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Primary FacultySecondary FacultyEmeritus FacultyResearch Faculty

Primary Faculty

Mark DumontMark E. Dumont, Ph.D.

Signal transduction; membrane protein structure, yeast molecular biology
Dmitri ErmolenkoDmitri N. Ermolenko, Ph.D.

Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Elizabeth GrayhackElizabeth Grayhack, Ph.D.

Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Alan GrossfieldAlan M. Grossfield, Ph.D.

Investigating membranes and membrane proteins via computer simulation
Barry GoldsteinBarry M. Goldstein, M.D., Ph.D.

Crystallography and structural chemistry of enzyme-ligand interactions.
Clara KielkopfClara L. Kielkopf, Ph.D.

Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Xin LiXin Zhiguo Li, Ph.D.

Small non-coding RNA regulation in germ cells; paternal aging; transgenerational inheritance.
David MathewsDavid H. Mathews, M.D., Ph.D.

Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Lynne MaquatLynne Maquat, Ph.D.

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Joshua MungerJoshua C. Munger, Ph.D.

Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Kermit MercerKermit Ray Mercer, B.S.

Electron paramagnetic resonance (epr) research and instrumentation
Mitchell O'ConnellMitchell O'Connell, Ph.D.

Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Eric PhizickyEric Phizicky, Ph.D.

tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Harold SmithHarold C. Smith, Ph.D.

RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.
Joseph WedekindJoseph E. Wedekind, Ph.D.

Structure and function analysis of gene regulation by riboswitches and microRNAs as a basis for therapeutic development.
Yi-Tao YuYi-Tao Yu, Ph.D.

RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.

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Secondary Faculty

Scott ButlerScott Butler, Ph.D.

Regulation of Gene Expression by Targeted Degradation of RNA
Michael BulgerMichael D. Bulger, Ph.D.

Chromatin domains and long-range activation by enhancers
Gloria CulverGloria Culver, Ph.D.

Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.
Chin-To FongChin-To Fong, M.D.

Genetics of orofacial clefts
David GoldfarbDavid S. Goldfarb, Ph.D.

Molecular mechanisms that control the exchange of molecules and information between the nucleus and cytoplasm
Hartmut LandHartmut Land, Ph.D.

Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Benjamin MillerBenjamin L. Miller, Ph.D.

Carbohydrate and protein recognition, molecular design, and biomolecular sensing
J. PuzasJ. Edward Puzas, Ph.D.

Molecular and Cellular Biology of the Skeletal System
Richard WaughRichard E. Waugh, Ph.D.

Cell Adhesion, Mechanical and thermodynamic properties of biological membranes; cellular mechanics and function of cytoskeletal proteins
Jian ZhuJian Zhu, Ph.D.

Host-virus interactions, particularly for HIV and herpes viruses

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Emeritus Faculty

Robert BambaraRobert A. Bambara, Ph.D.

Human genome stability, DNA damage response, HIV replication and evolution
Thomas GunterThomas E. Gunter, Ph.D.

Membrane transport, bioenergetics, calcium regulation
Russell HilfRussell Hilf, Ph.D.

Hormone action in mammory cancer; Photodynamic therapy of neoplasia
George KimmichGeorge Kimmich, Ph.D.

Regulation of neurotransmitter uptake by glial and neuronal cells
Christopher LawrenceChristopher W. Lawrence, Ph.D.

Molecular biology of DNA-damage induced mutagenesis
Mahin MainesMahin Maines, Ph.D.

Heme oxygenases and second messenger gases: CO and NO.
Terry PlattTerry Platt, Ph.D.

Molecular mechanisms of gene expression; transcription termination and mRNA 3' and formation in Escherichia coli and yeast; protein-nucleic acid.
William SimonWilliam Simon, Ph.D.

Optical pattern recognition of biological specimens
Alan SeniorAlan E. Senior, Ph.D.

Multidrug-resistance in cancer; ATP synthesis in bacteria and mitochondria

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Research Faculty

Reyad ElbarbaryReyad Elbarbary, Ph.D.

Roles of retrotransposons and non-coding RNAs in post-transcriptional regulation of gene expression
Peter GibbsPeter E. M. Gibbs, Ph.D.

The role of human biliverdin reductase in cell signaling pathways, and the regulation of its expression in the cell.
Karlene GunterKarlene K. Gunter, Ph.D.

Role of mitochondria in calcium homeostasis, apoptosis and metabolic control
Fred HagenFred Hagen, Ph.D.

Glycosyltransferases, proteomics, role of glycosylation in development
Jermaine JenkinsJermaine Jenkins, Ph.D.

Crystallography of RNA and Protein-RNA complexes
Scott KennedyScott D. Kennedy, Ph.D.

NMR imaging and spectroscopy; Tumor biology; RNA structure determination; anion transport
Tatsuaki KurosakiTatsuaki Kurosaki, Ph.D.

mRNA quality control (or mRNA surveillance) in human cells, fragile X syndrome
Bin LiuBin Liu, Ph.D.

Regulation of mRNA stability of monocyte chemoattractant protein-1 (MCP-1) by PDGF and Angiotensin II (Ang II) in smooth muscle cells (SMC)
Tihomir MiralemTihomir Miralem, Ph.D.

Elizabeth MathewElizabeth Mathew, Ph.D.

Structure and functions of G protein coupled receptors (GPCRs), in particular, the yeast GPCR, Ste2p
Bogdan PolevodaBogdan Polevoda, Ph.D.

The two cotranslational processes, cleavage of N-terminal methionine and N-terminal acetylation (N- acetylation).
Maximilian PoppMaximilian Popp, Ph.D.

mRNA metabolism in mammalian cells
Elena Rustchenko-BulgacElena P. Rustchenko-Bulgac, Ph.D.

Chromosomes instability of human fungal pathogen Candida albicans.
Hironao WakabayashiHironao Wakabayashi, M.D., Ph.D

Structural and functional analyses of factor VIII

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