Affiliated Faculty
Research Interest:
Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Pharmacology & Physiology
Research Interest: LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Mitochondrial Research and Innovation Group
Anesthesiology and Perioperative MedicinePharmacology & Physiology
Research Interest: Cardioprotection against ischemia-reperfusion (IR) injury. Role of Mitochondria and metabolism in ischemic preconditioning and anesthetic preconditioning.
Biochemistry & Biophysics
Research Interest: Chromatin domains and long-range activation by enhancers
Biochemistry & Biophysics
Research Interest: Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.
Neuroscience
Biomedical Engineering
Research Interest: Molecular mechanisms of neuropeptide signal transduction
Biochemistry & Biophysics
Research Interest: Signal transduction; membrane protein structure, yeast molecular biology
Biochemistry & Biophysics
Research Interest:
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Research Interest: Molecular mechanisms of prion propagation and pathogenesis
Research Interest:
Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.
Research Interest: Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Research Interest:
Investigating membranes and membrane proteins via computer simulation
Mitochondrial Research and Innovation Group
Biomedical GeneticsPharmacology & Physiology
Research Interest:
Understanding the roles of antioxidants in disease
William A. Bernhard Memorial Lab
Biochemistry & BiophysicsResearch Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function
Research Interest: Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Biomedical Genetics
Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Neurology
Research Interest: Determining the therapeutic promise of engineered tRNAs for treatment of nonsense associated diseases and investigating the pathomechanisms of skeletal muscle weakness and wasting in myotonic dystrophy
Research Interest:
Nuclear and cytoplasmic RNA metabolism in mammalian cells: Co- and post-transcriptional pre-mRNA processing; influence of pre-mRNA splicing on mRNA metabolism, including the structure and function of modular exon-junction complexes and effects of AKT-signaling; Nonsense-mediated mRNA decay; Fragile X Syndrome (FXS)/Autism/Intellectual disabilities; mRNP Structure and function in non-polar cells and in neurons; Development of FXS therapeutics.
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Biomedical Genetics
Research Interest:
Impact of iron deficiency on brain development and interactions with environmental toxicants and genetic factors.
Biomedical Engineering
Dermatology
Research Interest:
Research in the Miller group centers on (1) photonic sensors, particularly with regard to continuous monitoring of microphysiological systems and biomanufacturing; (2) medical diagnostics, including paper-based point-of-care and self-tests for RNA viruses.
Microbiology & Immunology
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Pharmacology & Physiology
Research Interest:
Molecular mechanisms and spatiotemporal regulation of cell signaling pathways using cryo-EM, biochemical, and pharmacologic studies; RNA/protein therapeutic targets and treatments; instrumentation and methods development in structural biology.
Research Interest: tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Mitochondrial Research and Innovation Group
Biomedical GeneticsMicrobiology & Immunology
Research Interest:
The role of metabolism in lineage differentiation
Medicine
Research Interest:
Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.
Research Interest: Cancer epigenetics: the role of DNA methylation and chromatin in driving cancer phenotypes and as a target for therapeutic intervention
Research Interest:
Mechanism and physiological importance of alternative polyadenylation; Integrator Complex and transcriptional control, development and application of next-generation sequencing technologies
Research Interest:
Cell biology, biochemistry, and molecular genetics; Organelle biogenesis; Organelle degradation through selective autophagy; Organelle aging and neurodegeneration; Cellular stress response
Research Interest: Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Mitochondrial Research and Innovation Group
Biochemistry & BiophysicsMedicine
Research Interest:
Pathophysiological function and molecular mechanism of new non-coding RNAs and RNA-binding proteins and translational control in cardiac system and cardiovascular disease
Research Interest: RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.