Xin Bi, Ph.D.
|Chromatin-mediated regulation of gene expression in eukaryotes.|
Dirk Bohmann, Ph.D.
Bohmann LabBiomedical Genetics
|The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease|
Paul S. Brookes, Ph.D.
|Mitochondria and free radicals in cardiac ischemia-reperfusion|
Michael D. Bulger, Ph.D.
|Chromatin domains and long-range activation by enhancers|
J. Scott Butler, Ph.D.
Butler LabMicrobiology & Immunology
|Regulation of Gene Expression by Targeted Degradation of RNA|
Gloria Culver, Ph.D.
|Assembly of the <em>E. coli</em> 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.|
Ian Dickerson, Ph.D.
|Molecular mechanisms of neuropeptide signal transduction|
Mark E. Dumont, Ph.D.
Dumont LabBiochemistry & Biophysics
|Signal transduction; membrane protein structure, yeast molecular biology|
Dmitri N. Ermolenko, Ph.D.
Ermolenko LabBiochemistry & Biophysics
|Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.|
Sina Ghaemmaghami, Ph.D.
|Molecular mechanisms of prion propagation and pathogenesis|
David S. Goldfarb, Ph.D.
|Molecular mechanisms that control the exchange of molecules and information between the nucleus and cytoplasm|
Vera Gorbunova, Ph.D.
|Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.|
Elizabeth Grayhack, Ph.D.
Grayhack LabBiochemistry & Biophysics
|Role of the genetic code in regulating protein synthesis and mRNA metabolism in <em>Saccharomyces cerevisiae</em>.|
Alan M. Grossfield, Ph.D.
Grossfield LabBiochemistry & Biophysics
|Investigating membranes and membrane proteins via computer simulation|
Jeffrey J. Hayes, Ph.D.
William A. Bernhard Memorial Lab
Hayes LabBiochemistry & Biophysics
|DNA structure; chromatin; protein-DNA interactions|
Clara L. Kielkopf, Ph.D.
Kielkopf LabBiochemistry & Biophysics
|Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.|
Hartmut Land, Ph.D.
Land LabBiomedical Genetics
|Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism|
Xin Zhiguo Li, Ph.D.
Li LabBiochemistry & Biophysics
|Small non-coding RNA regulation in germ cells; paternal aging; transgenerational inheritance.|
Mahin Maines, Ph.D.
Maines LabBiochemistry & Biophysics
|Heme oxygenases and second messenger gases: CO and NO.|
Lynne Maquat, Ph.D.
Maquat LabBiochemistry & Biophysics
|RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases. |
David H. Mathews, M.D., Ph.D.
Mathews LabBiochemistry & Biophysics
|Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.|
Margot Mayer-Pröschel, Ph.D.
Mayer-Pröschel LabBiomedical Genetics
|Stem Cells in the mammalian CNS / Gestational insults and embryonic CNS development / Astrocyte dysfunction|
Benjamin L. Miller, Ph.D.
Benjamin Miller LabDermatology
|Carbohydrate and protein recognition, molecular design, and biomolecular sensing|
Joshua C. Munger, Ph.D.
Munger LabBiochemistry & Biophysics
|Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.|
Mitchell O'Connell, Ph.D.
O'Connell LabBiochemistry & Biophysics
|Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development|
Archibald S. Perkins, M.D., Ph.D.
Perkins LabPathology & Laboratory Medicine
|Genes that impact the development of leukemias and other human malignancies|
Eric Phizicky, Ph.D.
Phizicky LabBiochemistry & Biophysics
|tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.|
Elaine Sia, Ph.D.
|Mutagenesis and repair of the mitochondrial genome.|
Harold C. Smith, Ph.D.
Smith LabBiochemistry & Biophysics
|RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.|
Laurie A. Steiner, M.D.
|Pediatric Biomedical Research|
Douglas H. Turner, Ph.D.
|Biophysical chemistry of RNA folding/stacking using NMR; RNA-targeted therapeutics|
Joseph E. Wedekind, Ph.D.
Wedekind LabBiochemistry & Biophysics
|Structure and function analysis of gene regulation by riboswitches and microRNAs as a basis for therapeutic development.|
Peng Yao, Ph.D.
|Pathophysiological function of microRNAs, RNA-binding proteins, and defects in protein synthesis in cardiovascular disease; RNA riboswitch-like mechanisms of gene regulation|
Yi-Tao Yu, Ph.D.
Yu LabBiochemistry & Biophysics
|RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.
Jiyong Zhao, Ph.D.
Zhao LabBiomedical Genetics
|Signal transduction and development of therapeutic agents in B-lymphomas; Cell cycle regulation|
Jian Zhu, Ph.D.
Zhu LabMicrobiology & Immunology
|Host-virus interactions, particularly for HIV and herpes viruses|