibers Expressing R4892W and G4896V Type 1 Ryanodine Receptor Disease Mutants.PLoS One 8 (1):e54042.

Mailly P, Aliane V, Groenewegen HJ, Haber SN, Deniau JM. (2013) The Rat Prefrontostriatal System Analyzed in 3D: Evidence for Multiple Interacting Functional Units. J. Neurosci. 33 (13) :5718-5727.

McLaughlin NC, Didie ER, Machado AG, Haber SN, Eskandar E, Greenberg BD. (2013) Improvements in anorexia symptoms after deep brain stimulation for intractable obsessive-compulsive disorder. Biol Psychiatry. 73 (9):e29-e31.

Monaco G, Decrock E, Nuyts K, Wagner Ii LE, Luyten T, Strelkov SV, Missiaen L, De Borggraeve WM, Leybaert L, Yule DI, De Smedt H, Parys JB, Bultynck G. (2013) Alpha-Helical Destabilization of the Bcl-2-BH4-Domain Peptide Abolishes Its Ability to Inhibit the IP3 Receptor. PLoS One 8 (8):e73386.

Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, Lanier SM. (2013) Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.J. Biol. Chem. 288 (5):3003-3015.

Provencher BA, Sromek AW, Li W, Russell SE, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. (2013) Synthesis and Pharmacological Evaluation Aminothiazolomorphinans at Mu and Kappa Opioid Receptors. J Med Chem. 14;56(21):8872-8878.

Ram R, Wescott AP, Varandas K, Dirksen RT, Blaxall BC. (2013) Mena associates with Rac1 and modulates connexin43 remodeling in cardiomyocytes.Am J Physiol Heart Circ Physiol. 306 (1):H154-H159.

Reifler A, Lenk GM, Li X, Groom L, Brooks SV, Wilson D, Bowerson M, Dirksen RT, Meisler MH, Dowling JJ. (2013) Murine Fig4 is dispensable for muscle development but required for muscle function. Skelet Muscle 3 (1):21.

Roy DC, Hocking DC. (2013) Recombinant Fibronectin Matrix Mimetics Specify Integrin Adhesion and Extracellular Matrix Assembly. Tissue Eng. Part A. 19 (3-4):558-570.

Roy DC, Mooney NA, Raeman CH, Dalecki D, Hocking DC. (2013) Fibronectin matrix mimetics promote full-thickness wound repair in diabetic mice. Tissue Eng Part A. 19 (21-22):2517-2526.

Sebag JA, Zhang C, Hinkle PM, Bradshaw AM, Cone RD. (2013) Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science 341 (6143):278-281.

Smrcka AV. (2013) Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics. Trends Pharmacol. Sci. 34 (5):290-298.

Sevilla CA, Dalecki D, Hocking DC. (2013) Regional Fibronectin and Collagen Fibril Co-Assembly Directs Cell Proliferation and Microtissue Morphology.PLoS One. 8 (10) :e77316.

Sumagin R, Sarelius IH. (2013) Emerging Understanding of Roles for Arterioles in Inflammation. Microcirculation 20 (8):679-692.

Sun Z, Smrcka AV, Chen S. (2013) WDR26 functions as a scaffolding protein to promote Gβγ-mediated PLCβ2 activation in leukocytes. J. Biol. Chem. 288 (23):16715-16725.

Tall GG. (2013) Ric-8 regulation of heterotrimeric G proteins. J. Recept. Signal. Transduct. Res. 33 (3):139-143.

Tall GG, Patel BR, Chan P. (2013) Ric-8 folding of G proteins better explains Ric-8 apparent amplification of G protein-coupled receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 110 (34):E3148.

Thompson JL, Shuttleworth TJ. (2013) Exploring the unique features of the ARC channel, a Store-independent Orai channel. Channels (Austin) 7 (5):364-373.

Thompson JL, Shuttleworth TJ. (2013) How Many Orai's Does It Take to Make a CRAC Channel? Sci. Rep. 3:1961.

Thompson JL, Shuttleworth TJ. (2013) Molecular basis of activation of the arachidonate-regulated ARC channel, a store-independent Orai channel, by plasma membrane STIM1. J. Physiol. 591 (Pt 14):3507-3523.

Thompson JL, Mignen O, Shuttleworth TJ. (2013) The ARC Channel-An Endogenous Store-Independent Orai Channel. Curr Top Membr. 71:125-148.

Tziortzi AC, Haber SN, Searle GE, Tsoumpas C, Long CJ, Shotbolt P, Douaud G, Jbabdi S, Behrens TE, Rabiner EA, Jenkinson M, Gunn RN. (2013) Connectivity-Based Functional Analysis of Dopamine Release in the Striatum Using Diffusion-Weighted MRI and Positron Emission Tomography. Cereb. Cortex. 24 (5):1165-1177.

Vanalstine MA, Wentland MP, Alvarez J, Cao Q, Cohen DJ, Knapp BI, Bidlack JM. (2013) Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors. Bioorg. Med. Chem. Lett. 23 (7):2128-2133.

Wei-Lapierre L, Carrell EM, Boncompagni S, Protasi F, Dirksen RT. (2013) Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue. Nat Commun. 4:2805.

Wei-Lapierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W. (2013) Respective Contribution of Mitochondrial Superoxide and pH to Mt-cpYFP Flash Activity. J. Biol. Chem. 288 (15):10567-10577.

Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Brown JH. (2013) PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart.Sci Signal. 6 (306):ra108.

Yarotskyy V, Protasi F, Dirksen RT. (2013) Accelerated Activation of SOCE Current in Myotubes from Two Mouse Models of Anesthetic- and Heat-Induced Sudden Death.PLoS One 8 (10):e77633.

Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV. (2013) Phospholipase cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell 153 (1):216-227.