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Kate Ackerman, M.D.Kate G. Ackerman, M.D.
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Pediatrics
Ackerman Lab

Congenital Diaphragmatic Hernia

Michael Apostolakos, M.D.Michael Apostolakos, M.D.
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Medicine

Patricia Chess, M.D.Patricia R. Chess, M.D.
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Pediatrics

Effects of strain on pulmonary epithelium

Carl D'Angio, M.D.Carl T. D'Angio, M.D.
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Pediatrics
Medical Humanities and Bioethics

Immunizations and infections in the premature infant

David Dean, Ph.D.David A. Dean, Ph.D.
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Pediatrics
Dean Lab

Delineating mechanisms that control DNA-protein complexes’ traffic through the cytoplasm, entry to the nucleus, and targeting to specific domains, and application of this to treat pulmonary diseases.

Alison Elder, Ph.D.Alison Elder, Ph.D.
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Environmental Medicine
Elder Lab

Defining the impact of inhaled ambient and workplace nano-/ultrafine particle-containing aerosols on the lung, cardiovascular system, and central nervous system, and defining the toxicological properties of the particles that are associated with a response.

Fabeha Fazal, Ph.D.Fabeha Fazal, Ph.D.
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Pediatrics

Understanding the role and regulation of actin-myosin interactions in endothelial cell (EC) inflammation, permeability, and apoptosis, especially in the settings of acute and chronic lung injury

Jacob Finkelstein, Ph.D.Jacob N. Finkelstein, Ph.D.
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Pediatrics
Finkelstein Lab

Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages.

Steve Georas, M.D.Steve Georas, M.D.
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Medicine
Georas Lab

Defining the role of environmental exposures on innate and adaptive immunity in asthma and other chronic lung diseases, with an emphasis on how particulate matter and endocrine disruptors act as risk factors.

Francis Gigliotti, M.D.Francis Gigliotti, M.D.
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Pediatrics

Pneumocystis carinii pneumonia; Infections in the immunocompromised host

Denise Hocking, Ph.D.Denise C. Hocking, Ph.D.
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Pharmacology & Physiology
Hocking Lab

Regulation of cell behavior by the extracellular matrix

Matthew Kottmann, M.D.Matthew Kottmann, M.D.
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Medicine
Sime Lab

B. Paige Lawrence, Ph.D.B. Paige Lawrence, Ph.D.
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Environmental Medicine
Lawrence Lab

Delineating mechanisms by which environmental exposures during different life stages alter immune function; discovering how environmental factors modulate epigenetic programming of the developing immune system, and the consequences of these changes on susceptibility to infectious, allergic, or autoimmune disease later in life.

Thomas Mariani, Ph.D.Thomas Mariani, Ph.D.
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Pediatrics
Mariani Lab

Systems Biology of Lung Development and Disease

Ravi Misra, Ph.D.Ravi Misra, Ph.D.
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Pediatrics

Understanding mechanisms of pathology in common inflammatory conditions of children

Michael O'Reilly, Ph.D.Michael A. O'Reilly, Ph.D.
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Pediatrics
O'Reilly Lab

Understanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan.

Günter Oberdörster, D.V.M., Ph.D.Günter Oberdörster, D.V.M., Ph.D.
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Environmental Medicine
Elder Lab

Biokinetics, Effects and Mechanisms of Inhaled Micro- and Nano- Particles: Dosimetry, Risk Extrapolation and Risk Assessment

Richard Phipps, Ph.D.Richard Phipps, Ph.D.
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Environmental Medicine
Phipps Lab

Investigating how environmental factors shape diseases involving immune and inflammatory components, including platelets, B cells, and lipid mediators, defining abnormal inflammatory and wound healing responses in the eye and lung, delineating molecular signaling in fibroblasts.

Anthony Pietropaoli, M.D., M.P.H.Anthony P. Pietropaoli, M.D., M.P.H.
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Medicine
Pietropaoli Lab

Team approaches to patient-centered, clinical and translational investigation in sepsis and critical illness

Gloria Pryhuber, M.D.Gloria S. Pryhuber, M.D.
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Pediatrics
Pryhuber Lab

Delineating multifactorial causes of respiratory morbidity in infants and young children, including environmental exposures on lung development, microbial infection and dysbiosis, and pulmonary immune responses; levering unique human lung and immune cell repositories that support the in vitro study of mechanisms of toxicity of environmental agents.

Arshad Rahman, Ph.D.Arshad Rahman, Ph.D.
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Pediatrics
Arshad Rahman Lab

Determining how exogenous agents change lung microvasculature permeability, leading to pulmonary inflammation.

Irfan Rahman, Ph.D.Irfan Rahman, Ph.D.
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Environmental Medicine
Irfan Rahman Lab

Defining effects of inhaled environmental tobacco smoke, e-cigarettes, flavoring chemicals, and water pipe smoke toxicants on mitochondrial function, exosomes, and epigenetic chromatin modifiers in lung cell senescence, oxidative stress, and inflammation.

Patricia Sime, M.D.Patricia Sime, M.D.
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Medicine
Sime Lab

Conducting clinical and translational toxicology research focusing on the lung, from studies of silica and radiation in lung fibrosis, to the effects of biomass and cigarette smoke exposure on lung inflammation and resolution pathways, to identifying key pathophysiologic pathways and developing novel therapeutics for lung inflammation and fibrosis.

Thomas Thatcher, Ph.D.Thomas Thatcher, Ph.D.
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Medicine
Sime Lab

David Topham, Ph.D.David Topham, Ph.D.
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Microbiology & Immunology
Topham Lab
Program for Advanced Immune Bioimaging

Conducting clinical and translational research on respiratory pathogens, immunity, and infectious disease, including the study of environmental factors that affect immune responses to influenza and vaccination, seeking new approaches to enhance immunity, reduce pathology, and prevent disease.

Mark Utell, M.D.Mark Utell, M.D.
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R. White, M.D., Ph.D.R. James White, M.D., Ph.D.
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Medicine
R. James White Lab

Role of mitochondria in hypoxic pulmonary vasoconstriction.

Jacqueline Williams, Ph.D.Jacqueline Patricia Williams, Ph.D.
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Environmental Medicine
Jacqueline Williams Lab

Discovering the effects of high (therapeutic) and low (environmentally-relevant) doses of radiation and their interactions with other toxic elements, such as commonly encountered infections, and better understanding differential effects of radiation in adults versus children.

Terry Wright, Ph.D.Terry W. Wright, Ph.D.
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Pediatrics