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Doug Anderson, Ph.D.Doug Anderson, Ph.D.
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Medicine

LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.

Xin Bi, Ph.D.Xin Bi, Ph.D.
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Biology
Bi Lab

Chromatin-mediated regulation of gene expression in eukaryotes.

Dirk Bohmann, Ph.D.Dirk Bohmann, Ph.D.
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Biomedical Genetics
Bohmann Lab

The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease

Kara Bren, Ph.D.Kara L. Bren, Ph.D.
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Chemistry
Bren Lab

Bioinorganic and Biophysical Chemistry of Metalloproteins

Paul Brookes, Ph.D.Paul S. Brookes, Ph.D.
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Anesthesiology
Brookes Lab

Mitochondria and free radicals in cardiac ischemia-reperfusion

Michael Bulger, Ph.D.Michael D. Bulger, Ph.D.
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Pediatrics
Bulger Lab

Chromatin domains and long-range activation by enhancers

Scott Butler, Ph.D.Scott Butler, Ph.D.
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Microbiology & Immunology
Butler Lab

Regulation of Gene Expression by Targeted Degradation of RNA

Gloria Culver, Ph.D.Gloria Culver, Ph.D.
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Biology
Culver Lab

Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.

Stephen Dewhurst, Ph.D.Stephen Dewhurst, Ph.D.
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Microbiology & Immunology
Dewhurst Lab

Influenza Viruses; Virus Polymerase HIV Vaccine Development; NeuroAIDS Research

Mark Dumont, Ph.D.Mark E. Dumont, Ph.D.
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Biochemistry & Biophysics
Dumont Lab

Signal transduction; membrane protein structure, yeast molecular biology

Paul Dunman, Ph.D.Paul Dunman, Ph.D.
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Microbiology & Immunology
Dunman Lab

Antimicrobial drug discovery using pathogenic Staphylococcus aureus and Acinetobacter baumannii: exploiting components of the bacterial RNA metabolism machinery; characterizing prokaryotic ribonucleases; understanding the impact of the host environment on antibiotic resistance and virulence factor expression.

Michael Elliott, Ph.D.Michael R. Elliott, Ph.D.
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Microbiology & Immunology
Elliott Lab

Regulation of macrophage function in innate immunity

Dmitri Ermolenko, Ph.D.Dmitri N. Ermolenko, Ph.D.
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Biochemistry & Biophysics
Ermolenko Lab

Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.

Dragony Fu, Ph.D.Dragony Fu, Ph.D.
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Biology
Fu Lab

Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.

Sina Ghaemmaghami, Ph.D.Sina Ghaemmaghami, Ph.D.
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Biology
Ghaemmaghami Lab

Molecular mechanisms of prion propagation and pathogenesis

Vera Gorbunova, Ph.D.Vera Gorbunova, Ph.D.
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Biology
Gorbunova Lab

Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.

Elizabeth Grayhack, Ph.D.Elizabeth Grayhack, Ph.D.
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Biochemistry & Biophysics
Grayhack Lab

Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.

Alan Grossfield, Ph.D.Alan M. Grossfield, Ph.D.
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Biochemistry & Biophysics
Grossfield Lab

Investigating membranes and membrane proteins via computer simulation

Jeffrey Hayes, Ph.D.Jeffrey J. Hayes, Ph.D.
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Biochemistry & Biophysics
William A. Bernhard Memorial Lab
Hayes Lab

DNA structure; chromatin; protein-DNA interactions

Paul Kammermeier, Ph.D.Paul J. Kammermeier, Ph.D.
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Pharmacology & Physiology
Kammermeier Lab

G protein coupled receptor signaling and modulation of ion channels in neurons

Clara Kielkopf, Ph.D.Clara L. Kielkopf, Ph.D.
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Biochemistry & Biophysics
Kielkopf Lab

Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.

Hartmut Land, Ph.D.Hartmut Land, Ph.D.
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Biomedical Genetics
Land Lab

Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism

Lynne Maquat, Ph.D.Lynne Maquat, Ph.D.
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Biochemistry & Biophysics
Maquat Lab

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.

Luis Martinez-Sobrido, Ph.D.Luis Martinez-Sobrido, Ph.D.
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Microbiology & Immunology
Martinez-Sobrido Lab

Molecular biology, immunology, and pathogenesis of negative-stranded viruses (Influenza viruses, Respiratory Syncytial Virus, Metapneumovirus, Arenavirus, Thogoto virus, Ebola virus, Crimean Congo Hemorrhagic Fever virus), positive-stranded viruses (Dengue virus, SARS coronavirus, Hepatitis virus), and RNA and DNA (cytomegalovirus and vaccinia virus)

David Mathews, M.D., Ph.D.David H. Mathews, M.D., Ph.D.
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Biochemistry & Biophysics
Mathews Lab

Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.

Benjamin Miller, Ph.D.Benjamin L. Miller, Ph.D.
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Dermatology
Benjamin Miller Lab

Carbohydrate and protein recognition, molecular design, and biomolecular sensing

Joshua Munger, Ph.D.Joshua C. Munger, Ph.D.
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Biochemistry & Biophysics
Munger Lab

Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.

Keith Nehrke, Ph.D.Keith Webster Nehrke, Ph.D.
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Medicine
Nehrke Lab

Integrative Physiology

Mitchell O'Connell, Ph.D.Mitchell O'Connell, Ph.D.
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Biochemistry & Biophysics
O'Connell Lab

Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development

Michael O'Reilly, Ph.D.Michael A. O'Reilly, Ph.D.
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Pediatrics
O'Reilly Lab

Understanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan.

Catherine Ovitt, Ph.D.Catherine E. Ovitt, Ph.D.
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Biomedical Genetics
Ovitt Lab

Analysis of Genes Involved in Salivary Gland Function

Archibald Perkins, M.D., Ph.D.Archibald S. Perkins, M.D., Ph.D.
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Pathology & Laboratory Medicine
Perkins Lab

Genes that impact the development of leukemias and other human malignancies

Richard Phipps, Ph.D.Richard Phipps, Ph.D.
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Environmental Medicine
Phipps Lab

Investigating how environmental factors shape diseases involving immune and inflammatory components, including platelets, B cells, and lipid mediators, defining abnormal inflammatory and wound healing responses in the eye and lung, delineating molecular signaling in fibroblasts.

Eric Phizicky, Ph.D.Eric Phizicky, Ph.D.
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Biochemistry & Biophysics
Phizicky Lab

tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.

Elaine Sia, Ph.D.Elaine Sia, Ph.D.
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Biology
Sia Lab

Mutagenesis and repair of the mitochondrial genome.

Eric Small, Ph.D.Eric M. Small, Ph.D.
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Medicine
Small Lab

Understanding how a cell can interpret biomechanical and humoral signals and activate a discrete transcriptional program during development or in response to injury.

Harold Smith, Ph.D.Harold C. Smith, Ph.D.
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Biochemistry & Biophysics
Smith Lab

RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.

Laurie Steiner, M.D.Laurie A. Steiner, M.D.
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Pediatrics
Medicine
Steiner Lab

Pediatric Biomedical Research

Charles Thornton, M.D.Charles A. Thornton, M.D.
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Neurology
Thornton Lab

Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.

Joseph Wedekind, Ph.D.Joseph E. Wedekind, Ph.D.
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Biochemistry & Biophysics
Wedekind Lab

Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.

Andrew Wojtovich, Ph.D.Andrew Wojtovich, Ph.D.
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Anesthesiology

Optogenetics to study the roles of Reactive Oxygen Species (ROS) in mitochondrial physiology and stress signaling.

Peng Yao, Ph.D.Peng Yao, Ph.D.
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Medicine
Yao Lab

Pathophysiological function of microRNAs, RNA-binding proteins, and defects in protein synthesis in cardiovascular disease; RNA riboswitch-like mechanisms of gene regulation

Yi-Tao Yu, Ph.D.Yi-Tao Yu, Ph.D.
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Biochemistry & Biophysics
Yu Lab

RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.

Jian Zhu, Ph.D.Jian Zhu, Ph.D.
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Microbiology & Immunology
Zhu Lab

Host-virus interactions, particularly for HIV and herpes viruses