Doug Anderson, Ph.D.
MedicineLncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.
Xin Bi, Ph.D.
BiologyChromatin-mediated regulation of gene expression in eukaryotes.
Dirk Bohmann, Ph.D.
Biomedical GeneticsThe biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease
Kara L. Bren, Ph.D.
ChemistryBioinorganic and Biophysical Chemistry of Metalloproteins
Paul S. Brookes, Ph.D.
AnesthesiologyMitochondria and free radicals in cardiac ischemia-reperfusion
Michael D. Bulger, Ph.D.
PediatricsChromatin domains and long-range activation by enhancers
Scott Butler, Ph.D.
Microbiology & ImmunologyRegulation of Gene Expression by Targeted Degradation of RNA
Gloria Culver, Ph.D.
BiologyAssembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.
Stephen Dewhurst, Ph.D.
Microbiology & ImmunologyInfluenza Viruses; Virus Polymerase HIV Vaccine Development; NeuroAIDS Research
Mark E. Dumont, Ph.D.
Biochemistry & BiophysicsSignal transduction; membrane protein structure, yeast molecular biology
Paul Dunman, Ph.D.
Microbiology & ImmunologyAntimicrobial drug discovery using pathogenic Staphylococcus aureus and Acinetobacter baumannii: exploiting components of the bacterial RNA metabolism machinery; characterizing prokaryotic ribonucleases; understanding the impact of the host environment on antibiotic resistance and virulence factor expression.
Michael R. Elliott, Ph.D.
Microbiology & ImmunologyRegulation of macrophage function in innate immunity
Dmitri N. Ermolenko, Ph.D.
Biochemistry & BiophysicsStructural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Dragony Fu, Ph.D.
BiologyNucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Sina Ghaemmaghami, Ph.D.
BiologyMolecular mechanisms of prion propagation and pathogenesis
Vera Gorbunova, Ph.D.
BiologyMechanisms of aging and the role of DNA repair and genomic instability in the aging process.
Elizabeth Grayhack, Ph.D.
Biochemistry & BiophysicsRole of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Alan M. Grossfield, Ph.D.
Biochemistry & BiophysicsInvestigating membranes and membrane proteins via computer simulation
Jeffrey J. Hayes, Ph.D.
Biochemistry & BiophysicsDNA structure; chromatin; protein-DNA interactions
William A. Bernhard Memorial Lab
Paul J. Kammermeier, Ph.D.
Pharmacology & PhysiologyG protein coupled receptor signaling and modulation of ion channels in neurons
Clara L. Kielkopf, Ph.D.
Biochemistry & BiophysicsSplicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Hartmut Land, Ph.D.
Biomedical GeneticsMolecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Lynne Maquat, Ph.D.
Biochemistry & BiophysicsRNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Luis Martinez-Sobrido, Ph.D.
Microbiology & ImmunologyMolecular biology, immunology, and pathogenesis of negative-stranded viruses (Influenza viruses, Respiratory Syncytial Virus, Metapneumovirus, Arenavirus, Thogoto virus, Ebola virus, Crimean Congo Hemorrhagic Fever virus), positive-stranded viruses (Dengue virus, SARS coronavirus, Hepatitis virus), and RNA and DNA (cytomegalovirus and vaccinia virus)
David H. Mathews, M.D., Ph.D.
Biochemistry & BiophysicsComputational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Benjamin L. Miller, Ph.D.
DermatologyCarbohydrate and protein recognition, molecular design, and biomolecular sensing
Benjamin Miller Lab
Joshua C. Munger, Ph.D.
Biochemistry & BiophysicsMechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Keith Webster Nehrke, Ph.D.
Mitchell O'Connell, Ph.D.
Biochemistry & BiophysicsBiochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Michael A. O'Reilly, Ph.D.
PediatricsUnderstanding how an aberrant oxygen environment at birth disrupts development of the lung and heart, leading to persistent functional changes over the lifespan.
Catherine E. Ovitt, Ph.D.
Biomedical GeneticsAnalysis of Genes Involved in Salivary Gland Function
Archibald S. Perkins, M.D., Ph.D.
Pathology & Laboratory MedicineGenes that impact the development of leukemias and other human malignancies
Richard Phipps, Ph.D.
Environmental MedicineInvestigating how environmental factors shape diseases involving immune and inflammatory components, including platelets, B cells, and lipid mediators, defining abnormal inflammatory and wound healing responses in the eye and lung, delineating molecular signaling in fibroblasts.
Eric Phizicky, Ph.D.
Biochemistry & BiophysicstRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Elaine Sia, Ph.D.
BiologyMutagenesis and repair of the mitochondrial genome.
Eric M. Small, Ph.D.
MedicineUnderstanding how a cell can interpret biomechanical and humoral signals and activate a discrete transcriptional program during development or in response to injury.
Harold C. Smith, Ph.D.
Biochemistry & BiophysicsRNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.
Laurie A. Steiner, M.D.
PediatricsPediatric Biomedical Research
Charles A. Thornton, M.D.
NeurologyMyotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.
Joseph E. Wedekind, Ph.D.
Biochemistry & BiophysicsStructure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Andrew Wojtovich, Ph.D.
AnesthesiologyOptogenetics to study the roles of Reactive Oxygen Species (ROS) in mitochondrial physiology and stress signaling.
Peng Yao, Ph.D.
MedicinePathophysiological function of microRNAs, RNA-binding proteins, and defects in protein synthesis in cardiovascular disease; RNA riboswitch-like mechanisms of gene regulation
Yi-Tao Yu, Ph.D.
Biochemistry & BiophysicsRNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.
Jian Zhu, Ph.D.
Microbiology & ImmunologyHost-virus interactions, particularly for HIV and herpes viruses