Research Interest: Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Research Interest: LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.
Research Interest: Pharmacology of brain and lymphocytic opioid receptors
Research Interest: The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Research Interest: Bioinorganic and Biophysical Chemistry of Metalloproteins
Research Interest: Cardioprotection against ischemia-reperfusion (IR) injury. Role of Mitochondria and metabolism in ischemic preconditioning and anesthetic preconditioning.
Research Interest: Chromatin domains and long-range activation by enhancers
Research Interest: Regulation of Gene Expression by Targeted Degradation of RNA
Research Interest: Influenza Viruses; Virus Polymerase HIV Vaccine Development; NeuroAIDS Research
Research Interest: Signal transduction; membrane protein structure, yeast molecular biology
Research Interest: Regulation of macrophage function in innate immunity
Research Interest: Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Research Interest: Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Research Interest: Molecular mechanisms of prion propagation and pathogenesis
Research Interest: Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.
Research Interest: Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Research Interest: Investigating membranes and membrane proteins via computer simulation
Research Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function
Research Interest: Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Research Interest: Epigenetic inheritance, small silencing non-coding RNAs, translational control, lead toxicity, and comparative genomics.
Research Interest: Determining the therapeutic promise of engineered tRNAs for treatment of nonsense associated diseases and investigating the pathomechanisms of skeletal muscle weakness and wasting in myotonic dystrophy
Research Interest: Mechanisms of neurotransmitter receptor function
Research Interest: RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Research Interest: Bacterial stress response; 3D Printing of Bacteria; Biomaterials
Research Interest: Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Research Interest: The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.
Research Interest: Integrative Physiology
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Research Interest: Understanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan.
Research Interest: Protective and regenerative strategies for salivary gland function and radiation therapies.
Research Interest: Biosynthesis of the Cell Wall of Mycobacterium tuberculosis; Biodefense Research
Research Interest: Genetic mechanisms in acute myeloid leukemia and myelodysplastic syndrome with focus on the zinc finger oncoprotein EVI1
Research Interest: tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Research Interest: Transcriptional regulation of fibroblast plasticity and cardiac fibrosis
Research Interest: Utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development in both normal and disease states
Research Interest: Molecular Mechanisms of Paramyxovirus Infection, Replication and Assembly
Research Interest: Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.
Research Interest: Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Research Interest: Optogenetics to study the roles of Reactive Oxygen Species (ROS) in mitochondrial physiology and stress signaling.
Research Interest: Pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease.
Research Interest: RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.