Research Interest: Genetics and bioinformatics
Research Interest: Co-Director of the Rochester Genomics CenterDirector, Wilmot Cancer Institute Shared ResourcesDirector, Functional Genomics Resource
Research Interest: The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease
Research Interest: Chromatin domains and long-range activation by enhancers
Research Interest: Activation induced cytidine deaminase (AID) impact on Follicular lymphoma (FL) tumors as a prognostic factor for Diffuse Large B-cell lymphoma (DLBCL)
Research Interest: Influenza Viruses; Virus Polymerase HIV Vaccine Development; NeuroAIDS Research
Research Interest: Developing and understanding community-driven solutions to public health problems
Research Interest: The genetic basis of evolutionary change and specifically interested in the role of changes in gene regulation
Research Interest: Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Research Interest: Microbial pathogens and the impact of human microbial flora on human health and disease.
Research Interest: Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Research Interest: Investigating membranes and membrane proteins via computer simulation
Research Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function
Research Interest: Artificial intelligence; Pervasive computing; Data science
Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Research Interest: Satellite DNA (repetitive DNA typically found at centromeres and telomeres), Meiotic Drive, and Selfish DNA using genomic, population genetic, molecular and cytological methods.
Research Interest: Epigenetic inheritance, small silencing non-coding RNAs, translational control, lead toxicity, and comparative genomics.
Research Interest: Neurobiology of glaucoma, molecular processes that lead to retinal ganglion cell death.
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Research Interest: Genetic mechanisms of susceptibility to chronic lung diseases, focusing on developmental antecedents and influence of environmental factors.
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Research Interest: Developing methods to estimate gene regulatory networks from gene perturbation experiments
Research Interest: Analysis of gene regulatory networks in cancer; role of immunogenetics in transplant
Research Interest: Effect of the Microbiome/Virome on Mucosal and Systemic Inflammation in Health and Disease
Research Interest: The regulation of cytokine responses of human and mouse T-cell subsets in infections asthma, allergy and autoimmunity
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Research Interest: The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Research Interest: Pediatric Neurology, Human Genetics
Research Interest: tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Research Interest: Glial progenitor cells and role of astrocytes as critical modulators in CNS disease and repair
Research Interest: Understanding the genetic, cell biological and molecular basis for age-driven proteostatic deterioration
Research Interest: Computational biology of RNA; RNA comparative sequence analysis; RNA structure prediction; analysis of HIV RNA genomes.
Research Interest: Utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development in both normal and disease states
Research Interest: Systems approach utilizing bioinformatics, and dynamic modeling tools to study immune response to infections and vaccination.
Research Interest: Multiple roles of virus-specific Band T cells in determining the outcome of viral infection of the respiratory tract. Long term protective effect of immunological mechanisms.
Research Interest: Evolutionary Genetics
Research Interest: Pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease.