Signal transduction; membrane protein structure, yeast molecular biology
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Crystallography and structural chemistry of enzyme-ligand interactions.
Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Investigating membranes and membrane proteins via computer simulation
DNA structure; chromatin; protein-DNA interactions
Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Small RNAs in germ cells; epigenetic inheritance; bioinformatics
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Electron paramagnetic resonance (epr) research and instrumentation
Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.
Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.