Faculty Because we are an institute-based (CTSI) and not a department-based Ph.D. program, we are able to recruit qualified faculty from all basic, clinical, and health sciences Ph.D. programs at the University of Rochester to serve as mentors for our predoctoral candidates. Representative faculty engaged in training in the Translational Biomedical Science Ph.D. program include: Jeffery Bazarian, M.D., M.P.H. (Emergency Medicine) - Research focus is on the diagnosis and consequences of concussions and traumatic brain injury in athletes. Nancy Bennett, M.D. (Medicine and Public Health Sciences) - Research focus is on population science and community interventions related to the prevention of communicable and chronic diseases. Danielle Benoit, Ph.D. (Biomedical Engineering) - Research projects are at the interface of medicine and engineering, with an emphasis on precisely controlling biomaterial functionality and architecture to treat diseases, control cell behavior, or answer fundamental biological questions. Deborah Cory-Slechta, Ph.D. (Environmental Medicine) – Behavioral effects of environmental toxins Stephen Dewhurst, Ph.D. (Microbiology and Immunology) – Host adaptation by emerging influenza viruses; HIV vaccine development; development of therapies for neuron-AIDS Robert Dirksen, Ph.D. (Pharmacology & Physiology) – Structural biology of the functional properties of muscle calcium channels; pathophysiology of muscle calcium channels Ann M. Dozier, Ph.D. (Public Health Sciences) - Current research and fieldwork focus in on program evaluation methods including integration of qualitative and quantitative research methods and on maternal child related health outcomes. Roman A. Eliseev, M.D., Ph.D. (Orthopaedics) - Research focus is on mitochondria, the "powerhouses" of the cell, to understand how cell metabolism determines cell fate and how it can be manipulated for the purposes of prevention and therapies, in particular using mesenchymal stem cells, common precursors of osteoblasts, chondrocytes, and adipocytes. Kevin Fiscella, M.D., M.P.H. (Family Medicine) Research interests are in the area of racial and socioeconomic disparities in health status, the effects of poverty on family function, and health services to underserved populations, particularly those at risk for cancer and heart disease. Steve Georas, M.D. (Medicine) – Mechanisms of dendritic cell and T cell activation in allergic diseases; defining molecular pathways by which allergens and particulate matter activate dendritic cells and influences allergen-specific immunity Francis Gigliotti, M.D. (Pediatrics) – Immunopathogenesis of Pneumocystis carinii pneumonia; understanding the surface structure of Pneumocystis carinii and its role in host-parasite interactions Robert Holloway, M.D., M.P.H. (Neurology) – Healthcare services delivery and reimbursement; medical and societal care for the patient with chronic neurological disease Karl Kieburtz, M.D., M.P.H. (Neurology) – Clinical trials methodology for novel experimental therapeutic strategies; clinical testing of therapeutic strategies for movement disorders Coeli Lopes, Ph.D. (Medicine) Studies mechanisms of heart function and cardiac arrhythmias, via the modulation of a cardiac potassium current and the effect of genetic mutations linked to Long QT syndrome. Michael McDermott, Ph.D. (Biostatistics and Computational Biology) – Order-restricted inference for developing novel approaches to hypothesis-testing problems involving order-constrained parameters; dose-response studies and clinical trials with multiple endpoints Joseph M. Miano, Ph.D. (Medicine) - Research focus is on the vascular smooth muscle cell and how this cell type's differentiation program is controlled through both key transcription factor binding sites and long noncoding RNAs. Jonathan Mink, M.D., Ph.D. (Neurology) - Research focuses on three areas: 1) on the function of the basal ganglia in normal control of movement and the pathophysiology of basal ganglia disorders characterized by abnormal involuntary movement; 2) on disease modifying therapeutics of Juvenile Neuronal Ceroid Lipofuscinosis (Batten Disease), a neurodegenerative disease of childhood; and 3) on the impact of Tourette Syndrome on children, their families, and the community. Craig Morrell, DVM, Ph.D. (Medicine) Studies two major functions of platelets: hemostastis/thrombosis and an immune regulatory function. Ekaterina I. Noyes, Ph.D. (Surgery and Public Health Sciences) – Cost-effectiveness studies in medicine and health; health services utilization in geriatric illness; quality of life assessment, medical decision-making, and analysis of clinical trials David Oakes, Ph.D. (Biostatistics and Computational Biology) – Clinical trial design; design and analysis studies of potential disease-modifying treatments M. Kerry O’Banion, M.D., Ph.D. (Neurobiology & Anatomy) – Role of inflammation in neurodegenerative disease; prostaglandin metabolism in the central nervous system John Olschowka, Ph.D. (Neurobiology & Anatomy) - Current research focus is on inflammation of the central nervous system following trauma, stroke, seizures, infection or radiation. Gary Paige, M.D., Ph.D. (Neurobiology & Anatomy) – Integration and processing of multisensory information in the nervous system to maintain and respond to spatial orientation James Palis, M.D. (Pediatrics/Hematology-Oncology) - Research focus is on the ontogeny of mammalian hematopoietic systems, erythroid precursor self-renewal and erythroid lineage differentiation, and response of the hematopoietic system to ionizing radiation. J. Edward Puzas, Ph.D. (Orthopaedics) - Research focus is on the consequences of heavy metal exposure on fracture healing and the Wnt/b-catenin signaling pathway, as well as osteoarthritis and inflammation. Nina Schor, M.D., Ph.D. (Pediatrics) – signal transduction in and design of novel therapeutic approaches to neural crest tumors; neurotrophin signaling in nervous system cancer and degenerative diseases Edward Schwarz, Ph.D. (Orthopaedics) – NFkB signal transduction and regulation of cellular response in innate and acquired immunity in joint and bone diseases Charles Thornton, M.D. (Neurology) Focused is on autosomal dominant forms of muscular dystrophy and myotonic dystrophy. Sally Thurston, Ph.D. (Biostatistics and Computational Biology) – Modeling multiple outcomes, correction for measurement error bias, exposure assessment; modeling multiple correlated environmental exposures; using biomarkers to improve cancer risk estimates. Edwin van Wijngaarden, Ph.D. (Public Health Sciences) - Research focus is on the potential health effects of occupational and toxic environmental exposures as they relate to the risk of developing cancer and neurologic conditions in both children and adults. John (Jack) Werren, Ph.D. (Biology) - Research focus is on evolutionary genetics using combined genetic, molecular and population approaches in parasitoid wasps as the model organism. David Yule, Ph.D. (Pharmacology & Physiology) – Understanding the mechanisms that underlie calcium signaling in pancreatic acinar cells and its role in the physiology and pathophysiology of exocrine cells in general Martin S. Zand, M.D., Ph.D. (Medicine/Nephrology) - Research focus is on understanding how B cells respond to vaccines and organ transplants to produce antibodies; the application of mathematical modeling to create individual treatment protocols for transplant patients and to improve population health and health care delivery.