Research Faculty

Research Interest: Studying the human hematopoietic stem cells and their interaction with their microenvironment

Research Interest: Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.

Research Interest: The treatment and comprehensive care for children with leukemia and lymphoma, including acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML), as well as the care for children with other cancers and blood diseases.

Research Interest: Role of cancer stem cell interactions with their microenvironment in disease progression

Research Interest: The development of novel therapeutics for patients with chronic lymphocytic leukemia and lymphoma.

Research Interest: Malignant stem cell populations in myeloid neoplasms

Research Interest: Population science and community interventions related to the prevention of communicable and chronic diseases.

Research Interest: Therapeutic biomaterials development for tissue engineering and drug delivery with applications ranging from bone regeneration to antioral biofilm treatments

Research Interest: Molecular and Cellular Mechanisms that Control Tissue Homeostasis and Somatic Stem Cells

Research Interest: The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease

Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.

Research Interest: Cardioprotection against ischemia-reperfusion (IR) injury. Role of Mitochondria and metabolism in ischemic preconditioning and anesthetic preconditioning.

Research Interest: Multiphoton Laser Scanning Microscopy, novel in vivo imaging and measurement techniques, tumor biology, angiogenesis

Research Interest: Activation induced cytidine deaminase (AID) impact on Follicular lymphoma (FL) tumors as a prognostic factor for Diffuse Large B-cell lymphoma (DLBCL)

Research Interest: The development and application of high-end flow cytometric assays to support the research programs of members of the URMC community

Research Interest: Cellular and Molecular Mechanisms of Microenvironmental Regulation of Hematopoietic Stem Cells in the Bone Marrow

Research Interest: The role of plant-based nutrition as a therapy in various diseases

Research Interest: Newly diagnosed and relapsed Hodgkin lymphoma, mantle cell lymphoma, diffuse large B cell lymphoma ,and peripheral T cell lymphoma

Research Interest: Contribution of stem cells to the maturation, regeneration and lifelong maintenance of skeletal muscle in growth aging and cancer

Research Interest: Androgen receptor / Steroid hormones function and pathophysiology in the Prostate

Research Interest: Radiation Oncology

Research Interest: Diffuse optics for in vivo cancer detection, diagnosis and therapy monitoring

Research Interest: The role and regulation of T cell responding to pathogens and tumors.

Research Interest: Understanding the toxicological and biochemical properties of nanomaterial interactions with skin and the immune system; develop in vivo models to investigate nanoparticle skin penetration mechanisms, and develop novel biosensors to improve transdermal drug delivery and tissue engineering approaches.

Research Interest: Influenza Viruses; Virus Polymerase HIV Vaccine Development; NeuroAIDS Research

Research Interest: Tissue characterization, inverse problems, breast imaging, elastography, cardiovascular disease, molecular imaging, ultrasound, and MRI

Research Interest: Role of Mitochondria in regulation of cell fate in normal stem cells and cancer cells

Research Interest: Bioorganic chemistry, chemical biology, and biomolecular engineering and evolution

Research Interest: Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages.

Research Interest: Photodynamic Therapy of Cancer and Microbial Infections

Research Interest: Differentiation of CD4 T lymphocytes in infectious and autoimmune disease

Research Interest: Immunity to Tumor Antigens.

Research Interest: Development of novel therapies for patients with lymphoma

Research Interest: Role of inflammatory mediators in bone marrow microenvironmental dysfunction during hematologic malignancies

Research Interest: Cancer control, particularly in the development, implementation, and dissemination of mHealth behavioral interventions to prevent and manage treatment- and cancer-related toxicities in cancer survivors, with a specific focus in cardiovascular complications from cancer treatment

Research Interest: Dr. Gerber is a tumor immunologist whose laboratory focuses on harnessing the immune system to recognize and kill cancerous cells. His lab uses an immunotherapeutic approach to enhance the efficacy of chemo/radiotherapies to treat both primary and metastatic malignancies. He is also the Co-Director of the Center for Tumor Immunology Research.

Research Interest: Microbial pathogens and the impact of human microbial flora on human health and disease.

Research Interest: Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.

Research Interest: Androgen Effects on Reproduction and Cancer

Research Interest: Understanding the roles of antioxidants in cancer

Research Interest: The molecular biology and genetics of pancreatic and biliary tract cancers

Research Interest: Early origins research, linking in utero environment to later life health and educational attainment

Research Interest: Utilization and costs of nursing home residents; Organization and management of nursing homes; Veterans Health Administration Geriatrics and Extended Care Data and Analyses Center; Evaluation of implemented programs; Big Data systems and infrastructure for efficient analyses of health care utilization and costs.

Research Interest: Understanding clinical, psychological, and biological mechanisms of cognitive difficulties in cancer patients

Research Interest: Factors that lead to health disparities among sexual and gender minority populations, specifically disparities in cancer-related health outcomes and psychological distress

Research Interest: Radiogenomics - the study of genetic factors that are associated with increased risk of developing late effects from radiotherapy used in treatment of cancer

Research Interest: Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.

Research Interest: Innate and adaptive immune responses and cancer immunotherapy

Research Interest: To ameliorate the symptoms of cancer and its treatment by leveraging an understanding how the brain processes the state of the body.

Research Interest: Adult stem cell biology; Tissue engineering and regenerative medicine; Embryonic tendon development; Scarless wound healing

Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism

Research Interest: Delineating mechanisms by which environmental exposures during different life stages alter immune function; discovering how environmental factors modulate epigenetic programming of the developing immune system, and the consequences of these changes on susceptibility to infectious, allergic, or autoimmune disease later in life.

Research Interest: Extracellular vesicles (Evs), Exosomes, for their roles in cancer development, progression and response to treatment in Urology cancers.

Research Interest: To determine the role of Six family transcription factors in the resistance of neuroblastoma to chemotherapeutic agents.

Research Interest: Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation

Research Interest: Cell Mediated Immunity to Tumors

Research Interest: Finding hidden groups and their meanings; latent variable modeling; methods and techniques for Bayesian solutions.

Research Interest: RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.

Research Interest: Development of Novel, Clinically Applicable Ultrasound Imaging Techniques

Research Interest: Developing methods to estimate gene regulatory networks from gene perturbation experiments

Research Interest: Smoking Cessation in special populations, Technology/Web Assisted Risk Behavior Intervention and Dissemination of effective interventions to physician practices

Research Interest: Analysis of gene regulatory networks in cancer; role of immunogenetics in transplant

Research Interest: Understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation.

Research Interest: Prostate and Bladder cancer

Research Interest: Understanding the role of cancer stem cells in the progression of brain tumors

Research Interest: Ovarian cancer biomarker research for the early detection and management of ovarian cancer

Research Interest: The regulation of cytokine responses of human and mouse T-cell subsets in infections asthma, allergy and autoimmunity

Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.

Research Interest: The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.

Research Interest: Neuro stem cell biology and medicine, developing pharmacological and cell based approaches to peripheral and spinal cord injury.

Research Interest: Defining neuro-inflammatory processes that contribute to pathology and disease progression in Alzheimer's disease, as well as late CNS effects following radiation exposure

Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development

Research Interest: Behavioral medicine and outcomes management include tobacco use and smoking interventions, obesity prevention and exercise

Research Interest: Protective and regenerative strategies for salivary gland function and radiation therapies.

Research Interest: Cellular and Molecular events underlying the ontogeny of the hematopoietic system.

Research Interest: The use of nutritional supplementation and exercise to treat the symptoms and side effects of cancer and its related treatment

Research Interest: Genetic mechanisms in acute myeloid leukemia and myelodysplastic syndrome with focus on the zinc finger oncoprotein EVI1

Research Interest: Biostatistics and Computational Biology

Research Interest: Redox signaling mechanism of Proinflammatory gene expression in pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants.

Research Interest: Using a comparative biology approach to advance immunotoxicology, leveraging the amphibian Xenopus and the pox-like ranavirus FV3, to address long-term effects of water pollutants on immune cell development and on antiviral immunity across the lifespan.

Research Interest: Urologic malignancies

Research Interest: Inflammatory bone loss as seen in rheumatoid arthritis, infections, tumor metastasis and wear debris induced osteolysis around prosthetic implants

Research Interest: Utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development in both normal and disease states

Research Interest: Circadian disruption, Cigarette smoke-induced chromatin modifications, cellular senescence and DNA damage/repair

Research Interest: Multiple roles of virus-specific Band T cells in determining the outcome of viral infection of the respiratory tract. Long term protective effect of immunological mechanisms.

Research Interest: Cancer epigenetics: the role of DNA methylation and chromatin in driving cancer phenotypes and as a target for therapeutic intervention

Research Interest: Discovering the effects of high (therapeutic) and low (environmentally-relevant) doses of radiation and their interactions with other toxic elements, such as commonly encountered infections, and better understanding differential effects of radiation in adults versus children.

Research Interest: Optogenetics to study the roles of Reactive Oxygen Species (ROS) in mitochondrial physiology and stress signaling.

Research Interest: Uncovering the biological mechanisms of radiation-induced skin toxicities

Research Interest: Genetic defects in kidney cancer cells and how these defects cause the disease

Research Interest: Regulation of bone cell function in inflammatory bone loss

Research Interest: Role of the estrogen receptor (ER) and androgen receptor (AR) in urological diseases, including prostate cancer, bladder cancer, benign prostatic hyperplasia (BPH) and male fertility.

Research Interest: RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.

Research Interest: Lymphoid Malignancy Research

Research Interest: Mechanisms of hematopoietic stem cells (HSC) and leukemia initiating cells (LIC) regulations