Dmitri N. Ermolenko, Ph.D.
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Elizabeth Grayhack, Ph.D.
Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Clara L. Kielkopf, Ph.D.
Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Xin Zhiguo Li, Ph.D.
Small non-coding RNA regulation in germ cells; paternal aging; transgenerational inheritance.
Lynne Maquat, Ph.D.
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Joshua C. Munger, Ph.D.
Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Mitchell O'Connell, Ph.D.
Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Eric Phizicky, Ph.D.
tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Harold C. Smith, Ph.D.
RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.
Joseph E. Wedekind, Ph.D.
Structure and function analysis of gene regulation by riboswitches and microRNAs as a basis for therapeutic development.
Yi-Tao Yu, Ph.D.
RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.