Faculty

Research Interest: Pharmacology of brain and lymphocytic opioid receptors

Research Interest: Contribution of stem cells to the maturation, regeneration and lifelong maintenance of skeletal muscle in growth aging and cancer

Research Interest: Molecular Mechanisms of Calcium Signaling in Striated Muscle

Research Interest: Molecular biology of programmed cell death

Research Interest: Role of cell-cell contact in regulating cellular function in both the normal and disease state

Research Interest: Basal ganglia and degenerative diseases

Research Interest: Mechanism by which extracellular matrix protein, fibronectin affects cell and issue functions critical for would repair.

Research Interest: G protein coupled receptor signaling and modulation of ion channels in neurons

Research Interest: Mechanotransduction of musculoskeletal cells and associated human disease; Physiology and pathophysiology of mechanosensitive ion channels

Research Interest: Determining the therapeutic promise of engineered tRNAs for treatment of nonsense associated diseases and investigating the pathomechanisms of skeletal muscle weakness and wasting in myotonic dystrophy

Research Interest: Mechanisms of neurotransmitter receptor function

Research Interest: Orphan G protein coupled receptors in brain and visual systems

Research Interest: Regulation of tyrosine hydroxylase gene expression in the nervous system

Research Interest: Identification of relevant cutting-edge microscopy technologies for implementation at the University of Rochester. Application of quantitative imaging and analysis techniques to a variety of research projects.

Director, Center for Advanced Light Microscopy and Nanoscopy

Research Interest: Molecular and signaling mechanisms of synaptic plasticity in memory formation and mental health

Research Interest: Mechanisms Underlying Ca²⁺ Signaling Events in Exocrine Cells

Research Interest: Purinergic signaling in peripheral nociceptive nerve, neurovascular coupling, stroke injury and astrocytic communication

Research Interest: LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.

Research Interest: Signaling transduction mechanisms in the vascular system

Research Interest: Cardioprotection against ischemia-reperfusion (IR) injury. Role of Mitochondria and metabolism in ischemic preconditioning and anesthetic preconditioning.

Research Interest: Internal Medicine

Research Interest: Cellular and Molecular Mechanisms of Microenvironmental Regulation of Hematopoietic Stem Cells in the Bone Marrow

Research Interest: Function and activation of voltage-gated Ca²⁺ channel and molecular mechanisms of downstream Ca²⁺ signaling in non-excitable tissues.

Research Interest: Molecular basis of glucose sensing in the brain and beta cells

Research Interest: Molecular mechanisms of gene delivery and development of gene therapies for lung disease

Research Interest: Molecular mechanisms of neuropeptide signal transduction

Research Interest: Role of Mitochondria in regulation of cell fate in normal stem cells and cancer cells

Research Interest: Role and regulation of actin-myosin interactions in endothelial cell (EC) inflammation, permeability, and apoptosis in acute and chronic lung injury

Research Interest: Molecular pharmacology of neuronal signal transduction and ion channel activity

Research Interest: Androgen Effects on Reproduction and Cancer

Research Interest:

Synaptic pharmaco-physiology of vestibular efferent-afferent interactions

Research Interest: Molecular mechanisms of Neurodegeneration

Research Interest: Innate and adaptive immune responses and cancer immunotherapy

Research Interest: Human Structure and Function

Research Interest: Integrative Physiology

Research Interest: Mechanisms that control the development of the heart

Research Interest: Endothelial cell biology and lung physiology as it relates to molecular analysis of signal transduction and gene regulation in the lung epithelium.

Research Interest: Vascular Effects of Alcohol-role of Notch

Research Interest: Neuron-neuroglia interactions

Research Interest: Transcriptional regulation of fibroblast plasticity and cardiac fibrosis

Research Interest: Cell Adhesion, Mechanical and thermodynamic properties of biological membranes; cellular mechanics and function of cytoskeletal proteins

Research Interest: Role of mitochondria in hypoxic pulmonary vasoconstriction.

Research Interest: Optogenetics to study the roles of Reactive Oxygen Species (ROS) in mitochondrial physiology and stress signaling.

Research Interest: Metabolism and toxicity of halogen- and sulfur-containing chemicals and on the design and synthesis of mitochondrially targeted drugs

Research Interest: Neural and neuroendocrine control of cardiovascular function

Research Interest: Molecular Mechanisms of Cell Regulation

Research Interest: Gap junctions, connexins, cell communication, calmodulin, calcium, channel gating

Research Interest: Vascular cell communication and signaling

Research Interest: The nature of the conductances responsible for agonist-induced Ca2+ entry in non-excitable cells, and their roles in modulating overall Ca2+ signals