EHSC Center Leadership & Administration
EHSC Charter Members
Therapeutic biomaterials development for tissue engineering and drug delivery with applications ranging from bone regeneration to antioral biofilm treatments
Research Interest: Defining the impact of environmental chemicals (e.g., metals and air pollution) on brain development and behavior, with emphasis on attributable risk to neurodevelopmental disorders.
Research Interest: Health effects of air pollution, with a current focus on the contribution of air pollution to individuals suffering from respiratory viral infections
Research Interest: Understanding the toxicological and biochemical properties of nanomaterial interactions with skin and the immune system; develop in vivo models to investigate nanoparticle skin penetration mechanisms, and develop novel biosensors to improve transdermal drug delivery and tissue engineering approaches.
Research Interest: Toxicology of inhaled ultrafine particles (UFPs) on the lung, cardiovascular and central nervous system
Research Interest: Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages.
Research Interest: Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Research Interest: Defining molecular pathways by which allergens and particulates activate epithelia and dendritic cells in the lung immune system
Research Interest: Asthma and Improving quality of care
Research Interest: Early origins research, linking in utero environment to later life health and educational attainment
Research Interest: Multivariate statistical methods for data analysis; Chemical characterization of ambient aerosol samples; Emissions and properties of solid biomass combustion systems; Characterization of source/receptor relationships for ambient air pollutants; Experimental studies of homogeneous, heterogeneous, and ion-induced nucleation; Indoor air quality; Exposure and risk assessment.
Research Interest: Environmental and Maternal and Child Health Epidemiology: Defining the impact of environmental chemicals on immunity and immune-mediated diseases and as a mechanism for susceptibility to other disease outcomes, such as neurobehavioral disorders.
Research Interest: Food allergies disorders, caused by milk, eggs and peanuts.
Research Interest: Community outreach and engagement, role of science in public decision-making
Research Interest: Influence of environmental factors on the development and function of the immune system
Research Interest: Epigenetic inheritance, small silencing non-coding RNAs, translational control, lead toxicity, and comparative genomics.
Research Interest: Investigating factors that both increase and decrease the risk of developing asthma, wheezing, and allergic disorders in childhood
Research Interest: Finding hidden groups and their meanings; latent variable modeling; methods and techniques for Bayesian solutions.
Genetic mechanisms of susceptibility to congenital and infectious lung diseases, focusing on developmental antecedents and the influence of environmental factors.
Research Interest: Developing and coordinating a wide variety of science education and outreach programs for students (elementary through high school), teachers, and the general community.
Research Interest: Identification of different stem and precursor cell pools in CNS that may be critical for cell replacement therapies or are targets of insults that lead to developmental pathologies.
Research Interest: Developing methods to estimate gene regulatory networks from gene perturbation experiments
Research Interest: Cell Motility, and Quantitative light microscopy
Research Interest: Epithelial injury and abnormal repair in pediatric and adult lung disease
Research Interest: Smoking Cessation in special populations, Technology/Web Assisted Risk Behavior Intervention and Dissemination of effective interventions to physician practices
The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.
Research Interest: Environmental toxins, specifically mercury; methyl mercury exposure
Research Interest: Neuro stem cell biology and medicine, developing pharmacological and cell based approaches to peripheral and spinal cord injury.
Research Interest: Defining neuro-inflammatory processes that contribute to pathology and disease progression in Alzheimer's disease, as well as late CNS effects following radiation exposure
Research Interest: The mechanisms by which early stress exposures, including prenatal maternal anxiety and caregiving stress, may persistently shape children's behavioral and biological health
Research Interest: Understanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan.
Research Interest: Univariate and multivariate survival analysis and in the analysis of multiple event-time data
Research Interest: Biokinetics, Effects and Mechanisms of Inhaled Micro- and Nano- Particles: Dosimetry, Risk Extrapolation and Risk Assessment
Behavioral medicine and outcomes management include tobacco use and smoking interventions, obesity prevention and exercise
Identify new targets susceptible to environmental perturbation in relevance with neurodevelopment or neurodegenerative diseases by utilizing functional genetics/genomics (RNAi and CRISPR screens and Next-Generation sequencing), and molecular benchwork. Discover the link between genetic polymorphism of the targets and neurological diseases. Explore novel roles of extracellular vesicles (EV) in receptor signaling and cell communication. Identify EV-encapsulated biomolecules released by the placenta in response to environmental perturbation. Explore the roles of placenta-derived EVs on neurodevelopment or neurodegeneration
Research Interest: Delineating multifactorial causes of respiratory morbidity in infants and young children, including environmental exposures on lung development, microbial infection and dysbiosis, and pulmonary immune responses; levering unique human lung and immune cell repositories that support the in vitro study of mechanisms of toxicity of environmental agents.
Research Interest: Molecular signals that govern osteoporosis and arthritis
Research Interest: Endothelial cell biology and lung physiology as it relates to molecular analysis of signal transduction and gene regulation in the lung epithelium.
Research Interest: Redox signaling mechanism of Proinflammatory gene expression in pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants.
Research Interest: Mechanisms of toxicity of the environmental contaminant and neurotoxicant methylmercury (MeHg), defining MeHg effects on early life development of neural and muscular systems at the molecular, cellular, and organismal levels using invertebrate and mammalian models, and detailed characterization of MeHg metabolism and elimination kinetics in humans.
Research Interest: Environmental, Cardiovascular, and Maternal and Child Health Epidemiology: Examining associations between air pollution and cardiopulmonary and pregnancy outcomes, examining mechanisms of such cardiopulmonary and pregnancy responses, and developing spatial-temporal models of air pollution to enable field studies of these biomarkers and clinical outcomes associated with residential air pollution exposure.
Research Interest: Experimental platform using the amphibian Xenopus for research in immunotoxicology, fundamental and medical immunology
Neurotoxicology, Etiology of neurobehavioral disease, Endocrine dysfunction, Synergistic Toxicity.
Research Interest: Studying epigenetic mechanisms underlying environment-induced adverse pregnancy and developmental outcomes, including how endocrine-disrupting chemicals change maternal health, mammalian reproduction, and the expression and function of imprinted genes.
Research Interest: Bayesian inference, modeling multiple outcomes, correction for measurement error bias, informative prior specification, latent variable models, and environmental health applications.
Research Interest: Multiple roles of virus-specific Band T cells in determining the outcome of viral infection of the respiratory tract. Long term protective effect of immunological mechanisms.
Research Interest: Discovering the effects of high (therapeutic) and low (environmentally-relevant) doses of radiation and their interactions with other toxic elements, such as commonly encountered infections, and better understanding differential effects of radiation in adults versus children.
Research Interest: Understanding the key molecular and cellular pathways involved in eye disease, with a particular focus on Thyroid Eye Disease (TED)
Research Interest: Molecular and signaling mechanisms of synaptic plasticity in memory formation and mental health
Research Interest: Risk stratification of cardiac death and on clinical usefulness and prognostic significance of ECG parameters
Research Interest: Environmental and Neurologic Epidemiology: Defining influences of environmental exposures, in particular toxic metals, on cognitive outcomes in children and adults.
Thomas Clarkson, Ph.D.
Philip Davidson, Ph.D.
Mark Frampton, M.D.
Thomas Gasiewicz, Ph.D.
Mark Utell, M.D.