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Xin Bi, Ph.D.
Xin Bi, Ph.D.
Associate Professor

Biology

Bi Lab

Chromatin-mediated regulation of gene expression in eukaryotes.
Dirk Bohmann, Ph.D.
Dirk Bohmann, Ph.D.
Professor

Biomedical Genetics

Bohmann Lab

The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease
Paul Brookes, Ph.D.
Paul S. Brookes, Ph.D.
Associate Professor

Anesthesiology

Brookes Lab

Mitochondria and free radicals in cardiac ischemia-reperfusion
Michael Bulger, Ph.D.
Michael D. Bulger, Ph.D.
Associate Professor

Pediatrics

Bulger Lab

Chromatin domains and long-range activation by enhancers
J. Butler, Ph.D.
J. Scott Butler, Ph.D.
Associate Professor

Microbiology & Immunology

Butler Lab

Regulation of Gene Expression by Targeted Degradation of RNA
Gloria Culver, Ph.D.
Gloria Culver, Ph.D.
Professor
Chair

Biology

Culver Lab

Assembly of the <em>E. coli</em> 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.
Ian Dickerson, Ph.D.
Ian Dickerson, Ph.D.
Associate Professor

Neuroscience

Dickerson Lab

Molecular mechanisms of neuropeptide signal transduction
Mark Dumont, Ph.D.
Mark E. Dumont, Ph.D.
Professor

Biochemistry & Biophysics

Dumont Lab

Signal transduction; membrane protein structure, yeast molecular biology
Dmitri Ermolenko, Ph.D.
Dmitri N. Ermolenko, Ph.D.
Assistant Professor

Biochemistry & Biophysics

Ermolenko Lab

Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Sina Ghaemmaghami, Ph.D.
Sina Ghaemmaghami, Ph.D.
Assistant Professor

Biology

Ghaemmaghami Lab

Molecular mechanisms of prion propagation and pathogenesis
David Goldfarb, Ph.D.
David S. Goldfarb, Ph.D.
Professor

Biology

Goldfarb Lab

Molecular mechanisms that control the exchange of molecules and information between the nucleus and cytoplasm
Vera Gorbunova, Ph.D.
Vera Gorbunova, Ph.D.
Professor

Biology

Gorbunova Lab

Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.
Elizabeth Grayhack, Ph.D.
Elizabeth Grayhack, Ph.D.
Associate Professor

Biochemistry & Biophysics

Grayhack Lab

Role of the genetic code in regulating protein synthesis and mRNA metabolism in <em>Saccharomyces cerevisiae</em>.
Alan Grossfield, Ph.D.
Alan M. Grossfield, Ph.D.
Associate Professor

Biochemistry & Biophysics

Grossfield Lab

Investigating membranes and membrane proteins via computer simulation
Jeffrey Hayes, Ph.D.
Jeffrey J. Hayes, Ph.D.
Professor
Chair

Biochemistry & Biophysics

William A. Bernhard Memorial Lab

Hayes Lab

DNA structure; chromatin; protein-DNA interactions
Clara Kielkopf, Ph.D.
Clara L. Kielkopf, Ph.D.
Associate Professor

Biochemistry & Biophysics

Kielkopf Lab

Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Hartmut Land, Ph.D.
Hartmut Land, Ph.D.
Professor
Chair

Biomedical Genetics

Land Lab

Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Xin Li, Ph.D.
Xin Zhiguo Li, Ph.D.
Assistant Professor

Biochemistry & Biophysics

Li Lab

Small non-coding RNA regulation in germ cells; paternal aging; transgenerational inheritance.
Mahin Maines, Ph.D.
Mahin Maines, Ph.D.
Professor Emeritus

Biochemistry & Biophysics

Maines Lab

Heme oxygenases and second messenger gases: CO and NO.
Lynne Maquat, Ph.D.
Lynne Maquat, Ph.D.
Professor

Biochemistry & Biophysics

Maquat Lab

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
David Mathews, M.D., Ph.D.
David H. Mathews, M.D., Ph.D.
Associate Professor

Biochemistry & Biophysics

Mathews Lab

Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Margot Mayer-Pröschel, Ph.D.
Margot Mayer-Pröschel, Ph.D.
Associate Professor

Biomedical Genetics

Mayer-Pröschel Lab

Stem Cells in the mammalian CNS / Gestational insults and embryonic CNS development / Astrocyte dysfunction
Benjamin Miller, Ph.D.
Benjamin L. Miller, Ph.D.
Professor

Dermatology

Benjamin Miller Lab

Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Joshua Munger, Ph.D.
Joshua C. Munger, Ph.D.
Associate Professor

Biochemistry & Biophysics

Munger Lab

Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Archibald Perkins, M.D., Ph.D.
Archibald S. Perkins, M.D., Ph.D.
Professor

Pathology & Laboratory Medicine

Perkins Lab

Genes that impact the development of leukemias and other human malignancies
Eric Phizicky, Ph.D.
Eric Phizicky, Ph.D.
Professor

Biochemistry & Biophysics

Phizicky Lab

tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Elaine Sia, Ph.D.
Elaine Sia, Ph.D.
Associate Professor

Biology

Sia Lab

Mutagenesis and repair of the mitochondrial genome.
Harold Smith, Ph.D.
Harold C. Smith, Ph.D.
Professor

Biochemistry & Biophysics

Smith Lab

RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.
Laurie Steiner, M.D.
Laurie A. Steiner, M.D.
Assistant Professor
Professor

Pediatrics
Medicine

Steiner Lab

Pediatric Biomedical Research
Douglas Turner, Ph.D.
Douglas H. Turner, Ph.D.
Professor

Chemistry

Turner Lab

Biophysical chemistry of RNA folding/stacking using NMR; RNA-targeted therapeutics
Joseph Wedekind, Ph.D.
Joseph E. Wedekind, Ph.D.
Professor

Biochemistry & Biophysics

Wedekind Lab

Structure and function analysis of gene regulation by riboswitches and microRNAs as a basis for therapeutic development.
Yi-Tao Yu, Ph.D.
Yi-Tao Yu, Ph.D.
Professor

Biochemistry & Biophysics

Yu Lab

RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.
Jiyong Zhao, Ph.D.
Jiyong Zhao, Ph.D.
Associate Professor

Biomedical Genetics

Zhao Lab

Signal transduction and development of therapeutic agents in B-lymphomas; Cell cycle regulation
Jian Zhu, Ph.D.
Jian Zhu, Ph.D.
Assistant Professor

Microbiology & Immunology

Zhu Lab

Host-virus interactions, particularly for HIV and herpes viruses