Ollivier Hyrien, PhD

Professor of Biostatistics and Computational Biology
Ph.D. (2001) University of Rennes I, France


Contact Information:

University of Rochester
Dept of Biostatistics and Computational Biology
265 Crittenden Boulevard, CU 420630 
Rochester, New York 14642-0630
Office: Saunders Research Building 4219
Phone: (585) 275-5303
Fax: (585) 273-1031
E-mail: Ollivier_Hyrien@urmc.rochester.edu
Ollivier Hyrien, PhD

Research Interests

My current research interests include finite mixtures, data clustering, stochastic processes, population dynamics, stochastic algorithms, and their applications to flow cytometry, image analysis, for example.

Selected References

Methodological Publications

  • Hyrien, O., and Baran, A. (2015). Fast nonparametric density-based clustering of large data sets using a stochastic approximation mean-shift algorithm. Journal of Computational and Graphical Statistics, accepted.
  • Hyrien, O., Yanev, N.M., and Jordan, C.T. (2015). A test of homogeneity for age-dependent branching processes with immigration. Electronic Journal of Statistics, accepted.
  • Hyrien, O., Peslak, S.A., Yanev, N.M., and Palis J. (2014). Stochastic modeling of stress erythropoiesis using a two-type age-dependent branching process with immigration. Journal of Mathematical Biology, to appear.
  • Chen. R. and Hyrien, O. (2014). On classes of equivalence and identifiability for age-dependent branching processes. Advances in Applied Probability, 46, 704-718.
  • Hyrien O. and Yanev N.M. (2012). Asymptotic behavior of cell populations described by two-type reducible age-dependent branching processes with non-homogeneous immigration. Mathematical Population Studies, 19, 164-176.
  • Chen R. and Hyrien O. (2011). Quasi- and pseudo-likelihood estimation for discretely observed Markov branching processes. Journal of Statistical Planning and Inference, 141, 2209-2227.
  • Chen R., Hyrien O., Mayer-Proschel M., and Noble M. (2011). A composite likelihood approach to the analysis of longitudinal clonal data under an age-dependent branching process. Biostatistics, 12, 173:191.
  • Hyrien O., Chen R., Mayer-Proschel M., and Noble M. (2010). Saddlepoint approximations to the moments of age-dependent branching processes, with applications. Biometrics, 66:567-577.
  • Hyrien O., Dietrich J., and Noble M. (2010). Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors. Cancer Research, 70, 10051-10059.
  • Hyrien O., Chen R., and Zand M.S. (2010). An age-dependent branching process model for the analysis of CFSE-labeling experiments. Biology Direct (Mathematical Biology section), 5:41.
  • Hocde S.A., Hyrien O., Waugh R.E. (2009). Molecular accessibility in relation to cell surface topography and compression against a flat substrate. Biophysical Journal, 97, 369-378.
  • Hocde S.A., Hyrien O., Waugh R.E. (2009). Cell adhesion molecule distribution relative to Neutrophil Surface Topography assessed by TIRFM. Biophysical Journal, 97, 379-387.
  • Hyrien O. and Zand M.S. (2008). A mixture model with dependent observations for the analysis of CFSE-labeling experiments. Journal of the American Statistical Association, 103, 222-239.
  • Hyrien O. (2007) A pseudo-maximum likelihood estimator for discretely observed multitype Bellman-Harris branching processes. Journal of Statistical Planning and Inference, 137, 1375-1388.
  • Hyrien O., Ambeskovic I., Mayer-Proschel M., Noble M., and Yakovlev A. (2006). Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data. Theoretical Biology and Medical Modelling 3:21.
  • Hanin L., Hyrien O., Bedford J., and Yakovlev A. (2006). A comprehensive stochastic model of irradiated cell population in cell culture. Journal of Theoretical Biology, 239, 401-416.
  • Hyrien O., Mayer-Proschel M., Noble and M., Yakovlev A. (2005). A stochastic model to analyze clonal data on multi-type cell populations. Biometrics, 61, 199-207.
  • Hyrien O., Mayer-Proschel M., Noble M., and Yakovlev A. (2005). Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture. Mathematical Biosciences, 193, 255-274.

Collaborative publications

  • Brady, M.T., Hilchey, S.P., Hyrien, O., Spence, S.A., and Bernstein, S.H. (2014). Mesenchymal stromal cells support the viability and differentiation of follicular lymphoma-infiltrating follicular helper T-cells. PLOS One, 9(5): e97597. doi:10.1371/journal.pone.0097597.
  • Petraglia, A.L., Plog, B.A., Dayawansa, S., Chen, M., Dashnaw, M.L., Czerniecka, K., Walker, C.T., Viterise, T., Hyrien, O., Iliff, J.F., Deane, R., Nedergaard, M., Huang, J.H. (2014). The Spectrum of neuro-behavioral sequelae following repetitive mild traumatic brain injury: A novel mouse model of chronic traumatic encephalopathy (CTE). Journal of Neurotrauma, 31:1211–1224.
  • Liesveld, J.L, Phillips, G.L., Becker, M.W., Constine, L.S., Friedberg, J.W., Andolina, J.R., Milner, L.A., Debolt, J., Smudzin, T., Hyrien, O., Erickson-Miller, C., Johnson, B., Dawson, K., and Chen, Y. (2013). A Phase 1 trial of eltrombopag in patients undergoing stem cell transplantation after total body irradiation. Biology of Blood and Marrow Transplantation, 19, 1745-1752.
  • Liesveld, J., Pawlowski, J., Chen, R., Hyrien, O., Debolt, J., Becker, M., Phillips, G., and Chen, Y. (2013). Clinical factors affecting engraftment and transfusion needs in stem cell transplantation; a single center retrospective analysis. Bone Marrow Transplantation, 48, 691-697.
  • Tong, J., Liu, W., Wang, X., Han, X., Hyrien, O., Samadani, U., Smith, D., Giger, R., Huang, J. (2013). Inhibition of Nogo-66 receptor 1 enhances recovery of cognitive function after traumatic brain injury in mice. Journal of Neurotrauma, 30, 247-258.
  • Zhang H., Travis L.B., Chen R., Hyrien, O., Milano M.T., Newlands S.D., and Chen Y. (2012). Impact of radiotherapy on laryngeal cancer survival: a population-based study of 13,808 U.S. patients. Cancer, 118, 1276-1287.
  • Hilchey S.P., Rosenberg A., Hyrien, O., Secor-Socha S., Cochran M.R., Wang J.C.E., Sanz I., Burack W.R., Quataert S.A., and Bernstein S.H. (2011). Follicular lymphoma tumor infiltrating T-helper (TH) cells have the same intrinsic polyfunctional potential upon stimulation as do reactive and normal nodal TH cells despite having skewed differentiation. Blood, 118, 3591-3602.
  • Chen Y., Pandya K., Hyrien, O., Keng P., Smudzin T., Anderson J., Qazi R., Smith B., Watson T., Feins R., and Johnstone D. (2011). Preclinical and pilot clinical study of docetaxel chemoradiation for stage III non-small cell lung cancer. International Journal of Radiation Oncology, Biology, Physics, 80, 1358-1364.
  • Bhogal N., Kaspler P., Jalali F., Hyrien, O., Chen R., Hill R.P., and Bristow R.G. (2010). Late residual H2AX FOCI in murine skin are dose-responsive and predict radiosensitivity in vivo. Radiation Research,173, 1-9.
  • Biswas T., Dhakal S., Chen R., Hyrien, O., Bernstein S., Friedberg J., Fisher R., Liesveld J., Phillips G., Constine L. (2010). Involved field radiation after autologous stem cell transplant for large B-cell lymphoma in the rituximab era. International Journal of Radiation Oncology, Biology, Physics, 77, 79-85.
  • Hilchey S.P., Kobie J.J., Cochran M.R., Secor-Socha S., Wang E., Hyrien, O., Mosmann T.R., Quataert S.A. and Bernstein S.H. (2009). Human follicular lymphoma CD39+ -infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness. Journal of Immunology, 183, 6157-6166.
  • Henn A.D., Rebhahn J., Brown M.A., Murphy A., Coca M.N., Hyrien, O., Pellegrin T., Mosmann T., Zand M.S. (2009). Cell division affects the frequency of antibody secreting cells but not the distribution of single-cell IgG secretion rates in CpG activated human memory B cells. Journal of Immunology, 183, 3177 -3187.
  • Sun H., Dertinger S.D., Hyrien, O., Wu D., and Chen Y. (2009). Gamma radiation induces micronucleated reticulocytes in ex-vivo 3-D bone marrow bioreactors. Mutation Research, 680, 49-55.
  • Khorana A.A., Francis C.W., Menzies K.E., Wang J.G., Hyrien, O., Hathcock J., Mackman N., and Taubman M.B. (2008). Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer. Journal of Thrombosis and Haemostasis, 11, 1983-1985.
  • Couderc J.P., McNitt S., Hyrien, O., Vaglio M., Xia X., Polonsky S., Moss A.J., Zareba W. (2008). Electrocardiographic abnormalities of repolarization induced by moxifloxacin: improving the detection of subtle IKr-inhibition. Drug Safety, 31(3) 249-260.
  • Connolly G.C., Chen R., Hyrien, O., Mantry P., Abt P., and Khorana A.A. (2008). Portal vein and systemic thromboses in hepatocellular carcinoma. Thrombosis Research, 122, 299-306.
  • Dertinger S.D., Tsai Y., Nowak I., Hyrien, O., Sun H., Bemis J.C., Torous D.K., Keng P., Palis J., and Chen Y. (2007). Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry. Mutation Research, 634, 1-2, 119-125.