Faculty
Faculty
Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism. 
Bioinorganic and Biophysical Chemistry of Metalloproteins
Understanding the interaction of HIV with glial cells; Developing an improved live attenuated influenza vaccine (LAIV); Elucidating the host cell response to infection by viral pathogens (with emphasis on SARS-CoV-2 and Adeno-associated virus, AAV)
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
How RNA modifications impact neurodevelopment and disease.
Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.
Investigating membranes and membrane proteins via computer simulation
Cancer immunotherapy/Host immune response to influenza infection/ Inflammation biology of sepsis
Biomimetic nanoparticles, super-resolution microscopy, and bio-inspired photocatalysis
Mechanisms of neurotransmitter receptor function
Nuclear and cytoplasmic RNA metabolism in mammalian cells: Co- and post-transcriptional pre-mRNA processing; influence of pre-mRNA splicing on mRNA metabolism, including the structure and function of modular exon-junction complexes and effects of AKT-signaling; Nonsense-mediated mRNA decay; Fragile X Syndrome (FXS)/Autism/Intellectual disabilities; mRNP Structure and function in non-polar cells and in neurons; Development of FXS therapeutics.
Research in the Miller group centers on (1) photonic sensors, particularly with regard to continuous monitoring of microphysiological systems and biomanufacturing; (2) medical diagnostics, including paper-based point-of-care and self-tests for RNA viruses.
Defining how gene environment interactions shape alveolar lung development and the risk for lung disease over the lifespan.
Molecular mechanisms and spatiotemporal regulation of G protein-coupled receptor (GPCR) signaling pathways using cryo-electron microscopy (cryo-EM), biochemical, and pharmacologic studies; instrumentation and methods development in cryo-EM; structural biology of RNA/protein therapeutic targets and treatments.
The role of metabolism in lineage differentiation
Cellular and molecular mechanisms of heart development, disease, and regeneration; Transcriptional regulation of fibroblast plasticity and cardiac fibrosis
Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.
Understanding the neural circuit mechanisms that generate and shape complex feeding behaviors
Mechanism and physiological importance of alternative polyadenylation; Integrator Complex and transcriptional control, development and application of next-generation sequencing technologies
Pathophysiological function and molecular mechanism of new non-coding RNAs and RNA-binding proteins and translational control in cardiac system and cardiovascular disease
