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Faculty

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Brian Altman
Research Interest:

Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism. 

Douglas Anderson
Research Interest: LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.

Jean Bidlack
Research Interest: Pharmacology of brain and lymphocytic opioid receptors

Paul Boutz
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.

Kara Bren
Research Interest:

Bioinorganic and Biophysical Chemistry of Metalloproteins

Paul Brookes
Research Interest: Cardioprotection against ischemia-reperfusion (IR) injury. Role of Mitochondria and metabolism in ischemic preconditioning and anesthetic preconditioning.

Stephen Dewhurst
Research Interest:

Understanding the interaction of HIV with glial cells; Developing an improved live attenuated influenza vaccine (LAIV); Elucidating the host cell response to infection by viral pathogens (with emphasis on SARS-CoV-2 and Adeno-associated virus, AAV)

Dmitri Ermolenko
Research Interest: Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.

Dragony Fu
Research Interest: Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.

Sina Ghaemmaghami
Research Interest: Molecular mechanisms of prion propagation and pathogenesis

Steven Gill
Research Interest: Microbial pathogens and the impact of human microbial flora on human health and disease.

Vera Gorbunova
Research Interest:

Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.

Alan Grossfield
Research Interest:

Investigating membranes and membrane proteins via computer simulation

Jeffrey Hayes
Research Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function

Clara Kielkopf
Research Interest: Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.

Todd Krauss
Research Interest:

Biomimetic nanoparticles, super-resolution microscopy, and bio-inspired photocatalysis

Amanda Larracuente
Research Interest: Satellite DNA (repetitive DNA typically found at centromeres and telomeres), Meiotic Drive, and Selfish DNA using genomic, population genetic, molecular and cytological methods.

John Lueck
Research Interest: Determining the therapeutic promise of engineered tRNAs for treatment of nonsense associated diseases and investigating the pathomechanisms of skeletal muscle weakness and wasting in myotonic dystrophy

David MacLean
Research Interest:

Mechanisms of neurotransmitter receptor function

Lynne Maquat
Research Interest:

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.

David Mathews
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.

Anne Meyer
Research Interest: Bacterial stress response; 3D Printing of Bacteria; Biomaterials

Benjamin Miller
Research Interest:

Carbohydrate and protein recognition, molecular design, and biomolecular sensing

Joshua Munger
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.

Patrick Murphy
Research Interest:

The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.

Mitchell O'Connell
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development

Michael O'Reilly
Research Interest: Understanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan.

Eric Small
Research Interest:

To better understand the mechanisms that control cell identity and lineage commitment by studying the transcriptional regulation and function of cardiac tissue-restricted genes

Laurie Steiner
Research Interest:

Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.

Charles Thornton
Research Interest: Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.

Paula Vertino
Research Interest: Cancer epigenetics: the role of DNA methylation and chromatin in driving cancer phenotypes and as a target for therapeutic intervention

Eric Wagner
Research Interest:

Mechanism and physiological importance of alternative polyadenylation; Integrator Complex and transcriptional control, development and application of next-generation sequencing technologies

Joseph Wedekind
Research Interest: Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.

Andrew Wojtovich
Research Interest: Optogenetics to study the roles of Reactive Oxygen Species (ROS) in mitochondrial physiology and stress signaling.

Peng Yao
Research Interest:

Pathophysiological function and molecular mechanism of new non-coding RNAs and RNA-binding proteins and translational control in cardiac system and cardiovascular disease

Yi-Tao Yu
Research Interest: RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.