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Faculty

Primary FacultyResearch FacultySecondary FacultyEmeritus Faculty

Primary Faculty

Mark Dumont

Mark E. Dumont, Ph.D.

Signal transduction; membrane protein structure, yeast molecular biology

Dmitri Ermolenko

Dmitri N. Ermolenko, Ph.D.

Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.

Barry Goldstein

Barry M. Goldstein, M.D., Ph.D.

Crystallography and structural chemistry of enzyme-ligand interactions.

Elizabeth Grayhack

Elizabeth Grayhack, Ph.D.

Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.

Alan Grossfield

Alan M. Grossfield, Ph.D.

Investigating membranes and membrane proteins via computer simulation

Clara Kielkopf

Clara L. Kielkopf, Ph.D.

Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.

Xin Li

Xin Zhiguo Li, Ph.D.

Small RNAs in germ cells; epigenetic inheritance; bioinformatics

Lynne Maquat

Lynne Maquat, Ph.D.

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.

David Mathews

David H. Mathews, M.D., Ph.D.

Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.

Kermit Mercer

Kermit Ray Mercer, B.S.

Electron paramagnetic resonance (epr) research and instrumentation

Joshua Munger

Joshua C. Munger, Ph.D.

Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.

Mitchell O'Connell

Mitchell O'Connell, Ph.D.

Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development

Eric Phizicky

Eric Phizicky, Ph.D.

tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.

Harold Smith

Harold C. Smith, Ph.D.

RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.

Joseph Wedekind

Joseph E. Wedekind, Ph.D.

Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.

Yi-Tao Yu

Yi-Tao Yu, Ph.D.

RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.

Research Faculty

Fred Hagen

Fred Hagen, Ph.D.

Glycosyltransferases, proteomics, role of glycosylation in development

Jermaine Jenkins

Jermaine Jenkins, Ph.D.

Crystallography of RNA and Protein-RNA complexes

Scott Kennedy

Scott D. Kennedy, Ph.D.

NMR imaging and spectroscopy; Tumor biology; RNA structure determination; anion transport

Tatsuaki Kurosaki

Tatsuaki Kurosaki, Ph.D.

mRNA quality control (or mRNA surveillance) in human cells, fragile X syndrome

Elizabeth Mathew

Elizabeth Mathew, Ph.D.

Structure and functions of G protein coupled receptors (GPCRs), in particular, the yeast GPCR, Ste2p

Tihomir Miralem

Tihomir Miralem, Ph.D.

Bogdan Polevoda

Bogdan Polevoda, Ph.D.

The two cotranslational processes, cleavage of N-terminal methionine and N-terminal acetylation (N- acetylation).

Maximilian Popp

Maximilian Popp, Ph.D.

mRNA metabolism in mammalian cells

Elena Rustchenko-Bulgac

Elena P. Rustchenko-Bulgac, Ph.D.

Chromosomes instability of human fungal pathogen Candida albicans.

Hironao Wakabayashi

Hironao Wakabayashi, M.D., Ph.D

Structural and functional analyses of factor VIII

Secondary Faculty

Michael Bulger

Michael D. Bulger, Ph.D.

Chromatin domains and long-range activation by enhancers

Scott Butler

Scott Butler, Ph.D.

Regulation of Gene Expression by Targeted Degradation of RNA

Gloria Culver

Gloria Culver, Ph.D.

Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.

Chin-To Fong

Chin-To Fong, M.D.

Genetics of orofacial clefts

David Goldfarb

David S. Goldfarb, Ph.D.

Molecular mechanisms that control the exchange of molecules and information between the nucleus and cytoplasm

Hartmut Land

Hartmut Land, Ph.D.

Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism

Benjamin Miller

Benjamin L. Miller, Ph.D.

Carbohydrate and protein recognition, molecular design, and biomolecular sensing

J. Edward Puzas

J. Edward Puzas, Ph.D.

Deciphering the molecular signals that govern osteoporosis and arthritis, as well as cellular changes that contribute to difficulties such as the loosening of artificial joints, including defining how environmental toxins such as lead, play a role in bone and joint diseases.

Richard Waugh

Richard E. Waugh, Ph.D.

Cell Adhesion, Mechanical and thermodynamic properties of biological membranes; cellular mechanics and function of cytoskeletal proteins

Jian Zhu

Jian Zhu, Ph.D.

Host-virus interactions, particularly for HIV and herpes viruses

Emeritus Faculty

Robert Bambara

Robert A. Bambara, Ph.D.

Human genome stability, DNA damage response, HIV replication and evolution

Thomas Gunter

Thomas E. Gunter, Ph.D.

Membrane transport, bioenergetics, calcium regulation

Russell Hilf

Russell Hilf, Ph.D.

Hormone action in mammory cancer; Photodynamic therapy of neoplasia

George Kimmich

George Kimmich, Ph.D.

Regulation of neurotransmitter uptake by glial and neuronal cells

Christopher Lawrence

Christopher W. Lawrence, Ph.D.

Molecular biology of DNA-damage induced mutagenesis

Mahin Maines

Mahin Maines, Ph.D.

Heme oxygenases and second messenger gases: CO and NO.

Terry Platt

Terry Platt, Ph.D.

Molecular mechanisms of gene expression; transcription termination and mRNA 3' and formation in Escherichia coli and yeast; protein-nucleic acid.

Alan Senior

Alan E. Senior, Ph.D.

Multidrug-resistance in cancer; ATP synthesis in bacteria and mitochondria

William Simon

William Simon, Ph.D.

Optical pattern recognition of biological specimens