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Xin Bi, Ph.D.
Xin Bi, Ph.D.
Associate Professor

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Bi Lab

Biology
Chromatin-mediated regulation of gene expression in eukaryotes.
Dirk Bohmann, Ph.D.
Dirk Bohmann, Ph.D.
Professor

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Bohmann Lab

Biomedical Genetics
The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease
Paul Brookes, Ph.D.
Paul S. Brookes, Ph.D.
Associate Professor

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Brookes Lab

Anesthesiology
Mitochondria and free radicals in cardiac ischemia-reperfusion
Michael Bulger, Ph.D.
Michael D. Bulger, Ph.D.
Associate Professor

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Bulger Lab

Pediatrics
Chromatin domains and long-range activation by enhancers
Scott Butler, Ph.D.
Scott Butler, Ph.D.
Associate Professor

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Butler Lab

Microbiology & Immunology
Regulation of Gene Expression by Targeted Degradation of RNA
Gloria Culver, Ph.D.
Gloria Culver, Ph.D.
Professor
Chair

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Culver Lab

Biology
Assembly of the <em>E. coli</em> 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.
Ian Dickerson, Ph.D.
Ian Dickerson, Ph.D.
Associate Professor

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Dickerson Lab

Neuroscience
Molecular mechanisms of neuropeptide signal transduction
Mark Dumont, Ph.D.
Mark E. Dumont, Ph.D.
Professor

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Dumont Lab

Biochemistry & Biophysics
Signal transduction; membrane protein structure, yeast molecular biology
Dmitri Ermolenko, Ph.D.
Dmitri N. Ermolenko, Ph.D.
Assistant Professor

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Ermolenko Lab

Biochemistry & Biophysics
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Sina Ghaemmaghami, Ph.D.
Sina Ghaemmaghami, Ph.D.
Assistant Professor

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Ghaemmaghami Lab

Biology
Molecular mechanisms of prion propagation and pathogenesis
David Goldfarb, Ph.D.
David S. Goldfarb, Ph.D.
Professor

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Goldfarb Lab

Biology
Molecular mechanisms that control the exchange of molecules and information between the nucleus and cytoplasm
Vera Gorbunova, Ph.D.
Vera Gorbunova, Ph.D.
Professor

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Gorbunova Lab

Biology
Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.
Elizabeth Grayhack, Ph.D.
Elizabeth Grayhack, Ph.D.
Associate Professor

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Grayhack Lab

Biochemistry & Biophysics
Role of the genetic code in regulating protein synthesis and mRNA metabolism in <em>Saccharomyces cerevisiae</em>.
Alan Grossfield, Ph.D.
Alan M. Grossfield, Ph.D.
Associate Professor

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Grossfield Lab

Biochemistry & Biophysics
Investigating membranes and membrane proteins via computer simulation
Jeffrey Hayes, Ph.D.
Jeffrey J. Hayes, Ph.D.
Professor
Chair

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William A. Bernhard Memorial Lab

Hayes Lab

Biochemistry & Biophysics
DNA structure; chromatin; protein-DNA interactions
Clara Kielkopf, Ph.D.
Clara L. Kielkopf, Ph.D.
Associate Professor

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Kielkopf Lab

Biochemistry & Biophysics
Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Hartmut Land, Ph.D.
Hartmut Land, Ph.D.
Professor
Chair

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Land Lab

Biomedical Genetics
Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Xin Li, Ph.D.
Xin Zhiguo Li, Ph.D.
Assistant Professor

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Li Lab

Biochemistry & Biophysics
Small non-coding RNA regulation in germ cells; paternal aging; transgenerational inheritance.
Lynne Maquat, Ph.D.
Lynne Maquat, Ph.D.
Professor

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Maquat Lab

Biochemistry & Biophysics
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
David Mathews, M.D., Ph.D.
David H. Mathews, M.D., Ph.D.
Associate Professor

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Mathews Lab

Biochemistry & Biophysics
Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Margot Mayer-Pröschel, Ph.D.
Margot Mayer-Pröschel, Ph.D.
Associate Professor

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Mayer-Pröschel Lab

Biomedical Genetics
Stem Cells in the mammalian CNS / Gestational insults and embryonic CNS development / Astrocyte dysfunction
Benjamin Miller, Ph.D.
Benjamin L. Miller, Ph.D.
Professor

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Benjamin Miller Lab

Dermatology
Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Joshua Munger, Ph.D.
Joshua C. Munger, Ph.D.
Associate Professor

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Munger Lab

Biochemistry & Biophysics
Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Mitchell O'Connell, Ph.D.
Mitchell O'Connell, Ph.D.
Assistant Professor

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O'Connell Lab

Biochemistry & Biophysics
Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Archibald Perkins, M.D., Ph.D.
Archibald S. Perkins, M.D., Ph.D.
Professor

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Perkins Lab

Pathology & Laboratory Medicine
Genes that impact the development of leukemias and other human malignancies
Eric Phizicky, Ph.D.
Eric Phizicky, Ph.D.
Professor

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Phizicky Lab

Biochemistry & Biophysics
tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Elaine Sia, Ph.D.
Elaine Sia, Ph.D.
Associate Professor

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Sia Lab

Biology
Mutagenesis and repair of the mitochondrial genome.
Harold Smith, Ph.D.
Harold C. Smith, Ph.D.
Professor

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Smith Lab

Biochemistry & Biophysics
RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.
Laurie Steiner, M.D.
Laurie A. Steiner, M.D.
Assistant Professor
Professor

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Steiner Lab

PediatricsMedicine
Pediatric Biomedical Research
Douglas Turner, Ph.D.
Douglas H. Turner, Ph.D.
Professor

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Turner Lab

Chemistry
Biophysical chemistry of RNA folding/stacking using NMR; RNA-targeted therapeutics
Joseph Wedekind, Ph.D.
Joseph E. Wedekind, Ph.D.
Professor

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Wedekind Lab

Biochemistry & Biophysics
Structure and function analysis of gene regulation by riboswitches and microRNAs as a basis for therapeutic development.
Peng Yao, Ph.D.
Peng Yao, Ph.D.
Assistant Professor

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Yao Lab

Medicine
Pathophysiological function of microRNAs, RNA-binding proteins, and defects in protein synthesis in cardiovascular disease; RNA riboswitch-like mechanisms of gene regulation
Yi-Tao Yu, Ph.D.
Yi-Tao Yu, Ph.D.
Professor

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Yu Lab

Biochemistry & Biophysics
RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.
Jiyong Zhao, Ph.D.
Jiyong Zhao, Ph.D.
Associate Professor

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Zhao Lab

Biomedical Genetics
Signal transduction and development of therapeutic agents in B-lymphomas; Cell cycle regulation
Jian Zhu, Ph.D.
Jian Zhu, Ph.D.
Assistant Professor

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Zhu Lab

Microbiology & Immunology
Host-virus interactions, particularly for HIV and herpes viruses