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Doug Anderson, Ph.D.Doug Anderson, Ph.D.
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Anderson Lab

LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.
Jean Bidlack, Ph.D.Jean M. Bidlack, Ph.D.
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Pharmacology & Physiology
Bidlack Lab

Pharmacology of brain and lymphocytic opioid receptors
Dirk Bohmann, Ph.D.Dirk Bohmann, Ph.D.
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Biomedical Genetics
Bohmann Lab

The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease
Paul Boutz, Ph.D.Paul L. Boutz, Ph.D.
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Biochemistry & Biophysics
Boutz Lab

Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Kara Bren, Ph.D.Kara L. Bren, Ph.D.
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Bren Lab

Bioinorganic and Biophysical Chemistry of Metalloproteins
Paul Brookes, Ph.D.Paul S. Brookes, Ph.D.
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Brookes Lab

Mitochondria and free radicals in cardiac ischemia-reperfusion
Michael Bulger, Ph.D.Michael D. Bulger, Ph.D.
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Bulger Lab

Chromatin domains and long-range activation by enhancers
Scott Butler, Ph.D.Scott Butler, Ph.D.
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Microbiology & Immunology
Butler Lab

Regulation of Gene Expression by Targeted Degradation of RNA
Stephen Dewhurst, Ph.D.Stephen Dewhurst, Ph.D.
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Microbiology & Immunology
Dewhurst Lab

Influenza Viruses; Virus Polymerase HIV Vaccine Development; NeuroAIDS Research
Mark Dumont, Ph.D.Mark E. Dumont, Ph.D.
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Biochemistry & Biophysics
Dumont Lab

Signal transduction; membrane protein structure, yeast molecular biology
Michael Elliott, Ph.D.Michael R. Elliott, Ph.D.
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Microbiology & Immunology
Elliott Lab

Regulation of macrophage function in innate immunity
Dmitri Ermolenko, Ph.D.Dmitri N. Ermolenko, Ph.D.
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Biochemistry & Biophysics
Ermolenko Lab

Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Dragony Fu, Ph.D.Dragony Fu, Ph.D.
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Fu Lab

Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Sina Ghaemmaghami, Ph.D.Sina Ghaemmaghami, Ph.D.
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Ghaemmaghami Lab

Molecular mechanisms of prion propagation and pathogenesis
Vera Gorbunova, Ph.D.Vera Gorbunova, Ph.D.
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Gorbunova Lab

Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.
Elizabeth Grayhack, Ph.D.Elizabeth Grayhack, Ph.D.
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Biochemistry & Biophysics
Grayhack Lab

Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Alan Grossfield, Ph.D.Alan M. Grossfield, Ph.D.
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Biochemistry & Biophysics
Grossfield Lab

Investigating membranes and membrane proteins via computer simulation
Clara Kielkopf, Ph.D.Clara L. Kielkopf, Ph.D.
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Biochemistry & Biophysics
Kielkopf Lab

Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Hartmut Land, Ph.D.Hartmut Land, Ph.D.
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Biomedical Genetics
Land Lab

Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Xin Li, Ph.D.Xin Zhiguo Li, Ph.D.
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Biochemistry & Biophysics
Li Lab

Our research is to define the RNA functions in reproduction and transgenerational epigenetic inheritance.
John Lueck, Ph.D.John D. Lueck, Ph.D.
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Pharmacology & Physiology
Lueck Lab

Use of engineered tRNAs for suppression of nonsense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) transcripts as therapeutic intervention for cystic fibrosis
David MacLean, Ph.D.David MacLean, Ph.D.
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Pharmacology & Physiology
MacLean Lab

Mechanisms of neurotransmitter receptor function
Lynne Maquat, Ph.D.Lynne Maquat, Ph.D.
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Biochemistry & Biophysics
Maquat Lab

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Luis Martinez-Sobrido, Ph.D.Luis Martinez-Sobrido, Ph.D.
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Microbiology & Immunology
Martinez-Sobrido Lab
Program for Advanced Immune Bioimaging

Molecular biology, immunology, and pathogenesis of negative-stranded viruses (Influenza viruses, Respiratory Syncytial Virus, Metapneumovirus, Arenavirus, Thogoto virus, Ebola virus, Crimean Congo Hemorrhagic Fever virus), positive-stranded viruses (Dengue virus, SARS coronavirus, Hepatitis virus), and RNA and DNA (cytomegalovirus and vaccinia virus)
David Mathews, M.D., Ph.D.David H. Mathews, M.D., Ph.D.
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Biochemistry & Biophysics
Mathews Lab

Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Benjamin Miller, Ph.D.Benjamin L. Miller, Ph.D.
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Benjamin Miller Lab

Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Joshua Munger, Ph.D.Joshua C. Munger, Ph.D.
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Biochemistry & Biophysics
Munger Lab

Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Patrick Murphy, Ph.D.Patrick J. Murphy, Ph.D.
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Biomedical Genetics
Murphy Lab

The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.
Mitchell O'Connell, Ph.D.Mitchell O'Connell, Ph.D.
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Biochemistry & Biophysics
O'Connell Lab

Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Michael O'Reilly, Ph.D.Michael A. O'Reilly, Ph.D.
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O'Reilly Lab

Understanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan.
Catherine Ovitt, Ph.D.Catherine E. Ovitt, Ph.D.
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Biomedical Genetics
Ovitt Lab

Analysis of Genes Involved in Salivary Gland Function
Martin Pavelka, Ph.D.Martin Pavelka, Ph.D.
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Microbiology & Immunology
Pavelka Lab

Biosynthesis of the Cell Wall of Mycobacterium tuberculosis; Biodefense Research
Archibald Perkins, M.D., Ph.D.Archibald S. Perkins, M.D., Ph.D.
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Pathology & Laboratory Medicine
Perkins / Zhang Lab

Genes that impact the development of leukemias and other human malignancies
Eric Phizicky, Ph.D.Eric Phizicky, Ph.D.
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Biochemistry & Biophysics
Phizicky Lab

tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Eric Small, Ph.D.Eric M. Small, Ph.D.
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Small Lab

Understanding how a cell can interpret biomechanical and humoral signals and activate a discrete transcriptional program during development or in response to injury.
Charles Thornton, M.D.Charles A. Thornton, M.D.
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Thornton Lab

Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.
Joseph Wedekind, Ph.D.Joseph E. Wedekind, Ph.D.
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Biochemistry & Biophysics
Wedekind Lab

Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Andrew Wojtovich, Ph.D.Andrew Wojtovich, Ph.D.
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Optogenetics to study the roles of Reactive Oxygen Species (ROS) in mitochondrial physiology and stress signaling.
Peng Yao, Ph.D.Peng Yao, Ph.D.
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Yao Lab

Pathophysiological function of microRNAs, RNA-binding proteins, and defects in protein synthesis in cardiovascular disease; RNA riboswitch-like mechanisms of gene regulation
Yi-Tao Yu, Ph.D.Yi-Tao Yu, Ph.D.
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Biochemistry & Biophysics
Yu Lab

RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.