Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Research Interest: Effects of strain on pulmonary epithelium
Research Interest: Wnt signaling in cardiovascular development
Research Interest: Immunizations and infections in the premature infant
Research Interest: Molecular mechanisms of gene delivery and development of gene therapies for lung disease
Research Interest: Understanding how fluctuation in oxygen such as intermittent hypoxia and hyperoxia affect respiratory function in preterm neonates. Coupling oxygen exposures with exposure to viruses to see how they alter lung development in rodent models.
Research Interest: Toxicology of inhaled ultrafine particles (UFPs) on the lung, cardiovascular and central nervous system
Research Interest: Role and regulation of actin-myosin interactions in endothelial cell (EC) inflammation, permeability, and apoptosis in acute and chronic lung injury
Research Interest: Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages.
Defining molecular mechanisms for respiratory-virus induced epithelial barrier dysfunction; exploring the use of oscillometry in the diagnosis and management of airways disorders; and determining how race neutral PFT interpretation strategies impact the utility of spirometry
Research Interest: Pneumocystis carinii pneumonia; Infections in the immunocompromised host
Understanding the mechanisms by which the extracellular matrix protein, fibronectin, affects cell and tissue functions that are critical for wound repair. We study both the structural mechanisms and intracellular signaling events that mediate cell and tissue responses to matrix fibronectin. In turn, we are using this information to develop novel technologies for tissue engineering, and therapeutic approaches to promote tissue regeneration in chronic wounds.
Food allergies disorders, caused by milk, eggs and peanuts.
Research Interest: Investigating how novel receptor-based therapeutics modify cytokine production to mitigate lung injury and fibrosis
Research Interest: Influence of environmental factors on the development and function of the immune system
Research Interest: Investigating factors that both increase and decrease the risk of developing asthma, wheezing, and allergic disorders in childhood
Research Interest: Determining the therapeutic promise of engineered tRNAs for treatment of nonsense associated diseases and investigating the pathomechanisms of skeletal muscle weakness and wasting in myotonic dystrophy
Genetic mechanisms of susceptibility to congenital and infectious lung diseases, focusing on developmental antecedents and the influence of environmental factors.
Research Interest: Epithelial injury and abnormal repair in pediatric and adult lung disease
Research Interest: Understanding mechanisms of pathology in common inflammatory conditions of children
Research Interest: Understanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan.
Research Interest: Biokinetics, Effects and Mechanisms of Inhaled Micro- and Nano- Particles: Dosimetry, Risk Extrapolation and Risk Assessment
Research Interest: Team approaches to patient-centered, clinical and translational investigation in sepsis and critical illness
Research Interest: Delineating multifactorial causes of respiratory morbidity in infants and young children, including environmental exposures on lung development, microbial infection and dysbiosis, and pulmonary immune responses; levering unique human lung and immune cell repositories that support the in vitro study of mechanisms of toxicity of environmental agents.
Research Interest: Juvenile Idiopathic arthritis. Imaging of lymph nodes as a martyr for arthritic flare in RA, lymphangiogenesis in Arthritic flare in murine model of erosive arthritis.
Research Interest: Endothelial cell biology and lung physiology as it relates to molecular analysis of signal transduction and gene regulation in the lung epithelium.
Research Interest: Redox signaling mechanism of Proinflammatory gene expression in pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants.
Neonatal immunology; T cell function in preterm infants
Research Interest: Multiple roles of virus-specific Band T cells in determining the outcome of viral infection of the respiratory tract. Long term protective effect of immunological mechanisms.
Research Interest: Role of mitochondria in hypoxic pulmonary vasoconstriction.
Research Interest: Discovering the effects of high (therapeutic) and low (environmentally-relevant) doses of radiation and their interactions with other toxic elements, such as commonly encountered infections, and better understanding differential effects of radiation in adults versus children.
Research Interest: Immune response and Pathogenesis of lung injury and related pulmonary inflammation