Research Interest: Genetics and bioinformatics
Research Interest: Co-Director of the Rochester Genomics CenterDirector, Wilmot Cancer Institute Shared ResourcesDirector, Functional Genomics Resource
Research Interest: The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease
Research Interest: Chromatin domains and long-range activation by enhancers
Research Interest: Activation induced cytidine deaminase (AID) impact on Follicular lymphoma (FL) tumors as a prognostic factor for Diffuse Large B-cell lymphoma (DLBCL)
Research Interest: Developing and understanding community-driven solutions to public health problems
Research Interest: The genetic basis of evolutionary change and specifically interested in the role of changes in gene regulation
Research Interest: Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Research Interest: Microbial pathogens and the impact of human microbial flora on human health and disease.
Research Interest: Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Investigating membranes and membrane proteins via computer simulation
Research Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function
Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Research Interest: Satellite DNA (repetitive DNA typically found at centromeres and telomeres), Meiotic Drive, and Selfish DNA using genomic, population genetic, molecular and cytological methods.
Research Interest: Neurobiology of glaucoma, molecular processes that lead to retinal ganglion cell death.
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Genetic mechanisms of susceptibility to congenital and infectious lung diseases, focusing on developmental antecedents and the influence of environmental factors.
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Research Interest: Developing methods to estimate gene regulatory networks from gene perturbation experiments
Research Interest: Analysis of gene regulatory networks in cancer; role of immunogenetics in transplant
Research Interest: Effect of the Microbiome/Virome on Mucosal and Systemic Inflammation in Health and Disease
Research Interest: The regulation of cytokine responses of human and mouse T-cell subsets in infections asthma, allergy and autoimmunity
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Research Interest: Pediatric Neurology, Human Genetics
Research Interest: tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Using primarily human pluripotent stem cell models, we examine astrocyte development in normal and pathological conditions, the role of astrocytes in modulating response to injury or stress, the role of altered RNA processing and translation in neural development, and the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy.
Research Interest: Understanding the genetic, cell biological and molecular basis for age-driven proteostatic deterioration
Research Interest: Computational biology of RNA; RNA comparative sequence analysis; RNA structure prediction; analysis of HIV RNA genomes.
Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.
Research Interest: Systems approach utilizing bioinformatics, and dynamic modeling tools to study immune response to infections and vaccination.
Research Interest: Multiple roles of virus-specific Band T cells in determining the outcome of viral infection of the respiratory tract. Long term protective effect of immunological mechanisms.
Research Interest: Evolutionary Genetics
Pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease.