David A. Dean, Ph.D.Email David
Delineating mechanisms that control DNA-protein complexes’ traffic through the cytoplasm, entry to the nucleus, and targeting to specific domains, and application of this to treat pulmonary diseases.
Alison Elder, Ph.D.Email Alison
Defining the impact of inhaled ambient and workplace nano-/ultrafine particle-containing aerosols on the lung, cardiovascular system, and central nervous system, and defining the toxicological properties of the particles that are associated with a response.
Fabeha Fazal, Ph.D.Email Fabeha
Understanding the role and regulation of actin-myosin interactions in endothelial cell (EC) inflammation, permeability, and apoptosis, especially in the settings of acute and chronic lung injury
Jacob N. Finkelstein, Ph.D.Email Jacob
Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages.
Steve Georas, M.D.Email Steve
Defining the role of environmental exposures on innate and adaptive immunity in asthma and other chronic lung diseases, with an emphasis on how particulate matter and endocrine disruptors act as risk factors.
B. Paige Lawrence, Ph.D.Email B. Paige
Delineating mechanisms by which environmental exposures during different life stages alter immune function; discovering how environmental factors modulate epigenetic programming of the developing immune system, and the consequences of these changes on susceptibility to infectious, allergic, or autoimmune disease later in life.
Gloria S. Pryhuber, M.D.Email Gloria
Delineating multifactorial causes of respiratory morbidity in infants and young children, including environmental exposures on lung development, microbial infection and dysbiosis, and pulmonary immune responses; levering unique human lung and immune cell repositories that support the in vitro study of mechanisms of toxicity of environmental agents.
Patricia Sime, M.D.Email Patricia
Conducting clinical and translational toxicology research focusing on the lung, from studies of silica and radiation in lung fibrosis, to the effects of biomass and cigarette smoke exposure on lung inflammation and resolution pathways, to identifying key pathophysiologic pathways and developing novel therapeutics for lung inflammation and fibrosis.