Research Interest: Dr. Heather Adams is a pediatric neuropsychologist who seeks to understand the developmental and behavioral impacts of rare genetic disorders.
Self-motion perception and adaptability of vestibular perception
Research Interest: Creating embodied and intelligent interfaces that transcend learning, communication and wellbeing for people with diverse abilities and backgrounds.
Photodynamic therapy and medical image processing
Understanding the health of children with medical complexity including children with IDD in a family context. He is studying the family, community, and health system factors that support family and caregiver resilience to better understand these children’s quality of life and healthcare utilization.
Research Interest: How HIV-1 can disrupt normal cognitive functions by altering homeostasis between microglia and synaptic networks
Includes ischemic and hemorrhagic stroke, brain aneurysms, cranial and spinal vascular malformations, moyamoya disease, and carotid atherosclerosis. He offers patients both endovascular and open microsurgical treatments for cerebrovascular disease.
Research Interest: Neurocognitive and communication deficits in autism and other developmental disabilities
Research Interest: Generic equivalence of anti-epilepsy drugs. Technology for healthcare
Research Interest: Signaling transduction mechanisms in the vascular system
Includes open cerebrovascular and endovascular treatment for spinal and cerebrovascular disease including stroke, aneurysms, AVMs, carotid/vertebral disease and trigeminal neuralgia.
Research Interest: Lysosomal and mitochondrial dysfunction in neurodegenerative diseases
Focuses upon neurologic disorders in resource-limited tropical settings.
Research Interest: Focus on understanding how specific neuronal circuits in the early visual system encode visual information and how attention impacts the encoding of visual information.
Multiphoton Laser Scanning Microscopy, novel in vivo imaging and measurement techniques, tumor biology, angiogenesis
Research Interest: Stroke rehabilitation
Research Interest: Histology, Human anatomy, Microscopy, Problem-based learning, neurodegenerative diseases, and Medical Education Research
Auditory Neuroscience; neurophysiological, behavioral, and computational studies of hearing; signal processing for hearing aids.
Research Interest: Molecular basis of glucose sensing in the brain and beta cells
Research Interest: Defining the impact of environmental chemicals (e.g., metals and air pollution) on brain development and behavior, with emphasis on attributable risk to neurodevelopmental disorders.
Research Interest: The interaction of vision, the vestibular system, and human disease on motion perception.
Biomedical ultrasound, acoustics, lithotripsy, biological effects of ultrasound.
Research Interest: Visual neuroscience; multi-sensory integration; neural coding; linking neurons to perception
Research Interest: Molecular mechanisms of neuropeptide signal transduction
Research Interest: Molecular Mechanisms of Calcium Signaling in Striated Muscle
Research Interest: How we process social information, make meaningful social connections, and how these processes vary across the full spectrum of health and psychiatric illness with a particular focus on schizophrenia-spectrum disorders using behavioral and neuroimaging (e.g., fMRI) methods.
Research Interest: Methodologies that lead to constructing the optimal sequence of treatments in chronic diseases where patients are monitored and treated throughout their life.
Flexible allocation of the brain’s limited processing resources in attention, perception, and working memory
Research Interest: Vulvar Disease, Vulvodynia, Interstitial Cystitis
Basic neurophysiology of schizophrenia and autism
Research Interest: Human neurophysiology in Aging and Alzheimer’s Disease, Dyslexia, Autism, Lysosomal Storage disorders, and sports concussions
Research Interest: Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Research Interest: Anatomy and neurochemistry of brain regions associated with symptoms in major psychiatric illnesses
Identifing molecular regulators of long-range trafficking of protein cargoes to distinct sub-domains of polarized cells, such as neurons
Mechanisms supporting conceptual processing, language, and action function in patients with brain tumor or epilepsy.
Medical, Graduate, and Undergraduate Education
Research Interest: Understanding the neural mechanisms that transform nociceptive input to painful perceptions in humans and how these mechanisms change in chronic pain
Research Interest: Molecular mechanisms and potential pharmacological and gene therapeutic interventions for neurologic disease associated with HIV-1 infection of the central nervous system.
Research Interest: Identify the expression patterns of the major categories of stem and progenitor cells of the adult human brain and to use that information to define the signaling pathways that distinguish one progenitor from another, as well as those that distinguish brain tumor stem and progenitor cells from their normal counterparts.
Understanding the neural mechanisms that mediate sensation and action with our hands.
Research Interest: Certified Deaf Interpreters’ experiences working with language deprivation Deaf individuals in medical settings, and Deaf population health and language deprivation.
Basal ganglia and degenerative diseases
Basic biological mechanisms of circadian synchrony and entrainment in health and disease. Understanding how circadian rhythms and sleep can enhance glymphatic, neuronal, and cerebrovascular function.
Research Interest: To define the transcriptional programs driving selective vulnerability and delayed neuron loss after stroke
Research Interest: Understanding of the underlying molecular mechanism in myotonic dystrophy type 1 and type 2.
Research Interest: Uncovering neuro-immune mechanisms driving synapse and neuron turnover as well as microglia dysregulation throughout the lifespan
Investigating if/how the production of rapid, coordinated movements requires control circuitry that can bypass sensory feedback delays by providing an estimate of the consequences resulting from a motor command.
Understanding the mechanisms by which the extracellular matrix protein, fibronectin, affects cell and tissue functions that are critical for wound repair. We study both the structural mechanisms and intracellular signaling events that mediate cell and tissue responses to matrix fibronectin. In turn, we are using this information to develop novel technologies for tissue engineering, and therapeutic approaches to promote tissue regeneration in chronic wounds.
Research Interest: Technology assessment and cost-effectiveness of neurological practices and policies, methods to improve the quality and safety of medical care, and conflicts of interest in research and practice
Synaptic pharmaco-physiology of vestibular efferent-afferent interactions
Chia (George) Hsu, Ph.D.
Research Assistant Professor
Programmed Cell Death (PCD) in cardiovascular disease (CVD). While great progress has been achieved in the unveiling of the molecular mechanisms of PCD, a new level of complexity, with important therapeutic implications, has begun to emerge. I am particularly interested in Pyroptosis, a highly inflammatory form of lytic PCD, and Ferroptosis, a form of PCD involved in metabolic imbalance and the perturbation of redox homeostasis.
In both pediatric epilepsy and general child neurology.
Neural mechanisms of visual recovery after stroke; optical correlates and molecular substrates of corneal wound healing and nerve regeneration; LIRIC
Research Interest: Understanding clinical, psychological, and biological mechanisms of cognitive difficulties in cancer patients
Research Interest: Relating symptomatic treatments to Parkinson’s disease patient outcomes and self-reported symptom burden
Research Interest: Statistical methodology for biomedical and public health applications including semi-parametric and non-parametric methods in missing data problems, measurement error, and survival analysis.
Research Interest: Molecular mechanisms of Neurodegeneration
Research Interest: G protein coupled receptor signaling and modulation of ion channels in neurons
Visual perceptual alterations in psychosis, behavioral psychophysics, eye-tracking, functional neuroimaging.
Research Interest: How the performance of liquid metal batteries depends on transport in their liquid layers
To ameliorate the symptoms of cancer and its treatment by leveraging an understanding how the brain processes the state of the body.
Research Interest: The biology of neural progenitor cells in developing and adult mammalian brain
Research Interest: The electrophysiology of human sensation, perception and cognition, especially in naturalistic environments.
Research Interest: Influence of environmental factors on the development and function of the immune system
Peripheral nerve regeneration/degeneration and vascularized composite allotransplantation.
Research Interest: Developing innovative models for delivery behavioral health service for medical and surgical patients and prevention of neuropsychiatric morbidity (e.g. delirium, depression, and dementia) after major surgery among the elders.
Research Interest: Neurobiology of glaucoma, molecular processes that lead to retinal ganglion cell death.
Optimizing the understanding, diagnosis and treatment of movement disorders with the use of neurophysiological techniques, and developing sustainable international collaborations that promote global equity in neurological education, research and patient care.
Research Interest: Role of cochlear outer hair cells in hearing and hearing loss
Pediatric neuromuscular disorders
Research Interest: Mechanisms of neurotransmitter receptor function
Research Interest: Auditory and multisensory processing in human listeners, using behavioral and electrophysiological methods.
Research Interest: Glia-neuron interactions during synaptic plasticity in health and disease
Research Interest: Identification of different stem and precursor cell pools in CNS that may be critical for cell replacement therapies or are targets of insults that lead to developmental pathologies.
Research Interest: Human Anatomy, Histology, Embryology, Neuroanatomy, Neuroprosthetics
Cell Motility, and Quantitative light microscopy
Investigation of the molecules, receptors, and neural circuits that influence social interactions, including the actions of mammalian pheromones
Key areas of clinical specialization and research have included Neuroimaging, Head and Neck imaging, Musculoskeletal MRI, MR and CT angiography.
Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Martha Mock, PhD
Professor (Clinical), Associate Dean for Academic Affairs, and Director of the Center for Disability and Education
College-age adults with intellectual disabilities
Research Interest: Attention multisensory integration sensory and perceptual processing executive function
Research Interest: Effect of the Microbiome/Virome on Mucosal and Systemic Inflammation in Health and Disease
Research Interest: Human Structure and Function
Research Interest: The basic biology of glial cells in the CNS and the role of astrocytes in several neurological diseases, including stroke, spinal cord injury, epilepsy, tremor, and ALS. Research is aimed at defining new strategies for the treatment of neurological diseases that target astrocytic dysfunction.
Research Interest: Vestibular anatomy and physiology, recovery from vestibular injury, vestibular control of head unrestrained gaze.
Research Interest: Neuro stem cell biology and medicine, developing pharmacological and cell based approaches to peripheral and spinal cord injury.
The neural computations that enable the perception of natural sounds, such as speech and music
Research Interest: Defining neuro-inflammatory processes that contribute to pathology and disease progression in Alzheimer's disease, as well as late CNS effects following radiation exposure
Research Interest: The mechanisms by which early stress exposures, including prenatal maternal anxiety and caregiving stress, may persistently shape children's behavioral and biological health
Research Interest: Mechanisms of neuroinflammation and neurodegeneration within the CNS, primarily Glial Cells and Vascular components of the brain.
Research Interest: Orphan G protein coupled receptors in brain
and visual systems
Research Interest: Pediatric Neurology, Human Genetics
Research Interest: Experimental and Computational Approaches to Sensory Perception
Research Interest: Gary D. Paige, MD, PhD, was the Kilian J. and Caroline F. Schmitt Professor and Chair of Neurobiology & Anatomy at the University of Rochester Medical Center, also holding joint appointments in Neurology, Ophthalmology, Otolaryngology, Biomedical Engineering, and Brain & Cognitive Science. His research focused on how the brain integrates and plastically adapts sensory inputs from the outside world (visual and auditory) with the internal senses (vestibular and somatosensory) to guide meaningful behavior through a cluttered environment.
Cortical Circuitry Underlying Memory-Guided Sensory Decisions
Research Interest: Hypothalamus: neuropeptides, neuroplasticity, seizures
Research Interest: Mechanisms, consequences and treatment of sleep disturbance (Canandaigua VA Center of Excellence for Suicide Prevention)
Research Interest: Epilepsy, Spine, Brain Tumors
Research Interest: Visual psychophysics, high-resolution eye tracking and gaze-contingent technology to study spatial updating, foveal vision and control of attention and eye movements at the fine scale
Research Interest: Care and study of individuals with memory disorders
Research Interest: Neural circuit development and function; Genetic control of behavior; Sex differences in neurobiology
Using primarily human pluripotent stem cell models, we examine astrocyte development in normal and pathological conditions, the role of astrocytes in modulating response to injury or stress, the role of altered RNA processing and translation in neural development, and the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy.
Dalin T. Pulsipher, PhD
Neuroimaging, epilepsy, concussion, performance validity testing, and statistics. Current research involves sub-classification of seizure syndromes based on neuropsychological and quantitative MRI findings.
Research Interest: Neural control of finger movements; Experiment control systems.
Research Interest: Optical instrumentation, system engineering, optical coherence tomography
Research Interest: Organization and functions of the primate prefrontal cortex
Multisensory integration, social neuroscience and autism spectrum disorder
Chronic illness, Palliative Care, Long-term childhood cancer survivors, Bereavement, Integrative medicine, Biofeedback, Chronic pain, Bioethics
Research Interest: Understanding the genetic, cell biological and molecular basis for age-driven proteostatic deterioration
Research Interest: Developing technologies to measure blood flow in the living Eye to examine the condition of the retina in health and disease.
Research Interest: Neural Control of Individuated Finger Movements
Research Interest: Care of patients with movement disorders
Research Interest: Vestibular systems, motor learning, physiological models, multi-sensory integration
Research Interest: Pregnancy and Epilepsy
Research Interest: Neuron-neuroglia interactions
Impairments of perceptual function and organization in schizophrenia and other neuropsychiatric disorders, their relationship to symptom emergence (e.g., in terms of altered predictive coding, or altered contextual modulation) and the possibility of performing visual remediation of low- and mid-level visual disturbances in these conditions.
Exploring the understudied and novel mechanisms by which neuromodulators mediate the interactions between neurons, astrocytes, and microglia in both normal and disease states
Research Interest: Activity in groups of neurons is dynamically coordinated to control information processing for goal-directed action
Use virtual reality (VR), multimodal magnetic resonance imaging (MRI), and machine learning to elucidate the psychological and neural signatures of psychopathologies
Research Interest: Therapeutic and harmful substance use
Research Interest: Understanding neural mechanisms of human visual perception using psychophysics, brain stimulation and computational modeling. Current work includes the study of vision in stroke, low-vision, TBI, autism, cognitive aging and schizophrenia.
Novel technologies, practice-based research, and palliative care in individuals with Parkinson disease and other movement disorders
Retinal degeneration and maladaptive plasticity in inner retinal circuits.
Schizophrenia, with a particular interest in the pathophysiology of positive symptoms
Research Interest: Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.
Clinical applications of advanced neuroimaging techniques such as functional MRI (fMRI), MR Spectroscopy (MRS), Diffusion Tensor Imaging (DTI), morphometry, Arterial Spin Labeling (ASL) and Dynamic Susceptibility Contrast (DSC)
Research Interest: Intersection of MRI physics and neuroscience
Research Interest: Neural circuit mechanisms underlying cognitive control of sensorimotor functions
Research Interest: Menopause and memory problems, pregnancy and memory problems
Research Interest: Sensory regeneration of the inner ear, or hair-cell regeneration
Research Interest: Optogenetics to study the roles of Reactive Oxygen Species (ROS) in mitochondrial physiology and stress signaling.
Research Interest: Behavioral Pharmacology and Toxicology; Substance Abuse; Inhalation Toxicology; Medications for Urologic Disorders (urge incontinence, interstitial cystitis, pain)
Research Interest: Molecular and signaling mechanisms of synaptic plasticity in memory formation and mental health
Research Interest: Innate immunity, Host-microbial interactions, Immunoparasitology, Mucosal immunology