CBI Faculty
Co-Director of the Rochester Genomics Center
Director, Wilmot Cancer Institute Shared Resources
Director, Functional Genomics Resource
The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease Dr. Bohmann works part-time and doesn’t accept new students.
Chromatin domains and long-range activation by enhancers
Understanding the interaction of HIV with glial cells; Developing an improved live attenuated influenza vaccine (LAIV); Elucidating the host cell response to infection by viral pathogens (with emphasis on SARS-CoV-2 and Adeno-associated virus, AAV)
How RNA modifications impact neurodevelopment and disease.
Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Investigating membranes and membrane proteins via computer simulation
Nuclear and cytoplasmic RNA metabolism in mammalian cells: Co- and post-transcriptional pre-mRNA processing; influence of pre-mRNA splicing on mRNA metabolism, including the structure and function of modular exon-junction complexes and effects of AKT-signaling; Nonsense-mediated mRNA decay; Fragile X Syndrome (FXS)/Autism/Intellectual disabilities; mRNP Structure and function in non-polar cells and in neurons; Development of FXS therapeutics.
Genetic and environmental susceptibility to developmental lung injury.
Developing methods to: model microRNA-seq data, analyze confocal microscopy images of microglia, and estimate gene regulatory networks from perturbation experiments.
Using primarily human pluripotent stem cell models, we examine astrocyte development in normal and pathological conditions, the role of astrocytes in modulating response to injury or stress, the role of altered RNA processing and translation in neural development, and the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy. 
Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.
Immune responses to respiratory viruses and experimental vaccines
Pathophysiological function and molecular mechanism of new non-coding RNAs and RNA-binding proteins and translational control in cardiac system and cardiovascular disease
