Research Interest: Health effects of air pollution, with a current focus on the contribution of air pollution to individuals suffering from respiratory viral infections
Research Interest: Molecular mechanisms of gene delivery and development of gene therapies for lung disease
Research Interest: Toxicology of inhaled ultrafine particles (UFPs) on the lung, cardiovascular and central nervous system
Research Interest: Role and regulation of actin-myosin interactions in endothelial cell (EC) inflammation, permeability, and apoptosis icute and chronic lung injury
Research Interest: Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages.
Research Interest: Defining molecular pathways by which allergens and particulates activate epithelia and dendritic cells in the lung immune system
Research Interest: Molecular regulation of vascular endothelial function
Research Interest: Community outreach and engagement, role of science in public decision-making
Research Interest: Delineating mechanisms by which environmental exposures during different life stages alter immune function; discovering how environmental factors modulate epigenetic programming of the developing immune system, and the consequences of these changes on susceptibility to infectious, allergic, or autoimmune disease later in life.
Research Interest: Extracellular vesicles (Evs), Exosomes, for their roles in cancer development, progression and response to treatment in Urology cancers.
Research Interest: Investigating factors that both increase and decrease the risk of developing asthma, wheezing, and allergic disorders in childhood
Research Interest: Genetic mechanisms of susceptibility to chronic lung diseases, focusing on developmental antecedents and influence of environmental factors.
Research Interest: Developing and coordinating a wide variety of science education and outreach programs for students (elementary through high school), teachers, and the general community.
Research Interest: Epithelial injury and abnormal repair in pediatric and adult lung disease
Research Interest: Smoking Cessation in special populations, Technology/Web Assisted Risk Behavior Intervention and Dissemination of effective interventions to physician practices
Research Interest: Understanding mechanisms of pathology in common inflammatory conditions of children
Research Interest: Understanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan.
Research Interest: Biokinetics, Effects and Mechanisms of Inhaled Micro- and Nano- Particles: Dosimetry, Risk Extrapolation and Risk Assessment
Research Interest: Behavioral medicine and outcomes management include tobacco use and smoking interventions, obesity prevention and exercise
Research Interest: The use of nutritional supplementation and exercise to treat the symptoms and side effects of cancer and its related treatment
Research Interest: Endothelial cell biology and lung physiology as it relates to molecular analysis of signal transduction and gene regulation in the lung epithelium.
Research Interest: Redox signaling mechanism of Proinflammatory gene expression in pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants.
Research Interest: Mechanisms of toxicity of the environmental contaminant and neurotoxicant methylmercury (MeHg), defining MeHg effects on early life development of neural and muscular systems at the molecular, cellular, and organismal levels using invertebrate and mammalian models, and detailed characterization of MeHg metabolism and elimination kinetics in humans.
Research Interest: Circadian disruption, Cigarette smoke-induced chromatin modifications, cellular senescence and DNA damage/repair
Research Interest: Studying epigenetic mechanisms underlying environment-induced adverse pregnancy and developmental outcomes, including how endocrine-disrupting chemicals change maternal health, mammalian reproduction, and the expression and function of imprinted genes.
Research Interest: Behavioral Pharmacology and Toxicology; Substance Abuse; Inhalation Toxicology; Medications for Urologic Disorders (urge incontinence, interstitial cystitis, pain)
Research Interest: Molecular mechanisms of skeletal repair in bone loss due to traumatic injury, tumor and bone graft.