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Faculty

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Brian Altman
Research Interest: Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.

Douglas Anderson
Research Interest: LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.

Jean Bidlack
Research Interest: Pharmacology of brain and lymphocytic opioid receptors

Dirk Bohmann
Research Interest: The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease

Paul Boutz
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.

Kara Bren
Research Interest: Bioinorganic and Biophysical Chemistry of Metalloproteins

Paul Brookes
Research Interest: Cardioprotection against ischemia-reperfusion (IR) injury. Role of Mitochondria and metabolism in ischemic preconditioning and anesthetic preconditioning.

Michael Bulger
Research Interest: Chromatin domains and long-range activation by enhancers

Scott Butler
Research Interest: Regulation of Gene Expression by Targeted Degradation of RNA

Stephen Dewhurst
Research Interest: Influenza Viruses; Virus Polymerase HIV Vaccine Development; NeuroAIDS Research

Mark Dumont
Research Interest: Signal transduction; membrane protein structure, yeast molecular biology

Michael Elliott
Research Interest: Regulation of macrophage function in innate immunity

Dmitri Ermolenko
Research Interest: Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.

Dragony Fu
Research Interest: Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.

Sina Ghaemmaghami
Research Interest: Molecular mechanisms of prion propagation and pathogenesis

Vera Gorbunova
Research Interest: Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.

Elizabeth Grayhack
Research Interest: Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.

Alan Grossfield
Research Interest: Investigating membranes and membrane proteins via computer simulation

Jeffrey Hayes
Research Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function

Clara Kielkopf
Research Interest: Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.

Hartmut Land
Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism

Xin Li
Research Interest: Epigenetic inheritance, small silencing non-coding RNAs, translational control, lead toxicity, and comparative genomics.

John Lueck
Research Interest: Determining the therapeutic promise of engineered tRNAs for treatment of nonsense associated diseases and investigating the pathomechanisms of skeletal muscle weakness and wasting in myotonic dystrophy

David MacLean
Research Interest: Mechanisms of neurotransmitter receptor function

Lynne Maquat
Research Interest: RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.

David Mathews
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.

Anne Meyer
Research Interest: Bacterial stress response; 3D Printing of Bacteria; Biomaterials

Benjamin Miller
Research Interest: Carbohydrate and protein recognition, molecular design, and biomolecular sensing

Joshua Munger
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.

Patrick Murphy
Research Interest: The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.

Mitchell O'Connell
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development

Michael O'Reilly
Research Interest: Understanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan.

Catherine Ovitt
Research Interest: Protective and regenerative strategies for salivary gland function and radiation therapies.

Martin Pavelka
Research Interest: Biosynthesis of the Cell Wall of Mycobacterium tuberculosis; Biodefense Research

Archibald Perkins
Research Interest: Genetic mechanisms in acute myeloid leukemia and myelodysplastic syndrome with focus on the zinc finger oncoprotein EVI1

Eric Phizicky
Research Interest: tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.

Eric Small
Research Interest: Transcriptional regulation of fibroblast plasticity and cardiac fibrosis

Laurie Steiner
Research Interest: Utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development in both normal and disease states

Toru Takimoto
Research Interest: Molecular Mechanisms of Paramyxovirus Infection, Replication and Assembly

Charles Thornton
Research Interest: Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.

Joseph Wedekind
Research Interest: Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.

Andrew Wojtovich
Research Interest: Optogenetics to study the roles of Reactive Oxygen Species (ROS) in mitochondrial physiology and stress signaling.

Peng Yao
Research Interest: Pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease.

Yi-Tao Yu
Research Interest: RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.