Cardiovascular and Endocrine Systems
Mouse models of arterial injury are used
to understand the pathology of vascular
disease and to develop novel therapeutic
interventions. Illustration courtesy of
Dr. Joseph Miano.
Did you know that the endocrine system coordinates many of the activities of cells and tissues, particularly those related to growth, metabolism, and reproduction? Many human diseases including cancer, cardiovascular disease, diabetes, infertility and bone disease are associated with defects in the endocrine signaling pathways.
Several current pathology students have projects investigating the endocrine system and its dysfunction including: the link between obesity and insulin action; the influence of estrogen and testosterone on prostate cancer; vitamin B12 and prostate cancer; bone turnover and the local hormonal microenvironment; and hormonal control of neural stem cell lineage dependency.
An exciting option for our pathology students is to pursue their research in the Aab Cardiovascular Research Institute at the University of Rochester.
Metabolic disorders: Leptin deficiency
(right) results in obesity and insulin
resistance. Compare with lean animal
shown on left.
Faculty are engaged in research to study how the cardiovascular system develops and responds to physiological and pathological changes. The goal is to provide insight into new therapeutic approaches.
Opportunities are available to students interested in the fields of cardiovascular disease and endocrinology. These projects offer access to state-of-the-art techniques in genomics, genetics, animal models, stem cell biology and molecular biology.
Faculty investigating the cardiovascular and endocrine systems: